Lunar IceCube: Development of Thermal Management System

Design of a thermal control system for Lunar IceCube faced several challenges. Firstly, components have vastly different requirements for operational temperature range and heat dissipation. Secondly, the spacecraft does not have enough external surface to reject waste heat by traditionally designed thermal control system. Thirdly, integration of components into a single thermal control system represents a challenge due to several factors: namely, thermal interference between components due to high packing density; incompatibility of some components which are made by different vendors. The paper discusses a successful solution of the mentioned above problems. It shows that customization of thermal control systems for each group of components with similar thermal requirements enables successful resolution of thermal challenges

Pathways from Child Maltreatment to Proactive and Reactive Aggression: The Role of Post-Traumatic Stress Symptom Clusters

Objective: Childhood aggression is related to a myriad of negative concurrent and long-term outcomes. To mitigate the risks associated with childhood aggression, it is important to understand risk factors that might predispose one to aggressive behaviors. One risk factor commonly associated with aggression is the experience of child maltreatment. A common outcome associated with child maltreatment is the development of post-traumatic stress symptoms (PTSS). Several prevailing theoretical models of both post-traumatic stress and aggression indicate that these constructs have similar underlying cognitive, behavioral, and emotional mechanisms. Therefore, the present study examined the relations between and among child maltreatment, PTSS clusters, and proactive and reactive aggression in children. Method: Children between the ages of 6 and 14 who were enrolled in a residential treatment program completed self-report measures to evaluate variables of interest. These variables were included as multiple outcomes in a path analysis model in which individual PTSS clusters were examined as potential multiple mediators of the relations between child maltreatment and proactive and reactive aggression. Results: Direct effects of child maltreatment and PTSS clusters on aggression were observed. Significant indirect effects of the intrusion PTSS cluster on the relation between child maltreatment and reactive aggression was found. Conclusions: Findings suggest that symptoms associated with these specific PTSS clusters might help explain the relation between child maltreatment and reactive aggression and therefore present important implications for clinical practice and future research

Theory of vortex excitation imaging via an NMR relaxation measurement

The temperature dependence of the site-dependent nuclear spin relaxation time T_1 around vortices is studied in s-wave and d-wave superconductors.Reflecting low energy electronic excitations associated with the vortex core, temperature dependences deviate from those of the zero-field case, and T_1 becomes faster with approaching the vortex core. In the core region, T_1^{-1} has a new peak below T_c. The NMR study by the resonance field dependence may be a new method to prove the spatial resolved vortex core structure in various superconductors.Comment: 5 pages, 3 figure

Comparing various multi-component global heliosphere models

Modeling of the global heliosphere seeks to investigate the interaction of the solar wind with the partially ionized local interstellar medium. Models that treat neutral hydrogen self-consistently and in great detail, together with the plasma, but that neglect magnetic fields, constitute a sub-category within global heliospheric models. There are several different modeling strategies used for this sub-category in the literature. Differences and commonalities in the modeling results from different strategies are pointed out. Plasma-only models and fully self-consistent models from four research groups, for which the neutral species is modeled with either one, three, or four fluids, or else kinetically, are run with the same boundary parameters and equations. They are compared to each other with respect to the locations of key heliospheric boundary locations and with respect to the neutral hydrogen content throughout the heliosphere. In many respects, the models' predictions are similar. In particular, the locations of the termination shock agree to within 7% in the nose direction and to within 14% in the downwind direction. The nose locations of the heliopause agree to within 5%. The filtration of neutral hydrogen from the interstellar medium into the inner heliosphere, however, is model dependent, as are other neutral results including the hydrogen wall. These differences are closely linked to the strength of the interstellar bow shock. The comparison also underlines that it is critical to include neutral hydrogen into global heliospheric models.Comment: 10 pages, 4 figures, submitted to a special section at A&A of an ISSI team "Determination of the physical Hydrogen parameters of the LIC from within the Heliosphere

Nonthermal Emission from a Supernova Remnant in a Molecular Cloud

In evolved supernova remnants (SNRs) interacting with molecular clouds, such as IC 443, W44, and 3C391, a highly inhomogeneous structure consisting of a forward shock of moderate Mach number, a cooling layer, a dense radiative shell and an interior region filled with hot tenuous plasma is expected. We present a kinetic model of nonthermal electron injection, acceleration and propagation in that environment and find that these SNRs are efficient electron accelerators and sources of hard X- and gamma-ray emission. The energy spectrum of the nonthermal electrons is shaped by the joint action of first and second order Fermi acceleration in a turbulent plasma with substantial Coulomb losses. Bremsstrahlung, synchrotron, and inverse Compton radiation of the nonthermal electrons produce multiwavelength photon spectra in quantitative agreement with the radio and the hard emission observed by ASCA and EGRET from IC 443. We distinguish interclump shock wave emission from molecular clump shock wave emission accounting for a complex structure of molecular cloud. Spatially resolved X- and gamma- ray spectra from the supernova remnants IC 443, W44, and 3C391 as might be observed with BeppoSAX, Chandra XRO, XMM, INTEGRAL and GLAST would distinguish the contribution of the energetic lepton component to the gamma-rays observed by EGRET.Comment: 14 pages, 4 figure, Astrophysical Journal, v.538, 2000 (in press

A magnetization and 11^{11}B NMR study of Mg1−x_{1-x}Alx_xB2_2 superconductors

We demonstrate for the first time the magnetic field distribution of the pure vortex state in lightly doped Mg$_{1-x}$Al$_x$B$_2$ ($x\leq 0.025$) powder samples, by using $^{11}$B NMR in magnetic fields of 23.5 and 47 kOe. The magnetic field distribution at T=5 K is Al-doping dependent, revealing a considerable decrease of anisotropy in respect to pure MgB$_2$. This result correlates nicely with magnetization measurements and is consistent with $\sigma$-band hole driven superconductivity for MgB$_2$

11^{11}B NMR study of pure and lightly carbon doped MgB2_2 superconductors

We report a $^{11}$B NMR line shape and spin-lattice relaxation rate ($1/(T_1T)$) study of pure and lightly carbon doped MgB$_{2-x}$C$_{x}$ for $x=0$, 0.02, and 0.04, in the vortex state and in magnetic field of 23.5 kOe. We show that while pure MgB$_2$ exhibits the magnetic field distribution from superposition of the normal and the Abrikosov state, slight replacement of boron with carbon unveils the magnetic field distribution of the pure Abrikosov state. This indicates a considerable increase of $H_{c2}^c$ with carbon doping with respect to pure MgB$_2$. The spin-lattice relaxation rate $1/(T_1T)$ demonstrates clearly the presence of a coherence peak right below $T_c$ in pure MgB$_2$, followed by a typical BCS decrease on cooling. However, at temperatures lower than $\approx 10$K strong deviation from the BCS behavior is observed, probably from residual contribution of the vortex dynamics. In the carbon doped systems both the coherence peak and the BCS temperature dependence of $1/(T_1T)$ weaken, an effect attributed to the gradual shrinking of the $\sigma$ hole cylinders of the Fermi surface with electron doping.Comment: 8 pages, 6 figures, submitted to Phys. Rev.

Site-selective nuclear magnetic relaxation time in a superconducting vortex state

The temperature and field dependences of the site-selective nuclear spin relaxation time T_1 around vortices are studied comparatively both for s-wave and d-wave superconductors, based on the microscopic Bogoliubov-de Gennes theory. Reflecting low energy electronic excitations associated with the vortex core, the site selective temperature dependences deviate from those of the zero-field case, and T_1 becomes faster with approaching the vortex core. In the core region, T_1^{-1} has a new peak below the superconducting transition temperature T_c. The field dependence of the overall T_1(T) behaviors for s-wave and d-wave superconductors is investigated and analyzed in terms of the local density of states. The NMR study by the resonance field dependence may be a new method to probe the spatial resolved vortex core structure in various conventional and unconventional superconductors.Comment: 14Pages, 26 figures, revte

Systemic Immunotherapy with Micellar Resiquimod–Polymer Conjugates Triggers a Robust Antitumor Response in a Breast Cancer Model

Resiquimod is an immunopotent toll-like receptor 7/8 agonist with antitumor activity. Despite being potent against skin cancers, it is poorly tolerated systemically due to toxicity. Integrating resiquimod into nanoparticles presents an avenue to circumvent the toxicity problem. Herein, the preparation of degradable nanoparticles with covalently bound resiquimod and their systemic application in cancer immunotherapy is reported. Dispersion in water of amphiphilic constructs integrating resiquimod covalently bound via degradable amide or ester linkages yields immune-activating nanoparticles. The degradable agonist-nanoparticle bonds allow the release of resiquimod from the carrier nanoparticles. In vitro assays with antigen presenting cells demonstrate that the nanoparticles retain the immunostimulatory activity of resiquimod. Systemic administration of the nanoparticles and checkpoint blockade (aPD-1) to a breast cancer mouse model with multiple established tumors triggers antitumor activity evidenced by suppressed tumor growth and enhanced CD8+ T-cell infiltration. Nanoparticles with ester links, which hydrolyze more readily, yield a stronger immune response with 75% of tumors eliminated when combined with aPD-1. The reduced tumor growth and the presence of activated CD8+ T-cells across multiple tumors suggest the potential for treating metastatic cancer

Can the Future Influence the Present?

One widely accepted model of classical electrodynamics assumes that a moving charged particle produces both retarded and advanced fields. This formulation first appeared at least 75 years ago. It was popularized in the 1940\u27s by work of Wheeler and Feynman. But the most fundamental question associated with the model has remained unanswered: When (if ever) does the two-body problem have a unique solution? The present paper gives an answer in one special case. Imagine two identical charged particles alone in the universe moving symmetrically along the x axis. One is at x(t) and the other is at −x(t). Their motion is then governed by a system of functional differential equations involving both retarded and advanced arguments. This system together with the Newtonian initial data x(0)=x0\u3e0 and x′(0)=0 has a unique solution for all time provided x0 is sufficiently large. Perhaps the existence and uniqueness proof given for this special case will pave the way for more general results on this curious two-body problem