Locally Delivered Salicylic Acid From a Poly(anhydride-ester): Impact on Diabetic Bone Regeneration

Diabetes mellitus (DM) involves metabolic changes that can impair bone repair, including a prolonged inflammatory response. A salicylic acid-based poly(anhydride-ester) (SA-PAE) provides controlled and sustained release of salicylic acid (SA) that locally resolves inflammation. This study investigates the effect of polymer-controlled SA release on bone regeneration in diabetic rats where enhanced inflammation is expected. Fifty-six Sprague–Dawley rats were randomly assigned to two groups: diabetic group induced by streptozotocin (STZ) injection or normoglycemic controls injected with citrate buffer alone. Three weeks after hyperglycemia development or vehicle injection, 5 mm critical sized defects were created at the rat mandibular angle and treated with SA-PAE/bone graft mixture or bone graft alone. Rats were euthanized 4 and 12 weeks after surgery, then bone fill percentage in the defect region was assessed by micro-computed tomography (CT) and histomorphometry. It was observed that bone fill increased significantly at 4 and 12 weeks in SA-PAE/bone graft-treated diabetic rats compared to diabetic rats receiving bone graft alone. Accelerated bone formation in normoglycemic rats caused by SA-PAE/bone graft treatment was observed at 4 weeks but not at 12 weeks. This study shows that treatment with SA-PAE enhances bone regeneration in diabetic rats and accelerates bone regeneration in normoglycemic animals

How to Select Replacement Grafts for Various Periodontal and Implant Indications

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/141520/1/cap0167.pd

Treatment of Periodontitis by Local Administration of Minocycline Microspheres: A Controlled Trial

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/141491/1/jper1535.pd

Evaluation of functional dynamics during osseointegration and regeneration associated with oral implants

The aim of this paper is to review current investigations on functional assessments of osseointegration and assess correlations to the peri-implant structure.The literature was electronically searched for studies of promoting dental implant osseointegration, functional assessments of implant stability, and finite element (FE) analyses in the field of implant dentistry, and any references regarding biological events during osseointegration were also cited as background information.Osseointegration involves a cascade of protein and cell apposition, vascular invasion, de novo bone formation and maturation to achieve the primary and secondary dental implant stability. This process may be accelerated by alteration of the implant surface roughness, developing a biomimetric interface, or local delivery of growth-promoting factors. The current available pre-clinical and clinical biomechanical assessments demonstrated a variety of correlations to the peri-implant structural parameters, and functionally integrated peri-implant structure through FE optimization can offer strong correlation to the interfacial biomechanics.The progression of osseointegration may be accelerated by alteration of the implant interface as well as growth factor applications, and functional integration of peri-implant structure may be feasible to predict the implant function during osseointegration. More research in this field is still needed. To cite this article: Chang P-C, Lang NP, Giannobile WV. Evaluation of functional dynamics during osseointegration and regeneration associated with oral implants. Clin. Oral Impl. Res . 21 , 2010; 1–12.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/78668/1/j.1600-0501.2009.01826.x.pd

On the Modelling and Characterisation of Photoconducting Antennas

In recent years, the interest in terahertz technology witnessed a constant increasing interest and attention from the scientific community, as it allows to unlock the THz bandwidth, that can be used for a wide range of applications: it helps the study of biological samples and help medical diagnostics; it serves as a harmless non-destructive testing technique for medical and pharmaceutical products; it is used to inspect food and other packaging for quality control in a non-invasive fashion; it is adopted in body scanner systems for security screenings of people...Tera-Hertz Sensin

Il LOFOPT: una griglia di osservazione per l'attivit\uc3\ua0 fisica adattata con pazienti psichiatrici

Le attivit\ue0 fisiche stanno trovando sempre pi\uf9 spazio nei programmi terapeutici e riabilitativi per pazienti psichiatrici, purtroppo risultano sviluppati solo pochi strumenti per valutare l\u2019efficacia di queste attivit\ue0. In questo lavoro vengono presentate la versione italiana del Lofopt ed una esperienza clinica di utilizzo dello strumento. Il Lofopt (Louvain Observation Scale For Objectives in Psychomotor Therapy) \ue8 una griglia di osservazione, sviluppata all\u2019Universit\ue0 Cattolica di Lovanio in Belgio nel 1989, che appare particolarmente adattabile a diverse realt\ue0 operative e che mette in luce alcuni tra gli obiettivi pi\uf9 importanti delle terapia a mediazione corporea in psichiatria