1,172 research outputs found
Dynamical Mean-Field Theory of Electron-Phonon Interactions in Correlated Systems: Application to Isotope Effects on Electronic Properties
We use a recently developed formalism (combining an adiabatic expansion and
dynamical mean-field theory) to obtain expressions for isotope effects on
electronic properties in correlated systems. As an example we calculate the
isotope effect on electron effective mass for the Holstein model as a function
of electron-phonon interaction strength and doping. Our systematic expansion
generates diagrams neglected in previous studies, which turn out to give the
dominant contributions. The isotope effect is small unless the system is near a
lattice instability. We compare this to experiment.Comment: 6 pages, 4 figures; added discussion of isotope effect away from half
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Sydnone Cycloaddition Route to Pyrazole-Based Analogs of Combretastatin A4.
The combretastatins are an important class of tubulin-binding agents. Of this family, a number of compounds are potent tumor Vascular Disrupting Agents (VDAs) and have shown promise in the clinic for cancer therapy. We have developed a modular synthetic route to combretastatin analogs based on a pyrazole core through highly-regioselective alkyne cycloaddition reactions of sydnones. These compounds show modest to high potency against human umbilical vein endothelial cell proliferation. Moreover, evidence is presented that these novel VDAs have the same mode of action as CA4P and bind reversibly to β-tubulin - believed to be a key feature in avoiding toxicity. The most active compound from in vitro studies was taken forward to an in vivo model and instigated an increase in tumor cell necrosis
Paragenesis of multiple platinum-group mineral populations in Shetland ophiolite chromitite: 3D X-ray tomography and in situ Os isotopes
Chromitite from the Harold’s Grave locality in the mantle section of the Shetland ophiolite complex is extremely enriched in Ru, Os and Ir, at µg/g concentrations. High-resolution X-ray computed tomography on micro-cores from these chromitites was used to determine the location, size, distribution and morphology of the platinum-group minerals (PGM). There are five generations of PGM in these chromitites. Small (average 5 µm in equivalent sphere diameter, ESD) euhedral laurites, often with Os-Ir alloys, are totally enclosed in the chromite and are likely to have formed first by direct crystallisation from the magma as the chromite crystallised. Also within the chromitite there are clusters of larger (50 µm ESD) aligned elongate crystals of Pt-, Rh-, Ir-, Os- and Ru-bearing PGM that have different orientations in different chromite crystals. These may have formed either by exsolution, or by preferential nucleation of PGMs in boundary layers around particular growing chromite grains. Thirdly there is a generation of large (100 µm ESD) composite Os-Ir-Ru-rich PGM that are all interstitial to the chromite grains and sometimes form in clusters. It is proposed that Os, Ir and Ru in this generation were concentrated in base metal sulfide droplets that were then re-dissolved into a later sulfide-undersaturated magma, leaving PGM interstitial to the chromite grains. Fourthly there is a group of almost spherical large (80 µm ESD) laurites, hosting minor Os-Ir-Ru-rich PGM that form on the edge or enclosed in chromite grains occurring in a sheet crosscutting a chromitite layer. These may be hosted in an annealed late syn- or post magmatic fracture. Finally a few of the PGM have been deformed in localised shear zones through the chromitites. The vast majority of the PGM – including small PGM enclosed within chromite, larger interstitial PGM and elongate aligned PGM – have Os isotope compositions that give Re-depletion model ages approximately equal to the age of the ophiolite at ∼492 Ma. A number of other PGM – not confined to a single textural group – fall to more or less radiogenic values, with four PGM giving anomalously unradiogenic Os corresponding to an older age of ∼1050 Ma. The 187Os/188Os isotopic ratios for PGM from Cliff and Quoys, from the same ophiolite section, are somewhat more radiogenic than those at Harold’s Grave. This may be due to a distinct mantle source history or possibly the assimilation of radiogenic crustal Os
Measurement of Fluorescence Phenomena from Yttrium and Gadolinium Oxysulfide Phosphors using a 45-MeV Proton Beam
This research was sponsored by the National Science Foundation Grant NSF PHY-931478
Generalized empty-interval method applied to a class of one-dimensional stochastic models
In this work we study, on a finite and periodic lattice, a class of
one-dimensional (bimolecular and single-species) reaction-diffusion models
which cannot be mapped onto free-fermion models.
We extend the conventional empty-interval method, also called
{\it interparticle distribution function} (IPDF) method, by introducing a
string function, which is simply related to relevant physical quantities.
As an illustration, we specifically consider a model which cannot be solved
directly by the conventional IPDF method and which can be viewed as a
generalization of the {\it voter} model and/or as an {\it epidemic} model. We
also consider the {\it reversible} diffusion-coagulation model with input of
particles and determine other reaction-diffusion models which can be mapped
onto the latter via suitable {\it similarity transformations}.
Finally we study the problem of the propagation of a wave-front from an
inhomogeneous initial configuration and note that the mean-field scenario
predicted by Fisher's equation is not valid for the one-dimensional
(microscopic) models under consideration.Comment: 19 pages, no figure. To appear in Physical Review E (November 2001
Persistent currents in a Bose-Einstein condensate in the presence of disorder
We examine bosonic atoms that are confined in a toroidal,
quasi-one-dimensional trap, subjected to a random potential. The resulting
inhomogeneous atomic density is smoothened for sufficiently strong, repulsive
interatomic interactions. Statistical analysis of our simulations show that the
gas supports persistent currents, which become more fragile due to the
disorder.Comment: 5 pages, RevTex, 3 figures, revised version, to appear in JLT
The application of stem cells from different tissues to cartilage repair
The degeneration of articular cartilage represents an ongoing challenge at the clinical and basic level. Tissue engineering and regenerative medicine using stem/progenitor cells have emerged as valid alternatives to classical reparative techniques. This review offers a brief introduction and overview of the field, highlighting a number of tissue sources for stem/progenitor cell populations. Emphasis is given to recent developments in both clinical and basic sciences. The relative strengths and weaknesses of each tissue type are discussed
Locally continuously perfect groups of homeomorphisms
The notion of a locally continuously perfect group is introduced and studied.
This notion generalizes locally smoothly perfect groups introduced by Haller
and Teichmann. Next, we prove that the path connected identity component of the
group of all homeomorphisms of a manifold is locally continuously perfect. The
case of equivariant homeomorphism group and other examples are also considered.Comment: 14 page
Evolution of the macroscopically entangled states in optical lattices
We consider dynamics of boson condensates in finite optical lattices under a
slow external perturbation which brings the system to the unstable equilibrium.
It is shown that quantum fluctuations drive the condensate into the maximally
entangled state. We argue that the truncated Wigner approximation being a
natural generalization of the Gross-Pitaevskii classical equations of motion is
adequate to correctly describe the time evolution including both collapse and
revival of the condensate.Comment: 14 pages, 10 figures, Discussion of reversibility of entanglement is
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Collective Diffusion and a Random Energy Landscape
Starting from a master equation in a quantum Hamiltonian form and a coupling
to a heat bath we derive an evolution equation for a collective hopping process
under the influence of a stochastic energy landscape. There results different
equations in case of an arbitrary occupation number per lattice site or in a
system under exclusion. Based on scaling arguments it will be demonstrated that
both systems belong below the critical dimension to the same universality
class leading to anomalous diffusion in the long time limit. The dynamical
exponent can be calculated by an expansion. Above the
critical dimension we discuss the differences in the diffusion constant for
sufficient high temperatures. For a random potential we find a higher mobility
for systems with exclusion.Comment: 15 pages, no figure
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