SP597FAVOURABLE BIOCHEMICAL OUTCOMES OF FREQUENT HEMODIALYSIS AT HOME USING THE NXSTAGE® SYSTEM ONE™ - THE EUROPEAN EXPERIENCE

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Country of patients and controls

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Opinion of the patients with prurigo (126 answers) and controls (2752 answers) concerning their appearance (%).

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Experimental Study of a Lyotropic Lamellar Phase Swollen with Polymer Solutions

We report on the effect of a hydrosoluble neutral polymer on the stability of a lamellar phase made of charged surfactant bilayers. In the system investigated, the smectic structure exists for a wide range of dilutions, with smectic periods continuously varying between 30 and 300 Å. Our results show that the lamellar structure still exists when pure water is replaced with aqueous solutions of polyethyleneglycol (PEG: radius of gyration $R_{\rm g}=29$ Å, molecular weight $M_{\rm w} = 22600$ g/mol). Large amounts of PEG can be solubilized in the mesophase: up to 50% of the water can be replaced by the polymer. However, the added polymer causes a reduction in the swelling of the phase and most remarkably produces at intermediate polymer and bilayer concentrations a phase separation between two lamellar phases of different periods. We have studied the system with static (X-ray or neutron) and dynamic (light) scattering techniques. The polymer gets partially associated to the surfactant bilayer, as revealed by the small decrease of the smectic spacing as a function of PEG concentration at constant surfactant cosurfactant volume fractions. Besides, the interactions between bilayers are less repulsive in the presence of PEG than the weakly-screened electrostatic repulsion expected with our ionic surfactant. Interactions may even become attractive, which leads to a phase separation between two lamellar phases. The decrease in the layer compression modulus $\bar{B}$ is studied through its consequences on Bragg peak linewidth, small angle scattering and baroclinic mode relaxation frequency. The eventual presence of critical points on the border of the closed-loop smectic-smectic miscibility gap is investigated

Use of Cosmetic Products in Pregnant and Breastfeeding Women and Young Children: Guidelines for Interventions during the Perinatal Period from the French National College of Midwives

International audienceWe conducted a literature review focusing on the use and health effects of cosmetics, especially among pregnant and lactating women and young children. Based on these data, we propose clinical practice guidelines for health care professionals to use for informing and advising their patients. These include the recommendations that families: (1) reduce the number and the frequency of use (grade B) and the amount applied (expert consensus) of all cosmetic products during the perinatal period and among children; (2) prefer simple, fragrance-free, and rinsable products, with short ingredient lists (expert consensus); and (3) for children, avoid industrial wipes and prefer water, with suitable soap when necessary. © 2022 by the American College of Nurse-Midwives

Elastic properties of polymer-doped dilute lamellar phases: A small-angle neutron scattering study

We investigate experimentally, using small-angle neutron scattering the elastic properties of polymer-doped dilute lamellar phases. In our system the polymer is water-soluble but nevertheless partially adsorbs onto the negatively charged surfactant bilayers. The effective polymer-mediated interaction between bilayers is less repulsive than the weakly screened electrostatic interaction that prevails at zero polymer content. It even becomes attractive in some regions of the phase diagram. Small-angle neutron scattering allows us to measure directly the Caillé exponent $\eta$ characterizing the bilayer fluctuations in lamellar (smectic A) phases, and thus indirectly estimate the compression modulus $\bar{B}$ as a measure of the strength of the bilayer-bilayer interactions. The compression modulus appears to be vanishing at a point located on the lamellar-lamellar phase separation boundary, a candidate critical point

Probabilistic exposure assessment to face and oral care cosmetic products by the French population

International audienceCosmetic exposure data for face and mouth are limited in Europe. The aim of the study was to assess the exposure to face cosmetics using recent French consumption data (Ficheux et al., 2016b, 2015). Exposure was assessed using a probabilistic method for thirty one face products from four lines of products: cleanser, care, make-up and make-up remover products and two oral care products. Probabilistic exposure was assessed for different subpopulation according to sex and age in adults and children. Pregnant women were also studied. The levels of exposure to moisturizing cream, lip balm, mascara, eyeliner, cream foundation, toothpaste and mouthwash were higher than the values currently used by the Scientific Committee on Consumer Safety (SCCS). Exposure values found for eye shadow, lipstick, lotion and milk (make-up remover) were lower than SCCS values. These new French exposure values will be useful for safety assessors and for safety agencies in order to protect the general population and the at risk populations. © 201

Alpha-helical coiled-coil oligomerization domains are almost ubiquitous in the collagen superfamily.

International audienceAlpha-helical coiled-coils are widely occurring protein oligomerization motifs. Here we show that most members of the collagen superfamily contain short, repeating heptad sequences typical of coiled coils. Such sequences are found at the N-terminal ends of the C-propeptide domains in all fibrillar procollagens. When fused C-terminal to a reporter molecule containing a collagen-like sequence that does not spontaneously trimerize, the C-propeptide heptad repeats induced trimerization. C-terminal heptad repeats were also found in the oligomerization domains of the multiplexins (collagens XV and XVIII). N-terminal heptad repeats are known to drive trimerization in transmembrane collagens, whereas fibril-associated collagens with interrupted triple helices, as well as collagens VII, XIII, XXIII, and XXV, were found to contain heptad repeats between collagen domains. Finally, heptad repeats were found in the von Willebrand factor A domains known to be involved in trimerization of collagen VI, as well as in collagen VII. These observations suggest that coiled-coil oligomerization domains are widely used in the assembly of collagens and collagen-like proteins.Alpha-helical coiled-coils are widely occurring protein oligomerization motifs. Here we show that most members of the collagen superfamily contain short, repeating heptad sequences typical of coiled coils. Such sequences are found at the N-terminal ends of the C-propeptide domains in all fibrillar procollagens. When fused C-terminal to a reporter molecule containing a collagen-like sequence that does not spontaneously trimerize, the C-propeptide heptad repeats induced trimerization. C-terminal heptad repeats were also found in the oligomerization domains of the multiplexins (collagens XV and XVIII). N-terminal heptad repeats are known to drive trimerization in transmembrane collagens, whereas fibril-associated collagens with interrupted triple helices, as well as collagens VII, XIII, XXIII, and XXV, were found to contain heptad repeats between collagen domains. Finally, heptad repeats were found in the von Willebrand factor A domains known to be involved in trimerization of collagen VI, as well as in collagen VII. These observations suggest that coiled-coil oligomerization domains are widely used in the assembly of collagens and collagen-like proteins