Projeto básico do Programa Esporte e Lazer da Cidade - Prefeitura Municipal de São Gonçalo do Rio Abaixo

O documento integra o acervo institucional do Programa Esporte e Lazer da Cidade/Vida Saudável/Ministério do Esporte.Projeto básico para renovação do Convênio do Ministério do Esporte com a Prefeitura Municipal de São Gonçalo do Rio Abaixo, MG, para núcleo do Programa Esporte e Lazer da Cidade, na modalidade urbana - todas as faixas etárias. Contem: dados de identificação do projeto e da entidade, dirigente, coordenador técnico, entidade de controle social, apresentação, justificativa, comunidade atendida, dados do município, parcerias, metas, atividades, eventos, formação, divulgação e inscrições, núcleos, itens solicitados do Programa Pintando a Liberdade, cadastro da classificação, cadastro de materiais e contrapartida.DoaçãoPELC e Vida Saudáve

Projeto básico do Programa Esporte e Lazer da Cidade - Prefeitura Municipal de São Gonçalo do Rio Abaixo

O documento integra o acervo institucional do Programa Esporte e Lazer da Cidade/Vida Saudável/Ministério do Esporte.Projeto básico para renovação do Convênio do Ministério do Esporte com a Prefeitura Municipal de São Gonçalo do Rio Abaixo, MG, para núcleo do Programa Esporte e Lazer da Cidade, na modalidade urbana - todas as faixas etárias. Contem: dados de identificação do projeto e da entidade, dirigente, coordenador técnico, entidade de controle social, apresentação, justificativa, comunidade atendida, dados do município, parcerias, metas, atividades, eventos, formação, divulgação e inscrições, núcleos, itens solicitados do Programa Pintando a Liberdade, cadastro da classificação, cadastro de materiais e contrapartida.DoaçãoPELC e Vida Saudáve

Transcriptome Analysis of Paracoccidioides brasiliensis Cells Undergoing Mycelium-to-Yeast Transition

Paracoccidioides brasiliensis is a thermodimorphic fungus associated with paracoccidioidomycosis (PCM), a systemic mycosis prevalent in South America. In humans, infection starts by inhalation of fungal propagules, which reach the pulmonary epithelium and transform into the yeast parasitic form. Thus, the mycelium-to-yeast transition is of particular interest because conversion to yeast is essential for infection. We have used a P. brasiliensis biochip carrying sequences of 4,692 genes from this fungus to monitor gene expression at several time points of the mycelium-to-yeast morphological shift (from 5 to 120 h). The results revealed a total of 2,583 genes that displayed statistically significant modulation in at least one experimental time point. Among the identified gene homologues, some encoded enzymes involved in amino acid catabolism, signal transduction, protein synthesis, cell wall metabolism, genome structure, oxidative stress response, growth control, and development. The expression pattern of 20 genes was independently verified by real-time reverse transcription-PCR, revealing a high degree of correlation between the data obtained with the two methodologies. One gene, encoding 4-hydroxyl-phenyl pyruvate dioxygenase (4-HPPD), was highly overexpressed during the mycelium-to-yeast differentiation, and the use of NTBC [2-(2-nitro-4-trifluoromethylbenzoyl)-cyclohexane-1,3-dione], a specific inhibitor of 4-HPPD activity, as well as that of NTBC derivatives, was able to inhibit growth and differentiation of the pathogenic yeast phase of the fungus in vitro. These data set the stage for further studies involving NTBC and its derivatives as new chemotherapeutic agents against PCM and confirm the potential of array-based approaches to identify new targets for the development of alternative treatments against pathogenic microorganisms

Implementation of a Brazilian Cardioprotective Nutritional (BALANCE) Program for improvement on quality of diet and secondary prevention of cardiovascular events: A randomized, multicenter trial

Background: Appropriate dietary recommendations represent a key part of secondary prevention in cardiovascular disease (CVD). We evaluated the effectiveness of the implementation of a nutritional program on quality of diet, cardiovascular events, and death in patients with established CVD. Methods: In this open-label, multicenter trial conducted in 35 sites in Brazil, we randomly assigned (1:1) patients aged 45 years or older to receive either the BALANCE Program (experimental group) or conventional nutrition advice (control group). The BALANCE Program included a unique nutritional education strategy to implement recommendations from guidelines, adapted to the use of affordable and regional foods. Adherence to diet was evaluated by the modified Alternative Healthy Eating Index. The primary end point was a composite of all-cause mortality, cardiovascular death, cardiac arrest, myocardial infarction, stroke, myocardial revascularization, amputation, or hospitalization for unstable angina. Secondary end points included biochemical and anthropometric data, and blood pressure levels. Results: From March 5, 2013, to Abril 7, 2015, a total of 2534 eligible patients were randomly assigned to either the BALANCE Program group (n = 1,266) or the control group (n = 1,268) and were followed up for a median of 3.5 years. In total, 235 (9.3%) participants had been lost to follow-up. After 3 years of follow-up, mean modified Alternative Healthy Eating Index (scale 0-70) was only slightly higher in the BALANCE group versus the control group (26.2 ± 8.4 vs 24.7 ± 8.6, P <.01), mainly due to a 0.5-serving/d greater intake of fruits and of vegetables in the BALANCE group. Primary end point events occurred in 236 participants (18.8%) in the BALANCE group and in 207 participants (16.4%) in the control group (hazard ratio, 1.15; 95% CI 0.95-1.38; P =.15). Secondary end points did not differ between groups after follow-up. Conclusions: The BALANCE Program only slightly improved adherence to a healthy diet in patients with established CVD and had no significant effect on the incidence of cardiovascular events or death. © 2019 The Author