10 research outputs found
Die Ander Christliche Leich-Predigt; Gehalten bey hochanschlichem Leich-Conduct deß ... Herrn Johann-Eberharden von Stockheim/ zu Schwieberdingen/ Nippenburg/ Wanckheim und Eck/ Bewesnen Hochfürstl. Durchl. zu Würtemberg getreusten Obern Raths Praesidis ... Als selbiger Mittwochs den 26. Jan. dises 1676.sten Jahrs ... zu Stuttgardt in dem Herrn Jesu seelig verschieden ... und den Leibe nach folgenden Mittwochs den 2. Febr. ... nach Schwieberdingen ... abgeführt/ und daselbst ... beygesetzet worden
No full textSoldaten-Postille: Darinnen die Sonn- Fest- und Feyertags-Evangelia deutlich erkläret/ Die Pflichten der Kriegs-Leute daraus bewiesen/ Die Atheisterey .... Anderer Theil. Mit einem Nöthigen Vorbericht/ Historischen und Systematischen Register, und Zugabe einer Commendanten-Predigt
No full textM. Johann Friderich Flattichs/ Evangelischen Garnison-Predigers in der Reichs-Vestung Kehl Soldaten-Postille: Darinnen die Sonn- Fest- und Feyertags-Evangelia deutlich erkläret/ Die Pflichten der Kriegs-Leute daraus bewiesen/ Die Atheisterey/ Indifferentisterey/ und das profane Leben der Soldaten/ und alle Höhe/ die sich erhebt wider das Erkantniß Gottes/ aus Gottes Wort/ der gefunden Vernunfft/ den H. Kirchen-Vättern/ und den Symbolischen Büchern der Evangelischen Kirche bestritten und verstöret werden
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Soldaten-Postille: Darinnen die Sonn- Fest- und Feyertags-Evangelia deutlich erkläret/ Die Pflichten der Kriegs-Leute daraus bewiesen/ Die Atheisterey ... /Johann Friedrich Flattich. Erster Theil
No full textNovel WYL domain-containing transcriptional activator acts in response to genotoxic stress in rapidly growing mycobacteria
No full textAbstract The WYL domain is a nucleotide-sensing module that controls the activity of transcription factors involved in the regulation of DNA damage response and phage defense mechanisms in bacteria. In this study, we investigated a WYL domain-containing transcription factor in Mycobacterium smegmatis that we termed stress-involved WYL domain-containing regulator (SiwR). We found that SiwR controls adjacent genes that belong to the DinB/YfiT-like putative metalloenzymes superfamily by upregulating their expression in response to various genotoxic stress conditions, including upon exposure to H2O2 or the natural antibiotic zeocin. We show that SiwR binds different forms of single-stranded DNA (ssDNA) with high affinity, primarily through its characteristic WYL domain. In combination with complementation studies of a M. smegmatis siwR deletion strain, our findings support a role of the WYL domains as signal-sensing activity switches of WYL domain-containing transcription factors (WYL TFs). Our study provides evidence that WYL TFs are involved in the adaptation of bacteria to changing environments and encountered stress conditions
Publisher Correction: Novel WYL domain-containing transcriptional activator acts in response to genotoxic stress in rapidly growing mycobacteria
No full textNovel WYL domain-containing transcriptional activator acts in response to genotoxic stress in rapidly growing mycobacteria
No full textThe WYL domain is a nucleotide-sensing module that controls the activity of transcription factors involved in the regulation of DNA damage response and phage defense mechanisms in bacteria. In this study, we investigated a WYL domain-containing transcription factor in Mycobacterium smegmatis that we termed stress-involved WYL domain-containing regulator (SiwR). We found that SiwR controls adjacent genes that belong to the DinB/YfiT-like putative metalloenzymes superfamily by upregulating their expression in response to various genotoxic stress conditions, including upon exposure to H₂O₂ or the natural antibiotic zeocin. We show that SiwR binds different forms of single-stranded DNA (ssDNA) with high affinity, primarily through its characteristic WYL domain. In combination with complementation studies of a M. smegmatis siwR deletion strain, our findings support a role of the WYL domains as signal-sensing activity switches of WYL domain-containing transcription factors (WYL TFs). Our study provides evidence that WYL TFs are involved in the adaptation of bacteria to changing environments and encountered stress conditions.ISSN:2399-364
