141 research outputs found
Observatoire de la Politique Climatique - Rapport annuel 2022
The cumulative scientific evidence is unequivocal: Climate change is a threat to human well-being and planetary health. Any further delay in concerted anticipatory
global action on adaptation and mitigation will miss a brief and rapidly closing window
of opportunity to secure a liveable and sustainable future for all.(very high confidence
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Pancreatic Ductal Adenocarcinoma: Long-Term Survival Does Not Equal Cure
Background: Pancreatic ductal adenocarcinoma represents 90% of pancreatic cancers and is an important cause of cancer death in the United States. Operative resection remains as the only treatment providing prolonged survival, but even after a curative resection, 5-year survival rates are low. Our aim was to identify the prognostic factors for long-term survival after resection of pancreatic ductal adenocarcinoma related to patients, treatments, and tumor biology. Methods: Retrospective review identified 959 patients who underwent resection of their pancreatic adenocarcinoma between February 1985 and December 2010, of whom 499 were resected before November 2006 and represent the cohort we describe in this study. Patient, tumor, and treatment-related variables were assessed for their associations with 5- and 10-year overall survival. Results: Of the 499 patients, 49% were female and median age was 65 years. The majority of patients had stage IIb disease (60%). Actual 5-year survival after resection of pancreatic adenocarcinoma was 19% (95/499), and actual 10-year survival was 10% (33/329). Significant clinicopathologic factors predicting 5- and 10-year survival were negative margins and negative nodal status. Interestingly, 41% (39/95) of long-term survivors had positive nodes and 24% (23/95) had positive margins. Conclusion: Pancreatic ductal adenocarcinoma demonstrates a very heterogeneous biology, but patients with negative resection margins and node negative cancers are more likely to survive 5 years after resection. However, our series demonstrates that the biology of the cancer rather than simple pathologic factors determine a patient's prognosis
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Stem cells and cancer immunotherapy: Arrowheadâs 2nd annual cancer immunotherapy conference
Investigators from academia and industry gathered on April 4 and 5, 2013, in Washington DC at the Arrowheadâs 2nd Annual Cancer Immunotherapy Conference. Two complementary concepts were discussed: cancer âstem cellsâ as targets and therapeutic platforms based on stem cells
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Does the Mechanism of Lymph Node Invasion Affect Survival in Patients with Pancreatic Ductal Adenocarcinoma?
Background: Lymph node metastases are prognostically significant in pancreatic ductal adenocarcinoma. Little is known about the significance of direct lymph node invasion. Aim: The aim of this study is to find out whether direct lymph node invasion has the same prognostic significance as regional nodal metastases. Methods: Retrospective review of patients resected between 1/1/1993 and 7/31/2008. âDirectâ was defined as tumor extension into adjacent nodes, and âregionalâ was defined as metastases to peripancreatic nodes. Results: Overall, 517 patients underwent pancreatic resection for adenocarcinoma, of whom 89 had one positive node (direct 26, regional 63), and 79 had two positive nodes (direct 6, regional 68, both 5). Overall, survival of node-negative patients was improved compared to patients with positive nodes (N0 30.8 months vs. N1 16.4 months; pâ<â0.001). There was no survival difference for patients with direct vs. regional lymph node invasion (pâ=â0.67). Patients with one positive node had a better overall survival compared to patients with â„2 positive nodes (22.3 and 15 months, respectively; pâ<â0.001). The lymph node ratio (+LN/total LN) was prognostically significant after Cox regression (pâ<â0.001). Conclusions: Isolated direct invasion occurs in 20% of patients with one to two positive nodes. Node involvement by metastasis or by direct invasion are equally significant predictors of reduced survival. Both the number of positive nodes and the lymph node ratio are significant prognostic factors
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Tumor engraftment in patient-derived xenografts of pancreatic ductal adenocarcinoma is associated with adverse clinicopathological features and poor survival
Patient-derived xenograft (PDX) tumors are powerful tools to study cancer biology. However, the ability of PDX tumors to model the biological and histological diversity of pancreatic ductal adenocarcinoma (PDAC) is not well known. In this study, we subcutaneously implanted 133 primary and metastatic PDAC tumors into immunodeficient mice. Fifty-seven tumors were successfully engrafted and even after extensive passaging, the histology of poorly-, moderately-, and well-differentiated tumors was maintained in the PDX models. Moreover, the fibroblast and collagen contents in the stroma of patient tumors were recapitulated in the corresponding PDX models. Analysis of the clinicopathological features of patients revealed xenograft tumor engraftment was associated with lymphovascular invasion (P = 0.001) and worse recurrence-free (median, 7 vs. 16 months, log-rank P = 0.047) and overall survival (median, 13 vs. 21 months, log-rank P = 0.038). Among successful engraftments, median time of growth required for reimplantation into new mice was 151 days. Reflective of the inherent biological diversity between PDX tumors with rapid (<151 days) and slow growth, differences in their growth were maintained during extensive passaging. Rapid growth was additionally associated with lymph node metastasis (P = 0.022). The association of lymphovascular invasion and lymph node metastasis with PDX formation and rapid growth may reflect an underlying biological mechanism that allows these tumors to adapt and grow in a new environment. While the ability of PDX tumors to mimic the cellular and non-cellular features of the parental tumor stroma provides a valuable model to study the interaction of PDAC cells with the tumor microenvironment, the association of successful engraftment with adverse clinicopathological features suggests PDX models over represent more aggressive forms of this disease
Attribution of the heavy rainfall events leading to severe flooding in Western Europe during July 2021
In July 2021 extreme rainfall across Western Europe caused severe flooding and substantial impacts, including over 200 fatalities and extensive infrastructure damage within Germany and the Benelux countries. After the event, a hydrological assessment and a probabilistic event attribution analysis of rainfall data were initiated and complemented by discussing the vulnerability and exposure context. The global mean surface temperature (GMST) served as a covariate in a generalised extreme value distribution fitted to observational and model data, exploiting the dependence on GMST to estimate how anthropogenic climate change affects the likelihood and severity of extreme events. Rainfall accumulations in Ahr/Erft and the Belgian Meuse catchment vastly exceeded previous observed records. In regions of that limited size the robust estimation of return values and the detection and attribution of rainfall trends are challenging. However, for the larger Western European region it was found that, under current climate conditions, on average one rainfall event of this magnitude can be expected every 400 years at any given location. Consequently, within the entire region, events of similar magnitude are expected to occur more frequently than once in 400 years. Anthropogenic climate change has already increased the intensity of the maximum 1-day rainfall event in the summer season by 3â19Â %. The likelihood of such an event to occur today compared to a 1.2 â C cooler climate has increased by a factor of 1.2â9. Models indicate that intensity and frequency of such events will further increase with future global warming. While attribution of small-scale events remains challenging, this study shows that there is a robust increase in the likelihood and severity of rainfall events such as the ones causing extreme impacts in July 2021 when considering a larger region
Attribution of the heavy rainfall events leading to severe flooding in Western Europe during July 2021
In July 2021 extreme rainfall across Western Europe caused severe flooding and substantial impacts, including over 200 fatalities and extensive infrastructure damage within Germany and the Benelux countries. After the event, a hydrological assessment and a probabilistic event attribution analysis of rainfall data were initiated and complemented by discussing the vulnerability and exposure context. The global mean surface temperature (GMST) served as a covariate in a generalised extreme value distribution fitted to observational and model data, exploiting the dependence on GMST to estimate how anthropogenic climate change affects the likelihood and severity of extreme events. Rainfall accumulations in Ahr/Erft and the Belgian Meuse catchment vastly exceeded previous observed records. In regions of that limited size the robust estimation of return values and the detection and attribution of rainfall trends are challenging. However, for the larger Western European region it was found that, under current climate conditions, on average one rainfall event of this magnitude can be expected every 400 years at any given location. Consequently, within the entire region, events of similar magnitude are expected to occur more frequently than once in 400 years. Anthropogenic climate change has already increased the intensity of the maximum 1-day rainfall event in the summer season by 3â19Â %. The likelihood of such an event to occur today compared to a 1.2Â C cooler climate has increased by a factor of 1.2â9. Models indicate that intensity and frequency of such events will further increase with future global warming. While attribution of small-scale events remains challenging, this study shows that there is a robust increase in the likelihood and severity of rainfall events such as the ones causing extreme impacts in July 2021 when considering a larger region
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Spectrophotometric Modeling and Mapping of (101955) Bennu
Using hyperspectral data collected by OVIRS, the visible and infrared spectrometer on board the Origins, Spectral Interpretation, Resource Identification, and Security-Regolith Explorer (OSIRIS-REx) spacecraft, we modeled the global average spectrophotometric properties of the carbonaceous asteroid (101955) Bennu and mapped their variations. We restricted our analysis to 0.4â2.5 ÎŒm to avoid the wavelengths where thermal emission from the asteroid dominates (>2.5 ÎŒm). Bennu has global photometric properties typical of dark asteroids; we found a geometric albedo of 0.046 ± 0.007 and a linear phase slope of 0.024 ± 0.007 mag degâ1 at 0.55 ÎŒm. The average spectral slope of Bennuâs normal albedo is â0.0030 ÎŒmâ1, and the phase-reddening parameter is 4.3 Ă 10â4 ÎŒmâ1 degâ1, both over the spectral range of 0.5â2.0 ÎŒm. We produced normal albedo maps and phase slope maps at all spectral channels, from which we derived spectral slope and phase-reddening maps. Correlation analysis suggests that phase slope variations on Bennu are likely due to photometric roughness variation. A correlation between photometric and thermal roughness is evident, implying that the roughness of Bennu is self-similar on scales from tens of microns to meters. Our analysis reveals latitudinal trends in the spectral color slope and phase reddening on Bennu. The equatorial region appears to be redder than the global average, and the spectral slope decreases toward higher latitudes. Phase reddening on Bennu is relatively weak in the equatorial region and shows an asymmetry between the northern and southern hemispheres. We attributed the latitudinal trend to the geophysical conditions on Bennu that result in a global pattern of mass flow toward the equator
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