695 research outputs found
Pseudohomozygous dysfibrinogenemia
Abstract Hypodysfibrinogenemia (HD) is a heterogeneous disorder in which plasma fibrinogen antigen and function are both reduced but discordant. This report addresses the key clinical question of whether genetic analysis enables clinically useful subclassification of patients with HD. We report a new case and identify a further eight previously documented cases that have the laboratory features of HD but biallelic inheritance of quantitative and qualitative fibrinogen gene variants. The cases displayed both bleeding and thrombosis and sometimes had undetectable fibrinogen activity. In all cases, the predicted effect of the coinherited variants is reduced levels of circulating fibrinogen that is all dysfunctional. We propose the term pseudohomozygous dysfibrinogenemia for this subtype of recessively inherited HD that is distinct from the more commonly recognized monoallelic HD caused by a single fibrinogen gene variant
New results on GP Com
We present high resolution optical and UV spectra of the 46 min orbital
period, helium binary, GP Com. Our data contains simultaneous photometric
correction which confirms the flaring behaviour observed in previous optical
and UV data. In this system all lines show a triple peaked structure where the
outer two peaks are associated with the accretion disc around the compact
object. The main aim of this paper is to constrain the origin of the central
peak, also called ``central spike''. We find that the central spike contributes
to the flare spectra indicating that its origin is probably the compact object.
We also detect that the central spike moves with orbital phase following an
S-wave pattern. The radial velocity semiamplitude of the S-wave is ~10 km/s
indicating that its origin is near the centre of mass of the system, which in
this case lies very close to the white dwarf. Our resolution is higher than
that of previous data which allows us to resolve structure in the central peak
of the line. The central spike in three of the HeI lines shows another peak
blueshifted with respect to the main peak. We propose that one of the peaks is
a neutral helium forbidden transition excited in a high electron density
region. This forbidden transition is associated with the permitted one (the
stronger peak in two of the lines). The presence of a high electron density
region again favours the white dwarf as their origin.Comment: 14 pages, 16 figures. Accepted for publication in A&
Fitting a 3D Morphable Model to Edges: A Comparison Between Hard and Soft Correspondences
We propose a fully automatic method for fitting a 3D morphable model to
single face images in arbitrary pose and lighting. Our approach relies on
geometric features (edges and landmarks) and, inspired by the iterated closest
point algorithm, is based on computing hard correspondences between model
vertices and edge pixels. We demonstrate that this is superior to previous work
that uses soft correspondences to form an edge-derived cost surface that is
minimised by nonlinear optimisation.Comment: To appear in ACCV 2016 Workshop on Facial Informatic
Enhancing the early student experience
This paper is concerned with identifying how the early student experience can be enhanced in order to improve levels of student retention and achievement. The early student experience is the focus of this project as the literature has consistently declared the first year to be the most critical in shaping persistence decisions. Programme managers of courses with high and low retention rates have been interviewed to identify activities that appear to be associated with good retention rates. The results show that there are similarities in the way programmes with high retention are run, with these features not being prevalent on programmes with low retention. Recommendations of activities that appear likely to enhance the early student experience are provided
Molecular evidence of Chlamydia pecorum and arthropod-associated Chlamydiae in an expanded range of marsupials
© 2017 The Author(s). The order Chlamydiales are biphasic intracellular bacterial pathogens infecting humans and domesticated animals. Wildlife infections have also been reported, with the most studied example being Chlamydia pecorum infections in the koala, an iconic Australian marsupial. In koalas, molecular evidence suggests that spill-over from C. pecorum infected livestock imported into Australia may have had a historical or contemporary role. Despite preliminary evidence that other native Australian marsupials also carry C. pecorum, their potential as reservoirs of this pathogen and other Chlamydia-related bacteria (CRBs) has been understudied. Mucosal epithelial samples collected from over 200 native Australian marsupials of different species and geographic regions across Australia were PCR screened for Chlamydiales. Previously described and genetically distinct C. pecorum genotypes and a range of 16S rRNA genotypes sharing similarity to different CRBs in the broader Chlamydiales order were present. One 16S rRNA Chlamydiales genotype recently described in Australian ticks that parasitise native Australian marsupials was also identified. This study provides further evidence that chlamydial infections are widespread in native fauna and that detailed investigations are required to understand the influence these infections have on host species conservation, but also whether infection spill-over plays a role in their epidemiology
Water Vapor Measurements by Howard University Raman Lidar during the WAVES 2006 Campaign
Retrieval of water vapor mixing ratio using the Howard University Raman Lidar is presented with emphasis on three aspects: i) performance of the lidar against collocated radiosondes and Raman lidar, ii) investigation of the atmospheric state variables when poor agreement between lidar and radiosondes values occurred and iii) a comparison with satellite-based measurements. The measurements were acquired during the Water Vapor Validation Experiment Sondes/Satellites 2006 field campaign. Ensemble averaging of water vapor mixing ratio data from ten night-time comparisons with Vaisala RS92 radiosondes shows on average an agreement within 10 % up to approx. 8 km. A similar analysis of lidar-to-lidar data of over 700 profiles revealed an agreement to within 20 % over the first 7 km (10 % below 4 km). A grid analysis, defined in the temperature - relative humidity space, was developed to characterize the lidar - radiosonde agreement and quantitatively localizes regions of strong and weak correlations as a function of altitude, temperature or relative humidity. Three main regions of weak correlation emerge: i) regions of low relative humidity and low temperature, ii) moderate relative humidity at low temperatures and iii) low relative humidity at moderate temperatures. Comparison of Atmospheric InfraRed Sounder and Tropospheric Emission Sounder satellites retrievals of moisture with that of Howard University Raman Lidar showed a general agreement in the trend but the formers miss a lot of the details in atmospheric structure due to their low resolution. A relative difference of about 20 % is usually found between lidar and satellites measurements
Non-Parametric Sequential Frame Decimation for Scene Reconstruction in Low-Memory Streaming Environments
Abstract not provide
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