Imaging diagnosis-computed tomography of traction bronchiectasis secondary to pulmonary fibrosis in a Patterdale Terrier

An 8-year-old, Patterdale terrier was referred for evaluation of tachypnoea, exercise intolerance, and weight loss. Computed tomographic images showed pneumomediastinum, diffuse pulmonary ground glass opacity, and marked dilatation of peripheral bronchi, but no evidence of thickened bronchial walls. The histopathologic diagnosis was diffuse pulmonary interstitial fibrosis, type II pneumocyte hyperplasia, and bronchiectasis. The lack of evidence of primary bronchitis supported a diagnosis of traction bronchiectasis. Traction bronchiectasis can occur as a sequela to pulmonary fibrosis in dogs. (C) 2016 American College of Veterinary Radiology

Natural age dispersion arising from the analysis of broken crystals, part I. Theoretical basis and implications for the apatite (U-Th)/He thermochronometer

Over the last decade major progress has been made in developing both the theoretical and practical aspects of apatite (U-Th)/He thermochronometry and it is now standard practice, and generally seen as best practice, to analyse single grain aliquots. These individual prismatic crystals are often broken and are fragments of larger crystals that have broken during mineral separation along the weak basal cleavage in apatite. This is clearly indicated by the common occurrence of only 1 or no clear crystal terminations present on separated apatite grains, and evidence of freshly broken ends when grains are viewed using a scanning electron microscope. This matters because if the 4He distribution within the whole grain is not homogeneous, because of partial loss due to thermal diffusion for example, then the fragments will all yield ages different from each other and from the whole grain age. Here we use a numerical model with a finite cylinder geometry to approximate 4He ingrowth and thermal diffusion within hexagonal prismatic apatite crystals. This is used to quantify the amount and patterns of inherent, natural age dispersion that arises from analysing broken crystals. A series of systematic numerical experiments were conducted to explore and quantify the pattern and behaviour of this source of dispersion using a set of 5 simple thermal histories that represent a range of plausible geological scenarios. In addition some more complex numerical experiments were run to investigate the pattern and behaviour of grain dispersion seen in several real data sets. The results indicate that natural dispersion of a set of single fragment ages (defined as the range divided by the mean) arising from fragmentation alone varies from c. 7% even for rapid (c. 10 ∘C/Ma), monotonic cooling to over 50% for protracted, complex histories that cause significant diffusional loss of 4He. The magnitude of dispersion arising from fragmentation scales with the grain cylindrical radius, and is of a similar magnitude to dispersion expected from differences in absolute grain size alone (spherical equivalent radii of 40 to 150 μm). This source of dispersion is significant compared with typical analytical uncertainties on individual grain analyses (c. 6%) and standard deviations on multiple grain analyses from a single sample (c. 10-20%). Where there is a significant difference in the U and Th concentration of individual grains (eU), the effect of radiation damage accumulation on 4He diffusivity (assessed using the RDAAM model of Flowers et al. (2009)) is the primary cause of dispersion for samples that have experienced a protracted thermal history, and can cause dispersion in excess of 100% for realistic ranges of eU conentration (i.e. 5-100 ppm). Expected natural dispersion arising from the combined effects of reasonable variations in grain size (radii 40-125 μm), eU concentration (5-150 ppm) and fragmentation would typically exceed 100% for complex thermal histories. In addition to adding a significant component of natural dispersion to analyses, the effect of fragmentation also acts to decouple and corrupt expected correlations between grain ages and absolute grain size and to a lesser extent between grain age and effective uranium concentration (eU). Considering fragmentation explicitly as a source of dispersion and analysing how the different sources of natural dispersion all interact with each other provides a quantitative framework for understanding patterns of dispersion that otherwise appear chaotic. An important outcome of these numerical experiments is that they demonstrate that the pattern of age dispersion arising from fragmentation mimics the pattern of 4He distribution within the whole grains, thus providing an important source of information about the thermal history of the sample. We suggest that if the primary focus of a study is to extract the thermal history information from (U-Th)/He analyses then sampling and analytical strategies should aim to maximise the natural dispersion of grain ages, not minimise it, and should aim to analyse circa 20-30 grains from each sample. The key observations and conclusions drawn here are directly applicable to other thermochronometers, such as the apatite, rutile and titanite U-Pb systems, where the diffusion domain is approximated by the physical grain size

First scattered light images of debris disks around HD 53143 and HD 139664

We present the first scattered light images of debris disks around a K star (HD 53143) and an F star (HD 139664) using the coronagraphic mode of the Advanced Camera for Surveys (ACS) aboard the Hubble Space Telescope (HST). With ages 0.3 - 1 Gyr, these are among the oldest optically detected debris disks. HD 53143, viewed ~45 degrees from edge-on, does not show radial variation in disk structure and has width >55 AU. HD 139664 is seen close to edge-on and has belt-like morphology with a dust peak 83 AU from the star and a distinct outer boundary at 109 AU. We discuss evidence for significant diversity in the radial architecture of debris disks that appears unconnected to stellar spectral type or age. HD 139664 and possibly the solar system belong in a category of narrow belts 20-30 AU wide. HD 53143 represents a class of wide disk architecture with characteristic width >50 AU.Comment: 7 pages, 3 figure

ΦCrAss001 represents the most abundant bacteriophage family in the human gut and infects Bacteroides intestinalis

peer-reviewedCrAssphages are an extensive and ubiquitous family of tailed bacteriophages, predicted to infect bacteria of the order Bacteroidales. Despite being found in ~50% of individuals and representing up to 90% of human gut viromes, members of this viral family have never been isolated in culture and remain understudied. Here, we report the isolation of a CrAssphage (ΦCrAss001) from human faecal material. This bacteriophage infects the human gut symbiont Bacteroides intestinalis, confirming previous in silico predictions of the likely host. DNA sequencing demonstrates that the bacteriophage genome is circular, 102 kb in size, and has unusual structural traits. In addition, electron microscopy confirms that ΦcrAss001 has a podovirus-like morphology. Despite the absence of obvious lysogeny genes, ΦcrAss001 replicates in a way that does not disrupt proliferation of the host bacterium, and is able to maintain itself in continuous host culture during several weeks

‘It’s not about disability, I want to win as many medals as possible’: The social construction of disability in high-performance coaching.

This article draws on the theoretical concepts of Pierre Bourdieu to provide a critical analysis of the social construction of disability in high-performance sport coaching. Data were generated using a qualitative cross-case comparative methodology, comprising 18 months of ethnographic fieldwork in high-performance disability sport, and interviews with coaches and athletes from a cross-section of Paralympic sports. We discuss how in both cases ‘disability’ was assimilated into the ‘performance logic’ of the sporting field as a means of maximising symbolic capital. Furthermore, coaches were socialised into a prevailing legitimate culture in elite disability sport that was reflective of ableist, performance-focused and normative ideologies about disability. In this article we unpack the assumptions that underpin coaching in disability sport, and by extension use sport as a lens to problematise the construction of disability in specific social formations across coaching cultures. In so doing, we raise critical questions about the interrelation of disability and sport

A Ring of Warm Dust in the HD 32297 Debris Disk

We report the detection of a ring of warm dust in the edge-on disk surrounding HD 32297 with the Gemini-N/MICHELLE mid-infrared imager. Our N'-band image shows elongated structure consistent with the orientation of the scattered-light disk. The Fnu(11.2 um) = 49.9+/-2.1 mJy flux is significantly above the 28.2+/-0.6 mJy photosphere. Subtraction of the stellar point spread function reveals a bilobed structure with peaks 0.5"-0.6" from the star. An analysis of the stellar component of the SED suggests a spectral type later than A0, in contrast to commonly cited literature values. We fit three-dimensional, single-size grain models of an optically thin dust ring to our image and the SED using a Markov chain Monte Carlo algorithm in a Bayesian framework. The best-fit effective grain sizes are submicron, suggesting the same dust population is responsible for the bulk of the scattered light. The inner boundary of the warm dust is located 0.5"-0.7" (~65 AU) from the star, which is approximately cospatial with the outer boundary of the scattered-light asymmetry inward of 0.5". The addition of a separate component of larger, cooler grains that provide a portion of the 60 um flux improves both the fidelity of the model fit and consistency with the slopes of the scattered-light brightness profiles. Previous indirect estimates of the stellar age (~30 Myr) indicate the dust is composed of debris. The peak vertical optical depths in our models (~0.3-1 x 1e-2) imply that grain-grain collisions likely play a significant role in dust dynamics and evolution. Submicron grains can survive radiation pressure blow-out if they are icy and porous. Similarly, the inferred warm temperatures (130-200 K) suggest that ice sublimation may play a role in truncating the inner disk.Comment: ApJ accepted, 8 pages, 4 figure

New Mexico Youth Risk & Resiliency 2015 Survey Results Report: Alcohol Use and Related Behaviors.

Alcohol is the most commonly used and abused drug by youth in the United States. Youth who drink alcohol before age 15 are six times more likely to develop alcohol dependence or abuse later in life than those who begin drinking at age 21 or older. Binge drinking (5 or more drinks on a single occasion) accounts for about 90% of the alcohol consumed by youth 12–20 years of age in the United States. The New Mexico Youth Risk & Resiliency Survey (NM-YRRS) includes questions about alcohol use, access, attitudes, and behaviors as well as protective (resiliency) factors that can help reduce these risky behaviors

New Mexico Youth Risk & Resiliency 2015 Survey Results Report: Drug Use and Related Behaviors.

New Mexico Youth Risk & Resiliency 2015 Survey Results Report: Drug Use and Related Behaviors. Epidemiology and Response Division, New Mexico Department of Health, School and Family Support Bureau, New Mexico Public Education Department, and the University of New Mexico Prevention Research Center