A study of the United States coal resources

Geologically significant coal resources were identified. Statistically controlled tonnage estimates for each resource type were prepared. Particular emphasis was placed on the identification and description of coals in terms of seam thickness, inclination, depth of cover, discontinuities caused by faulting and igneous intrusion, and occurrence as isolated or multiseam deposits. The national resource was organized into six major coal provinces: the Appalachian Plateau, the Interior Basins, the Gulf Coastal Plain, the Rocky Mountain Basins, the High Plains, and North Alaska. Each basin within a province was blocked into subareas of homogeneous coal thickness. Total coal tonnage for a subarea was estimated from an analysis of the cumulative coal thickness derived from borehole or surface section records and subsequently categorized in terms of seam thickness, dip, overburden, multiseam proportions, coal quality, and tonnage impacted by severe faulting and igneous intrusions. Confidence intervals were calculated for both subarea and basin tonnage estimates

On the corrosion and soiling effects on materials by air pollution in Athens, Greece

In the frame of the European project, entitled MULTI-ASSESS, specimens of structural metals, glass, stone and concrete materials were exposed to air pollution at a station, which was installed for this purpose on a building, located in the centre of Athens. The main purpose of this project was to determine the corrosion and soiling effects of air pollution on materials. A set of the specimens was exposed in a position that was sheltered from rain and partly from wind, and another set was exposed in unsheltered positions on the roof of the above said building. In addition, other specimens were exposed at different heights on the same building, in order to investigate for the first time the corrosion and soiling effects on various materials as a function of height. For the determination of these effects, chemical analysis of the specimens was performed and basic parameters as the weight change, the layer thickness and the optical properties were calculated. Finally, the results obtained are discussed and their plausible interpretation is attempted

Individual Exposure to NO2 in Relation to Spatial and Temporal Exposure Indices in Stockholm, Sweden: The INDEX Study

Epidemiology studies of health effects from air pollution, as well as impact assessments, typically rely on ambient monitoring data or modelled residential levels. The relationship between these and personal exposure is not clear. To investigate personal exposure to NO2 and its relationship with other exposure metrics and time-activity patterns in a randomly selected sample of healthy working adults (20–59 years) living and working in Stockholm. Personal exposure to NO2 was measured with diffusive samplers in sample of 247 individuals. The 7-day average personal exposure was 14.3 µg/m3 and 12.5 µg/m3 for the study population and the inhabitants of Stockholm County, respectively. The personal exposure was significantly lower than the urban background level (20.3 µg/m3). In the univariate analyses the most influential determinants of individual exposure were long-term high-resolution dispersion-modelled levels of NO2 outdoors at home and work, and concurrent NO2 levels measured at a rural location, difference between those measured at an urban background and rural location and difference between those measured in busy street and at an urban background location, explaining 20, 16, 1, 2 and 4% (R2) of the 7-day personal NO2 variation, respectively. A regression model including these variables explained 38% of the variation in personal NO2 exposure. We found a small improvement by adding time-activity variables to the latter model (R2 = 0.44). The results adds credibility primarily to long-term epidemiology studies that utilise long-term indices of NO2 exposure at home or work, but also indicates that such studies may still suffer from exposure misclassification and dilution of any true effects. In contrast, urban background levels of NO2 are poorly related to individual exposure

The future of the planning system in England: Written evidence submitted by the Bartlett School of Planning, University College London

This document is the response from nineteen academics based at the Bartlett School of Planning, University College London (UCL) to the government’s White Paper Planning for the Future. The Bartlett School of Planning is one of the world’s leading centres for planning education and research. This response draws on the research and understanding of scholars with considerable relevant expertise across planning, urban design and real estate

Planning for the Future White Paper: Consultation response from academics based at the Bartlett School of Planning, UCL

This document is the response from nineteen academics based at the Bartlett School of Planning, University College London (UCL) to the government’s White Paper Planning for the Future. The Bartlett School of Planning is one of the world’s leading centres for planning education and research. This response draws on the research and understanding of scholars with considerable relevant expertise across planning, urban design and real estate

Caregiver perceptions of children who have complex communication needs following a home-based intervention using augmentative and alternative communication in rural Kenya: an intervention note:Home-based intervention using AAC in rural Kenya

A high level of unmet communication need exists amongst children with developmental disabilities in sub-Saharan Africa. This study investigated preliminary evidence of the impact associated with a home-based, caregiver-implemented intervention employing AAC methods, with nine children in rural Kenya who have complex communication needs. The intervention used mainly locally-sourced low-tech materials, and was designed to make use of the child's strengths and the caregiver's natural expertise. A pretest-posttest design was used in the study. Data were gathered using an adapted version of the Communication Profile, which was based on the International Classification of Functioning, Disability, and Health (ICF) framework. The non-parametric Wilcoxon signed-rank test was applied to data from the first two sections of the Communication Profile-Adapted. Qualitative analysis was conducted on the final section. The data provided evidence of statistically significant positive changes in caregiver perceptions of communication at the levels of Body Structure and Function, and Activities for Communication. Also, analysis of the Participation for Communication section revealed some expansion to the children's social activities. The potential impact of the home-based intervention would benefit from investigation on a larger scale. Limitations of the study are discussed

Multicenter phase II study of plitidepsin in patients with relapsed/refractory non-Hodgkin's lymphoma

This phase II clinical trial evaluated the efficacy, safety and pharmacokinetics of plitidepsin 3.2 mg/m2 administered as a 1-hour intravenous infusion weekly on days 1, 8 and 15 every 4 weeks in 67 adult patients with relapsed/refractory aggressive non-Hodgkin's lymphoma. Patients were divided into two cohorts: those with non-cutaneous peripheral T-cell lymphoma (n=34) and those with other lymphomas (n=33). Efficacy was evaluated using the International Working Group criteria (1999). Of the 29 evaluable patients with non-cutaneous peripheral T-cell lymphoma, six had a response (overall response rate 20.7%; 95% confidence interval, 8.0%-39.7%), including two complete responses and four partial responses. No responses occurred in the 30 evaluable patients with other lymphomas (including 27 B-cell lymphomas). The most common plitidepsin-related adverse events were nausea, fatigue and myalgia (grade 3 in <10% of cases). Severe laboratory abnormalities (lymphopenia, anemia, thrombo- cytopenia, and increased levels of transaminase and creatine phosphokinase) were transient and easily managed by plitidepsin dose adjustments. The pharmacokinetic profile did not differ from that previously reported in patients with solid tumors. In conclusion, plitidepsin monotherapy has clinical activity in relapsed/refractory T-cell lymphomas. Combinations of plitidepsin with other chemotherapeutic drugs deserve further evaluation in patients with non-cutaneous peripheral T-cell lymphoma. (clinicaltrials.gov identifier: NCT00884286)

Solving the chemical master equation using sliding windows

<p>Abstract</p> <p>Background</p> <p>The chemical master equation (CME) is a system of ordinary differential equations that describes the evolution of a network of chemical reactions as a stochastic process. Its solution yields the probability density vector of the system at each point in time. Solving the CME numerically is in many cases computationally expensive or even infeasible as the number of reachable states can be very large or infinite. We introduce the sliding window method, which computes an approximate solution of the CME by performing a sequence of local analysis steps. In each step, only a manageable subset of states is considered, representing a "window" into the state space. In subsequent steps, the window follows the direction in which the probability mass moves, until the time period of interest has elapsed. We construct the window based on a deterministic approximation of the future behavior of the system by estimating upper and lower bounds on the populations of the chemical species.</p> <p>Results</p> <p>In order to show the effectiveness of our approach, we apply it to several examples previously described in the literature. The experimental results show that the proposed method speeds up the analysis considerably, compared to a global analysis, while still providing high accuracy.</p> <p>Conclusions</p> <p>The sliding window method is a novel approach to address the performance problems of numerical algorithms for the solution of the chemical master equation. The method efficiently approximates the probability distributions at the time points of interest for a variety of chemically reacting systems, including systems for which no upper bound on the population sizes of the chemical species is known a priori.</p

Determination of nitrogen dioxide, sulfur dioxide, ozone, and ammonia in ambient air using the passive sampling method associated with ion chromatographic and potentiometric analyses

Concentrations of nitrogen dioxide (NO2), sulfur dioxide (SO2), ozone (O3), and ammonia (NH3) were determined in the ambient air of Al-Ain city over a year using the passive sampling method associated with ion chromatographic and potentiometric detections. IVL samplers were used for collecting nitrogen and sulfur dioxides whereas Ogawa samplers were used for collecting ozone and ammonia. Five sites representing the industrial, traffic, commercial, residential, and background regions of the city were monitored in the course of this investigation. Year average concentrations of ≤59.26, 15.15, 17.03, and 11.88 μg/m3 were obtained for NO2, SO2, O3, and NH3, respectively. These values are lower than the maxima recommended for ambient air quality standards by the local environmental agency and the world health organization. Results obtained were correlated with the three meteorological parameters: humidity, wind speed, and temperature recorded during the same period of time using the paired t test, probability p values, and correlation coefficients. Humidity and wind speed showed insignificant effects on NO2, SO2, O3, and NH3 concentrations at 95% confidence level. Temperature showed insignificant effects on the concentrations of NO2 and NH3 while significant effects on SO2 and O3 were observed. Nonlinear correlations (R2 ≤ 0.722) were obtained for the changes in measured concentrations with changes in the three meteorological parameters. Passive samplers were shown to be not only precise (RSD ≤ 13.57) but also of low cost, low technical demand, and expediency in monitoring different locations