Neurological changes post-covid-19 infection: signs and symptoms that remain

Since 2019, humanity has faced the pandemic outbreak of COVID-19 disease, caused by the new coronavirus, SARS-CoV-2. Respiratory symptoms of the disease were investigated and monitored worldwide, however, the nervous system lesions induced by COVID-19 did not receive as much attention. The aim of this study was to highlight the neurological alterations after infection of the new coronavirus, thus highlighting the symptoms that remained after Infection by SARS-CoV-2. The review shows relevant data on drugs and SARS-CoV-2, neurological alterations, complications and adverse effects related to COVID-19. At the time of writing this article, in mid-2022, SARS-CoV-2 is still spreading in several countries and infecting the population, leaving many people with temporary or permanent sequelae because of COVID-19

Health-related quality of life in patients with type 1 diabetes mellitus in the different geographical regions of Brazil : data from the Brazilian Type 1 Diabetes Study Group

Background: In type 1 diabetes mellitus (T1DM) management, enhancing health-related quality of life (HRQoL) is as important as good metabolic control and prevention of secondary complications. This study aims to evaluate possible regional differences in HRQoL, demographic features and clinical characteristics of patients with T1DM in Brazil, a country of continental proportions, as well as investigate which variables could influence the HRQoL of these individuals and contribute to these regional disparities. Methods: This was a retrospective, cross-sectional, multicenter study performed by the Brazilian Type 1 Diabetes Study Group (BrazDiab1SG), by analyzing EuroQol scores from 3005 participants with T1DM, in 28 public clinics, among all geographical regions of Brazil. Data on demography, economic status, chronic complications, glycemic control and lipid profile were also collected. Results: We have found that the North-Northeast region presents a higher index in the assessment of the overall health status (EQ-VAS) compared to the Southeast (74.6 ± 30 and 70.4 ± 19, respectively; p < 0.05). In addition, North- Northeast presented a lower frequency of self-reported anxiety-depression compared to all regions of the country (North-Northeast: 1.53 ± 0.6; Southeast: 1.65 ± 0.7; South: 1.72 ± 0.7; Midwest: 1.67 ± 0.7; p < 0.05). These findings could not be entirely explained by the HbA1c levels or the other variables examined. Conclusions: Our study points to the existence of additional factors not yet evaluated that could be determinant in the HRQoL of people with T1DM and contribute to these regional disparities

Alterações orais na alfa-manosidose: relato de caso

Alpha-Mannosidosis (-Manosidosis) is an extremely rare autosomal recessive disease worldwide, with an approximate prevalence of 1 in every 500,000 - 1,000,000 births. It is characterized by alpha-mannosidase deficiency, caused by mutations in the MAN2B1 gene, this lysosomal enzyme is responsible for the degradation of mannose rich oligosaccharides, its absence leads to the accumulation of this substance in all tissues causing functional disturbances of cells. This syndrome can affect individuals of any ethnicity, the main features of the disease are mental retardation, hearing loss and gross facial appearance, including oral characteristics and changes, which are not yet fully understood. The objective of this case report is to demonstrate a case of a patient with this disease, especially the oral manifestations found during the dental examination. A 17-year-old male patient, white -skinned, diagnosed at age 6 by a geneticist from an alpha-mannosidosis urine test, attended the Dental Radiology Center and treated the patient with Piquet Carneiro Polyclinic Special Needs - PPC /UERJ, complaining of erythematous gum. Extraoral physical examination revealed changes such as: gross facial appearance, intellectual disability, skeletal deformation and hearing loss. The intraoral physical examination showed spaced teeth, healthy and gingivitis. Radiographic examination revealed molar taurodontics. This report shows the oral manifestations of the disease, and the need for further reports, as the disease is extremely rareA Alfa-Manosidose (a-Manosidose), é uma doença autossómica recessiva extremamente rara em todo o mundo, com uma prevalência aproximada de 1 em cada 500000 - 1000000 nascimentos. É caracterizada pela deficiência de alfa-manosidase, causada por mutações no gene MAN2B1, esta enzima lisossômica é responsável pela degradação de oligossacarídeos ricos em manose, a sua ausência leva à acumulação dessa substância em todos os tecidos causando distúrbios funcionais das células. Essa síndrome pode afetar indivíduos de qualquer etnia, as principais características da doença são atraso mental, perda auditiva e aparência facial grosseira, incluindo características e alterações orais, que ainda não estão completamente esclarecidas. O objetivo deste relato de caso é demonstrar um caso de paciente com esta doença, especialmente as manifestações orais encontradas durante o exame odontológico. Paciente sexo masculino, 17 anos, cor de pele branca, diagnosticado aos 6 anos pela geneticista a partir de um exame de urina com Alfa-Manosidose, compareceu ao Núcleo de Radiologia Odontológica e Atendimento a Paciente com Necessidades Especiais da Policlínica Piquet Carneiro – PPC/UERJ, com queixa de gengiva eritematosa. Ao exame físico extraoral foram observadas alterações como: aparência facial grosseira, deficiência intelectual, deformação esquelética e perda auditiva. Ao exame físico intraoral foi observado dentes espaçados, hígidos e gengivite. Ao exame radiográfico foi observado taurodontia nos molares. Este relato mostra as manifestações orais da doença, e a necessidade de mais relatos, visto que a doença é extremamente rar

Dental Treatment under General Anesthesia in Patients with Special Needs Provided by Private and Public Healthcare Services—A Retrospective, Comparative Study

In special care dentistry, general anesthesia (GA) is considered as an alternative option to facilitate treatment for uncooperative patients with special needs (PSN) who require invasive dental interventions. Objective: to evaluate the profile of dental treatment procedures performed and the characteristics of PSN who underwent dental treatment under GA, provided by private and public healthcare providers. Methods: A retrospective, observational study involving a sample of 100 PSN treated in hospital and specialist secondary care settings. Demographic data and clinical information were collected. The analysis of data was performed using descriptive analysis and frequency statistical tests. Results: out of 100 participants, 63% of the PSN who received care in the private sector and the remaining 37% of PSN registered with public-funded care providers, aged 6 to 80 years old, were treated under GA. Autistic spectrum disorder was the most common medical diagnosis recorded (33%). More than half (52%) of the PSN treated by private care providers sought specialist care in an outpatient setting prior to GA vs. 5% of the PSN treated by public-funded providers. The utilization of sedation prior to GA was more common in the private sector. A vast majority (86%) of all subjects underwent multiple dental extractions (86%) and restorations (62%). Conclusions: comprehensive dental care under GA, which composes an integral part of special care dentistry, can be safely provided in a hospital setting, in both private and public sectors. While early intervention using sedation and behavioral management partially mitigates the need for dental care under GA, the vast majority of PSN may require dental treatment under GA in future to facilitate complex dental care

Interaction of stromal and microvascular components in keratocystic odontogenic tumors

Submitted by Ana Maria Fiscina Sampaio ([email protected]) on 2017-03-21T12:44:22Z No. of bitstreams: 1 Sousa Neto ES Interaction of....pdf: 1105446 bytes, checksum: 8a693c108a6bfd7f88997105886da938 (MD5)Approved for entry into archive by Ana Maria Fiscina Sampaio ([email protected]) on 2017-03-21T13:08:08Z (GMT) No. of bitstreams: 1 Sousa Neto ES Interaction of....pdf: 1105446 bytes, checksum: 8a693c108a6bfd7f88997105886da938 (MD5)Made available in DSpace on 2017-03-21T13:08:08Z (GMT). No. of bitstreams: 1 Sousa Neto ES Interaction of....pdf: 1105446 bytes, checksum: 8a693c108a6bfd7f88997105886da938 (MD5) Previous issue date: 2016Federal University of Bahia. School of Dentistry. Dentistry and Health Postgraduate Program. Salvador, BA, BrazilFederal University of Bahia. School of Dentistry. Dentistry and Health Postgraduate Program. Salvador, BA, Brazil / Federal University of Bahia. School of Dentistry. Department Dental Public Health. Salvador, BA, BrazilFederal University of Bahia. School of Dentistry. Dentistry and Health Postgraduate Program. Salvador, BA, Brazil / Fiocruz. Oswaldo Cruz Foundation. Human Pathology Postgraduate Program. Salvador, BA, Brazil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, BrasilFiocruz. Oswaldo Cruz Foundation. Human Pathology Postgraduate Program. Salvador, BA, BrazilFederal University of Bahia. School of Dentistry. Dentistry and Health Postgraduate Program. Salvador, BA, Brazil / Federal University of Bahia. School of Dentistry. Laboratory of Oral Surgical Pathology. Salvador, BA, BrazilFederal University of Bahia. School of Dentistry. Dentistry and Health Postgraduate Program. Salvador, BA, Brazil / Federal University of Bahia. School of Dentistry. Division of Periodontics. Salvador, BA, BrazilFederal University of Bahia. School of Dentistry. Dentistry and Health Postgraduate Program. Salvador, BA, Brazil / Federal University of Bahia. School of Dentistry. Department of Oral and Maxillofacial Surgery. Salvador, BA, BrazilUniversity of Catania. Department of Medical and Surgical Sciences. Catania, ItalyFederal University of Bahia. School of Dentistry. Dentistry and Health Postgraduate Program. Salvador, BA, Brazil / Fiocruz. Oswaldo Cruz Foundation. Human Pathology Postgraduate Program. Salvador, BA, Brazil / Federal University of Bahia. School of Dentistry. Laboratory of Oral Surgical Pathology. Salvador, BA, Brazil /Little is known about the interaction of stromal components in odontogenic tumors. Thus, the aim of this study was to investigate mast cells (MCs), myofibroblasts, macrophages, and their possible association with angiogenesis and lymphangiogenesis in keratocystic odontogenic tumors (KCOTs). MATERIAL AND METHODS: Thirty cases of KCOTs were included and analyzed by immunohistochemistry for mast cell tryptase, a-SMA, CD34, CD163, and D240. For comparative purpose, 15 radicular cysts (CRs) and 7 pericoronal follicles (PFs) were included. RESULTS: There was an increase in MCs for RCs and this difference was significant when they were compared to KCOTS and PFs. A significant increase in the density of MFs was observed for KCOTs when compared to RCs and PFs (P = 0.00). No significant difference in CD163- positive macrophages (P = 0.084) and CD34-positive vessels (P = 0.244) densities was observed between KCOTs, RCs, and PFs, although KCOTs showed a higher density of all proteins. Significant difference in lymphatic vessel density was observed for KCOTs when compared to RCs and PFs (P = 0.00). Positive correlation was observed between mast cell tryptase and CD34 in KCOTs (P = 0.025). CONCLUSIONS: A significant interaction between the MC population and CD34-positive vessels in KCOTs supported the hypothesis that MCs and blood vessels contribute to the stromal scaffold of KCO

Health-related quality of life in patients with type 1 diabetes mellitus in the different geographical regions of Brazil : data from the Brazilian Type 1 Diabetes Study Group

Background: In type 1 diabetes mellitus (T1DM) management, enhancing health-related quality of life (HRQoL) is as important as good metabolic control and prevention of secondary complications. This study aims to evaluate possible regional differences in HRQoL, demographic features and clinical characteristics of patients with T1DM in Brazil, a country of continental proportions, as well as investigate which variables could influence the HRQoL of these individuals and contribute to these regional disparities. Methods: This was a retrospective, cross-sectional, multicenter study performed by the Brazilian Type 1 Diabetes Study Group (BrazDiab1SG), by analyzing EuroQol scores from 3005 participants with T1DM, in 28 public clinics, among all geographical regions of Brazil. Data on demography, economic status, chronic complications, glycemic control and lipid profile were also collected. Results: We have found that the North-Northeast region presents a higher index in the assessment of the overall health status (EQ-VAS) compared to the Southeast (74.6 ± 30 and 70.4 ± 19, respectively; p < 0.05). In addition, North- Northeast presented a lower frequency of self-reported anxiety-depression compared to all regions of the country (North-Northeast: 1.53 ± 0.6; Southeast: 1.65 ± 0.7; South: 1.72 ± 0.7; Midwest: 1.67 ± 0.7; p < 0.05). These findings could not be entirely explained by the HbA1c levels or the other variables examined. Conclusions: Our study points to the existence of additional factors not yet evaluated that could be determinant in the HRQoL of people with T1DM and contribute to these regional disparities