X-shooter search for outgassing from Main Belt Comet P/2012 T1 (Pan-STARRS)

Context. Main Belt Comets are a recently identified population of minor bodies with stable asteroid-like orbits but cometary appearances. Sublimation of water ice is the most likely mechanism for their recurrent activity (i.e. dust tails and dust comae), although there has been no direct detection of gas. These peculiar objects could hold the key to the origin of water on Earth. Aims. In this paper we present a search for the gas responsible for lifting dust from P/2012 T1 (Pan-STARRS), and review previous attempts at such measurements. To date such searches have mainly been indirect, looking for the common cometary gas CN rather than gasses related to water itself. Methods. We use the VLT and X-shooter to search for emission from OH in the UV, a direct dissociation product of water. Results. We do not detect any emission lines, and place an upper limit on water production rate from P/2012 T1 of 8 − 9 × 1025 molecules s−1. This is similar to limits derived from observations using the Herschel space telescope. Conclusions. We conclude that the best current facilities are incapable of detecting water emission at the exceptionally low levels required to produce the observed activity in Main Belt Comets

Magnetically asymmetric interfaces in a (LaMnO3_3)/(SrMnO3_3) superlattice due to structural asymmetries

Polarized neutron reflectivity measurements of a ferromagnetic [(LaMnO$_3$)$_{11.8}$/(SrMnO$_3$)$_{4.4}$]$_6$ superlattice reveal a modulated magnetic structure with an enhanced magnetization at the interfaces where LaMnO$_3$ was deposited on SrMnO$_3$ (LMO/SMO). However, the opposite interfaces (SMO/LMO) are found to have a reduced ferromagnetic moment. The magnetic asymmetry arises from the difference in lateral structural roughness of the two interfaces observed via electron microscopy, with strong ferromagnetism present at the interfaces that are atomically smooth over tens of nanometers. This result demonstrates that atomic-scale roughness can destabilize interfacial phases in complex oxide heterostructures.Comment: 5 pages, 4 figure

Detailed analysis of the flow within the boundary layer and wake of a full-scale ship

This article presents a detailed numerical flow assessment of the boundary layer and wake of a full-scale cargo ship. The assessment was conducted using a sophisticated numerical approach that is able to resolve large turbulent scale vortices contained in the flow. The physical flow features of the boundary layer and wake investigated include mean-velocity, near-wall shear stress and vorticity fields. Also, the evolution of the wake from the thick boundary layer over the stern is displayed and analysed in the highest possible detail. Additionally, the detailed information extracted from the boundary layer and wake was the primary input to assess the overall hydrodynamic efficiency of the full-scale general cargo ship. The analysis method followed during this work has been a determinant factor for fast and efficient design of energy saving devices, propellers or rudders that work within the limits of the boundary layer of a ship. In particular, this thorough analysis avoided the necessity to use the commonly used practice of trial and error that is typically followed in the maritime industry

Spinal release of tumour necrosis factor activates c-Jun N-terminal kinase and mediates inflammation-induced hypersensitivity.

BackgroundMounting evidence points to individual contributions of tumour necrosis factor-alpha (TNF) and the c-Jun N-terminal kinase (JNK) pathway to the induction and maintenance of various pain states. Here we explore the role of spinal TNF and JNK in carrageenan-induced hypersensitivity. As links between TNF and JNK have been demonstrated in vitro, we investigated if TNF regulates spinal JNK activity in vivo.MethodsTNF levels in lumbar cerebrospinal fluid (CSF) were measured by enzyme-linked immunosorbent assay, spinal TNF gene expression by real-time polymerase chain reaction and TNF protein expression, JNK and c-Jun phosphorylation by western blotting. The role of spinal TNF and JNK in inflammation-induced mechanical and thermal hypersensitivity was assessed by injecting the TNF inhibitor etanercept and the JNK inhibitors SP600125 and JIP-1 intrathecally (i.t.). TNF-mediated regulation of JNK activity was examined by assessing the effect of i.t. etanercept on inflammation-induced spinal JNK activity.ResultsTNF levels were increased in CSF and spinal cord following carrageenan-induced inflammation. While JNK phosphorylation followed the same temporal pattern as TNF, c-jun was only activated at later time points. Intrathecal injection of TNF and JNK inhibitors attenuated carrageenan-induced mechanical and thermal hypersensitivity. TNF stimulation induced JNK phosphorylation in cultured spinal astrocytes and blocking the spinal actions of TNF in vivo by i.t. injection of etanercept reduced inflammation-induced spinal JNK activity.ConclusionsHere we show that spinal JNK activity is dependent on TNF and that both TNF and the JNK signalling pathways modulate pain-like behaviour induced by peripheral inflammation

On the full scale and model scale cavitation comparisons of a Deep-V catamaran research vessel

In pushing for greener ships and more sustainable operations, designers and researchers are being challenged to increase vessel performance whilst reducing environmental impact. One topical, and a somewhat challenging aspect of this pursuit, is the reduction in Underwater Radiated Noise (URN). There are several European Collaborative Research Projects currently underway that aim to outline a framework for noise standards, amongst these projects is the Seventh Framework Project (FP7) “Suppression of Underwater Noise Induced by Cavitation” (SONIC) that has been tasked with concentrating on the URN from propeller cavitation; the main contributor to underwater noise generation. As one of the participants of the SONIC project the Newcastle University was involved in the full-scale trials and model-scale propeller testing campaign. The full-scale trial conducted on board Newcastle University’s catamaran research vessel R/V The Princess Royal involved cavitation observations though the dedicated observation windows above each propeller, Propeller Excited Vibration measurements as well as the off-board URN measurements. The model scale tests were made in The Emerson Cavitation Tunnel using a 1:3.5 scale dummy model of the starboard side demi-hull of the vessel. These tests tried to emulate, as best as possible, the full-scale trials in terms of measurement locations and viewing angles

Delta Doping of Ferromagnetism in Antiferromagnetic Manganite Superlattices

We demonstrate that delta-doping can be used to create a dimensionally confined region of metallic ferromagnetism in an antiferromagnetic (AF) manganite host, without introducing any explicit disorder due to dopants or frustration of spins. Delta-doped carriers are inserted into a manganite superlattice (SL) by a digital-synthesis technique. Theoretical consideration of these additional carriers show that they cause a local enhancement of ferromagnetic (F) double-exchange with respect to AF superexchange, resulting in local canting of the AF spins. This leads to a highly modulated magnetization, as measured by polarized neutron reflectometry. The spatial modulation of the canting is related to the spreading of charge from the doped layer, and establishes a fundamental length scale for charge transfer, transformation of orbital occupancy and magnetic order in these manganites. Furthermore, we confirm the existence of the canted, AF state as was predicted by de Gennes [P.-G. de Gennes, Phys. Rev. 118, 141 (1960)], but had remained elusive

Heavy Crane Foundations on Soft Clay

A very large mobile crane was used to lift a 3,150 kN steam generator through the roof of the containment building of a nuclear power plant. The maximum load on the crane was 19.8 MN, giving a track pressure of almost 600 kPa. Soil conditions were stiff clay underlain by softer clay. This paper describes the bearing capacity and settlement analysis performed to establish a suitable shallow foundation for the crane. The foundation load test confirmed that soil conditions had been adequately defined and that the foundation design was satisfactory

Development and evaluation of a Gal4-mediated LUC/GFP/GUS enhancer trap system in Arabidopsis

BACKGROUND: Gal4 enhancer trap systems driving expression of LacZ and GFP reporters have been characterized and widely used in Drosophila. However, a Gal4 enhancer trap system in Arabidopsis has not been described in the primary literature. In Drosophila, the reporters possess a Gal4 upstream activation sequence (UAS) as five repeats (5XUAS) and lines that express Gal4 from tissue specific enhancers have also been used for the ectopic expression of any transgene (driven by a 5XUAS). While Gal4 transactivation has been demonstrated in Arabidopsis, wide use of a trap has not emerged in part because of the lack of detailed analysis, which is the purpose of the present study. RESULTS: A key feature of this study is the use of luciferase (LUC) as the primary reporter and rsGFP-GUS as secondary reporters. Reporters driven by a 5XUAS are better suited in Arabidopsis than those containing a 1X or 2X UAS. A 5XUAS-LUC reporter is expressed at high levels in Arabidopsis lines transformed with Gal4 driven by the full, enhanced 35S promoter. In contrast, a minimum 35S (containing the TATA region) upstream of Gal4 acts as an enhancer trap system. Luciferase expression in trap lines of the T1, T2, and T3 generations are generally stable but by the T4 generation approximately 25% of the lines are significantly silenced. This silencing is reversed by growing plants on media containing 5-aza-2'-deoxycytidine. Quantitative multiplex RT-PCR on the Gal4 and LUC mRNA indicate that this silencing can occur at the level of Gal4 or LUC transcription. Production of a 10,000 event library and observations on screening, along with the potential for a Gal4 driver system in other plant species are discussed. CONCLUSION: The Gal4 trap system described here uses the 5XUAS-LUC and 5XUAS rsGFP-GUS as reporters and allows for in planta quantitative screening, including the rapid monitoring for silencing. We conclude that in about 75% of the cases silencing is at the level of transcription of the Gal4 transgene and is at an acceptable frequency to make the Gal4 trap system in Arabidopsis of value. This system will be useful for the isolation and comprehensive characterization of specific reporter and driver lines