Profilaxis antibiótica en Cirugía Oral y Maxilofacial

La profilaxis antibiótica en cirugía oral y maxilofacial tiene como fin la prevención de la infección en la herida quirúrgica, ya sea por las características de la cirugía o por el estado general del paciente. Este riesgo se incrementa cuanto más se contamine el campo quirúrgico, siendo necesario realizar tratamiento profiláctico de la infección en cirugías limpias-contaminadas y contaminadas y tratamiento de la infección en cirugías sucias. Además, una adecuada técnica quirúrgica colabora con la reducción de la aparición de infección postquirúrgica. La antibioterapia de elección varía entre derivados de la penicilina con inhibidores de las betalactamasas (amoxicilina-clavulánico, ampicilina-sulbactam), cefalosporinas de segunda o tercera generación, quinolonas o clindamicina. La indicación de su uso variará en función del tipo de cirugía en cada ámbito de la cirugía oral y maxilofacial, según el grado de contaminación de la misma. De este modo en cirugía oral y en patología de glándulas salivares la literatura parece demostrar que no hay mejor pronóstico en cuanto al uso de antibioterapia profiláctica respecto a no usarla en pacientes sanos. En traumatología se justifica en fracturas compuestas o con comunicación con senos paranasales. En cirugía ortognática hay discrepancia en cuanto al criterio de empleo de profilaxis antibiótica, si bien se prefieren ciclos cortos de tratamiento. En cuanto a la cirugía oncológica, se ha demostrado la reducción de la incidencia de infección postquirúrgica con el uso de antibioterapia profiláctica peroperatoria, fundamentalmente en los casos en que se pone en contacto la mucosa oral con la región cervical.Antibiotic prophylaxis in oral and maxillofacial surgery aims the prevention of the infection of the surgical wound, either due to the characteristics of the surgery or the general state of the patient. This risk increases with the contamination of the surgical operation area, making it necessary to imply a prophylactic treatment of the infection in clean-contaminated and contaminated surgeries and treatment of the infection in dirty surgeries. Moreover, a proper surgical technique helps to reduce the development of the postsurgical infection. The elective antibiotic chemotherapy ranges from penicillin-derivates with betalactamase inhibitors (amoxycillin-clavulanate, ampicilin-sulbactam) to second or third generation cephalosporins, quinolones or clindamycin. The indication for the use of these antibiotics depends on the type of surgery in oral and maxillofacial surgery, according to the degree of contamination. Thus in oral surgery and surgery of the salivary glands the literature demonstrates that there is not a better prognosis when using prophylactic antibiotherapy instead of not using it in healthy patients. In traumatology this prophylaxis is justified in compound fractures and those communicating with paranasal sinuses. In orthognatic surgery there is disagreement according to the criteria of using antibiotic prophylaxis, but short term treatment is preferred in case of using it. In oncological surgery it has been demonstrated the reduce in incidence of postsurgical infection using prophylactic peroperative antibiotherapy, mostly in those cases in which oral mucosa and cervical area contact

Antibiotic prophylaxis in Oral and Maxillofacial Surgery

La profilaxis antibiótica en cirugía oral y maxilofacial tiene como fin la prevención de la infección en la herida quirúrgica, ya sea por las características de la cirugía o por el estado general del paciente. Este riesgo se incrementa cuanto más se contamine el campo quirúrgico, siendo necesario realizar tratamiento profiláctico de la infección en cirugías limpiascontaminadas y contaminadas y tratamiento de la infección en cirugías sucias. Además, una adecuada técnica quirúrgica colabora con la reducción de la aparición de infección postquirúrgica. La antibioterapia de elección varía entre derivados de la penicilina con inhibidores de las betalactamasas (amoxicilina-clavulánico, ampicilina-sulbactam), cefalosporinas de segunda o tercera generación, quinolonas o clindamicina. La indicación de su uso variará en función del tipo de cirugía en cada ámbito de la cirugía oral y maxilofacial, según el grado de contaminación de la misma. De este modo en cirugía oral y en patología de glándulas salivares la literatura parece demostrar que no hay mejor pronóstico en cuanto al uso de antibioterapia profiláctica respecto a no usarla en pacientes sanos. En traumatología se justifica en fracturas compuestas o con comunicación con senos paranasales. En cirugía ortognática hay discrepancia en cuanto al criterio de empleo de profilaxis antibiótica, si bien se prefieren ciclos cortos de tratamiento. En cuanto a la cirugía oncológica, se ha demostrado la reducción de la incidencia de infección postquirúrgica con el uso de antibioterapia profiláctica peroperatoria, fundamentalmente en los casos en que se pone en contacto la mucosa oral con la región cervical

On rational cuspidal projective plane curves

In 2002, L. Nicolaescu and the fourth author formulated a very general conjecture which relates the geometric genus of a Gorenstein surface singularity with rational homology sphere link with the Seiberg--Witten invariant (or one of its candidates) of the link. Recently, the last three authors found some counterexamples using superisolated singularities. The theory of superisolated hypersurface singularities with rational homology sphere link is equivalent with the theory of rational cuspidal projective plane curves. In the case when the corresponding curve has only one singular point one knows no counterexample. In fact, in this case the above Seiberg--Witten conjecture led us to a very interesting and deep set of `compatibility properties' of these curves (generalising the Seiberg--Witten invariant conjecture, but sitting deeply in algebraic geometry) which seems to generalise some other famous conjectures and properties as well (for example, the Noether--Nagata or the log Bogomolov--Miyaoka--Yau inequalities). Namely, we provide a set of `compatibility conditions' which conjecturally is satisfied by a local embedded topological type of a germ of plane curve singularity and an integer $d$ if and only if the germ can be realized as the unique singular point of a rational unicuspidal projective plane curve of degree $d$. The conjectured compatibility properties have a weaker version too, valid for any rational cuspidal curve with more than one singular point. The goal of the present article is to formulate these conjectured properties, and to verify them in all the situations when the logarithmic Kodaira dimension of the complement of the corresponding plane curves is strictly less than 2

3D Visual Odometry for Road Vehicles

This paper describes a method for estimating the vehicle global position in a network of roads by means of visual odometry. To do so, the ego-motion of the vehicle relative to the road is computed using a stereo-vision system mounted next to the rear view mirror of the car. Feature points are matched between pairs of frames and linked into 3D trajectories. Vehicle motion is estimated using the non-linear, photogrametric approach based on RANSAC. This iterative technique enables the formulation of a robust method that can ignore large numbers of outliers as encountered in real traffic scenes. The resulting method is defined as visual odometry and can be used in conjunction with other sensors, such as GPS, to produce accurate estimates of the vehicle global position. The obvious application of the method is to provide on-board driver assistance in navigation tasks, or to provide a means for autonomously navigating a vehicle. The method has been tested in real traffic conditions without using prior knowledge about the scene nor the vehicle motion. We provide examples of estimated vehicle trajectories using the proposed method and discuss the key issues for further improvement

On rational cuspidal plane curves, open surfaces and local singularities

Let C be an irreducible projective plane curve in the complex projective space P(2). The classification of such curves, up to the action of the automorphism group PGL(3, C) on P(2), is a very difficult open problem with many interesting connections. The main goal is to determine, for a given d, whether there exists a projective plane curve of degree d having a fixed number of singularities of given topological type. In this note we are mainly interested in the case when C is a rational curve. The aim of this article is to present some of the old conjectures and related problems, and to complete them with some results and new conjectures from the recent work of the authors

Identification of the Immunological Changes Appearing in the CSF During the Early Immunosenescence Process Occurring in Multiple Sclerosis

Immunitat adaptativa; Envelliment; Esclerosi múltipleInmunidad adaptativa; Envejecimiento; Esclerosis múltipleAdaptive immunity; Aging; Multiple sclerosisPatients with multiple sclerosis (MS) suffer with age an early immunosenescence process, which influence the treatment response and increase the risk of infections. We explored whether lipid-specific oligoclonal IgM bands (LS-OCMB) associated with highly inflammatory MS modify the immunological profile induced by age in MS. This cross-sectional study included 263 MS patients who were classified according to the presence (M+, n=72) and absence (M-, n=191) of LS-OCMB. CSF cellular subsets and molecules implicated in immunosenescence were explored. In M- patients, aging induced remarkable decreases in absolute CSF counts of CD4+ and CD8+ T lymphocytes, including Th1 and Th17 cells, and of B cells, including those secreting TNF-alpha. It also increased serum anti-CMV IgG antibody titers (indicative of immunosenescence) and CSF CHI3L1 levels (related to astrocyte activation). In contrast, M+ patients showed an age-associated increase of TIM-3 (a biomarker of T cell exhaustion) and increased values of CHI3L1, independently of age. Finally, in both groups, age induced an increase in CSF levels of PD-L1 (an inductor of T cell tolerance) and activin A (part of the senescence-associated secretome and related to inflammaging). These changes were independent of the disease duration. Finally, this resulted in augmented disability. In summary, all MS patients experience with age a modest induction of T-cell tolerance and an activation of the innate immunity, resulting in increased disability. Additionally, M- patients show clear decreases in CSF lymphocyte numbers, which could increase the risk of infections. Thus, age and immunological status are important for tailoring effective therapies in MS.This work was supported by grants FIS-PI15/00513, FIS-PI18/00572 and RD16/0015/0001 from the Instituto de Salud Carlos III. Ministerio de Ciencia e Innovación, Spain and FEDER: "Una manera de hacer Europa"

Retropharyngeal tendinitis, brachial plexopathy and Horner's syndrome from an anomalous cervical posture

[ES] Introducción y objetivo: Presentamos el caso clínico de un paciente que, a consecuencia de una mala postura cervical, manifiesta una sintomatología y exploración compatibles con tendinitis retrofaríngea, síndrome de Horner y plexopatía braquial del mismo lado. No habiendo encontrado en la literatura una descripción similar, analizamos las características y posible fisiopatología de esta rara asociación. Caso clínico: Tras consumir en exceso alcohol y drogas, un hombre joven se queda dormido, inmóvil durante horas, con la cabeza inclinada sobre el hombro izquierdo. Al despertar acude a urgencias por presentar un intenso dolor de nuca y pérdida de sensibilidad en el cuello y miembro superior derecho. Posteriormente refiere dolor de garganta. La exploración clínica, analítica y radiológica permite el diagnóstico de síndrome de Horner, plexopatía braquial y tendinitis retrofaríngea del lado derecho. Discusión: Son pocos los casos publicados en los que una mala postura desencadene una tendinitis retrofaríngea, una plexopatía braquial o un síndrome de Horner y el único conocido por nosotros donde la extensión cervical forzada sea la causa de esta triple asociación. Las alteraciones neurológicas se diagnosticaron a través de la exploración clínica y radiológica, pero la tendinitis retrofaríngea ofrece una sintomatología y una exploración que puede confundirse con otras patologías de mayor transcendencia. Conclusión: Creemos que la postura produjo un estiramiento del “músculo longus colli”, del plexo braquial y de las fibras cervicales simpáticas preganglionares, desencadenando este cuadro clínico, que nunca hemos visto anteriormente descrito en la literatura. [EN] Introduction and objective: We present a clinical case of a patient who, because of an incorrect cervical posture, displayed symptoms and examination compatible with retropharyngeal tendinitis, Horner's syndrome and brachial plexopathy all on the same side. We have not seen a similar case described in the literature. The characteristics and possible physiopathology of this rare association is analysed. Case report: After excessive alcohol and drug consumption, a young man fell asleep and lay immobile for hours with his head bent towards his left shoulder. Upon awakening, he went to emergency services due to severe pain in the nape of his neck and loss of feeling in his neck and upper right arm. He later reported severe throat pain. Physical examination, analytical tests and x-rays yielded the diagnosis of retropharyngeal tendinitis, Horner's syndrome and brachial plexopathy of the right side. Discussion: There are few published cases where poor posture triggers a tendinitis retropharyngeal, brachial plexopathy or Horner Syndrome and the only one we know, where forced cervical extension causes the association of the three pictures. Neurological alterations were quickly diagnosed through clinical and radiological examination, but the retropharyngeal tendinitis offers a symptomatology and exploration which can be confused with other pathologies of greater importance. Conclusions: We feel the patient's posture stretched the “longus colli muscle”, brachial plexus and preganglionic sympathetic fibres, triggering this associated condition, which we have not seen before in the literature

Study of the effect of EAFD in polymer composites usig DoE

This study assesses the processing behaviour and mechanical properties of different polymers widely used in several industry fields formulated with Electric Arc Furnace Dust (EAFD) as filler. Design of Experiments (DoE) has been proved to be an effective tool to obtain the maximum information with the minimum number of experiments. In this experimental design mechanical properties as well as the melt flow index were chosen as dependent variables. The effect of CaCO3, BaSO4 and EAFD fillers as well as different polymer matrix has been evaluated.Peer ReviewedPostprint (published version

Filósofos de la intemperie IV: efectos sociales del cinismo

Proyecto dedicado al estudio y análisis de la corriente de filosofía cínica y su repercusión histórica y social a través del tiempo, articulado en torno a actividades vertebradas alrededor de un seminario que ha realizado este curso su cuarta edición. Es continuación de tres proyectos de innovación docente anteriores

Role of B Cell Profile for Predicting Secondary Autoimmunity in Patients Treated With Alemtuzumab

Células B; Alemtuzumab; AutoinmunidadLimfòcits B; Alemtuzumab; AutoimmunitatB cells; Alemtuzumab; AutoimmunityObjective: To explore if baseline blood lymphocyte profile could identify relapsing remitting multiple sclerosis (RRMS) patients at higher risk of developing secondary autoimmune adverse events (AIAEs) after alemtuzumab treatment. Methods: Multicenter prospective study including 57 RRMS patients treated with alemtuzumab followed for 3.25 [3.5-4.21] years, (median [interquartile range]). Blood samples were collected at baseline, and leukocyte subsets determined by flow cytometry. We had additional samples one year after the first cycle of alemtuzumab treatment in 39 cases. Results: Twenty-two patients (38.6%) developed AIAEs during follow-up. They had higher B-cell percentages at baseline (p=0.0014), being differences mainly due to plasmablasts/plasma cells (PB/PC, p=0.0011). Those with no AIAEs had higher percentages of CD4+ T cells (p=0.013), mainly due to terminally differentiated (TD) (p=0.034) and effector memory (EM) (p=0.031) phenotypes. AIAEs- patients also showed higher values of TNF-alpha-producing CD8+ T cells (p=0.029). The percentage of PB/PC was the best variable to differentiate both groups of patients. Baseline values >0.10% closely associated with higher AIAE risk (Odds ratio [OR]: 5.91, 95% CI: 1.83-19.10, p=0.004). When excluding the 12 patients with natalizumab, which decreases blood PB/PC percentages, being the last treatment before alemtuzumab, baseline PB/PC >0.1% even predicted more accurately the risk of AIAEs (OR: 11.67, 95% CI: 2.62-51.89, p=0.0007). The AIAEs+ group continued having high percentages of PB/PC after a year of alemtuzumab treatment (p=0.0058). Conclusions: A PB/PC percentage <0.1% at baseline identifies MS patients at low risk of secondary autoimmunity during alemtuzumab treatment.​This work was supported by grants from Red Española de Esclerosis Múltiple (REEM) (RD16/0015/0001; RD16/0015/0004; RD16/0015/0006; RD16/0015/0013) and PI18/00572 integrated in the Plan Estatal I+D+I and co-funded by ISCIII-Subdirección General de Evaluación and Fondo Europeo de Desarrollo Regional (FEDER, “Una manera de hacer Europa”)