Modeling the Broadband Spectral Energy Distribution of the Microquasars XTE J1550-564 and H 1743-322

We report results from a systematic study of the spectral energy distribution (SED) and spectral evolution of XTE J1550--564 and H 1743--322 in outburst. The jets of both sources have been directly imaged at both radio and X-ray frequencies, which makes it possible to constrain the spectrum of the radiating electrons in the jets. We modelled the observed SEDs of the jet `blobs' with synchrotron emission alone and with synchrotron emission plus inverse Compton scattering. The results favor a pure synchrotron origin of the observed jet emission. Moreover, we found evidence that the shape of the electron spectral distribution is similar for all jet `blobs' seen. Assuming that this is the case for the jet as a whole, we then applied the synchrotron model to the radio spectrum of the total emission and extrapolated the results to higher frequencies. In spite of significant degeneracy in the fits, it seems clear that, while the synchrotron radiation from the jets can account for nearly 100% of the measured radio fluxes, it contributes little to the observed X-ray emission, when the source is relatively bright. In this case, the X-ray emission is most likely dominated by emission from the accretion flows. When the source becomes fainter, however, the jet emission becomes more important, even dominant, at X-ray energies. We also examined the spectral properties of the sources during outbursts and the correlation between the observed radio and X-ray variabilities. The implication of the results is discussed.Comment: 9 pages, 11 figures, MNRAS, accepted; the paper has been much expanded (e.g., arguments strengthened, another source H 1743-322 added) and rewritten (e.g., title changed, abstract revised); the main conclusions remain unchange

Resolving galaxies in time and space: II: Uncertainties in the spectral synthesis of datacubes

In a companion paper we have presented many products derived from the application of the spectral synthesis code STARLIGHT to datacubes from the CALIFA survey, including 2D maps of stellar population properties and 1D averages in the temporal and spatial dimensions. Here we evaluate the uncertainties in these products. Uncertainties due to noise and spectral shape calibration errors and to the synthesis method are investigated by means of a suite of simulations based on 1638 CALIFA spectra for NGC 2916, with perturbations amplitudes gauged in terms of the expected errors. A separate study was conducted to assess uncertainties related to the choice of evolutionary synthesis models. We compare results obtained with the Bruzual & Charlot models, a preliminary update of them, and a combination of spectra derived from the Granada and MILES models. About 100k CALIFA spectra are used in this comparison. Noise and shape-related errors at the level expected for CALIFA propagate to 0.10-0.15 dex uncertainties in stellar masses, mean ages and metallicities. Uncertainties in A_V increase from 0.06 mag in the case of random noise to 0.16 mag for shape errors. Higher order products such as SFHs are more uncertain, but still relatively stable. Due to the large number statistics of datacubes, spatial averaging reduces uncertainties while preserving information on the history and structure of stellar populations. Radial profiles of global properties, as well as SFHs averaged over different regions are much more stable than for individual spaxels. Uncertainties related to the choice of base models are larger than those associated with data and method. Differences in mean age, mass and metallicity are ~ 0.15 to 0.25 dex, and 0.1 mag in A_V. Spectral residuals are ~ 1% on average, but with systematic features of up to 4%. The origin of these features is discussed. (Abridged)Comment: A&A, accepte

Growth pattern of the middle ear in the gray short-tailed opossum, Monodelphis domestica

We studied the mass growth trajectories of middle ear ossicles and tympanic membrane and oval window area in 19 specimens of postnatal ages 30???180 days of the gray short-tailed opossum Monodelphis domestica. We weighed the skull mass and the mass of the three middle ear ossicles with appropriate balances. Using a binocular microscope provided with a grid, we measured the length of malleus and incus, as well as the longest axis and the one perpendicular to it on both the tympanic membrane and the stapes footplate. The size variation was studied with least squares regression analyses between various measurements. The incus and stapes change little in mass after 40 days of postnatal life, while the malleus does, reaching maximum mass at around 100 PND (postnatal days). This modularity in growth trajectory is in contrast with the shared evolutionary origin of malleus and incus from branchial arch 1. The maturation of the middle ??? and as indicated by previous work, that of the inner ear ??? is coupled with the improvement of hearing sensitivity at low and high frequencies after the initial onset of hearing at 29 PND.Peer reviewe

CHK1 expression in gastric cancer is modulated by p53 and RB1/E2F1: Implications in chemo/radiotherapy response

Radiation has a limited but relevant role in the adjuvant therapy of gastric cancer (GC) patients. Since Chk1 plays a critical function in cellular response to genotoxic agents, we aimed to analyze the role of Chk1 in GC as a biomarker for radiotherapy resistance. We analyzed Chk1 expression in AGS and MKN45 human GC cell lines by RT-QPCR and WB and in a small cohort of human patient’s samples. We demonstrated that Chk1 overexpression specifically increases resistance to radiation in GC cells. Accordingly, abrogation of Chk1 activity with UCN-01 and its expression with shChk1 increased sensitivity to bleomycin and radiation. Furthermore, when we assessed Chk1 expression in human samples, we found a correlation between nuclear Chk1 accumulation and a decrease in progression free survival. Moreover, using a luciferase assay we found that Chk1’s expression is controlled by p53 and RB/E2F1 at the transcriptional level. Additionally, we present preliminary data suggesting a posttranscriptional regulation mechanism, involving miR-195 and miR-503, which are inversely correlated with expression of Chk1 in radioresistant cells. In conclusion, Chk1/microRNA axis is involved in resistance to radiation in GC, and suggests Chk1 as a potential tool for optimal stratification of patients susceptible to receive adjuvant radiotherapy after surgeryThis work was supported by Instituto de Salud Carlos III–Fondo de Investigación Sanitaria (PS09/1988 to ISP; PI11-00949, pI014-1495 and Feder Funds to RP); Comunidad Autónoma de Madrid-Universidad Autónoma de Madrid (CCG10-UAM/BIO-5871 to ISP); Fundación Leticia Castillejo Castillo and Ministerio de Ciencia e Innovación (SAF2012-30862 to RSP), Spain

Bayesian variable selection and survival modeling: assessing the Most important comorbidities that impact lung and colorectal cancer survival in Spain

ancer survival represents one of the main indicators of interest in cancer epidemiology. However, the survival of cancer patients can be affected by several factors, such as comorbidities, that may interact with the cancer biology. Moreover, it is interesting to understand how different cancer sites and tumour stages are affected by different comorbidities. Identifying the comorbidities that affect cancer survival is thus of interest as it can be used to identify factors driving the survival of cancer patients. This information can also be used to identify vulnerable groups of patients with comorbidities that may lead to worst prognosis of cancer. We address these questions and propose a principled selection and evaluation of the effect of comorbidities on the overall survival of cancer patients. In the first step, we apply a Bayesian variable selection method that can be used to identify the comorbidities that predict overall survival. In the second step, we build a general Bayesian survival model that accounts for time-varying effects. In the third step, we derive several posterior predictive measures to quantify the effect of individual comorbidities on the population overall survival. We present applications to data on lung and colorectal cancers from two Spanish population-based cancer registries. The proposed methodology is implemented with a combination of the R-packages mombf and rstan. We provide the code for reproducibility at https://github.com/migariane/BayesVarImpComorbiCancer

X-ray states and radio emission in the black hole candidate XTE J1550-564

We report on radio and X-ray observations of the black hole candidate (BHC) XTE J1550-564 performed during its 2000 X-ray outburst. Observations have been conducted with the Australia Telescope Compact Array (ATCA) and have allowed us to sample the radio behavior of XTE J1550-564 in the X-ray Low Hard and Intermediate/Very High states. We observed optically thin radio emission from XTE J1550-564 five days after a transition to an Intermediate/Very High state, but we observed no radio emission six days later, while XTE J1550-564 was still in the Intermediate/Very High state. In the Low Hard state, XTE J1550-564 is detected with an inverted radio spectrum. The radio emission in the Low Hard state most likely originates from a compact jet; optical observations suggest that the synchrotron emission from this jet may extend up to the optical range. The total power of the compact jet might therefore be a significant fraction of the total luminosity of the system. We suggest that the optically thin synchrotron radio emission detected five days after the transition to the Intermediate/Very High state is due to a discrete ejection of relativistic plasma during the state transition. Subsequent to the decay of the optically thin radio emission associated with the state transition, it seems that in the Intermediate/Very High state the radio emission is quenched by a factor greater than 50, implying a suppression of the outflow. We discuss the properties of radio emission in the X-ray states of BHCs.Comment: 15 pages, including 3 figures. Accepted for publication in ApJ, scheduled for the vol. 553 Jun 1, 2001 issu