Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

Venezuela y el comercio agroalimentario con Mercosur

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Soto Acosta, Willy (editor). Política Internacional e Integración Regional Comparada en América Latina.

[email protected]

Información Investigador: Fernández Guillén, Óscar Eduardo

Economista con distinción Cum Laude, egresado de la Universidad de Los Andes (ULA, Mérida-Venezuela). Docente e Investigador Ordinario de la ULA, adscrito al Centro de Investigaciones Agroalimentarias "Edgar Abreu Olivo" (CIAAL-EAO) de la Facultad de Ciencias Económicas y Sociales (FACES). Miembro fundador del Grupo de Estudios Económicos sobre Asia (GEEA), adscrito al Instituto de Investigaciones Económicas y Sociales (IIES) de la FACES, ULA. Investigador del Grupo de Estudios sobre Regionalismo, Integración Económica y Desarrollo (GRID) de la ULA. Investigador miembro del Programa de Estímulo a la Investigación e Innovación (PEII) del Observatorio Nacional de Ciencia y Tecnología (ONCTI), nivel A-1 (2015). Investigador miembro del Programa de Estímulo a la Investigación (PEI) del CDCHTA de la ULA (2015, 2017). Perteneció al Programa de Formación de Generación de Relevo (Plan II) de la ULA, adscrito al CIAAL-EAO (cohorte 2014-2016). Durante sus estudios de pregrado ejerció los cargos de Preparador, adscrito al Departamento de Economía, Consejero de Facultad y Pasante Académico en Docencia (FACES, ULA).Universitariohttp://webdelprofesor.ula.ve/economia/oscaredEconomía internacionalRelaciones económicas internacionalesComercio internacionalComercio exteriorComercio exterior agroalimentarioCooperación internacionalIntegración económicaRegionalismoDesarrolloHistoria económicaMicroeconomía aplicadaEconomista+58 274 2401031; +58 274 2403855Profesor [email protected]. Núcleo La Liria, edificio G Leocadio Hontoria, 2º piso, CIAA

Celso furtado: vision and validity of development and integration in Latin America

El desarrollo y la integración de las naciones latinoamericanas son temas de álgida discusión, cuya vigencia descansa en la adopción de políticas, por parte de los gobiernos locales, destinadas a poner en práctica mecanismos que conduzcan a la superación del subdesarrollo y en la necesidad de hacer frente como bloque cohesionado ante los desafíos que, en el escenario de las relaciones internacionales, plantea un mundo globalizado. No obstante, las teorías sobre ambos aspectos en el contexto de América Latina no son nuevas; comenzaron a gestarse durante la primera mitad del siglo XX gracias a valiosos aportes de pensadores sudamericanos. Este artículo evalúa las contribuciones realizadas por Celso Furtado en el campo del desarrollo y la integración en América Latina, como elementos de una teorización propia que nació de la realidad latinoamericana para contrarrestar la importación de recetas tomadas de experiencias foráneas y, así, ajustarse a los fenómenos económicos [email protected] development and integration of Latin American nations are topics of current discussion, whose validity rests on the adoption of policies, by the local governments, destined to implement mechanisms that lead to overcoming underdevelopment and in the need to address as cohesive block the challenges that on the stage of international relations poses a globalized world. However, theories about both aspects in the context of Latin America are not new; they began to take shape during the first half of the twentieth century thanks to the valuable contributions of South American thinkers. This article evaluates the contributions made by Celso Furtado in the field of development and integration in Latin America, as elements of an autonomous theorizing born of Latin American reality to counter the importation of recipes taken from foreign experiences and explain the own economic phenomena

Discovering HIV related information by means of association rules and machine learning

Acquired immunodeficiency syndrome (AIDS) is still one of the main health problems worldwide. It is therefore essential to keep making progress in improving the prognosis and quality of life of affected patients. One way to advance along this pathway is to uncover connections between other disorders associated with HIV/AIDS-so that they can be anticipated and possibly mitigated. We propose to achieve this by using Association Rules (ARs). They allow us to represent the dependencies between a number of diseases and other specific diseases. However, classical techniques systematically generate every AR meeting some minimal conditions on data frequency, hence generating a vast amount of uninteresting ARs, which need to be filtered out. The lack of manually annotated ARs has favored unsupervised filtering, even though they produce limited results. In this paper, we propose a semi-supervised system, able to identify relevant ARs among HIV-related diseases with a minimal amount of annotated training data. Our system has been able to extract a good number of relationships between HIV-related diseases that have been previously detected in the literature but are scattered and are often little known. Furthermore, a number of plausible new relationships have shown up which deserve further investigation by qualified medical experts

Teachers' network and digital repository of educational resources: A history of contemporary capitalism I. The crisis of the liberal State and the first globalization through filmic, literary and aesthetic sources.

Se trata de crear un repositorio digital de apoyo a la docencia virtual, con contribuciones innovadoras en el empleo de fuentes artísticas y culturales para el estudio de la crisis del Estado liberal y de la primera globalización (1920-1930).This project aims to create a digital repository to support virtual teaching, with innovative contributions in the use of artistic and cultural sources for the study of the crisis of the liberal State and the first globalization (1920-1930).Depto. de Filosofía y SociedadFac. de FilosofíaFALSEUCMsubmitte

Stoma-free Survival After Rectal Cancer Resection With Anastomotic Leakage: Development and Validation of a Prediction Model in a Large International Cohort.

Objective:To develop and validate a prediction model (STOMA score) for 1-year stoma-free survival in patients with rectal cancer (RC) with anastomotic leakage (AL).Background:AL after RC resection often results in a permanent stoma.Methods:This international retrospective cohort study (TENTACLE-Rectum) encompassed 216 participating centres and included patients who developed AL after RC surgery between 2014 and 2018. Clinically relevant predictors for 1-year stoma-free survival were included in uni and multivariable logistic regression models. The STOMA score was developed and internally validated in a cohort of patients operated between 2014 and 2017, with subsequent temporal validation in a 2018 cohort. The discriminative power and calibration of the models' performance were evaluated.Results:This study included 2499 patients with AL, 1954 in the development cohort and 545 in the validation cohort. Baseline characteristics were comparable. One-year stoma-free survival was 45.0% in the development cohort and 43.7% in the validation cohort. The following predictors were included in the STOMA score: sex, age, American Society of Anestesiologist classification, body mass index, clinical M-disease, neoadjuvant therapy, abdominal and transanal approach, primary defunctioning stoma, multivisceral resection, clinical setting in which AL was diagnosed, postoperative day of AL diagnosis, abdominal contamination, anastomotic defect circumference, bowel wall ischemia, anastomotic fistula, retraction, and reactivation leakage. The STOMA score showed good discrimination and calibration (c-index: 0.71, 95% CI: 0.66-0.76).Conclusions:The STOMA score consists of 18 clinically relevant factors and estimates the individual risk for 1-year stoma-free survival in patients with AL after RC surgery, which may improve patient counseling and give guidance when analyzing the efficacy of different treatment strategies in future studies