Mood, motility and 17-hydroxycorticoid excretion - a polyvariable case study

Mood, motility, and 17-hydroxycorticoid excretion in cyclic manic-depressive patien

Prediction the Effect of Maintenance Alternative on Pavement Performance Indicators

A road pavement continues to deteriorate under the combined actions of traffic loading and the environment. The ability of the road to satisfy the demands of traffic and the environment over its design life is known as performance. The most common indicators of pavement performance are: pavement condition index (PCI), riding quality or (IRI) and skid resistance or (IFI). Understanding the maintenance effects can benefit pavement maintenance decision-making. Accordingly, this research presents the effect of maintenance alternative on pavment performance indicators.Using the right maintenance treatment at the right time will help to get the maximum benefit and keeping the pavement performance indicator's values in a good level. Keywords: pavement performance, pavement performance indicators, maintenance alternative, multi-objective optimization

Prediction of Optimal Maintenance Alternative for Iraqi Pavement Management Based on Multi-Objective Optimization Technique and Constraint Genetic Algorithm

Pavement management systems (PMS) are widely used to assist the transportation agencies to support the decision makers to select the best maintenance alternatives. To maintain a pavement network under a performance-based efficiently and cost-effectively in a long-term horizon, the local related agencies such as SCRB, mayoralty of Baghdad and Ministry of Municipalities need to provide balance multiple objectives (e.g., cost minimum, performance maximum) which are often different from the requirements of the traditional asset preservation practices. Accordingly, the main objective of this research is to develop a multi-objective optimization model to support the multi-year decision making process of the Iraqi pavement maintenance management system. Two optimization objectives are considered; maintenance cost minimization and pavement condition maximization. This study selects the flexible pavement section (R4/B-Expressway No.1) as the study area. Different field measurements are carried out to estimate the pavement performance indicators (PPI) which included; Pavement Condition Index (PCI), International Friction Index (IFI), and International Roughness Index (IRI) to formulate multi-objective optimization models to select optimal maintenance alternative for the selected case study. Keywords: pavement management system, pavement maintenance, multi-objective optimization, genetic algorithm

Introduction to World Taekwondo Peace Corps

[EN] The World Taekwondo Pace Corps (TPC) was created by the World Taekwondo Federation ..

Phenoconversion from probable rapid eye movement sleep behavior disorder to mild cognitive impairment to dementia in a population-based sample

© 2017 The Authors Introduction Rapid eye movement sleep behavior disorder (RBD) is strongly associated with synucleinopathies. In 2012, we reported an increased risk of mild cognitive impairment (MCI) and Parkinson disease (PD) in cognitively normal Olmsted County, Minnesota, residents, aged 70 to 89 years with probable RBD. Here, we examine their progression to dementia and other neurodegenerative phenotypes. Methods Fifteen participants with RBD who were diagnosed with either MCI or PD were longitudinally followed, and their subsequent clinical courses were reviewed. Results Over 6.4 ± 2.9 years, six of the 14 participants with MCI developed additional neurodegenerative signs, five of whom had Lewy body disease features. Four of them progressed to dementia at a mean age 84.8 ± 4.9 years, three of whom met the criteria for probable dementia with Lewy bodies. One subject with PD developed MCI, but not dementia. Discussion Our findings from the population-based sample of Olmsted County, Minnesota, residents suggest that a substantial number of RBD patients tend to develop overt synucleinopathy features over time, and RBD patients who develop MCI and subsequent dementia have clinical features most consistent with dementia with Lewy bodies

Automatic summarization of rushes video using bipartite graphs

In this paper we present a new approach for automatic summarization of rushes, or unstructured video. Our approach is composed of three major steps. First, based on shot and sub-shot segmentations, we filter sub-shots with low information content not likely to be useful in a summary. Second, a method using maximal matching in a bipartite graph is adapted to measure similarity between the remaining shots and to minimize inter-shot redundancy by removing repetitive retake shots common in rushes video. Finally, the presence of faces and motion intensity are characterised in each sub-shot. A measure of how representative the sub-shot is in the context of the overall video is then proposed. Video summaries composed of keyframe slideshows are then generated. In order to evaluate the effectiveness of this approach we re-run the evaluation carried out by TRECVid, using the same dataset and evaluation metrics used in the TRECVid video summarization task in 2007 but with our own assessors. Results show that our approach leads to a significant improvement on our own work in terms of the fraction of the TRECVid summary ground truth included and is competitive with the best of other approaches in TRECVid 2007

Oxalate Oxidase Model Studies – Substrate Reactivity

The synthesis and structure of [MnLCl]0.5H2O (1·0.5H2O, HL = 1‐benzyl‐4‐acetato‐1,4,7‐triazacyclononane) is reported. Complex 1 exists as a coordination polymer in the solid state, and the MnII center is bonded to three amine nitrogen atoms, one carboxylate oxygen atom, a chlorido ligand, and an adjacent carboxylate group in a chelating fashion to afford a seven‐coordinate center. The dissolution of 1 in acetonitrile containing excess oxalate (ox) ions results in a monomeric species. When mixtures of 1 and oxalate ions are exposed to oxygen under ambient conditions, a dark pink EPR‐silent species is generated. The pink species is believed to be [MnIII(ox)2]–, which results from the displacement of the ligand L– by an oxalate ion. The decomposition of this species ultimately results in the formation of 1 equiv. of CO2 per oxalate ion consumed, a HCO3– ion, and a MnII species. Further reaction of the resulting MnII species with excess oxalate in the presence of oxygen leads to additional oxalate degradation.MnLCl (HL = 1‐benzyl‐4‐acetato‐1,4,7‐triazacyclononane) is investigated as a structural and functional model for oxalate oxidase. MnLCl effects the catalytic degradation of oxalate ions under ambient conditions. MnLCl is converted to a light‐sensitive intermediate during catalysis. Analysis of the reaction mixture indicates that 1 equiv. of CO2 per oxalate ion is produced along with a HCO3– ion.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/110613/1/646_ftp.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/110613/2/ejic_201402835_sm_miscellaneous_information.pd

Thermally Induced Oxidation of [FeII(tacn)2](OTf)2 (tacn = 1,4,7‐triazacyclononane)

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/141624/1/ejic201701190_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/141624/2/ejic201701190-sup-0001-SupMat.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/141624/3/ejic201701190.pd

Challenges and opportunities for improving the landscape for Lewy body dementia clinical trials.

Lewy body dementia (LBD), including dementia with Lewy bodies and Parkinson\u27s disease dementia, affects over a million people in the USA and has a substantial impact on patients, caregivers, and society. Symptomatic treatments for LBD, which can include cognitive, neuropsychiatric, autonomic, sleep, and motor features, are limited with only two drugs (cholinesterase inhibitors) currently approved by regulatory agencies for dementia in LBD. Clinical trials represent a top research priority, but there are many challenges in the development and implementation of trials in LBD. To address these issues and advance the field of clinical trials in the LBDs, the Lewy Body Dementia Association formed an Industry Advisory Council (LBDA IAC), in addition to its Research Center of Excellence program. The LBDA IAC comprises a diverse and collaborative group of experts from academic medical centers, pharmaceutical industries, and the patient advocacy foundation. The inaugural LBDA IAC meeting, held in June 2019, aimed to bring together this group, along with representatives from regulatory agencies, to address the topic of optimizing the landscape of LBD clinical trials. This review highlights the formation of the LBDA IAC, current state of LBD clinical trials, and challenges and opportunities in the field regarding trial design, study populations, diagnostic criteria, and biomarker utilization. Current gaps include a lack of standardized clinical assessment tools and evidence-based management strategies for LBD as well as difficulty and controversy in diagnosing LBD. Challenges in LBD clinical trials include the heterogeneity of LBD pathology and symptomatology, limited understanding of the trajectory of LBD cognitive and core features, absence of LBD-specific outcome measures, and lack of established standardized biologic, imaging, or genetic biomarkers that may inform study design. Demands of study participation (e.g., travel, duration, and frequency of study visits) may also pose challenges and impact trial enrollment, retention, and outcomes. There are opportunities to improve the landscape of LBD clinical trials by harmonizing clinical assessments and biomarkers across cohorts and research studies, developing and validating outcome measures in LBD, engaging the patient community to assess research needs and priorities, and incorporating biomarker and genotype profiling in study design