What do you need to know to set up CPD as a professional body?

Setting up an effective CPD system as a professional body is a complex task that involves advocating the importance to health care professionals, communication with the regulators, setting and maintaining standards and monitoring the process

Antioxidant properties and fruit quality during long-term storage of “rocha” pear: effects of maturity and storage conditions

Free radical scavenging activity and the content of ascorbic acid and glutathione were investigated during long-term storage of the pear (Pyrus communis L. ‘Rocha’) fruit harvested at different maturity stages, stored in air or under controlled atmosphere and subjected to postharvest treatments with diphenylamine (DPA) and 1-methylcyclopropene (1-MCP). Harvest maturity had a significant effect on storage disorders, fruit firmness, soluble solids content and acidity. Differences in ascorbate content and free radical scavenging activity at harvest did not persist during storage. Controlled atmosphere and DPA strongly reduced the incidence and severity of browning disorders and superficial scald, whereas 1-MCP provided the most effective control. Neither DPA nor 1-MCP affected the free radical scavenging activityinfo:eu-repo/semantics/publishedVersio

The effects of spinal anaesthesia for elective caesarean section on uterine and umbilical arterial pulsatility indexes in normotensive and chronic hypertensive pregnant women: a prospective, longitudinal study

Background: Despite the known effects of neuraxial blockade on major vessel function and the rapid decrease in uterine vascular impedance, it is unclear how the blockade affects the utero-placental circulation in the near-term. We hypothesize that among women with chronic hypertension, a loss of sympathetic tonus consequent to spinal block may cause significant changes in the utero-placental haemodynamics than the changes typical in normal pregnant women. Therefore, the main study objective was to analyse the effect of spinal anaesthesia for caesarean section on uterine and umbilical arterial impedance in pregnant women at term diagnosed with stage-1 chronic hypertension. Methods: A prospective, longitudinal study was performed in singleton pregnant women (203 low-risk and 33 with hypertension) scheduled to undergo elective caesarean section. The mean arterial blood pressure and pulsatility indexes for the uterine and umbilical arteries were recorded before and after spinal anaesthesia was performed using 8–9 mg hyperbaric bupivacaine (5 mg/mL) and 2–2.5 μg sufentanil (5 μg/mL). Multiple linear regression models with errors capable of correlation or with unequal variances were fitted using the generalized least squares. Results: In normotensive women, the mean arterial blood pressure decreased after administering spinal anaesthesia (p < 0.05). The pulsatility index of the uterine and umbilical arteries did not change after spinal anaesthesia. In the hypertensive women, the mean arterial blood pressure (p < 0.05) and uterine artery pulsatility index (p < 0.05) decreased. In both groups, the umbilical artery pulsatility index did not change after spinal anaesthesia. Conclusions: In stage-1 chronic hypertensive pregnant women at term, spinal anaesthesia for caesarean section reduces uterine artery impedance but not umbilical artery impedance. Electronic supplementary material The online version of this article (doi:10.1186/1471-2393-14-291) contains supplementary material, which is available to authorized users

Electro-Hydraulic Transient Regimes in Isolated Pumps Working as Turbines with Self-Excited Induction Generators

[EN] The use of pumps working as turbines (PATs) is a sustainable technical measure that contributes to the improvement of energy efficiency in water systems. However, its performance analysis in off-grid recovery systems is a complex task that must consider both hydraulic (PAT) and electrical machines (typically a self-excited induction generator-SEIG). Aside from several kinds of research that analyze the PAT-SEIG behavior under steady-state constant hydraulic and electrical conditions, this research focuses on the analysis of PAT-SEIG transient regimes, by analyzing their variation when a sudden change occurs in the hydraulic or electrical components. Analytical models were developed to represent the operation of SEIG, PAT, and the PAT-SEIG coupled system. Hydraulic and electromechanical experimental tests validated these models. An excellent fit was obtained when analytical and experimental values were compared. With these models, the impact on the operation of the PAT-SEIG system was examined when sudden change occurred in the excitation capacitances, resistive loads, or recovered head. With a sudden increase of resistive load, the hydraulic power and SEIG stator current remain almost constant. However, there is an increase of SEIG reactive power, decreasing the PAT-SEIG efficiency. Also, with a sudden increase of SEIG capacitors or PAT hydraulic head, the SEIG stator current increases once and not again, while PAT-SEIG efficiency decreases, but the induction generator can be overloaded. The development of this research is key to the advancement of future models which can analyze the coupling of micro-hydropower solutions.This research received some support from the project REDAWN (Reducing Energy Dependency in Atlantic Area Water Networks) EAPA_198/2016 from INTERREG ATLANTIC AREA.Madeira, FC.; Fernandes, JFP.; Pérez-Sánchez, M.; López Jiménez, PA.; Ramos, HM.; Costa Branco, PJ. (2020). Electro-Hydraulic Transient Regimes in Isolated Pumps Working as Turbines with Self-Excited Induction Generators. Energies. 13(17):1-23. https://doi.org/10.3390/en13174521S1231317Postacchini, M., Darvini, G., Finizio, F., Pelagalli, L., Soldini, L., & Di Giuseppe, E. (2020). Hydropower Generation Through Pump as Turbine: Experimental Study and Potential Application to Small-Scale WDN. Water, 12(4), 958. doi:10.3390/w12040958Capelo, B., Pérez-Sánchez, M., Fernandes, J. F. P., Ramos, H. M., López-Jiménez, P. A., & Branco, P. J. C. (2017). Electrical behaviour of the pump working as turbine in off grid operation. Applied Energy, 208, 302-311. doi:10.1016/j.apenergy.2017.10.039Fecarotta, O., Aricò, C., Carravetta, A., Martino, R., & Ramos, H. M. (2014). Hydropower Potential in Water Distribution Networks: Pressure Control by PATs. Water Resources Management, 29(3), 699-714. doi:10.1007/s11269-014-0836-3Ramos, H., & Borga, A. (1999). Pumps as turbines: an unconventional solution to energy production. Urban Water, 1(3), 261-263. doi:10.1016/s1462-0758(00)00016-9Fernandes, J. F. P., Pérez-Sánchez, M., da Silva, F. F., López-Jiménez, P. A., Ramos, H. M., & Branco, P. J. C. (2019). Optimal energy efficiency of isolated PAT systems by SEIG excitation tuning. Energy Conversion and Management, 183, 391-405. doi:10.1016/j.enconman.2019.01.016Yi, Y., Zhang, Z., Chen, D., Zhou, R., Patelli, E., & Tolo, S. (2017). State feedback predictive control for nonlinear hydro-turbine governing system. Journal of Vibration and Control, 107754631774001. doi:10.1177/1077546317740013Khan, M. F., & Khan, M. R. (2016). Analysis of voltage build-up and speed disturbance ride through capability of a self-excited induction generator for renewable energy application. International Journal of Power and Energy Conversion, 7(2), 157. doi:10.1504/ijpec.2016.076521Han, Y., & Tan, L. (2020). Dynamic mode decomposition and reconstruction of tip leakage vortex in a mixed flow pump as turbine at pump mode. Renewable Energy, 155, 725-734. doi:10.1016/j.renene.2020.03.142Pérez-Sánchez, M., Sánchez-Romero, F. J., López-Jiménez, P. A., & Ramos, H. M. (2018). PATs selection towards sustainability in irrigation networks: Simulated annealing as a water management tool. Renewable Energy, 116, 234-249. doi:10.1016/j.renene.2017.09.060Pérez-Sánchez, M., López-Jiménez, P., & Ramos, H. (2018). PATs Operating in Water Networks under Unsteady Flow Conditions: Control Valve Manoeuvre and Overspeed Effect. Water, 10(4), 529. doi:10.3390/w1004052

Dual drug delivery from hydrophobic and hydrophilic intraocular lenses: in-vitro and in-vivo studies

Posterior capsule opacification (PCO) still remains the most frequent long term complication after cataract surgery, while endophthalmitis is rare but severe and should be prevented at all cost. Intraocular lenses (IOLs) with different designs (eg. edge and body-haptics angle) and materials (acrylic hydrophobic and acrylic hydrophilic surfaces) have been studied to reduce PCO. For the prevention of endophthalmitis, intracameral injection followed or not by topical treatment with antibiotics and anti-inflammatories are usually prescribed. The objective of this work was to investigate the use of IOLs as controlled release platforms of two drugs, the antibiotic moxifloxacin (MXF) and the anti-inflammatory ketorolac (KTL) that could advantageously substitute the usual treatment. Two types of IOLs were chosen, hydrophobic and hydrophilic. Hydrophobic IOLs have shown better results in the prevention of PCO because they adhere better to the posterior capsular bag, while hydrophilic IOLs are advised in the case of patients with uveitis, glaucoma or diabetes. The IOLs were loaded with MXF + KTL and sterilized by high hydrostatic pressure. Both IOLs reduced the tendency for adhesion of LECs. In vivo tests were done to compare the concentration of the drugs in the aqueous humor obtained after eye drops administration and drug-loaded IOLs implantation. The developed IOLs were able to release MXF and KTL at therapeutic levels, in a sustained way, which contrasts with the eye drops prophylaxis. No PCO signs were detected and histological analyses demonstrated biocompatibility of these devices.publishe

Capturing the wisdom of the crowd: health professions’ educators meet at a virtual world café

Background: Conversations about educational challenges and potential solutions among a globally and culturally diverse group of health professions’ educators can facilitate identity formation, mentoring relationships and professional network building. The COVID-19 pandemic has made it even more important to co-create and disseminate knowledge, specifically regarding online and flexible learning formats. Approach: Based on the principles of social learning, we combined speed mentoring and world café formats to offer a virtual Zoom™ workshop, with large and small group discussions, to reach health professions’ educators across the globe. The goal was to establish a psychologically safe space for dialogue regarding adaptation to online teaching-learning formats. Evaluation: We aimed to establish psychological safety to stimulate thought-provoking discussions within the various small groups and obtain valuable contributions from participants. From these conversations, we were able to formulate ‘hot tips’ on how to adapt to (sometimes new) online teaching-learning formats while nurturing teacher and student wellbeing. Reflection: Through this virtual workshop we realized that despite contextual differences, many challenges are common worldwide. We experienced technological difficulties during the session, which needed rapid adaptation by the organising team. We encouraged, but did not pressure, participants to use video and audio during breakout discussions as we wanted them to feel safe and comfortable. The large audience size and different time zones were challenging; therefore, leadership had to be resilient and focussed. Although this virtual format was triggered by the pandemic, the format can be continued in the future to discuss other relevant global education topics

Twelve tips for organising speed mentoring events for healthcare professionals at small or large-scale venues

Mentors play a critical role in the development of professionals, influencing their job satisfaction, career aspirations and evolving professional identity. A variety of mentoring models exist, each with distinct benefits and challenges. Speed mentoring, based on the concept of speed dating, provides mentees with opportunities to meet multiple mentors over a short time and pose focussed career development questions. At large-scale events such as the annual AMEE (Association for Medical Education in Europe) meeting, speed mentoring sessions can successfully connect aspiring, novice and mid-career educators with international educational leaders to facilitate transfer of valuable insights for professional growth. For some mentors and mentees, this might spur ongoing communications or even longitudinal relationships. In this paper, we aim to provide strategies for planning and implementing speed mentoring events, combining insights gained from the literature and our experience of organising speed mentoring at the 2019 AMEE meeting in Vienna. These tips will be useful to a variety of professionals planning to organise speed mentoring initiatives

A Cohort Analysis

Publisher Copyright: © 2022Background and Aims: The donor risk index (DRI) quantifies donor-related characteristics potentially associated with increased risk of early graft failure. We aimed to assess the impact of the DRI, recipient and perioperative factors on post liver transplant (LT) outcomes. Methods: This was a single-center retrospective cohort study including all adult (≥18 years) patients who underwent LT from 01/2019 to 12/2019 at Curry Cabral Hospital, Lisbon, Portugal. Primary endpoint was 1-year graft failure post LT. Associations were studied with logistic regression. Results: A total of 131 cadaveric donor LT procedures were performed in 116 recipients. Recipients' median (IQR) age was 57 (47-64) years and 101/131 (77.1%) were males. Cirrhosis was the underlying etiology in 95/131 (81.2%) transplants. Based on 8 predefined donors' characteristics, median (IQR) DRI was 1.96 (1.67-2.16). Following adjustment for MELDNa score pre LT and SOFA score (adjusted odds ratio [aOR], 95% confidence interval [CI] = 0.91 [0.56-1.47]) or lactate (aOR [95% CI] = 2.76 [0.71-10.7]) upon intensive care unit (ICU) admission post LT, DRI was not associated with 1-year graft failure. However, higher SOFA score (aOR [95% CI] = 1.20 [1.05-1.37]) or lactate (aOR [95% CI] = 1.27 [1.10-1.46]) upon ICU admission post LT were independently associated with higher odds of 1-year graft failure. Conclusions: In a recent cohort of patients who underwent LT, DRI, despite being high, was not associated with 1-year graft failure, but SOFA score or lactate upon ICU admission post LT were.publishersversionepub_ahead_of_prin