Why do People Stay? Insider Advantages and Immobility

The low mobility of people in Europe is considered a problem for adjustment to asymmetric shocks and regional convergence in the European Monetary Union. We suggest a complement to the traditional migration theories, the insider advantages approach to explain why most Europeans prefer to stay. Staying immobile they have accumulated work- and leisure-oriented insider advantages that are location-specific and would be lost in the case of emigration. Therefore, the longer people have stayed - and the more insider advantages they have accumulated -, the less likely they are to move. Using a new micro dataset covering all people resident in Sweden in 1994 and their mobility experience since 1985, we find a strong positive duration dependence of the probability to stay. Traditional micro-economic characteristics prove helpful in explaining immobility, while regional macro-economic differences have surprisingly little impact on individual mobility decisions. A large proportion of the moves between Swedish labour markets seem to be related to specific life-course events rather than to pure labour market issues. Wieso ist die Mobilität der Arbeitskräfte innerhalb der Europäischen Union - aller Freizügigkeit zum Trotz - so gering? Traditionelle Theorieansätze vermögen die schwach ausgeprägte Wanderungsintensität der EU-Angehörigen nur begrenzt zu er - klären. Denn eigentlich sollten die teilweise beträchtlichen Einkommens - und Beschäftigungsunterschiede zu weit mehr Migration innerhalb der EU führen. In diesem Diskussionspapier entwickeln wir eine Idee, die sehr wohl zu erklären vermag, weshalb für die meisten Menschen "stehen" die bessere Alternative als "gehen" ist. Der Insider-Ansatz macht deutlich, weshalb für die individuelle Entscheidung eine grenz- und kulturraumüberschreitende Wanderung die Ausnahme und nicht die Regel ist. Die empirische Überprüfung mit Hilfe eines neuen originären Mikro-Datensets, das die gesamte schwedische Wohnbevölkerung enthält, bestätigt die These, dass die Verweil- dauer einen direkten positiven Einfluss auf die Verharrenswahrscheinlichkeit ausübt. Wer lange an einem Ort lebt, wird immer wahrscheinlicher an diesem Ort bleiben!Labor and Human Capital, F22, J60, R23,

Synthesis, X-ray Structures, Electronic Properties, and O\u3csub\u3e2\u3c/sub\u3e/NO Reactivities of Thiol Dioxygenase Active-Site Models

Mononuclear non-heme iron complexes that serve as structural and functional mimics of the thiol dioxygenases (TDOs), cysteine dioxygenase (CDO) and cysteamine dioxygenase (ADO), have been prepared and characterized with crystallographic, spectroscopic, kinetic, and computational methods. The high-spin Fe(II) complexes feature the facially coordinating tris(4,5-diphenyl-1-methylimidazol-2-yl)phosphine (Ph2TIP) ligand that replicates the three histidine (3His) triad of the TDO active sites. Further coordination with bidentate l-cysteine ethyl ester (CysOEt) or cysteamine (CysAm) anions yielded five-coordinate (5C) complexes that resemble the substrate-bound forms of CDO and ADO, respectively. Detailed electronic-structure descriptions of the [Fe(Ph2TIP)(LS,N)]BPh4 complexes, where LS,N = CysOEt (1) or CysAm (2), were generated through a combination of spectroscopic techniques [electronic absorption, magnetic circular dichroism (MCD)] and density functional theory (DFT). Complexes 1 and 2 decompose in the presence of O2 to yield the corresponding sulfinic acid (RSO2H) products, thereby emulating the reactivity of the TDO enzymes and related complexes. Rate constants and activation parameters for the dioxygenation reactions were measured and interpreted with the aid of DFT calculations for O2-bound intermediates. Treatment of the TDO models with nitric oxide (NO)—a well-established surrogate of O2—led to a mixture of high-spin and low-spin {FeNO}7 species at low temperature (−70 °C), as indicated by electron paramagnetic resonance (EPR) spectroscopy. At room temperature, these Fe/NO adducts convert to a common species with EPR and infrared (IR) features typical of cationic dinitrosyl iron complexes (DNICs). To complement these results, parallel spectroscopic, computational, and O2/NO reactivity studies were carried out using previously reported TDO models that feature an anionic hydrotris(3-phenyl-5-methyl-pyrazolyl)borate (Ph,MeTp–) ligand. Though the O2 reactivities of the Ph2TIP- and Ph,MeTp-based complexes are quite similar, the supporting ligand perturbs the energies of Fe 3d-based molecular orbitals and modulates Fe–S bond covalency, suggesting possible rationales for the presence of neutral 3His coordination in CDO and ADO

Uric Acid as a Potential Peripheral Biomarker for Disease Features in Huntington's Patients.

Oxidative stress has long been implicated in the pathophysiology and progression of Huntington's disease (HD). Uric acid (UA) is a naturally occurring antioxidant that is present in the brain and periphery. Growing evidence has implicated UA as a molecular biomarker for several neurodegenerative diseases, most notably Parkinson's disease (PD). In this study, we investigated UA levels in clinical samples from HD patients and normal controls (NCs) and assessed potential relationships between UA levels and disease and clinical data. UA levels were measured in plasma (n = 107) and saliva (n = 178) samples from premanifest (pre-HD) and manifest HD patients and control subjects. Gender effects of UA levels were observed in both biofluids, with male patients showing higher UA levels compared to female patients. Comparisons of UA levels across diagnostic groups, separated by gender, revealed that both plasma and salivary UA levels were significantly lower in female pre-HD and manifest HD patients compared to NCs. Salivary levels of UA were also significantly lower in male manifest HD patients versus controls, but not in plasma. Correlations of peripheral UA levels to clinical data also showed differences according to gender. In male HD patients, both plasma and salivary UA levels were significantly negatively correlated with total functional capacity (TFC), while positive correlations were observed with total motor score (TMS). Female HD patients showed a significant positive correlation between plasma UA levels and TMS, while salivary UA levels from female patients were significantly correlated to disease burden. Finally, in a separate cohort, we show that UA levels are decreased in postmortem prefrontal cortical samples (n = 20) from HD subjects compared to matched controls. These findings suggest that decreased levels of UA in the brains of HD patients can be reflected in peripheral fluids, with salivary measures of UA particularly offering significant promise as a potentially relevant, non-invasive biomarker of disease symptoms and burden. Our findings further highlight the impact of sexual dimorphism in HD pathophysiology

Growth, Condition, and Trophic Relations of Stocked Trout in Southern Appalachian Mountain Streams

Stream trout fisheries are among the most popular and valuable in the United States, but many are dependent on hatcheries to sustain fishing and harvest. Thus, understanding the ecology of hatchery‐reared trout stocked in natural environments is fundamental to management. We evaluated the growth, condition, and trophic relations of Brook Trout Salvelinus fontinalis, Brown Trout Salmo trutta, and Rainbow Trout Oncorhynchus mykiss that were stocked in southern Appalachian Mountain streams in western North Carolina. Stocked and wild (naturalized) trout were sampled over time (monthly; September 2012–June 2013) to compare condition and diet composition and to evaluate temporal dynamics of trophic position with stable isotope analysis. Relative weights (Wr) of stocked trout were inversely associated with their stream residence time but were consistently higher than those of wild trout. Weight loss of harvested stocked trout was similar among species and sizes, but fish stocked earlier lost more weight. Overall, 40% of 141 stomachs from stocked trout were empty compared to 15% of wild trout stomachs (N = 26). We identified a much higher rate of piscivory in wild trout (18 times that of stocked trout), and wild trout were 4.3 times more likely to consume gastropods relative to stocked trout. Hatchery‐reared trout were isotopically similar to co‐occurring wild fish for both δ13C and δ15N values but were less variable than wild trout. Differences in sulfur isotope ratios (δ34S) between wild and hatchery‐reared trout indicated that the diets of wild fish were enriched in δ34S relative to the diets of hatchery‐reared fish. Although hatcheryreared trout consumed prey items similar to those of wild fish, differences in consumption or behavior (e.g., reduced feeding) may have resulted in lower condition and negative growth. These findings provide critical insight on the trophic dynamics of stocked trout and may assist in developing and enhancing stream trout fisheries

Consequences Of Fully Dressing Quark-Gluon Vertex Function With Two-Point Gluon Lines

We extend recent studies of the effects of quark-gluon vertex dressing upon the solutions of the Dyson-Schwinger equation for the quark propagator. A momentum delta function is used to represent the dominant infrared strength of the effective gluon propagator so that the resulting integral equations become algebraic. The quark-gluon vertex is constructed from the complete set of diagrams involving only 2-point gluon lines. The additional diagrams, including those with crossed gluon lines, are shown to make an important contribution to the DSE solutions for the quark propagator, because of their large color factors and the rapid growth in their number

Legitimising EU Policymaking: What Role for National Parliaments? EPC Discussion Paper, 28 January 2014

The ‘euro crisis’ has sparked a renewed interest in how national parliaments can help to improve the democratic nature of European decision making. According to various treaties, assemblies in the Member States are now guaranteed a full spectrum of rights including access to information, participation and the ability to object to EU legislation. The authors of this Discussion Paper argue that there is still room to refine and promote a more responsible use of existing instruments. Moreover, the possibility of adding new mechanisms to the available toolkit is part of the discussion on the topic but the authors warn that any proposals must be carefully considered on a case-by-case basis, especially in the context of the European economic governance reform process. Ultimately, according to the authors, the most straightforward and effective way for national parliaments to strengthen their direct involvement in EU policy formulation is to focus on building capacity to perform their two key domestic responsibilities: to hold their own governments to account, also on EU affairs, and to maintain the link with voters, including by communicating and debating ‘Europe’ at ‘home’