The use of provenance in information retrieval

The volume of electronic information that users accumulate is steadily rising. A recent study [2] found that there were on average 32,000 pieces of information (e-mails, web pages, documents, etc.) for each user. The problem of organizin

Design and develop virtual reality games utilising the 'anti‐gravity' arm support for stroke rehabilitation therapy

Approximately 16,000 Australians each year are left with a disability as a direct consequence of stroke. The number of strokes that occur in Australia each year is increasing, putting a strong reliance on home and community based rehabilitation having an increasing role in the rehabilitation process. Strokes are caused by a sudden disruption to the flow of blood to parts of the brain. If an artery is blocked, the brain cells (neurons) cannot make enough energy and will eventually stop working. Stroke affects patients in a number of different ways depending on the severity of the stroke and the type of stroke in which the patient suffers from. There two main types of disabilities that are a result of stroke: hemiplegia and hemiparesis. The project aims to develop a virtual reality application to assist in the rehabilitation of the upper extremities of stoke patients who suffer from hemiparesis. The project will endeavour to design a low cost, home based system that will motivate patients by creating intermediate goals that can be adopted into the rehabilitation process. The project will utilise the 'anti‐gravity' arm support system to lessen the affect of reduced muscle strength and control. The project objectives are to: - Research relevant background information on the effects of stroke. - Research traditional methods of stroke rehabilitation and assessment of rehabilitation progression. - Implement hardware and program for position data acquisition. - Develop virtual reality application for exercise and rehabilitation assessment. The project is based around detecting the movement or the patients arm and creating a computer representation. This has been performed by monitoring the potentiometers on the 'anti‐gravity' arm support utilizing the PIC AXE microcontroller. The microcontroller to converts the signal into a digital integer and transfers them to the computer via a serial link. The games were designed around conventional physiotherapy exercises allowing the user to complete the exercises in a self motivating environment. The games were developed in both 2D and 3D environments utilizing Microsoft's XNA games studio. The project has been successful in accurately representing a user's movement within a virtual environment. This has been tested by use of advance 3D mapping techniques; however the project is still not a stage where it is practical to perform clinical trials

Propofol Waste Reduction in the Operating Room

Propofol is the most wasted intravenous medication used in anesthesia in the operating room (OR) (More, Dabhade, & Ghongane, 2015). Propofol, a sedative anxiolytic, is utilized as a continuous infusion in sedation procedures, or monitored anesthesia care (Nagelhout & Elisha, 2014). Inherent to these infusions is unpredictability in determining the amount of medication needed for the duration of a procedure. This project implemented customized propofol preparation charts consistent with the literature to aid the administering professional in determining the approximate milliliter requirement for the duration of a procedure. The pre-intervention steps consisted of voluntary data collection among anonymous anesthesia professionals in the OR regarding infusion characteristics. Patient weight, a commonly used infusion rate, and the duration of procedure were used in the calculation within customized charts. Post-intervention data collection was conducted in the same manner to capture the impact of the charts. This data was measured simultaneously at a local healthcare system’s main hospital and separate surgery center site, and waste reduction from baseline data was found to be 49% and 60%, respectively. This project was conducted over a four-month period and translates to a potential yearly savings of greater than $15,000 for the healthcare system. A culture of waste reduction leads to savings for anesthesia departments and healthcare organizations as a whole

Integrating rich user feedback into intelligent user interfaces

The potential for machine learning systems to improve via a mutually beneficial exchange of information with users has yet to be explored in much detail. Previously, we found that users were willing to provide a generous amount of rich feedback to machine learning systems, and that the types of some of this rich feedback seem promising for assimilation by machine learning algorithms. Following up on those findings, we ran an experiment to assess the viability of incorporating real-time keyword-based feedback in initial training phases when data is limited. We found that rich feedback improved accuracy but an initial unstable period often caused large fluctuations in classifier behavior. Participants were able to give feedback by relying heavily on system communication in order to respond to changes. The results show that in order to benefit from the user’s knowledge, machine learning systems must be able to absorb keyword-based rich feedback in a graceful manner and provide clear explanations of their predictions

Hyaluronic Acid: Its Versatile Use in Ocular Drug Delivery with a Specific Focus on Hyaluronic Acid-Based Polyelectrolyte Complexes.

Extensive research is currently being conducted into novel ocular drug delivery systems (ODDS) that are capable of surpassing the limitations associated with conventional intraocular anterior and posterior segment treatments. Nanoformulations, including those synthesised from the natural, hydrophilic glycosaminoglycan, hyaluronic acid (HA), have gained significant traction due to their enhanced intraocular permeation, longer retention times, high physiological stability, inherent biocompatibility, and biodegradability. However, conventional nanoformulation preparation methods often require large volumes of organic solvent, chemical cross-linkers, and surfactants, which can pose significant toxicity risks. We present a comprehensive, critical review of the use of HA in the field of ophthalmology and ocular drug delivery, with a discussion of the physicochemical and biological properties of HA that render it a suitable excipient for drug delivery to both the anterior and posterior segments of the eye. The pivotal focus of this review is a discussion of the formation of HA-based nanoparticles via polyelectrolyte complexation, a mild method of preparation driven primarily by electrostatic interaction between opposing polyelectrolytes. To the best of our knowledge, despite the growing number of publications centred around the development of HA-based polyelectrolyte complexes (HA-PECs) for ocular drug delivery, no review articles have been published in this area. This review aims to bridge the identified gap in the literature by (1) reviewing recent advances in the area of HA-PECs for anterior and posterior ODD, (2) describing the mechanism and thermodynamics of polyelectrolyte complexation, and (3) critically evaluating the intrinsic and extrinsic formulation parameters that must be considered when designing HA-PECs for ocular application

Irish Ocean Climate and Ecosystem Status Report

Summary report for Irish Ocean Climate & Ecosystem Status Report also published here. This Irish Ocean Climate & Ecosystem Status Summary for Policymakers brings together the latest evidence of ocean change in Irish waters. The report is intended to summarise the current trends in atmospheric patterns, ocean warming, sea level rise, ocean acidification, plankton and fish distributions and abundance, and seabird population trends. The report represents a collaboration between marine researchers within the Marine Institute and others based in Ireland’s higher education institutes and public bodies. It includes authors from Met Éireann, Maynooth University, the University of Galway, the Atlantic Technological University, National Parks and Wildlife, Birdwatch Ireland, Trinity College Dublin, University College Dublin, Inland Fisheries Ireland, The National Water Forum, the Environmental Protection Agency, and the Dundalk Institute of Technology.This report is intended to summarise the current trends in Ireland’s ocean climate. Use has been made of archived marine data held by a range of organisations to elucidate some of the key trends observed in phenomena such as atmospheric changes, ocean warming, sea level rise, acidification, plankton and fish distributions and abundance, and seabirds. The report aims to summarise the key findings and recommendations in each of these areas as a guide to climate adaptation policy and for the public. It builds on the previous Ocean Climate & Ecosystem Status Report published in 2010. The report examines the recently published literature in each of the topic areas and combines this in many cases with analysis of new data sets including long-term time series to identify trends in essential ocean variables in Irish waters. In some cases, model projections of the likely future state of the atmosphere and ocean are presented under different climate emission scenarios.Marine Institut

Sorting the Wheat From the Chaff: Programmed Cell Death as a Marker of Stress Tolerance in Agriculturally Important Cereals

Conventional methods for screening for stress-tolerant cereal varieties rely on expensive, labour-intensive field testing and molecular biology techniques. Here, we use the root hair assay (RHA) as a rapid screening tool to identify stress-tolerant varieties at the early seedling stage. Wheat and barley seedlings had stress applied, and the response quantified in terms of programmed cell death (PCD), viability and necrosis. Heat shock experiments of seven barley varieties showed that winter and spring barley varieties could be partitioned into their two distinct seasonal groups based on their PCD susceptibility, allowing quick data-driven evaluation of their thermotolerance at an early seedling stage. In addition, evaluating the response of eight wheat varieties to heat and salt stress allowed identification of their PCD inflection points (35°C and 150 mM NaCl), where the largest differences in PCD levels arise. Using the PCD inflection points as a reference, we compared different stress effects and found that heat-susceptible wheat varieties displayed similar vulnerabilities to salt stress. Stress-induced PCD levels also facilitated the assessment of the basal, induced and cross-stress tolerance of wheat varieties using single, combined and multiple individual stress exposures by applying concurrent heat and salt stress in a time-course experiment. Two stress-susceptible varieties were found to have low constitutive resistance as illustrated by their high PCD levels in response to single and combined stress exposure. However, both varieties had a fast, adaptive response as PCD levels declined at the other time-points, showing that even with low constitutive resistance, the initial stress cue primes cross-stress tolerance adaptations for enhanced resistance even to a second, different stress type. Here, we demonstrate the RHA’s suitability for high-throughput analysis (~4 days from germination to data collection) of multiple cereal varieties and stress treatments. We also showed the versatility of using stress-induced PCD levels to investigate the role of constitutive and adaptive resistance by exploring the temporal progression of cross-stress tolerance. Our results show that by identifying suboptimal PCD levels in vivo in a laboratory setting, we can preliminarily identify stress-susceptible cereal varieties and this information can guide further, more efficiently targeted, field-scale experimental testing

The StcE metalloprotease of enterohaemorrhagic Escherichia coli reduces the inner mucus layer and promotes adherence to human colonic epithelium ex vivo

Enterohaemorrhagic E. coli (EHEC) is a major foodborne pathogen and tightly adheres to human colonic epithelium by forming attaching/effacing lesions. To reach the epithelial surface, EHEC must penetrate the thick mucus layer protecting the colonic epithelium. In this study, we investigated how EHEC interacts with the intestinal mucus layer using mucin-producing LS174T colon carcinoma cells and human colonic mucosal biopsies. The level of EHEC binding and A/E lesion formation in LS174T cells was higher compared to mucin-deficient colon carcinoma cell lines, and initial adherence was independent of the presence of flagellin, E. coli common pilus or long polar fimbriae. While EHEC infection did not affect gene expression of secreted mucins, it resulted in reduced MUC2 glycoprotein levels. This effect was dependent on the catalytic activity of the secreted metalloprotease StcE which reduced the inner mucus layer and thereby promoted EHEC access and binding to the epithelium in vitro and ex vivo. Given the lack of efficient therapies against EHEC infection, StcE may represent a suitable target for future treatment and prevention strategies. This article is protected by copyright. All rights reserved