Geochemistry and petrology of primitive achondrite meteorites LEW 88280, MAC 88177, ALHA 81187, EET 84302, and LEW 88663

Primitive achondrites are meteorites that have mineral and bulk chemical compositions similar to the most primitive meteorites (chondrites) but have textures similar to more evolved meteorites (achondrites). The unique geochemistry and texture of the primitive achondrites suggest these meteorites may be genetic intermediates between chondrites and achondrites and may preserve evidence of processes occurring in the early solar system. Five primitive achondrites LEW 88280, MAC 88177, ALHA 81187, EET 84302, and LEW 88663 were examined in this study in order to classify the meteorites and to determine processes that have affected them. Bulk chemical analyses of Nap, K2O, CaO, FeO, Cr, Co, Ni, Sc, Ir, Au, As, Sb, Se, Br, Cs, Ba, La, Ce, Nd, Sm, Eu, Tb, Yb, and Lu were determined for each meteorite by Instrumental Neutron Activation Analysis (INAA). Concentrations of Hf, U, and Th were determined for some meteorites. Polished thin sections of the five meteorites were examined in transmitted and reflected light microscopy to identify minerals and examine petrographic relationships. Minerals found in the meteorites include olivine, orthopyroxene, clinopyroxene, plagioclase, Cr-spinel, phosphates, troilite, kamecite, and taenite along with other minor phases. Mineral compositions were determined with an electron microprobe. The initial study suggests that the meteorites have been altered by metamorphic processes although igneous processes may also have played a role in the evolution of these rocks. Further studies of isotope and bulk chemistry are planned for these meteorites

Perceptions of the learning environment in higher specialist training of doctors: implications for recruitment and retention.

INTRODUCTION: Career choice, sense of professional identity and career behaviour are influenced, subject to change and capable of development through interaction with the learning environment. In this paper workplace learning discourses are used to frame ongoing concerns associated with higher specialist training. Data from the first stage of a multimethods investigation into recruitment into and retention in specialties in the West Midlands is used to consider some possible effects of the specialist learning environment on recruitment and retention. METHODS: The aim of the study was to identify issues, through interviews with 6 consultants and questionnaires completed by specialist registrars from specialties representing a range of recruitment levels. These would inform subsequent study of attributes and dispositions relevant to specialist practice and recruitment. The data were analysed using NVivo software for qualitative data management. RESULTS: Participants' perceptions are presented as bipolar dimensions, associated with: curriculum structure, learning relationships, assessment of learning, and learning climate. They demonstrate ongoing struggle between different models of workplace learning. CONCLUSION: Changes in the postgraduate education of doctors seem set to continue well into the future. How these are reflected in the balance between workplace learning models, and how they influence doctors' sense of identity as specialists suggests a useful basis for examination of career satisfaction and recruitment to specialties

School District Stress Prevention Practices in a Southern U.S. State

The growing recognition that stress is a risk factor for youth health problems has spawned research on school-based stress prevention programs and services. While such programs and services are now available for adoption by schools, there is an absence of data on their use in U.S. schools systems. In the current study, Everett Rogers\u27s diffusion of innovations model provided the theoretical framework for the investigation of school district stress prevention practices in one southern U.S. state. The sample for this quantitative descriptive study consisted of 135 out of 136 active public districts, and 72% of school systems completed and returned the survey (N = 97). Participants were designated school system personnel (83% administrators) who accepted either the e-mail or postal invitation to take part in the study. Descriptive data were gathered on the prevalence and characteristics of stress prevention programs and services for students, and the relationship between school district characteristics and programming and services prevalence was examined via chi-square and Fisher\u27s exact tests. The frequency results indicate that 19% of districts provide programming, 22% provide services, and 23% provide both programming and services to students, and the Fisher\u27s exact test revealed that programming prevalence is highest among urban districts compared to small town/rural school systems (p = 0.12). Recommendations for future research include the study of stress prevention practices with students and school system personnel at the national level. The findings of this study may contribute to the health and welfare of children and adolescents by informing the efforts of school systems to promote the adaptive competence of general student populations

Roflumilast, a Novel Phosphodiesterase 4 Inhibitor, for COPD Patients with a History of Exacerbations

Acute exacerbations of COPD (AECOPD) are major clinical events. They are associated with a more rapid decline in lung function, poorer quality of life scores, and an increased risk of dying. Exacerbations that require hospitalization have particular significance. Approximately 40% of the AECOPD patients who require hospitalization will die in the subsequent year. Since many AECOPD require hospitalization, they account for most of the expense of caring for COPD patients. Treatment with long-acting bronchodilators and combination inhaled corticosteroid/long-acting bronchodilator inhalers reduces but does not eliminate AECOPD. Roflumilast, a selective phosphodiesterase 4 (PDE4) inhibitor, is an anti-inflammatory medication that improves lung function in patients with COPD. In patients with more severe airway obstruction, clinical features of chronic bronchitis, and a history of AECOPD, roflumilast reduces the frequency of AECOPD when given in combination with short-acting bronchodilators, long-acting bronchodilators, or inhaled corticosteroids. It is generally well tolerated but the most common adverse effects include diarrhea, nausea, weight loss, and headaches. In clinical trials, patients treated with roflumilast experienced weight loss that averaged just over 2 kg but was primarily due to the loss of fat tissue. Weight loss was least in underweight patients and obese patients experienced the greatest weight loss. An unexpected benefit of treatment with roflumilast was that fasting blood glucose and hemoglobin A1c levels improved in patients with comorbid type 2 diabetes mellitus. Roflumilast, the first selective PDE4 inhibitor to be marketed, is a promising drug for the management of COPD patients with more severe disease

Blood group polymorphisms in Southern Africa and innate resistance to plasmodium falciparum

A research report submitted to the faculty of Medicine, University of the Witwatersrand, Johannesburg, in part fulfillment of the requirements for the degree of Master of Medicine (in the branch of Haematology) Johannesburg 1992.The observation by Haldane in 1949 that the distribution of malaria and certain thalassaemias were similar and that the former disease must be a selective force tor the continued existence of the latter by preservation of the heterozygotes. This theory which later became known as lithe malaria hypothesis" has been applied to other inherited conditions such as G6PD deficiency, membranopathies, certain blood group polymorphisms, other heamoglobinopathies such as sickle cell disease, blood group polymorphisms and more recently HLA phenotypes. It has been shown that the Duffy blood group antigens are the receptors for. Plasmodium vivax and since these antigens are lacking in most black Africans this species of malaria is virtually absent in Africa. It has also been shown that the glycophorins are at least in part the receptors for Pfalciparum. Several variants of the glycophorins exist and the biochemistry and, where known, the molecular mechanisms by which these arise is reviewed. Experimental work is carried out to establish the growth characteristics of Pfalciparum in an in vitro culture system using cells with glycophorin variants on their membranes. Three such variants were compared to normal cells and two (S~s-U-and Dantu) were found to be partially resistant to invasion by Pfalciparum merozoites whereas the third (Henshaw) was found to be no different to controls.MT201

Feedback on Academic Essay Writing through pre-Emptive Hints: Moving Towards "Advice for Action"

This paper adopts an “advice for action” approach to feedback in educational practice: addressing how provision of “hints” to participants before they write academic essays can support their understanding and performance in essay-writing tasks. We explored differences in performance by type of hint, and whether there was a transfer of better performance in subsequent essays. Fifty participants were recruited, consisting of eight men and 42 women aged 18-80. Participants were assigned in rotation to four groups, and asked to write two essays. Groups 1 and 3 received hints before Essay 1, whilst Groups 2 and 4 received hints before Essay 2. Groups 1 and 2 received essential hints; Groups 3 and 4 received helpful hints. Essays were marked against set criteria. The results showed that an “advice for action” approach to essay-writing, in the form of hints, can significantly improve writers’ marks. Specifically higher marks were gained for the introduction, conclusion and use of evidence: critical components of “good” academic essays. As the hints given were content-free, this approach has the potential to instantly benefit tutors and students across subject domains and institutions and is informing the development of a technical system that can offer formative feedback as students draft essays

A geochemical study of acapulcoite and lodranite meteorites

Lodranites and acapulcoites (primitive achondrites) are two classes of meteorites with geochemical signatures similar to chondrite meteorites. Lodranites and acapulcoites, however, have few or none of the chondrules characteristic of the chondrites. Texturally the primitive achondrites appear to have been recystallized though planetary igneous or metamorphic processes. A study of five primitive achondrites, two lodranites, two acapulcoites, and one supposedly intermediate acapulcoite/lodranite, were analyzed petrographically and geochemically to determine the igneous and metamorphic processes which have affected them. Acapulcoites show little evidence of melt extraction. The geochemistry of lodranite samples indicates silicate and metal/sulfide melts were removed from the rocks. The mineralogy and geochemistry of the intermediate meteorite suggest the rock is a metal rich acapulcoite and not a lodranite