Memantine Augmentation in a Down's Syndrome Adolescent with Treatment- Resistant Obsessive-Compulsive Disorder

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/140323/1/cap.2015.0073.pd

THE ECONOMIC CONSEQUENCES OF EUROPEAN UNION A Symposium on Some Policy Aspects. THE ECONOMIC AND SOCIAL RESEARCH INSTITUTE, DUBLIN, 1986

The papers published here, together with the Matthews paper, address some of the economic questions on which discussion of further European integration should be based. Will European prosperity bring Irish prosperity? Does a free market threaten traditional Irish industry, or aid new Irish industry, or both? How can a small peripheral economy survive and prosper in a monetary union? How much autonomy does an Irish government at present enjoy in monetary and fiscal policy? Are Ireland’s interests close to the Community average? Questions such as these are asked by politicians, who expect economists to answer them; economists tend to react by asking further questions, by demanding quantitative data on which to base their assessments. It is one of the positive points of these papers that the economists have been willing to be drawn out on some of these current issues of political economy, even if others remain to be tackled. I believe that the burden of these papers does not suggest any reason for doubting that in the long term it is in Ireland’s interest that the Community should be economically and politically strong, and that Ireland should be a full partner in that Community

Photometric and proper motion study of neglected open cluster NGC 2215

Optical UBVRI photometric measurements using the Faulkes Telescope North were taken in early 2011 and combined with 2MASS JHK$_s$ and WISE infrared photometry as well as UCAC4 proper motion data in order to estimate the main parameters of the galactic open cluster NGC 2215 of which large uncertainty exists in the current literature. Fitting a King model we estimate a core radius of 1.12$'\pm$0.04$'$ (0.24$\pm$0.01pc) and a limiting radius of $4.3'\pm$0.5$'$ (0.94$\pm$0.11pc) for the cluster. The results of isochrone fits indicates an age of $log(t)=8.85\pm0.10$ with a distance of $d=790\pm90$pc, a metallicity of $[Fe/H]=-0.40\pm0.10$ dex and a reddening of $E(B-V)=0.26\pm0.04$. A proportion of the work in this study was undertaken by Australian and Canadian upper secondary school students involved in the Space to Grow astronomy education project, and is the first scientific publication to have utilized our star cluster photometry curriculum materials.Comment: 10 pages, 9 Figures, 3 Table

Management of bovine tuberculosis in Michigan wildlife: Current status and near term prospects

Surveillance and control activities for bovine tuberculosis (bTB) in free-ranging Michigan white-tailed deer (Odocoileus virginianus) have now been underway for over a decade. Significant progress has been made, lowering apparent prevalence in deer in the core area by >60%, primarily via reduction of deer densities through hunting, and restrictions on public feeding and baiting of deer. These broad strategies of the Michigan Department of Natural Resources (MDNR), implemented with the cooperation of Michigan deer hunters, halved the deer population in the bTB endemic area. However, as hunters see fewer deer, their willingness to sustain aggressive harvests has waned, and public resentment of control measures has grown. During the past four years, apparent prevalence in core area deer has held approximately steady just below 2%. After bottoming out in 2004 at an estimated 10–12 deer/km2, deer numbers have since rebounded by ∼30%. Public compliance with baiting and feeding restrictions has been variable. In general, hunters in the core area do not perceive bTB as a problem, in spite of 13 years of MDNR outreach. To date, MDNR has expended more than US$23 million on TB-related activities. Of late, a substantial portion of that funding has been diverted to support other programs which have suffered from budget shortfalls. Livestock herd breakdowns continue to occur sporadically, averaging 3–4 per year 2005 to present. In total, 46 cattle and 4 captive deer herds have been diagnosed bTB positive statewide, the majority yielding only 1 positive animal. Five cattle herds were twice infected, one thrice. Michigan Department of Agriculture (MDA) policy emphasis has shifted towards obtaining producer support for wildlife risk mitigation and farm biosecurity. Funding has proven a limiting factor, with the majority of the US$63 million spent to date devoted to whole herd testing. Nevertheless, some initiatives justify cautious optimism. Promising research to support eventual vaccination of wild deer continues. Some hunters and landowners have begun to recognize the costs of high deer densities and supplemental feeding. A peninsula-wide ban on baiting and feeding was enacted. Some cattle producers, recognizing their precarious circumstances, have begun work to change long-held prevailing opinions among their peers about farm biosecurity. Yet formidable challenges remain, and evidence suggests that eradication of bTB, if it can be achieved, will take decades, and will require greater public and political resolve than has been demonstrated thus far

Antimicrobial Susceptibility Testing of Mycobacterium bovis Isolates from Michigan White-Tailed Deer during the 2009 Hunting Season

Michigan has had an ongoing outbreak of endemic Mycobacterium bovis which has been recognized within and sustained by its free-ranging white-tailed deer population since 1994. Worldwide, organisms within the Mycobacterium tuberculosis complex have exhibited the ability to develop resistance to antimicrobial agents, resulting in both the multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains of human tuberculosis. Michigan's Bovine Tuberculosis Working Group has conducted active antimicrobial susceptibility testing on wildlife isolates of the endemic M. bovis organism at five-year intervals to detect any emerging drug resistance patterns. The results of 33 white-tailed deer origin isolates collected from the 2009 hunting season are reported here. There continues to be no evidence of any drug resistance except for pyrazinamide resistance. These results are likely due to the lack of antibacterial treatment applied to either wildlife or domestic animals which would provide selection pressure for the development of drug resistance

Overt Mycobacterium avium subsp. paratuberculosis Infection: An Infrequent Occurrence in Archived Tissue from False TB Reactor Cattle in Michigan, USA

The objective of this study was to retrospectively determine whether or not cattle from the state of Michigan which were classified as bovine tuberculosis reactors, based on currently approved field and laboratory testing methods, were overtly infected with Mycobacterium avium subsp. paratuberculosis (MAP). Included in this study were 384 adult cattle submitted to the Diagnostic Center for Population and Animal Health over a seven-year period. Cattle were tested utilizing standard methods to confirm that all cattle were lesion and culture negative for infection with Mycobacterium bovis at postmortem examination. Retrospective analysis of formalin-fixed, paraffin-embedded sections of ileum and ileocecal lymph node were evaluated by histopathology, acid-fast staining, and PCR assays to detect MAP. Overall, only 1.04 percent of cattle showed overt infection with MAP on visual examination of sections of ileum and/or ileo-cecal lymph node. This increased slightly to 2.1 percent of cattle likely infected with MAP after additional testing using a PCR assay. Based on these results, we found no evidence that overt infection with MAP plays a major role in the false tuberculosis reactor test results for cattle examined in this study

Edwards thermodynamics of the jamming transition for frictionless packings: ergodicity test and role of angoricity and compactivity

This paper illustrates how the tools of equilibrium statistical mechanics can help to explain a far-from-equilibrium problem: the jamming transition in frictionless granular materials. Edwards ideas consist of proposing a statistical ensemble of volume and stress fluctuations through the thermodynamic notion of entropy, compactivity, X, and angoricity, A (two temperature-like variables). We find that Edwards thermodynamics is able to describe the jamming transition (J-point). Using the ensemble formalism we elucidate the following: (i)We test the combined volume-stress ensemble by comparing the statistical properties of jammed configurations obtained by dynamics with those averaged over the ensemble of minima in the potential energy landscape as a test of ergodicity. Agreement between both methods supports the idea of "thermalization" at a given angoricity and compactivity. (ii) A microcanonical ensemble analysis supports the idea of maximum entropy principle for grains. (iii) The intensive variables describe the approach to jamming through a series of scaling relations as A {\to} 0+ and X {\to} 0-. Due to the force-volume coupling, the jamming transition can be probed thermodynamically by a "jamming temperature" TJ comprised of contributions from A and X. (iv) The thermodynamic framework reveals the order of the jamming phase transition by showing the absence of critical fluctuations at jamming in observables like pressure and volume. (v) Finally, we elaborate on a comparison with relevant studies showing a breakdown of equiprobability of microstates.Comment: 22pages, 24 figure

Experimental Aerosol Inoculation and Investigation of Potential Lateral Transmission of Mycobacterium bovis in Virginia Opossum (Didelphis virginiana)

An endemic focus of Mycobacterium bovis (M. bovis) infection in the state of Michigan has contributed to a regional persistence in the animal population. The objective of this study was to determine if Virginia opossums (Didelphis virginiana) contribute to disease persistence by experimentally assessing intraspecies lateral transmission. One wild caught pregnant female opossum bearing 11 joeys (young opossum) and one age-matched joey were obtained for the study. Four joeys were aerosol inoculated with M. bovis (inoculated), four joeys were noninoculated (exposed), and four joeys plus the dam were controls. Four replicate groups of one inoculated and one exposed joey were housed together for 45 days commencing 7 days after experimental inoculation. At day 84 opossums were sacrificed. All four inoculated opossums had a positive test band via rapid test, culture positive, and gross/histologic lesions consistent with caseogranulomatous pneumonia. The exposed and control groups were unremarkable on gross, histology, rapid test, and culture. In conclusion, M. bovis infection within the inoculated opossums was confirmed by gross pathology, histopathology, bacterial culture, and antibody tests. However, M. bovis was not detected in the control and exposed opossums. There was no appreciable lateral transmission of M. bovis after aerosol inoculation and 45 days of cohabitation between infected and uninfected opossums

Histological Lesions in Mink Jaws are a Highly Sensitive Biomarker of Effect after Exposure to TCDD-like Chemicals: Field and Literature-based Confirmations

The mink (Mustela vison) is one of the most sensitive mammals to 2,3,7,8 tetrachlorodibenzo-p-dioxin (TCDD)-like chemicals. By literature review we established that a histological lesion of the jaw bone of mink, evidenced by squamous epithelial hyperplasia in the gingival tissue that forms nests or cords that infiltrate the periodontal ligament and alveolar bone causing osteolysis of the mandible and maxilla that could lead to squamous cell carcinoma, is the most sensitive known biomarker of effect following exposure of mink to TCDD-like chemicals. Lesions have been observed when total TCDD toxic equivalents (TEQ: dioxins, furans, co-planar polychlorinated biphenyls or PCBs) in liver exceed 40 ng/kg-ww or when total PCB exceeds 1,698 ng/g-ww. This is the second report of histological evidence of this lesion in wild-caught mink, and it is the first report of the lesion being grossly detectable in naturally exposed mink. Some mink living near the south shore of Lake Ontario (exposed to the lake’s food web) but not inland mink (not exposed to the lake’s food web) accumulate more than 40 ng total TEQ/kg or 2 1,698 ng total PCB/kg in liver. Because of its sensitivity, the jaw lesion biomarker is very useful for assessing the health of wildlife populations exposed to TCDD-like chemicals