Effect of mao-A and mao-B inhibitors in ganglia and nerve endings

Se estudio el efecto de clorgilina y deprenil sobre la liberación y el metabolismo de 3H-noradrenalina (3H-NA) en elganglio superior (GCS) y en la membrana nictitante (MN) de gato. Nuestros resultados muestran que en el GCS,clorgilina y deprenil redujeron del mismo modo la formación de 3,4-dihidroxi-fenilglicol (DOPEG) mientras que enla MN la disminución del DOPEG fue mayor con clorgilina que con deprenil. En el GCS la monoaminooxidasa(MAO) A y B cataliza la deaminación de NA a 3H-DOPEG, a 3H-3,4-acido-dihidroximandílico (3H-DOMA) o a losmetabolitos 3H—O-metilados deaminados (3H-OMDA). En la MN la MAO-A presináptica cataliza la deaminaciónde NA principalmente a 3H-DOPEG, la MAO-B postsináptica a 3H-NMN y; la MAO-A y B a 3H-DOMA y 3H-OMDA

Towards an HPC certification program

The HPC community has always considered the training of new and existing HPC practitioners to be of high importance to its growth. This diversification of HPC practitioners challenges the traditional training approaches, which are not able to satisfy the specific needs of users, often coming from non-traditionally HPC disciplines, and only interested in learning a particular set of competences. Challenges for HPC centres are to identify and overcome the gaps in users’ knowledge, while users struggle to identify relevant skills. We have developed a first version of an HPC certification program that would clearly categorize, define, and examine competences. Making clear what skills are required of or recommended for a competent HPC user would benefit both the HPC service providers and practitioners. Moreover, it would allow centres to bundle together skills that are most beneficial for specific user roles and scientific domains. From the perspective of content providers, existing training material can be mapped to competences allowing users to quickly identify and learn the skills they require. Finally, the certificates recognized by the whole HPC community simplify inter-comparison of independently offered courses and provide additional incentive for participation

The Human Understanding of Garments: An Exploratory Study on Technology Inspired Clothing Design for Young Adults with Anxiety

Kirmser Undergraduate Research Award - Group category, grand prizeYingying WuThe purpose of this exploratory study investigates the clothing preferences and choices of people who have anxiety issues. The goal of this project is three-fold: 1) studying the relationship between people's anxiety and their clothing choices; 2) experiment with different apparel technologies to accommodate the wants and needs of people who have anxiety issues, and 3) developing an apparel collection that incorporates apparel technologies to address the anxiety issues of the wearer. The basis for this project revolves around innovative apparel technology, anxiety issues, and their relationships with clothing preferences and choices. The research study included questions about the effect of color, comfort, and fit in clothing in correspondence to participants' anxiety as well as their demographics. Our project “HUG” is focused on the subjects within our 18–25-year target market

The HPC certification forum: toward a globally acknowledged HPC certification

The goal of the HPC Certification Forum is to categorize, define, and examine competencies expected from proficient HPC practitioners. The community-led forum is working toward establishing a globally acknowledged HPC certification process, a process that engages with HPC centres to identify gaps in users’ knowledge, and with users to identify the skills required to perform their tasks. In this article, we introduce the forum and summarize the progress made over the last two years. The release of the first officially supported certificate is planned for the second half of 2020

Impact of IFRS on Deferred Taxes Methodology in the Czech Republic and comparison with IFRS for SMEs

Investigating impact of IFRS on the accounting regulatory system in the Czech Republic, there should be highlighted that IFRS were introduced into the regulatory system gradually as a separate regulatory system for determined group of accounting entities, on the other hand IFRS have had influence on the development of the local accounting rules during last decade. It was awaited by practitioners and academics too, that the process of deferred taxes reform will be finalized by issuing the Decree on accounting for business entities and by the Czech Accounting Standard on deferred taxes. But the reform as for deferred taxes was realized only partially and wasn’t adopted a holistic approach of IFRS implementation into local national accounting regulatory system. Based on the criticism of partial implementation of IAS 12 into local accounting rules, this article is focused on comparability of Czech accounting rules for deferred taxes with IFRS for SME. Conclusion from this investigation might become fundamentals for similar European accounting systems to the Czech Republic

Impact of IAS 12 on Deferred Taxes Regulation in the Czech Republic.

This article investigates the impact of IAS 12 on deferred taxes regulation in the Czech Republic, where local accounting regulations includes accounting standards only by names, but not as an output of regular due process and which are not issued by the professional accounting body at all, not even partially. The article deals with the development and description of the Czech accounting system from early nineties of last century till present time as a background for IFRS implementation. Then the article followed subsequent steps of IAS 12 implementation into the hierarchy of legal rules for accounting, starting with the Act on accounting, decree on business entities and Czech accounting standard for deferred taxes. IAS 12 implementation into Czech accounting system is an example of partial and incomplete implementation of IFRS into domestic accounting rules based on different law presumption than under which are IFRS developed. Example of IAS 12 implementation into Czech accounting regulatory system, provide the reader clear demonstration of wrong philosophy how to reach comparable accounting information. Based on the published criticism, the recommendation is not to continue in partial IFRS implementation but make good rule for entities to allow them to choose either full IFRS or domestic rules applicable in compliance with the approach “think small first”

Effect of monocrotaline on blood-brain barrier permeability in rats

We studied if monocrotaline (MCT) portal hypertensive model modifies blood-brain barrier (BBB) condition. Male Wistar rats were used: Group MCT injected i.p. with MCT (60 mg/kg of body weight) and Group Sham (GS) with saline. Forty-four days after injection rats were sacrificed. Trypan blue and Evans blue tests were performed to evaluate BBB integrity in both groups. In cerebrospinal fluid (CF), protein and glucose were determined. Alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (AP) were measured in serum samples. Portal pressure rose after MCT injection. Trypan blue diffused into hippocampus, Evans blue increased concentrations in brain of Group MCT and CF showed an increase in protein and glucose content in Group MCT. Serum AST, ALT and AP activities were significantly increased in Group MCT rats. It is suggested that liver damage and vasoconstrictor substances could produce portal hypertension, associated to toxic effects on brain and modifying thereby the BBB permeability.Colegio de Farmacéuticos de la Provincia de Buenos Aire

Evaluating impacts of improved flooring on enteric and parasitic infections in rural households in Kenya: study protocol for a cluster-randomised controlled trial

Introduction: Earthen floors are often damp or dusty and difficult to clean, providing an ideal environment for faecal pathogens and parasites. Observational studies have revealed associations between household flooring and health outcomes, but robust experimental evidence is scant. This study will evaluate the impact of an improved household flooring intervention on enteric infections, soil-transmitted helminth (STH) infections and tungiasis through implementation of a cluster-randomised trial in two rural settings in Kwale and Bungoma Counties, Kenya. Methods and analyses: 440 clusters (households) across both sites are allocated to control or intervention group, in which a low-cost, sealed, washable, cement-based floor is installed in eligible buildings of the dwelling, alongside a floor-care guide provided during an induction meeting. Following baseline assessments in both groups, all individuals over 1 year receive albendazole and those infected with tungiasis receive benzyl benzoate. Primary outcomes are as follows: prevalence of enteric infections in children under 5 years assessed via stool surveys and PCR; prevalence of tungiasis infection in children 1–14 years based on clinical exam; and prevalence of STH infection in all household members over 1 year assessed via Kato-Katz. Secondary outcomes include the following: intensity of STH and tungiasis infections; prevalence of caregiver-reported gastrointestinal illness in children under 5; quality of life and well-being measures; and environmental contamination. A process evaluation investigates intervention acceptability, durability, practicality and cost. Ethics and dissemination: The protocol has been approved by ethics committees of The Kenya Medical Research Institute, The Kenya National Commission for Science Technology and Innovation, and The London School of Hygiene & Tropical Medicine. Following the 12-month implementation period and final assessments, control households are offered improved floors. Results will be disseminated within Kenya, to the Ministries of Health and of Lands, Public Works, Housing and Urban Development, and to subnational leadership and communities. Dissemination will also occur through publications and conference presentations. Trial registration number: NCT05914363

L’aventure... aux champs

Tout d'abord, nous allons explorer une pensée scientifique où le mythe trouve sa place, notamment dans les écrits du physicien Bernard d'Espagnat et, sans perdre de vue la source et la fôret, nous allons consulter les interprétations de ces êtres vivants ; interprétations fondatrices de la Mythologie, d'après les enseignements d'Heinz Wismann. Notre hypothèse est que la convergence de la science et du mythe dans sa relation avec le Pouvoir aurait la vertu de nous ramener vers l'intérieur de l'être et vers une pensée contemplative, aux dires de Max Weber. S'il est plausible de rendre compte de cette pensée, de cette tendance qui acquiert une dimension citoyenne, on peut aussi rendre possible le réveil nature!, le réveil dans la Nature, cette Nature qui a tant inspiré Gaston Bachelard, auteur incontournable dans cet article