A case of neuroleptic malignant syndrome on withdrawal of benzhexol

The neuroleptic malignant syndrome is a rare and potentially lethal reaction which is usually associated with the use of medications with antidopaminergic properties. This article describes the case of an elderly gentleman who developed the neuroleptic malignant syndrome after withdrawal of the anticholinergic agent benzhexol (trihexyphenidyl hydrochloride), which he was taking for Parkinson’s disease. The patient improved rapidly after treatment was restarted. This case adds to the evidence that antidopaminergic agents may not be necessary for the development of this syndrome, and increased awareness of this possibility is advisable in such circumstances.peer-reviewe

Searching for Ha-Selected Planetary Nebulae in the UWISH2 Galactic Plane Molecular Hydrogen Survey

This thesis seeks to analyse and quantify the differences present in 2 different emission mechanisms seen in Planetary Nebulae (PN). These are H emission from recombination of ionised hydrogen and H2 emission from photoexcitation of molecular hydrogen gas. Firstly, I have gathered images from the UKIRT Widefield Infrared Survey for H2 (UWISH2), which correspond to PN in the Macquarie/AAO/Strasbourg H (MASH) Planetary Nebula Galactic Cataloge, which have been compared and contrasted, and the full extent of which will be featured in the appendices of this report. Secondly, I have gathered images from the UWISH2, which correspond to PN found in the INT/WFC Photometric H Survey (IPHAS) of the Northern Galactic plane by Viironen et al. 2009, which have been compared and contrasted and will be featured in the appendices of this report. The results gained from this work challenge the assumption of Gatley's Rule that molecular hydrogen is a predictor for bipolar emission in PN with more than half of the PN in the MASH sample showing such emission, and approximately 80% of the PN in the IPHAS sample as well. This work has shown that H2 emission is a good method of searching for PN and may further be used as a tool to further confirm objects as true PN

A new policy toolkit is needed as countries exit COVID-19 lockdowns. Bruegel Policy Contribution Issue n ̊12 | June 2020.

When it became clear that the COVID-19 pandemic required widespread lockdown of all but essential firms, most governments took measures to protect vulnerable workers and firms from the worst effects of the sudden drop in activity. These measures included unemploy- ment benefits, grants, transfers, loans at low rates and tax deferrals. Their nearly exclusive focus was protection. As lockdowns are lifted, as some of these measures come to an end, and as it becomes clear that some sectors will have to contract and others expand, the focus must progressively shift. As usual in the aftermath of a major shock, protection must be balanced with reallocation, taking into account changing prospects for sectors and firms. Incentives must be given to firms and workers to resume activity, and, when needed, to adjust. Debt inherited from the freeze must be restructured if unsustainable. But policymakers must also consider the consequences of heightened uncertainty about the course of the pandemic and the economy, and the large increase in the number of workers out of work. In other words, as governments in advanced economies move from freeze to exit, they must design measures that will limit the pain of adjustment. This Policy Contribution explores how such measures can be designed. Section 1 briefly describes the measures that were taken to accompany the lockdown, in particular in Europe and the United States. Section 2 presents the protection and reallocation architecture that should underlie the new measures, namely a combination of unemployment benefits to help workers, wage subsidies and partially guaranteed loans to help firms, and a process-light restructuring of legacy debts. Section 3 concludes

Toxoplasmose congénitale : Etat des lieux et modalités de dépistage et surveillance

La toxoplasmose congénitale est depuis plusieurs années l’objet de nombreuses controverses. La littérature concernant les différents aspects de prise en charge de la toxoplasmose congénitale ne permet pas à ce jour d’obtenir des évidences de qualité suffisante pour des recommandations. Il en découle de ce fait des stratégies diverses et variées à travers le monde. Dès 2008, un changement majeur de la prévention a eu lieu en Suisse, à savoir l’arrêt du dépistage sérologique prénatal systématique des femmes enceintes. Dès lors, la prévention primaire est devenue le seul moyen utile pour prévenir une toxoplasmose congénitale. La prévention primaire consiste principalement en des mesures d’éviction de denrées alimentaires potentiellement souillées par de la terre contaminée, de laver abondamment les fruits et légumes contaminés par de la terre et de les manger de préférence cuits plutôt que crus, de bien cuire la viande, d’éviter de s’occuper de l’hygiène de la litière du chat ou alors de porter des gants. La plupart des toxoplasmoses congénitales sont asymptomatiques, cependant les cas symptomatiques ne sont pas anodins et peuvent se manifester par le biais d’une choriorétinite, des calcifications intracérébrales, une microcéphalie, une hydrocéphalie et une anémie-thrombocytopénie. Des recommandations suisses de prise en charge des nouveau-nés infectés existent et consistent principalement en un bilan complémentaire afin de dépister les cas symptomatiques. Ces derniers se verront proposer un traitement antiparasitaire dans le but de limiter la progression des atteintes cliniques, voire de diminuer l’apparition de nouvelles lésions. Dans le contexte d’un abandon du dépistage prénatal, sur demande du groupe suisse de travail pour la toxoplasmose et avec le soutien de l’Office Fédéral de la Santé publique, une surveillance sérologique néonatale de la toxoplasmose congénitale a été implémentée au sein des maternités des Hôpitaux Universitaires de Bâle et de Lausanne. A Lausanne, entre janvier 2010 et janvier 2013, 8090 femmes ont été admises à l’issue de leur grossesse afin d’y accoucher, 5477 femmes ont accepté l’étude donnant naissance à 5585 enfants. Au sein de ces 5585 nouveau-nés, 7 ont eu des sérologies positives compatibles avec une toxoplasmose congénitale, soit une prévalence de 0,13%. Parmi les cas détectés, aucun ne s’est révélé être symptomatique de cette infection. La prévalence observée par cette étude est nettement plus élevée que celle observée de par le passé. Ce manuscrit revoit les différents aspects de la toxoplasmose congénitale et intègre les résultats et les limites méthodologiques de cette étude. Il pose également la question du moyen optimal de surveillance à adopter face au problème de santé publique que représente la toxoplasmose congénitale en Suisse

Direct conversion of rheological compliance measurements into storage and loss moduli

We remove the need for Laplace/inverse-Laplace transformations of experimental data, by presenting a direct and straightforward mathematical procedure for obtaining frequency-dependent storage and loss moduli ($G'(\omega)$ and $G"(\omega)$ respectively), from time-dependent experimental measurements. The procedure is applicable to ordinary rheological creep (stress-step) measurements, as well as all microrheological techniques, whether they access a Brownian mean-square displacement, or a forced compliance. Data can be substituted directly into our simple formula, thus eliminating traditional fitting and smoothing procedures that disguise relevant experimental noise.Comment: 4 page

The Effect of Switching Cost and Product Return Management on Repurchase Intent: A Case Study in the B2B Distribution Channel Context in Indonesia

Business-to-Business (B2B) market normally deals with fewer customers; thus it creates a close relationship between customers and sellers. This relationship must be managed in a way so that it can encourage customer willingness to purchase again. As such, switching cost risk will become less as the customers keep buying from the same channel. At the same time, good return management system also plays an important role for stimulating re-purchase intent in addition to other factors such as customer satisfaction and customer value. This study aimed to analyse the effect of switching cost and product return management on re-purchase intent with customer satisfaction and customer value playing as moderating variables. Company A, a wholesaler that operates in the construction building material business in East Java was selected as the case study object for examining the relationships among the measured concepts. The survey was completed in three cities in which 200 retail stores of Company A’s customers are located. The result showed that switching cost and product return management both had a significant effect on retailers’ re- purchase intent. Meanwhile, customer value as a moderating variable did not have a significant effect on how switching cost and product return management affecting re-purchase intent. In addition, customer satisfaction had a significant effect on how switching cost influencing re-purchase intent

The Effect of Switching Cost and Product Return Management on Repurchase Intent: A Case Study in the B2B Distribution Channel Context in Indonesia

Business-to-Business (B2B) market normally deals with fewer customers; thus it creates a close relationship between customers and sellers. This relationship must be managed in a way so that it can encourage customer willingness to purchase again. As such, switching cost risk will become less as the customers keep buying from the same channel. At the same time, good return management system also plays an important role for stimulating re-purchase intent in addition to other factors such as customer satisfaction and customer value. This study aimed to analyse the effect of switching cost and product return management on re-purchase intent with customer satisfaction and customer value playing as moderating variables. Company A, a wholesaler that operates in the construction building material business in East Java was selected as the case study object for examining the relationships among the measured concepts. The survey was completed in three cities in which 200 retail stores of Company A’s customers are located The result showed that switching cost and product return management both had a significant effect on retailers’ re-purchase intent. Meanwhile, customer value as a moderating variable did not have a significant effect on how switching cost and product return management affecting re-purchase intent. In addition, customer satisfaction had a significant effect on how switching cost influencing re-purchase intent

The Effect of Switching Cost and Product Return Management on Repurchase Intent: A Case Study in the B2B Distribution Channel Context in Indonesia

Business-to-Business (B2B) market normally deals with fewer customers; thus it creates a close relationship between customers and sellers. This relationship must be managed in a way so that it can encourage customer willingness to purchase again. As such, switching cost risk will become less as the customers keep buying from the same channel. At the same time, good return management system also plays an important role for stimulating re-purchase intent in addition to other factors such as customer satisfaction and customer value. This study aimed to analyse the effect of switching cost and product return management on re-purchase intent with customer satisfaction and customer value playing as moderating variables. Company A, a wholesaler that operates in the construction building material business in East Java was selected as the case study object for examining the relationships among the measured concepts. The survey was completed in three cities in which 200 retail stores of Company A’s customers are located. The result showed that switching cost and product return management both had a significant effect on retailers’ re- purchase intent. Meanwhile, customer value as a moderating variable did not have a significant effect on how switching cost and product return management affecting re-purchase intent. In addition, customer satisfaction had a significant effect on how switching cost influencing re-purchase intent

The Effect of Switching Cost and Product Return Management on Repurchase Intent: A Case Study in the B2B Distribution Channel Context in Indonesia

Business-to-Business (B2B) market normally deals with fewer customers; thus it creates a close relationship between customers and sellers. This relationship must be managed in a way so that it can encourage customer willingness to purchase again. As such, switching cost risk will become less as the customers keep buying from the same channel. At the same time, good return management system also plays an important role for stimulating re-purchase intent in addition to other factors such as customer satisfaction and customer value. This study aimed to analyse the effect of switching cost and product return management on re-purchase intent with customer satisfaction and customer value playing as moderating variables. Company A, a wholesaler that operates in the construction building material business in East Java was selected as the case study object for examining the relationships among the measured concepts. The survey was completed in three cities in which 200 retail stores of Company A’s customers are located. The result showed that switching cost and product return management both had a significant effect on retailers’ re- purchase intent. Meanwhile, customer value as a moderating variable did not have a significant effect on how switching cost and product return management affecting re-purchase intent. In addition, customer satisfaction had a significant effect on how switching cost influencing re-purchase intent

The Effect of Switching Cost and Product Return Management on Repurchase Intent: A Case Study in the B2B Distribution Channel Context in Indonesia

Business-to-Business (B2B) market normally deals with fewer customers; thus it creates a close relationship between customers and sellers. This relationship must be managed in a way so that it can encourage customer willingness to purchase again. As such, switching cost risk will become less as the customers keep buying from the same channel. At the same time, good return management system also plays an important role for stimulating re-purchase intent in addition to other factors such as customer satisfaction and customer value. This study aimed to analyse the effect of switching cost and product return management on re-purchase intent with customer satisfaction and customer value playing as moderating variables. Company A, a wholesaler that operates in the construction building material business in East Java was selected as the case study object for examining the relationships among the measured concepts. The survey was completed in three cities in which 200 retail stores of Company A’s customers are located. The result showed that switching cost and product return management both had a significant effect on retailers’ re- purchase intent. Meanwhile, customer value as a moderating variable did not have a significant effect on how switching cost and product return management affecting re-purchase intent. In addition, customer satisfaction had a significant effect on how switching cost influencing re-purchase intent