9 research outputs found
Preliminary report on sand-streaming in Agadez and Tahoua Departments, Republic of Niger
There are no author-identified significant results in this report
A Bayesian Nonparametric Approach to Modeling Motion Patterns
The most difficult—and often most essential—
aspect of many interception and tracking tasks is constructing
motion models of the targets to be found. Experts can
often provide only partial information, and fitting parameters
for complex motion patterns can require large amounts
of training data. Specifying how to parameterize complex
motion patterns is in itself a difficult task.
In contrast, nonparametric models are very flexible and
generalize well with relatively little training data. We propose
modeling target motion patterns as a mixture of Gaussian
processes (GP) with a Dirichlet process (DP) prior over
mixture weights. The GP provides a flexible representation
for each individual motion pattern, while the DP assigns observed
trajectories to particular motion patterns. Both automatically
adjust the complexity of the motion model based
on the available data. Our approach outperforms several parametric
models on a helicopter-based car-tracking task on
data collected from the greater Boston area
Pharmacogenetic interaction analysis of VEGFR-2 and IL-8 polymorphisms in advanced breast cancer patients treated with paclitaxel and bevacizumab.
AIM: To investigate pharmacogenetic interactions among VEGF-A, VEGFR-2, IL-8,
HIF-1??, EPAS-1 and TSP-1 SNPs and their role on progression-free survival in a
population of metastatic breast cancer patients treated with bevacizumab in
combination with first-line paclitaxel.
PATIENTS & METHODS: Analyses were performed on germline DNA obtained from blood
samples and SNPs were investigated by real-time polymerase chain reaction
technique. The multifactor dimensionality reduction methodology was applied to
investigate the interaction between SNPs.
RESULTS: One hundred and thirteen patients were enrolled from eight Italian
Oncology Units ( clinicaltrial.gov : NCT01935102). The multifactor dimensionality
reduction software provided two pharmacogenetic interaction profiles consisting
of the combination between specific VEGFR-2 rs11133360 and IL-8 rs4073 genotypes.
The median progression-free survival was 14.1 months (95% CI: 11.4-16.8) and 10.2
months (95% CI: 8.8-11.5) for the favorable and the unfavorable genetic profile,
respectively (HR: 0.44, 95% CI: 0.29-0.66, p < 0.0001).
CONCLUSION: The pharmacogenetic statistical interaction between VEGFR-2
rs11133360 and IL-8 rs4073 genotypes may identify a population of patients with a
better outcome