Making financial markets safer for consumers: lessons from consumer goods markets and beyond

In the wake of the mortgage meltdown, policymakers are discussing how best to protect consumers in financial product markets.Consumer protection ; Financial markets

Line-Graph Lattices: Euclidean and Non-Euclidean Flat Bands, and Implementations in Circuit Quantum Electrodynamics

Materials science and the study of the electronic properties of solids are a major field of interest in both physics and engineering. The starting point for all such calculations is single-electron, or non-interacting, band structure calculations, and in the limit of strong on-site confinement this can be reduced to graph-like tight-binding models. In this context, both mathematicians and physicists have developed largely independent methods for solving these models. In this paper we will combine and present results from both fields. In particular, we will discuss a class of lattices which can be realized as line graphs of other lattices, both in Euclidean and hyperbolic space. These lattices display highly unusual features including flat bands and localized eigenstates of compact support. We will use the methods of both fields to show how these properties arise and systems for classifying the phenomenology of these lattices, as well as criteria for maximizing the gaps. Furthermore, we will present a particular hardware implementation using superconducting coplanar waveguide resonators that can realize a wide variety of these lattices in both non-interacting and interacting form

Protocol for the United Kingdom Rotator Cuff Study (UKUFF) : a randomised controlled trial of open and arthroscopic rotator cuff repair

This project was funded by the NIHR Health Technology Assessment programme (project number 05/47/02). J. L. Rees has received a grant from Oxford University which is related to this paper. J. Dawson reports that Oxford University has received a grant from HTA which is related to this paper, as well as a study grant.Peer reviewedPublisher PD

Implications of CoGeNT and DAMA for Light WIMP Dark Matter

In this paper, we study the recent excess of low energy events observed by the CoGeNT collaboration, and discuss the possibility that these events originate from the elastic scattering of a light (m_DM ~ 5-10 GeV) dark matter particle. We find that such a dark matter candidate may also be capable of generating the annual modulation reported by DAMA, as well as the small excess recently reported by CDMS, without conflicting with the null results from other experiments, such as XENON10. A dark matter interpretation of the CoGeNT and DAMA observations favors a region of parameter space that is especially attractive within the context of Asymmetric Dark Matter models. In such models, the cosmological dark matter density arises from the baryon asymmetry of the universe, naturally leading to the expectation that m_DM ~ 1-10 GeV. We also discuss neutralino dark matter from extended supersymmetric frameworks, such as the NMSSM. Lastly, we explore the implications of such a dark matter candidate for indirect searches, and find that the prospects for detecting the neutrino and gamma ray annihilation products of such a particle to be very encouraging.Comment: 16 pages, 14 figures. v2: references added, fig 4 and surrounding discussion modified

Compound C inhibits nonsense-mediated RNA decay independently of AMPK

The nonsense mediated RNA decay (NMD) pathway safeguards the integrity of the transcriptome by targeting mRNAs with premature translation termination codons (PTCs) for degradation. It also regulates gene expression by degrading a large number of non-mutant RNAs (including mRNAs and noncoding RNAs) that bear NMD-inducing features. Consequently, NMD has been shown to influence development, cellular response to stress, and clinical outcome of many genetic diseases. Small molecules that can modulate NMD activity provide critical tools for understanding the mechanism and physiological functions of NMD, and they also offer potential means for treating certain genetic diseases and cancer. Therefore, there is an intense interest in identifying small-molecule NMD inhibitors or enhancers. It was previously reported that both inhibition of NMD and treatment with the AMPK-selective inhibitor Compound C (CC) induce autophagy in human cells, raising the possibility that CC may be capable of inhibiting NMD. Here we show that CC indeed has a NMD-inhibitory activity. Inhibition of NMD by CC is, however, independent of AMPK activity. As a competitive ATP analog, CC does not affect the kinase activity of SMG1, an essential NMD factor and the only known kinase in the NMD pathway. However, CC treatment down-regulates the protein levels of several NMD factors. The induction of autophagy by CC treatment is independent of ATF4, a NMD target that has been shown to promote autophagy in response to NMD inhibition. Our results reveal a new activity of CC as a NMD inhibitor, which has implications for its use in basic research and drug development

IVOA Recommendation: SAMP - Simple Application Messaging Protocol Version 1.3

SAMP is a messaging protocol that enables astronomy software tools to interoperate and communicate. IVOA members have recognised that building a monolithic tool that attempts to fulfil all the requirements of all users is impractical, and it is a better use of our limited resources to enable individual tools to work together better. One element of this is defining common file formats for the exchange of data between different applications. Another important component is a messaging system that enables the applications to share data and take advantage of each other's functionality. SAMP builds on the success of a prior messaging protocol, PLASTIC, which has been in use since 2006 in over a dozen astronomy applications and has proven popular with users and developers. It is also intended to form a framework for more general messaging requirements

Global bifurcation of homoclinic trajectories of discrete dynamical systems

We prove the existence of an unbounded connected branch of nontrivial homoclinic trajectories of a family of discrete nonautonomous asymptotically hyperbolic systems parametrized by a circle under assumptions involving the topological properties of the asymptotic stable bundles.Comment: 28 pages. arXiv admin note: text overlap with arXiv:1111.140