Comparing the performance of the SF-6D and the EQ-5D in different patient groups

Introduction: This research aims to explore the performance of the SF-6D and the EQ-5D in patients suffering from asthma, chronic obstructive pulmonary disease, cataracts, and rheumatoid arthritis. In particular, the aim of this research is twofold: 1) to study the level of agreement between the indexes and the descriptive systems of the dimensions of the SF-6D and the EQ-5D, and 2) to analyze the discriminative ability of the instruments. Material and Methods: A sample of 643 patients completed both the SF-36v2 and the EQ-5D. The discriminative ability of the instruments was analyzed. Furthermore, the level of agreement between the indexes and the descriptive systems of the dimensions of the SF-6D and the EQ-5D were studied. The level of agreement between instruments was investigated using correlation coefficients and the Bland-Altman plots, while the influence of medical condition and other socio-demographic variables was analyzed using non-parametric tests. Paired-samples tests were used to identify differences between the scores. Results and Discussion: The results show a strong correlation and agreement between both indexes. Overall, questionnaire indexes differ by medical condition and socio-demographic groups and both instruments are able to discriminate between socio-demographic groups. Conclusion: This study confirmed the hypothesis that the SF-6D generates higher utility values in less healthy individuals. The SF-6D and the EQ-5D seem to perform differently in each of the diseases studied since the descriptive statistics differ between instruments and the level of correlation is not uniform. Results show that the instruments generate different utility values, but there is a strong agreement between both indexes. Thus, the two instruments are not interchangeable and their results cannot be directly comparable.Portuguese Foundation for Science and Technology (Fundacao para a Ciencia e a Tecnologia)info:eu-repo/semantics/publishedVersio

A few cosmological implications of tensor nonlocalities

We consider nonlocal gravity theories that include tensor nonlocalities. We show that in the cosmological context, the tensor nonlocalities, unlike scalar ones, generically give rise to growing modes. An explicit example with quadratic curvature terms is studied in detail. Possible consequences for recent nonlocal cosmological models proposed in the literature are also discussed.Comment: 7 pages. New references include

Exploring the consistency of the SF-6D

Objective: The six dimensional health state short form (SF-6D) was designed to be derived from the short-form 36 health survey (SF-36). The purpose of this research was to compare the SF-6D index values generated from the SF 36 (SF-6D(SF-36)) with those obtained from the SF-6D administered as an independent instrument (SF-6D(Ind)). The goal was to assess the consistency of respondents answers to these two methods of deriving the SF-6D. Methods: Data were obtained from a sample of the Portuguese population (n = 414). Agreement between the instruments was assessed on the basis of a descriptive system and their indexes. The analysis of the descriptive system was performed by using a global consistency index and an identically classified index. Agreement was also explored by using correlation coefficients. Parametric tests were used to identify differences between the indexes. Regression models were estimated to understand the relationship between them. Results: The SF-6D(Ind) generates higher values than does the SF-6D(SF-36), There were significant differences between the indexes across sociodemographic groups. There was a significant ceiling effect in the SF-6D(Ind) a but not in the SF-6D(SF-36). The correlation between the indexes was high but less than what was anticipated. The global consistency index identified the dimensions with larger differences. Considerable differences were found in two dimensions, possibly as a result of different item contexts. Further research is needed to fully understand the role of the different layouts and the length of the questionnaires in the respondents' answers. Conclusions: The results show that as the SF-6D was designed to derive utilities from the SF-36 it should be used in this way and not as an independent instrument.Fundacao para a Ciencia e a Tecnologia (FCT

Public health: The voice of professionals

To monitor, for the first time in Portugal, job satisfaction on public health units (PHUs).info:eu-repo/semantics/publishedVersio

Stability of neutral minima against charge breaking in the Higgs triplet model

We analyse the possibility of charge breaking minima developing in the Higgs triplet model, and under what conditions they are deeper than charge-preserving ones. Analytical expressions relating the depth of minima of different types are deduced. A global symmetry of the model leads to increased stability for charge-preserving vacua. However, if that symmetry is broken by a soft term, deeper charge-breaking minima may occur more easily. We identify the vev configurations most likely to produce charge breaking minima.info:eu-repo/semantics/publishedVersio

Observing the temperature of the Big Bang through large scale structure

It is widely accepted that the Universe underwent a period of thermal equilibrium at very early times. One expects a residue of this primordial state to be imprinted on the large scale structure of space time. In this paper we study the morphology of this thermal residue in a universe whose early dynamics is governed by a scalar field. We calculate the amplitude of fluctuations on large scales and compare it to the imprint of vacuum fluctuations. We then use the observed power spectrum of fluctuations on the cosmic microwave background to place a constraint on the temperature of the Universe before and during inflation. We also present an alternative scenario where the fluctuations are predominantly thermal and near scale-invariant

Comparing the performance of the EQ-5D-3L and the EQ-5D-5L in young Portuguese adults

Background Some studies have reported a ceiling effect in EQ-5D-3L, especially in healthy and/or young individuals. Recently, two further levels have been included in its measurement model (EQ-5D-5L). The purposes of this study were (1) to assess the properties of the EQ-5D-5L in comparison with the standard EQ-5D-3L in a sample of young adults, (2) to foreground the importance of collecting qualitative data to confirm, validate or refine the EQ-5D questionnaire items and (3) to raise questions pertaining to the wording in these questionnaire items. Methods The data used came from a sample of respondents aged 30 or under (n = 624). They completed both versions of the EQ-5D, which were compared in terms of feasibility, level of inconsistency and ceiling effect. Agreement between the instruments was assessed using correlation coefficients and Bland-Altman plots. Known-groups validity of the EQ-5D-5L was also assessed using non-parametric tests. The discriminative properties were compared using receiver operating characteristic curves. Finally, four interviews were conducted for retrospective reports to elicit respondents’ understanding and perceptions of the format, instructions, items, and responses. Results Quantitative results show a ceiling effect reduction of 25.3 % and a high level agreement between both indices. Known-groups validity was confirmed for the EQ-5D-5L. Explorative interviews indicated ambiguity and low degree of certainty in regards to conceptualizing differences between levels moderate-slight across three dimensions. Conclusions The EQ-5D-5L performed better than the EQ-5D-3L. However, the explorative interviews demonstrated several limitations in the EQ-5D questionnaire wording and high context-dependent answers point to lack of illnesses’ experience amongst young adults

Five models for lepton mixing

We produce five flavour models for the lepton sector. All five models fit perfectly well - at the 1 sigma level - the existing data on the neutrino mass-squared differences and on the lepton mixing angles. The models are based on the type I seesaw mechanism, on a Z(2) symmetry for each lepton flavour, and either on a (spontaneously broken) symmetry under the interchange of two lepton flavours or on a (spontaneously broken) CP symmetry incorporating that interchange - or on both symmetries simultaneously. Each model makes definite predictions both for the scale of the neutrino masses and for the phase delta in lepton mixing; the fifth model also predicts a correlation between the lepton mixing angles theta(12) and theta(23)

Adaptação e validação intercultural da versão portuguesa do Physical Therapy Outpatient Satisfaction Survey

ABSTRACT - The aim of this study was to adapt and validate the Physical Therapy Outpatient Satisfaction Survey (PTOPS) for the Portuguese culture. This version was obtained by a forward/ backward translation, consensus panels, and pre-test. The Portuguese PTOPS was administered to 76 physical therapy outpatients in 10 health services. The content analysis (panels of experts and lay people) and the factor analysis resulted in a reduction of the original 34 items to 28 items that validly identify 3 constructs. The reliability was acceptable for both internal consistency (Cronbach’s alpha = 0.73) and reproducibility (ICC between 0.84 and 0.87), which represent acceptable levels of validity and reliability.RESUMO - Foi objetivo deste estudo adaptar e validar para a cultura portuguesa o Physical Therapy Outpatient Satisfaction Survey (PTOPS). Esta versão resultou do processo de tradução, retroversão, painéis de consenso e pré teste. A PTOPS foi administrada a 76 doentes ambulatórios de fisioterapia, em 10 instituições de saúde. Da análise de conteúdo (painéis de peritos e gente comum) e da análise fatorial resultou uma redução dos 34 itens da versão original para 28 itens, que identificam validamente 3 constructos. A fiabilidade foi aceitável quer na coerência interna (α de Cronbach = 0,73), quer na reprodutibilidade (ICC entre 0,84 e 0,87). Evidenciando níveis aceitáveis de validade e fiabilidade.info:eu-repo/semantics/publishedVersio