A laboratory study of iceberg side melting in vertically sheared flows

Author Posting. © American Meteorological Society, 2018. This article is posted here by permission of American Meteorological Society for personal use, not for redistribution. The definitive version was published in Journal of Physical Oceanography 48 (2018): 1367-1373, doi:10.1175/JPO-D-17-0185.1.An earlier study indicates that the side melting of icebergs subject to vertically homogeneous horizontal velocities is controlled by two distinct regimes, which depend on the melt plume behavior and produce a nonlinear dependence of side melt rate on velocity. Here, we extend this study to consider ice blocks melting in a two-layer vertically sheared flow in a laboratory setting. It is found that the use of the vertically averaged flow speed in current melt parameterizations gives an underestimate of the submarine side melt rate, in part because of the nonlinearity of the dependence of the side melt rate on flow speed but also because vertical shear in the horizontal velocity profile fundamentally changes the flow splitting around the ice block and consequently the velocity felt by the ice surface. An observational record of 90 icebergs in a Greenland fjord suggests that this effect could produce an average underestimate of iceberg side melt rates of 21%.A. F. was supported by NA14OAR4320106 from the National Oceanic and Atmospheric Administration, U.S. Department of Commerce. C. C. was supported by NSF OCE-1658079 and F. S. was supported by NSF OCE-1657601 and NSF PLR-1743693.2018-12-1

Nonlinear response of iceberg side melting to ocean currents

Author Posting. © American Geophysical Union, 2017. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Geophysical Research Letters 44 (2017): 5637–5644, doi:10.1002/2017GL073585.Icebergs calving into Greenlandic Fjords frequently experience strongly sheared flows over their draft, but the impact of this flow past the iceberg is not fully captured by existing parameterizations. We present a series of novel laboratory experiments to determine the dependence of submarine melting along iceberg sides on a background flow. We show, for the first time, that two distinct regimes of melting exist depending on the flow magnitude and consequent behavior of melt plumes (side-attached or side-detached), with correspondingly different meltwater spreading characteristics. When this velocity dependence is included in melt parameterizations, melt rates estimated for observed icebergs in the attached regime increase, consistent with observed iceberg submarine melt rates. We show that both attached and detached plume regimes are relevant to icebergs observed in a Greenland fjord. Further, depending on the regime, iceberg meltwater may either be confined to a surface layer or distributed over the iceberg draft.National Oceanic and Atmospheric Administration, U.S. Department of Commerce Grant Number: NA14OAR4320106; NSF Grant Numbers: OCE-1434041, OCE-1658079, PLR-1332911, OCE-14340412017-12-1

Effect of a sheared flow on iceberg motion and melting

Author Posting. © American Geophysical Union, 2016. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Geophysical Research Letters 43 (2016): 12,520–12,527, doi:10.1002/2016GL071602.Icebergs account for approximately half the freshwater flux into the ocean from the Greenland and Antarctic ice sheets and play a major role in the distribution of meltwater into the ocean. Global climate models distribute this freshwater by parameterizing iceberg motion and melt, but these parameterizations are presently informed by limited observations. Here we present a record of speed and draft for 90 icebergs from Sermilik Fjord, southeastern Greenland, collected in conjunction with wind and ocean velocity data over an 8 month period. It is shown that icebergs subject to strongly sheared flows predominantly move with the vertical average of the ocean currents. If, as typical in iceberg parameterizations, only the surface ocean velocity is taken into account, iceberg speed and basal melt may have errors in excess of 60%. These results emphasize the need for parameterizations to consider ocean properties over the entire iceberg draft.National Oceanic and AtmosphericAdministration Grant Number: NA14OAR4320106; National Oceanic and Atmospheric Administration, U.S. Department of Commerce NSF Grant Numbers: PLR-1332911, OCE-1434041, OCE-1434041, PLR-13329112017-06-2

Altered Expression of ACOX2 In Non-Small Cell Lung Cancer

Peroxisomes are organelles that play essential roles in many metabolic processes, but also play roles in innate immunity, signal transduction, aging and cancer. One of the main functions of peroxisomes is the processing of very-long chain fatty acids into metabolites that can be directed to the mitochondria. One key family of enzymes in this process are the peroxisomal acyl-CoA oxidases (ACOX1, ACOX2 and ACOX3), the expression of which has been shown to be dysregulated in some cancers. Very little is however known about the expression of this family of oxidases in non-small cell lung cancer (NSCLC). ACOX2 has however been suggested to be elevated at the mRNA level in over 10% of NSCLC, and in the present study using both standard and bioinformatics approaches we show that expression of ACOX2 is significantly altered in NSCLC. ACOX2 mRNA expression is linked to a number of mutated genes, and associations between ACOX2 expression and tumour mutational burden and immune cell infiltration were explored. Links between ACOX2 expression and candidate therapies for oncogenic driver mutations such as KRAS were also identified. Furthermore, levels of acyl-CoA oxidases and other associated peroxisomal genes were explored to identify further links between the peroxisomal pathway and NSCLC. The results of this biomarker driven study suggest that ACOX2 may have potential clinical utility in the diagnosis, prognosis and stratification of patients into various therapeutically targetable options

An Analysis of JADE2 in Non-Small Cell Lung Cancer (NSCLC)

The JADE family comprises three members encoded by individual genes and roles for these proteins have been identified in chromatin remodeling, cell cycle progression, cell regeneration and the DNA damage response. JADE family members, and in particular JADE2 have not been studied in any great detail in cancer. Using a series of standard biological and bioinformatics approaches we investigated JADE2 expression in surgically resected non-small cell lung cancer (NSCLC) for both mRNA and protein to examine for correlations between JADE2 expression and overall survival. Additional correlations were identified using bioinformatic analyses on multiple online datasets. Our analysis demonstrates that JADE2 expression is significantly altered in NSCLC. High expression of JADE2 is associated with a better 5-year overall survival. Links between JADE2 mRNA expression and a number of mutated genes were identified, and associations between JADE2 expression and tumor mutational burden and immune cell infiltration were explored. Potential new drugs that can target JADE2 were identified. The results of this biomarker-driven study suggest that JADE2 may have potential clinical utility in the diagnosis, prognosis and stratification of patients into various therapeutically targetable options

“Lest we forget” : An overview of Australia’s response to the recovery and identification of unrecovered historic military remains

Peer reviewedPostprin

Change in depressive symptoms over higher education and professional establishment - a longitudinal investigation in a national cohort of Swedish nursing students

<p>Abstract</p> <p>Background</p> <p>There are indications of a high prevalence of psychological distress among students in higher education and also that distress increases over the course of study. However, not all studies on student distress controlled for sociodemographic differences and few followed development of distress over an extended period through professional establishment. We investigated if there is an independent effect of time in education and the first two years in the profession on depressive symptoms and mapped change over the period in a national cohort of students.</p> <p>Methods</p> <p>Data came from LANE, a nation-wide longitudinal panel survey of Swedish nursing students (N = 1700) who responded to annual questionnaires over five years from 2002 to 2007. Depressive symptoms were measured by the Major Depression Inventory and change over time analysed in a linear mixed effects model for repeated measures.</p> <p>Results</p> <p>There was a significant change in level of depressive symptoms over time: an increase from the first to later years in education and a decrease to levels similar to baseline after graduation and a year in the profession. The change in symptoms remained significant after adjustment for sociodemographic factors (p < 0.01). Symptom levels differed due to age, gender, household composition and prior nurse assistant training but change over time was similar in all groups. The correlation among the repeated measures, representing within individual correlation over time, varied between 0.44-0.60.</p> <p>Conclusions</p> <p>The findings indicate an independent but transitional effect of time in education and professional establishment on depressive symptoms. We think heightened distress over education abates as the graduate accommodates to the profession. Nevertheless, within education, the differences in depressive symptoms associated to demographic factors can help identify student groups more vulnerable to distress. Also, as individual differences in distress seem to persist over time, perhaps students highly distressed in the beginning of education can be helped by awareness among educators of the elevated levels of distress in late education.</p

Systematic meta-analyses, field synopsis and global assessment of the evidence of genetic association studies in colorectal cancer

Objective: To provide an understanding of the role of common genetic variations in colorectal cancer (CRC) risk, we report an updated field synopsis and comprehensive assessment of evidence to catalogue all genetic markers for CRC (CRCgene2). Design: We included 869 publications after parallel literature review and extracted data for 1063 polymorphisms in 303 different genes. Meta-Analyses were performed for 308 single nucleotide polymorphisms (SNPs) in 158 different genes with at least three independent studies available for analysis. Scottish, Canadian and Spanish data from genome-wide association studies (GWASs) were incorporated for the meta-Analyses of 132 SNPs. To assess and classify the credibility of the associations, we applied the Venice criteria and Bayesian False-Discovery Probability (BFDP). Genetic associations classified as â € positive' and â € less-credible positive' were further validated in three large GWAS consortia conducted in populations of European origin. Results: We initially identified 18 independent variants at 16 loci that were classified as â € positive' polymorphisms for their highly credible associations with CRC risk and 59 variants at 49 loci that were classified as â € less-credible positive' SNPs; 72.2% of the â € positive' SNPs were successfully replicated in three large GWASs and the ones that were not replicated were downgraded to â € less-credible' positive (reducing the â € positive' variants to 14 at 11 loci). For the remaining 231 variants, which were previously reported, our meta-Analyses found no evidence to support their associations with CRC risk. Conclusion: The CRCgene2 database provides an updated list of genetic variants related to CRC risk by using harmonised methods to assess their credibility.</p

Transmissibility of Atypical Scrapie in Ovine Transgenic Mice: Major Effects of Host Prion Protein Expression and Donor Prion Genotype

Atypical scrapie or Nor98 has been identified as a transmissible spongiform encephalopathy (TSE) that is clearly distinguishable from classical scrapie and BSE, notably regarding the biochemical features of the protease-resistant prion protein PrPres and the genetic factors involved in susceptibility to the disease. In this study we transmitted the disease from a series of 12 French atypical scrapie isolates in a transgenic mouse model (TgOvPrP4) overexpressing in the brain ∼0.25, 1.5 or 6× the levels of the PrPARQ ovine prion protein under the control of the neuron-specific enolase promoter. We used an approach based on serum PrPc measurements that appeared to reflect the different PrPc expression levels in the central nervous system. We found that transmission of atypical scrapie, much more than in classical scrapie or BSE, was strongly influenced by the PrPc expression levels of TgOvPrP4 inoculated mice. Whereas TgOvPrP4 mice overexpressing ∼6× the normal PrPc level died after a survival periods of 400 days, those with ∼1.5× the normal PrPc level died at around 700 days. The transmission of atypical scrapie in TgOvPrP4 mouse line was also strongly influenced by the prnp genotypes of the animal source of atypical scrapie. Isolates carrying the AF141RQ or AHQ alleles, associated with increased disease susceptibility in the natural host, showed a higher transmissibility in TgOvPrP4 mice. The biochemical analysis of PrPres in TgOvPrP4 mouse brains showed a fully conserved pattern, compared to that in the natural host, with three distinct PrPres products. Our results throw light on the transmission features of atypical scrapie and suggest that the risk of transmission is intrinsically lower than that of classical scrapie or BSE, especially in relation to the expression level of the prion protein