3,260 research outputs found
Particle Number Fluctuations in Statistical Model with Exact Charge Conservation Laws
Even though the first momenta i.e. the ensemble average quantities in
canonical ensemble (CE) give the grand canonical (GC) results in large
multiplicity limit, the fluctuations involving second moments do not respect
this asymptotic behaviour. Instead, the asymptotics are strikingly different,
giving a new handle in study of statistical particle number fluctuations in
relativistic nuclear reactions. Here we study the analytical large volume
asymptotics to general case of multispecies hadron gas carrying fixed baryon
number, strangeness and electric charge. By means of Monte Carlo simulations we
have also studied the general multiplicity probability distributions taking
into account the decay chains of resonance states.Comment: 4 pages, 2 figures. The report of the talk given in Strangeness in
Quark Matter 2004, Cape Town. Submitted to J. Phys. G: Nucl. Part. Phy
Pion Number Fluctuations and Correlations in the Statistical System with Fixed Isospin
The statistical system of pions with zero total isospin is studied. The
suppression effects for the average yields due to isospin conservation are the
same for , and . However, a behavior of the corresponding
particle number fluctuations are different. For neutral pions there is the
enhancement of the fluctuations, whereas for charged pions the isospin
conservation suppresses fluctuations. The correlations between the numbers of
charged and neutral pions are observed for finite systems. This causes a
maximum of the total pion number fluctuations for small systems. The
thermodynamic limit values for the scaled variances of neutral and charged
pions are calculated. The enhancements of the fluctuations due to Bose
statistics are found and discussed
Protective effects of exosomes derived from lyophilized porcine liver against acetaminophen damage on HepG2 cells
Background: Recently, extracellular vesicles have come to the fore following their emerging role in cell communication, thanks to their ability to reach cells into the human body without dissipating their cargo, transferring biological active molecules, such as proteins, nucleic acids, lipids, etc. They appear as a promising tool in medicine, because of their capability to modulate cellular response in recipient cells. Moreover, a considerable number of publications suggests that exosome uptake is selective but not specific, and it can cross species and cell-type boundaries. This study aims to explore the potential role of porcine liver derived extracellular vesicles, exosomes in particular, to protect human cells from acute damage induced by acetaminophen. Methods: Extracellular vesicles were isolated from porcine lyophilized liver using polymer-based precipitation and a further enrichment was performed using affinity beads. The effects of obtained fractions, total extracellular vesicles and enriched extracellular vesicles, were assessed on human liver derived HepG2 cells. Cell growth and survival were tested, with MTT and area coverage analysis designed by us, as well as protein expression, with immunofluorescence and Western blot. Oxidative stress in live cells was also measured with fluorogenic probes. Results: After proving that porcine extracellular vesicles did not have a toxic effect on HepG2, quite the contrary total extracellular vesicle fraction improved cell growth, we investigated their protective capability with a preconditioning strategy in APAP-induced damage. EVs displayed not only the ability to strongly modulate cell survival responses, but they also were able to boost cell cycle progression. Conclusions: Extracellular vesicles derived from farm animal food derivatives are able to modulate human hepatic cell metabolism, also improving cell survival in a damaged context
Serum sE-selectin levels and carcinoembryonic antigen mRNA-expressing cells in peripheral blood as prognostic factors in colorectal cancer patients
This study analyzed the possible prognostic value of presurgical serum soluble (s)E-selectin levels and/or carcinoembryonic antigen (CEA) mRNA positivity in predicting the disease-free survival of colorectal cancer (CRC) patients
Prognostic value of vascular endothelial growth factor tumor tissue content of colorectal cancer
A longitudinal study was designed to quantify tumor tissue content of vascular endothelial growth factor (VEGF) in patients with colorectal cancer (CRC) and to evaluate its prognostic value in respect to the relapse-free and overall survivals
First bolometric measurement of the two neutrino double beta decay of Mo with a ZnMoO crystals array
The large statistics collected during the operation of a ZnMoO array, for
a total exposure of 1.3 kg day of Mo, allowed the first
bolometric observation of the two neutrino double beta decay of Mo. The
observed spectrum of each crystal was reconstructed taking into account the
different background contributions due to environmental radioactivity and
internal contamination. The analysis of coincidences between the crystals
allowed the assignment of constraints to the intensity of the different
background sources, resulting in a reconstruction of the measured spectrum down
to an energy of 300 keV. The half-life extracted from the data is
T= [7.15 0.37 (stat) 0.66 (syst)] 10
y.Comment: 6 pages, 2 figure, Accepted for publication in Journal of Physics G:
Nuclear and Particle Physic
Prognostic value of carcinoembryonic antigen and vascular endothelial growth factor tumor tissue content in colorectal cancer
This study was designed to assess the prognostic significance of the combined measurement of vascular endothelial growth factor (VEGF) and carcinoembryonic antigen (CEA) tissue content with respect to relapse-free and overall survival of patients with colorectal cancer (CRC)
CUPID-0: the first array of enriched scintillating bolometers for 0decay investigations
The CUPID-0 detector hosted at the Laboratori Nazionali del Gran Sasso, Italy, is the first large array of enriched scintillating cryogenic detectors for the investigation of82Se neutrinoless double-beta decay (0). CUPID-0 aims at measuring a background index in the region of interest (RoI) for 0at the level of 10- 3 counts/(keV kg years), the lowest value ever measured using cryogenic detectors. CUPID-0 operates an array of Zn82Se scintillating bolometers coupled with bolometric light detectors, with a state of the art technology for background suppression and thorough protocols and procedures for the detector preparation and construction. In this paper, the different phases of the detector design and construction will be presented, from the material selection (for the absorber production) to the new and innovative detector structure. The successful construction of the detector lead to promising preliminary detector performance which is discussed here
First array of enriched ZnSe bolometers to search for double beta decay
The R&D activity performed during the last years proved the potential of ZnSe
scintillating bolometers to the search for neutrino-less double beta decay,
motivating the realization of the first large-mass experiment based on this
technology: CUPID-0. The isotopic enrichment in Se, the ZnSe
crystals growth, as well as the light detectors production have been
accomplished, and the experiment is now in construction at Laboratori Nazionali
del Gran Sasso (Italy). In this paper we present the results obtained testing
the first three ZnSe crystals operated as scintillating bolometers, and
we prove that their performance in terms of energy resolution, background
rejection capability and intrinsic radio-purity complies with the requirements
of CUPID-0
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