Do Blue Flag promotions influence tourists’ willingness to pay a price premium for coastal destinations?

The Blue Flag is a popular eco-label in tourism. This study aims at examining the effectiveness of Blue Flag promotion on tourists' willingness to pay a price premium to coastal destinations via two online experiments. Study 1 shows (n = 152) that the Blue Flag stimulates higher willingness to pay a price premium for coastal destinations directly as well as indirectly through self-congruity and destination brand identification. Study 2 (n = 160) used a new sample to enhance external validity and generalizability of the Study 1 findings. Study 2 shows that destination brand quality and destination brand identification serially mediate the effect of Blue Flag promotions on the tourist's willingness to pay a price premium. The findings suggest that destination managers should deploy the Blue Flag Logo in destination promotions to enhance self-congruence, destination brand identification, perceived destination quality, and the tourist's willingness to pay a price premium

The Impact of Political Factors on International Student Mobility

International student mobility contributes to a knowledge-based economy and forms an important component of a highly educated migration. This article aims to identify how far political factors – including political discrimination, restrictions, freedom, UK migration policies and social cultural norms and policies - enhance or inhibit individuals’ capabilities to become mobile. It offers a novel conceptualisation of mobility drawing on Structuration Theory and Capability Approach to reveal the link between structure, capability and agency in the mobility process. Semi-structured in-depth interviews were conducted with forty PhD students, two professors from Turkey in the UK and three international education experts. A capability list established shows how mobility occurs when students’ capabilities (freedoms) fail to flourish and they lose their power (capacity) to influence society due to the political environment in the home country. ‘Impo-mobility’, derived from the word ‘imposed’, is proposed to refer to highly educated people having to become mobile as a result of impositions placed upon them by home and host government political practices. An appealing political environment is necessary if Turkey is not to lose highly educated individuals and the UK is to remain a global player in international higher education

Phase 2 of the Multiple Provider Employment Zones Qualitative Study, DWP Research Report 399

This report presents the findings of a qualitative study of the operation and impact of the Multiple Provider Employment Zone (MPEZ) initiatives that have operated in four cities (London, Birmingham, Liverpool and Glasgow) since 20041. The study builds on earlier work by Cambridge Policy Consultants (Hirst et al. 2006), which concentrated on issues related to the early establishment of the MPEZ initiative and the initial experiences of Providers, Jobcentre Plus districts and customers. The Phase 2 research took place approximately one year on from the Phase 1 study and focused on tracking developments in the operation of MPEZ as the initiative became more established. The study involved interviews with EZ Providers (managers and Advisers), Jobcentre Plus representatives (managers and Advisers) and customers (young people (aged 18-24) claiming Jobseeker’s Allowance (JSA), who would otherwise have returned to New Deal for Young People (NDYP)2, lone parents receiving Income Support and early entrants – see section 1.6 for full details). In order to gain a wider perspective, researchers also spoke to representatives of organisations that have employed MPEZ participants and a number of stakeholder organisations with a broad interest in local labour market policies and programmes in the MPEZ areas. In total, the research involved interviews or group discussions with over 300 individuals, providing a range and depth of qualitative information that allows a detailed picture to be established of the way that MPEZs developed between mid- 2005 and mid-2006, including the experiences of employers and the labour market destinations of MPEZ participants. A central issue addressed in the research and in this report is the ‘multiple’ element of the initiative and the value that is added through the existence of more than one Provider in each MPEZ area. Questions of allocation, choice, specialisation, competition and innovation are considered from the perspectives of Providers, Jobcentre Plus, customers, employers and stakeholders and the final sections present some conclusions and issues for consideration in relation to these topics

Beyond advocacy: making space for conservation scientists in public debate

The topic of advocacy by scientists has been debated for decades, yet there is little agreement about whether scientists can or should be advocates. The fear of crossing a line into advocacy continues to hold many scientists back from contributing to public discourse, impoverishing public debate about important issues. We believe that progress in this debate is limited by a misconception about the relationship between scientific integrity and objectivity. We begin by unpacking this relationship and debunking three common misconceptions about advocacy by scientists: namely, that advocacy is harmful to scientific credibility, beyond the scope of science, and incompatible with science, which is value-free. We propose new ways of thinking about responsible advocacy by conservation scientists, drawing on practices from the health sciences, where researchers and professional bodies are empowered to act as health advocates.In so doing, we hope to open further space for conservation scientists to actively and legitimately engage in public debate about conservation issues

Use of archival versus newly collected tumor samples for assessing PD-L1 expression and overall survival : an updated analysis of KEYNOTE-010 trial

Background: In KEYNOTE-010, pembrolizumab versus docetaxel improved overall survival (OS) in patients with programmed death-1 protein (PD)-L1-positive advanced non-small-cell lung cancer (NSCLC). A prespecified exploratory analysis compared outcomes in patients based on PD-L1 expression in archival versus newly collected tumor samples using recently updated survival data. Patients and methods: PD-L1 was assessed centrally by immunohistochemistry (22C3 antibody) in archival or newly collected tumor samples. Patients received pembrolizumab 2 or 10 mg/kg Q3W or docetaxel 75 mg/m2 Q3W for 24 months or until progression/intolerable toxicity/other reason. Response was assessed by RECIST v1.1 every 9 weeks, survival every 2 months. Primary end points were OS and progression-free survival (PFS) in tumor proportion score (TPS) 50% and 1%; pembrolizumab doses were pooled in this analysis. Results: At date cut-off of 24 March 2017, median follow-up was 31 months (range 23-41) representing 18 additional months of follow-up from the primary analysis. Pembrolizumab versus docetaxel continued to improve OS in patients with previously treated, PD-L1-expressing advanced NSCLC; hazard ratio (HR) was 0.66 [95% confidence interval (CI): 0.57, 0.77]. Of 1033 patients analyzed, 455(44%) were enrolled based on archival samples and 578 (56%) on newly collected tumor samples. Approximately 40% of archival samples and 45% of newly collected tumor samples were PD-L1 TPS 50%. For TPS 50%, the OS HRs were 0.64 (95% CI: 0.45, 0.91) and 0.40 (95% CI: 0.28, 0.56) for archival and newly collected samples, respectively. In patients with TPS 1%, OS HRs were 0.74 (95% CI: 0.59, 0.93) and 0.59 (95% CI: 0.48, 0.73) for archival and newly collected samples, respectively. In TPS 50%, PFS HRs were similar across archival [0.63 (95% CI: 0.45, 0.89)] and newly collected samples [0.53 (95% CI: 0.38, 0.72)]. In patients with TPS 1%, PFS HRs were similar across archival [0.82 (95% CI: 0.66, 1.02)] and newly collected samples [0.83 (95% CI: 0.68, 1.02)]. Conclusion: Pembrolizumab continued to improve OS over docetaxel in intention to treat population and in subsets of patients with newly collected and archival samples

A vibration powered wireless mote on the Forth Road Bridge

The conventional resonant-approaches to scavenge kinetic energy are typically confined to narrow and single-band frequencies. The vibration energy harvester device reported here combines both direct resonance and parametric resonance in order to enhance the power responsiveness towards more efficient harnessing of real-world ambient vibration. A packaged electromagnetic harvester designed to operate in both of these resonant regimes was tested in situ on the Forth Road Bridge. In the field-site, the harvester, with an operational volume of ~126 cm3, was capable of recovering in excess of 1 mW average raw AC power from the traffic-induced vibrations in the lateral bracing structures underneath the bridge deck. The harvester was integrated off-board with a power conditioning circuit and a wireless mote. Duty- cycled wireless transmissions from the vibration-powered mote was successfully sustained by the recovered ambient energy. This limited duration field test provides the initial validation for realising vibration-powered wireless structural health monitoring systems in real world infrastructure, where the vibration profile is both broadband and intermittent

A selective retinoid X receptor agonist bexarotene (LGD1069, targretin) inhibits angiogenesis and metastasis in solid tumours

The present study determined the influence of a retinoid X receptor agonist bexarotene on angiogenesis and metastasis in solid tumours. In the experimental lung metastasis xenograft models, treatment with bexarotene inhibited the development of the lung tumour nodule formation compared to control. In vivo angiogenesis assay utilising gelfoam sponges, bexarotene reduced angiogenesis in sponges containing vascular endothelial growth factor, epidermal growth factor and basic fibroblast growth factor to various extent. To determine the basis of these observations, human breast and non-small-cell lung cancer cells were subjected to migration and invasion assays in the presence of bexarotene. Our data showed that bexarotene decrease migration and invasiveness of tumour cells in a dose-dependent manner. Furthermore, bexarotene inhibited angiogenesis by directly inhibiting human umbilical vein endothelial cell growth and indirectly inhibiting tumour cell-mediated migration of human umbilical vein endothelial cells through Matrigel matrix. Analysis of tumour-conditioned medium indicated that bexarotene decreased the secretion of angiogenic factors and matrix metalloproteinases and increased the tissue inhibitor of matrix metalloproteinases. The ability of bexarotene to inhibit angiogenesis and metastasis was dependent on activation of its heterodimerisation partner peroxisome proliferator-activated receptor γ. Collectively, our results suggest a role of bexarotene in treatment of angiogenesis and metastasis in solid tumours