1,100 research outputs found

    Efeito do cruzamento sobre o crescimento de caprinos no Ceará.

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    Cruzaram-se, na Fazenda Iracema, da Empresa de Pesquisa Agropecuaria do Ceara - EPACE -, em Quixada, CE, 420 cabras Sem Raça Definida (SRD) com reprodutores das raças e/ou tipos Nativos - Marota, Canindé, Moxoto, Repartida e SRD - e exoticas Anglo-Nubiana e Bhuj. Pesaram-se as crias ao nascer e a intervalos de 28 dias até 112 dias (desmama) e a cada dois meses, até 12 meses. 0 peso ao nascer, dos descendentes de raças exoticas, foi maior que o das lrças nativas. Subseqüentemente, os pesos foram idênticos em todos os grupos, refletindo efeito materno. Aos 12 meses, os descendentes de Anglo-Nubiana tenderam a ser mais pesados que os de Bhuj e SRD, e estes, que aqueles das raças nativas (22,09; 20,55 e 19 kg). Os descendentes das raças nativas foram levemente inferiores aos de SRD, mostrando que essas raças podem estar estreitamente relacionadas corn o tipo SRD. Os machos foram mais pesados que as fêmeas, ao nascer (2,28 e 1,94 kg) e no período pos-desmama. Os nascidos de partos simples foram mais pesados que os nascidos de partos gemelares, até seis meses de idade. 0 peso da mae no parto influenciou o peso das crias no nascimento. [Cross-breed effect upon the growth of goats in Ceará state]. Abstract: Four hundred and twenty SRD (nondescripted breed) does were cross-breeded at Iracerna Farm of the Empresa de Pesquisa Agropecuária do Ceará in Quixadá, Ceará, CE, Brazil, with sires of the nativo breeds Marota, Canindé, Repartida, Moxotó and SRD and exotic breeds Anglo-Nubian and Bhuj. The kids were weighed at birth and each 28 days up to weaning and each two months frorn weaning to 12 months of age. At birth, livo weight were higher for exotics cross-breeded kids as compared to native ones. Subsequently, live weights were the sarne for ali kids, showing great maternal effect on the growth of kids. By 12 rnonths old Anglo-Nubian cross-breeded kids were heavier than Bhuj and SRD, and these were heavier than the nativo ones (22.09, 20.55 and 19kg). Nativa breed progeny did not show advantage over SRD crosses. This suggests that native breeds may be closely reiated to SRD. Male kids were havier than female at birth (2.28 to 1.94 kg), and even during post-weaning growth. Kids bom single were heavier than twins from birth to Mx month old. Does weight at parturition affected the kids weight at birth

    Preliminary assessment of cardiac short term safety and efficacy of manganese chloride for cardiovascular magnetic resonance in humans

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    <p>Abstract</p> <p>Background</p> <p>Manganese based agents are intracellular and accumulate inside myocytes allowing for different imaging strategies compared to gadolinium contrasts. While previous agents release manganese very slowly in the circulation, MnCl<sub>2 </sub>allows for rapid Mn2<sup>+ </sup>uptake in myocytes, creating a memory effect that can be potentially explored. Data on animal models are very encouraging but the safety and efficacy of this approach in humans has not yet been investigated. Therefore, our objectives were to study the safety and efficacy of a rapid infusion of manganese chloride (MnCl<sub>2</sub>) for cardiovascular magnetic resonance (CMR) in humans.</p> <p>Methods</p> <p>Fifteen healthy volunteers underwent a CMR scan on a 1.5 T scanner. Before the infusion, cardiac function was calculated and images of a short axis mid-ventricular slice were obtained using a 2D and 3D gradient-echo inversion recovery (GRE-IR) sequence, a phase-sensitive IR sequence and a single breath-hold segmented IR prepared steady-state precession acquisition for T<sub>1 </sub>calculations. MnCl<sub>2 </sub>was infused over three minutes at a total dose of 5 μMol/kg. Immediately after the infusion, and at 15 and 30 minutes later, new images were obtained and cardiac function re-evaluated.</p> <p>Results</p> <p>There was a significant decrease in T<sub>1 </sub>values compared to baseline, sustained up to 30 minutes after the MnCl<sub>2 </sub>infusion (pre,839 ± 281 ms; 0 min, 684 ± 99; 15 min, 714 ± 168; 30 min, 706 ± 172, P = 0.003). The 2D and 3D GRE-IR sequence showed the greatest increase in signal-to-noise ratio compared to the other sequences (baseline 6.6 ± 4.2 and 9.7 ± 5.3; 0 min, 11.3 ± 4.1 and 15.0 ± 8.7; 15 min, 10.8 ± 4.0 and 16.9 ± 10.2; 30 min, 10.6 ± 5.2 and 16.5 ± 8.3, P < 0.001 for both). There was a slight increase in systolic pressure and heart rate after three and four minutes of the infusion with normalization of these parameters thereafter. Patients showed good tolerance to MnCl<sub>2 </sub>with no major adverse events, despite all reporting transient facial flush.</p> <p>Conclusions</p> <p>In the short term, MnCl<sub>2 </sub>appears safe for human use. It effectively decreases myocardium T<sub>1</sub>, maintaining this effect for a relatively long period of time and allowing for the development of new imaging strategies in CMR, especially in ischemia research.</p

    Desempenho de caprinos nativos e ovinos Morada Nova em diferentes pastagens no Ceará.

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    Resumo: As taxas de parição, mortalidade de adultos e gemelidade de caprinos nativos e ovinos Morada Nova, foram avaliadas de 1977 a 1979, em três tipos de pastagens - Nativa de Caatinga, Nativa Raleada e de capim-buffel (Cenchrus ciliaris L.). O ensaio foi conduzido na Fazenda Iracema, da Empresa de Pesquisa Agropecuária do Ceará - EPACE -, em Quixadá, CE. As taxas de parição foram diferentes para anos, espécies, anos x espécies e espécies x pastagens. Os caprinos apresentaram 55,7%, 91,6% e 70,8% de parição e os ovinos, 89,1%, 85,2% e 86,9% em 1977, 1978 e 1979, respectivamente. A taxa de gemelidade foi significativamente maior nos caprinos (43,0%) que nos ovinos (25,8%). As taxas de mortalidade de adultos foram diferentes para anos, espécies, anos x espécies e espécies x pastagens. A sobrevivência dos ovinos foi de 87,6%, 98,0% e 85,1%; e dos caprinos, 92,9%, 95,3% e 98,6% em 1977, 1978 e 1979, respectivamente. Os ovinos morreram mais na pastagem nativa de caatinga enquanto os caprinos não foram afetados pelo tipo de pastagem. A capacidade de suporte da pastagem cultivada foi maior em 350% a da nativa de caatinga e em 182% a da nativa raleada. [Native goat and "Morada Nova" sheep performance in different pastures in Ceará]. Nativo goat and Morada Nova sheep parturition, adult mortality and gemelarity ratos were evaluated trem 1977 to 1979, in three pasture types - nativo caatinga, clearsd caatinga and buftelgrass (Cenchrus ciliaris LI. It was conducted at Iracema Farni of Empresa de Pesquisa Agropecuária do Ceará - EPACE - in Quixadá, CE, Brazil. Parturition ratos were different for year, species, year x x species and year x pasture type. Goats had 55.7%, 91.6%. and 70.8% of parturition, and sheeps 89.1%, 85.2% and 86.9% of parturition in 1977, 1978 and 1979, respectively. Adult mortality ratos were affected by year, species, year x species and species x pasture type. Sheep survival was 87.6%, 98.0% and 85.1%, and for goats, 92.9%, 95.3% and 98.6% respectively for 1977, 1978 and 1979. Sheep mortality was greater in native caatinga pasture whereas goats were not affected by the pasture types. Gemelarity ratos were different for species, goats with 43.0% and sheeps with 25.8%. Buffel-grass pasture carrying capacity was 350% higher than nativo caatinga and 182% than cleared caatinga pastures

    Volatiles of the Inflorescences of the Madeiran Orchids, Goodyera macrophylla Lowe and Gennaria diphylla (Link) Parl. and Their Role in Pollination

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    Goodyera macrophylla, considered a rare endemic, and Gennaria diphylla are two native terrestrial Orchidaceae species that can be found mainly in Madeiran Laurisilva. The volatile compounds contributing to the floral scent of these two Madeiran orchids were analysed and compared for the first time. The volatiles, isolated by distillation-extraction in a Likens-Nickersontype apparatus, and those extracted by headspace sorption, were analysed by GC and GC-MS. The main volatile components isolated by distillation-extraction were γ-terpinene (13%) and n-nonanal (11%) in G. macrophylla and n-octacosane (19%) and n-heptacosane (13%) in G. diphylla. The main volatile components isolated by headspace sorption were p-cymene (21%), α-pinene (15%) and linalool (14%) in G. macrophylla and cis-arbusculone (28%) and lilac alcohol (26%) in G. diphylla. The importance of the volatiles in the pollination of these orchids is discussed.Portuguese Foundation for the Science and Technology (FCT, Fundação para a Ciência e Tecnologia) has sponsored this work, through the Centre of Macaronesian Studies (CEM). The authors are also grateful to the Madeiran Centre of Science and Technology (CITMA) for financial support.info:eu-repo/semantics/publishedVersio

    O SENTIMENTO DE FINITUDE DO PORTADOR DE TUBERCULOSE PULMONAR, NO ATO DE CUIDAR NA TERAPIA OCUPACIONAL

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    Objective: To analyze the contribution of occupational therapy adherence to tuberculosis treatment, and identify strategies to facilitate the linkage to treatment. Method: Qualitative study. We obtain data through Creativity Workshops. Participated in the workshops eleven customers with pulmonary tuberculosis, which carried out the activity of collage. We use the method of content analysis of Bardin, who works with the universe of meanings, to uncover the beliefs and values of the subjects in this study. Results: Occupational therapy favored the disclosure of blocked content and enabled the flowering of the nuclei of aggression, rebellion, stress, dependency, control and finitude, which were in the unconscious of each participant. Conclusion: Occupational Therapy through the Creativity Workshop has benefited: the act out of feelings, compliance, facilitated the relief of emotional stress, increased self-esteem and provided better quality of life. Descriptors: Occupational Therapy, Pulmonary Tuberculosis, Qualitative Research, Content Analysis.Objetivo: Analisar a contribuição da Terapia Ocupacional a aderência ao tratamento da tuberculose e identificar estratégias que facilitem o vínculo ao tratamento. Método: Estudo qualitativo. Obtemos os dados por meio das Oficinas de Criatividade. Participaram das oficinas onze clientes com tuberculose pulmonar, os quais executaram a atividade de colagem. Utilizamos o método de análise de conteúdo de Bardin, que trabalha com o universo de significados, para desvendar as crenças e valores dos sujeitos desta pesquisa. Resultados: A Terapia Ocupacional favoreceu o desvelamento dos conteúdos bloqueados e possibilitou o desabrochar dos núcleos de agressividade, rebeldia, tensão, dependência, controle e finitude, que se encontravam no inconsciente de cada participante. Conclusão: A Terapia Ocupacional por meio da Oficina de Criatividade beneficiou: o exteriorizar de sentimentos, adesão ao tratamento, facilitou o alívio da tensão emocional, aumentou da auto-estima e proporcionou melhoria da qualidade de vida. Descritores: Terapia Ocupacional, Tuberculose Pulmonar, Pesquisa Qualitativa, Análise de Conteúdo

    Partial and simultaneous remission of nephritis and autoimmune hemolytic anemia in patients with lupus after treatment with biological agent: a case report

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    Systemic lupus erythematosus (SLE) is a chronic inflammatory disease, systemic, of unknown cause and autoimmune nature. It features variable prognosis, depending on the affected organ or system. The renal impairment is the condition most often related to morbidity and mortality. This manuscript aims to contribute to the further evidence that early diagnosis of lupus associated with quickly aggressive therapy could increase the success outcome rate. Also, immediate recognition of therapeutic failures and change the treatment strategy must be applied. In this regard, a new therapeutic option seems to be the biological drug rituximab described in this study and which it is emphasised because of its possible and still supposed ability to act as a rescue agent for nephritis and hemolytic lupus anaemia, simultaneously, with effectiveness and safety. This article presents the case of female lupus patient with both severe refractory hematologic disorder and renal impairment, which had an evolution of the simultaneous restoration of urine output, and clinical and laboratory improvement of autoimmune anaemia after rituximab administration. The persistence of renal damage could not be ruled out, so the response to treatment was considered to be partialO Lúpus Eritematoso Sistêmico (LES) é uma doença inflamatória crônica, sistêmica, de causa desconhecida e de natureza autoimune. Apresenta prognóstico variável, dependente do órgão ou sistema acometido, sendo o comprometimento renal uma das condições mais frequentemente relacionadas à morbimortalidade. O presente manuscrito propõe-se a contribuir como mais um indício de que o diagnóstico precoce e a terapia agressiva inicial, no lúpus, elevam sobremaneira o índice de sucesso clinico. Falhas no tratamento devem ser reconhecidas de imediato, com rápida mudança de estratégia, quando necessário. Neste sentido, uma nova opção terapêutica parece ser o agente biológico rituximab, descrito neste estudo e para o qual é dada ênfase devido à sua possível e ainda suposta capacidade de atuar como agente de resgate para a nefrite e para a anemia hemolítica lúpicas, simultaneamente, com efetividade e segurança. Apresenta-se o caso de paciente lúpica com acometimento renal e hematológico grave e refratário, que evoluiu simultaneamente com restabelecimento do débito urinário e melhora clínico-laboratorial da anemia autoimune após administração de rituximab, resposta considerada parcial, posto que a existência de dano renal persistente não pode ser descartad
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