When is going with the grain making the problem worse?

In order to realise change, development practitioners sometimes make compromises with groups that do not always share the same ideals. Following a recent workshop on social accountability, Tom Kirk and Annette JE Fisher reflect on the discussions held and ask when, and how, ‘going with the grain’ can make a problem worse

Privies and Parasites: The Archaeology of Health Conditions in Albany, New York

Large numbers of parasites were identified in archaeological samples collected from privies and other features in excavations in Albany, New York. This information provides the largest database available for the study of parasite infections in historical period American cities. The greatest numbers of parasites were in contexts related to the expansion of the city in the late-18th century. Parasites remained, but their quantities decreased in the 19th century during another period of rapid population growth. The city was able to control parasite infection during this period through several means, including new techniques of privy construction, new water supply systems, and medical treatments. Use of medical treatments against parasites varied among residents of the city and was evident in the archaeological record

Far-Term Exploration of Advanced Single-Aisle Subsonic Transport Aircraft Concepts

Far-term single-aisle class aircraft concepts for potential entry-into-service of 2045 were investigated using an Interactive Reconfigurable Matrix of Alternatives (IRMA) approach. The configurations identified through this design space exploration were then distilled into three advanced aircraft concepts best characterizing the prominent features identified through the IRMA exploration. These three aircraft concepts were then configured and sized for a 150-passenger capacity and a 3,500 nautical mile design mission. Mission block fuel burn was estimated and compared to a far-term conventional configuration baseline concept and a 2005 l. These comparisons suggest considerable potential improvements in fuel efficiency from the investigated advanced concepts

Results of the 2016 Indianapolis Biodiversity Survey, Marion County, Indiana

Surprising biodiversity can be found in cities, but urban habitats are understudied. We report on a bioblitz conducted primarily within a 24-hr period on September 16 and 17, 2016 in Indianapolis, Indiana, USA. The event focused on stretches of three waterways and their associated riparian habitat: Fall Creek (20.6 ha; 51 acres), Pleasant Run (23.5 ha; 58 acres), and Pogue’s Run (27.1 ha; 67 acres). Over 75 scientists, naturalists, students, and citizen volunteers comprised 14 different taxonomic teams. Five hundred ninety taxa were documented despite the rainy conditions. A brief summary of the methods and findings are presented here. Detailed maps of survey locations and inventory results are available on the Indiana Academy of Science website (https://www.indianaacademyofscience.org/)

Prophylactic methylprednisolone to reduce inflammation and improve outcomes from one lung ventilation in children: a randomized clinical trial.

BACKGROUND: One lung ventilation (OLV) results in inflammatory and mechanical injury, leading to intraoperative and postoperative complications in children. No interventions have been studied in children to minimize such injury. OBJECTIVE: We hypothesized that a single 2-mg·kg(-1) dose of methylprednisolone given 45-60 min prior to lung collapse would minimize injury from OLV and improve physiological stability. METHODS: Twenty-eight children scheduled to undergo OLV were randomly assigned to receive 2 mg·kg(-1) methylprednisolone (MP) or normal saline (placebo group) prior to OLV. Anesthetic management was standardized, and data were collected for physiological stability (bronchospasm, respiratory resistance, and compliance). Plasma was assayed for inflammatory markers related to lung injury at timed intervals related to administration of methylprednisolone. RESULTS: Three children in the placebo group experienced clinically significant intraoperative and postoperative respiratory complications. Respiratory resistance was lower (P = 0.04) in the methylprednisolone group. Pro-inflammatory cytokine IL-6 was lower (P = 0.01), and anti-inflammatory cytokine IL-10 was higher (P = 0.001) in the methylprednisolone group. Tryptase, measured before and after OLV, was lower (P = 0.03) in the methylprednisolone group while increased levels of tryptase were seen in placebo group after OLV (did not achieve significance). There were no side effects observed that could be attributed to methylprednisolone in this study. CONCLUSIONS: Methylprednisolone at 2 mg·kg(-1) given as a single dose prior to OLV provides physiological stability to children undergoing OLV. In addition, methylprednisolone results in lower pro-inflammatory markers and higher anti-inflammatory markers in the children\u27s plasma

A Proposed Fast Luminosity Feedback for the Super-B Accelerator

We present a possible design for a fast luminosity feedback for the SuperB Interaction Point (IP). The design is an extension of the fast luminosity feedback installed on the PEP-II accelerator. During the last two runs of PEP-II and BaBar (2007-2008), we had an improved luminosity feedback system that was able to maintain peak luminosity with faster correction speed than the previous system. The new system utilized fast dither coils on the High-Energy Beam (HEB) to independently dither the x position, the y position and the y angle at the IP, at roughly 100 Hz. The luminosity signal was then read out with three independent lock-in amplifiers. An overall correction was computed based on the lock-in signal strengths and beam corrections for position in x and y and in the y angle at the IP were simultaneously applied to the HEB. With the 100 times increase in luminosity for the SuperB design, we propose using a similar fast luminosity feedback that can operate at frequencies between DC and 1 kHz, high enough to follow any beam motion from the final focusing magnets