Actions for novel teacher training: design and implementation of learning activities and resources on LMS support

El presente artículo describe el desarrollo de un Proyecto formativo para la implementación de actividades y recursos de aprendizaje en la plataforma UCO-Moodle por parte de profesorado novel, bajo tutela y coordinación de profesorado con experiencia previa contrastada. Se trata de un trabajo multidisciplinar donde las acciones se han ejecutado para ocho asignaturas de cuatro Áreas de conocimiento. El impacto de las innovaciones introducidas en varias asignaturas, afectó a más de 500 alumnos pertenecientes a seis títulos de grado de la Universidad de Córdoba. El trabajo realizado se completó con una evaluación de satisfacción por parte de los alumnos de los nuevos recursos de aprendizaje así como la autoevaluación del profesorado novel sobre la experiencia desarrollada.This article describes a project for the implementation of learning activities and resources in the UCO-Moodle platform by training teachers has been developed under the supervision and coordination of senior teaching staff with proven previous experience. It is a multidisciplinary work where the actions have been executed for eight different subjects in four Areas of knowledge. The impact of the learning activities introduced in different subjects was extended to more than 500 students belonging to six undergraduate degrees from the University of Cordoba. The experience has included an evaluation of students' satisfaction with the new learning resources as well as the self-assessment of the new teaching staff on the executed actions

The Tissue-Specific Rep8/UBXD6 Tethers p97 to the Endoplasmic Reticulum Membrane for Degradation of Misfolded Proteins

The protein known as p97 or VCP in mammals and Cdc48 in yeast is a versatile ATPase complex involved in several biological functions including membrane fusion, protein folding, and activation of membrane-bound transcription factors. In addition, p97 plays a central role in degradation of misfolded secretory proteins via the ER-associated degradation pathway. This functional diversity of p97 depends on its association with various cofactors, and to further our understanding of p97 function it is important that these cofactors are identified and analyzed. Here, we isolate and characterize the human protein named Rep8 or Ubxd6 as a new cofactor of p97. Mouse Rep8 is highly tissue-specific and abundant in gonads. In testes, Rep8 is expressed in post-meiotic round spermatids, whereas in ovaries Rep8 is expressed in granulosa cells. Rep8 associates directly with p97 via its UBX domain. We show that Rep8 is a transmembrane protein that localizes to the ER membrane with its UBX domain facing the cytoplasm. Knock-down of Rep8 expression in human cells leads to a decreased association of p97 with the ER membrane and concomitantly a retarded degradation of misfolded ER-derived proteasome substrates. Thus, Rep8 tethers p97 to the ER membrane for efficient ER-associated degradation

Disruption of the PRKCD-FBXO25-HAX-1 axis attenuates the apoptotic response and drives lymphomagenesis.

We searched for genetic alterations in human B cell lymphoma that affect the ubiquitin-proteasome system. This approach identified FBXO25 within a minimal common region of frequent deletion in mantle cell lymphoma (MCL). FBXO25 encodes an orphan F-box protein that determines the substrate specificity of the SCF (SKP1-CUL1-F-box)(FBXO25) ubiquitin ligase complex. An unbiased screen uncovered the prosurvival protein HCLS1-associated protein X-1 (HAX-1) as the bona fide substrate of FBXO25 that is targeted after apoptotic stresses. Protein kinase Cδ (PRKCD) initiates this process by phosphorylating FBXO25 and HAX-1, thereby spatially directing nuclear FBXO25 to mitochondrial HAX-1. Our analyses in primary human MCL identify monoallelic loss of FBXO25 and stabilizing HAX1 phosphodegron mutations. Accordingly, FBXO25 re-expression in FBXO25-deleted MCL cells promotes cell death, whereas expression of the HAX-1 phosphodegron mutant inhibits apoptosis. In addition, knockdown of FBXO25 significantly accelerated lymphoma development in Eμ-Myc mice and in a human MCL xenotransplant model. Together we identify a PRKCD-dependent proapoptotic mechanism controlling HAX-1 stability, and we propose that FBXO25 functions as a haploinsufficient tumor suppressor and that HAX1 is a proto-oncogene in MCL

Product differentiation and entry barriers: Mediterranean export firms in the American markets for olive oil prior to World War II

This article analyses the entry process of Mediterranean export firms in the American markets for packaged olive oil between the 1880s and the 1930s. It explores whether those entry barriers traditionally identified by the literature emerged and to what extent they influenced such an entry process. Using trade data for the early 1930s, the article shows higher average levels of exporters' concentration in the Americas than elsewhere. It also documents that by around 1930 most of the Mediterranean firms leading packaged olive oil exports to Argentina and the USA had entered the markets on the other side of the Atlantic before World War I. Finally, it identifies product differentiation as a source of entry barrier in markets for packaged olive oil in the early 1930s. The article suggests that as the American markets for this product matured early-entrant advantages associated with the use of modern marketing became more apparent, which probably raised the cost of entry to new Mediterranean export firms during the inter-war period.olive oil, international trade, nineteenth and twentieth centuries, Mediterranean, Americas, brands, marketing, product differentiation, entry barriers, early-movers advantages, industrial organisation, economic history, international business history,