Note illustrative della Carta Geologica d’Italia alla scala 1:50.000, foglio 079 “Bagolino”

Il Foglio 079-Bagolino della Carta Geologica d’Italia a scala 1:50 .000 è stato realizzato nell’ambito del Progetto CARG (Legge 226/1999), attraverso convenzioni tra il Servizio Geologico d’Italia, la Regione Lombardia e la Provincia Autonoma di Trento che hanno affidato il Coordinamento Scientifico del Foglio all’Università degli Studi di Bologna. L’area del Foglio 079-Bagolino si localizza nel settore meridionale del Gruppo montuoso dell’Adamello-Presanella, a cavallo tra la Provincia di Trento (ad E) e la Regione Lombardia (ad O).Sheet 079-Bagolino of the 1:50 .000 Geological Map of Italy covers the Southern area of the Adamello-Presanella Massif, between Trento Province (Eastern side) and Lombardy (Western side)

Note illustrative della Carta Geologica d’Italia alla scala 1:50.000, foglio 078 “Breno”. Servizio Geologico d’Italia

Tectonic structure and permo-triassic stratigraphy. In the northern area, new data allow to update the lithostratigraphic subdivision of Lower Permian succession, according to the new scheme proposed by CARG Commission. Tre Valli Bresciane Group is divided into a basal coarse clastic unit (Conglomerato Basale), followed by volcanites of Lower Quartz Porphiry, and then in succession by Collio Fm., in turn divided into two informal members, one characterized by fine alluvial deposits (Pian delle Baste mb.), the other by coarser sediments (Val Dorizzo mb.). The succession is closed by partially etheropic Dosso dei Galli conglomerate and Auccia volcanite, rhyolitic ignombrites representing the final activity of Permian subsident Collio Basin

Sub-lingual administration of a polyvalent mechanical bacterial lysate (PMBL) in patients with moderate, severe, or very severe chronic obstructive pulmonary disease (COPD) according to the GOLD spirometric classification: A multicentre, double-blind, randomised, controlled, phase IV study (AIACE study: Advanced Immunological Approach in COPD Exacerbation)

Polyvalent mechanical bacterial lysates (PMBLs) have been shown to reduce the number of infectious episodes in patients with recurrent infections of the respiratory tract. Some previous investigations have also shown the effectiveness of PMBLs in reducing exacerbations of chronic obstructive pulmonary disease (COPD). The AIACE study, which was developed according to criteria of evidence-based medicine, evaluated whether the administration of PMBLs to COPD patients, in addition to the recommended treatment, was able to reduce the number of exacerbations by 25%. Two hundred eighty-eight patients with moderate to very severe COPD were recruited and randomly assigned to either placebo or PMBLs. The placebo or PMBLs were administered according to the standard scheme. The primary outcome of the study was not achieved. However, the number of days with fever (21 days per year versus 40.15; p < 0.001), the days of hospitalisation (65 days vs 162 days; p < 0.001), the interval between the first and second exacerbations (123.89 days vs 70.36; p = 0.03) and the number of days in poor health (109 days/year vs 171 days/year; p < 0.001) were significantly better in the PMBL group than in the placebo group. In conclusion, the results of this trials showed that Ismigen, in addition to guideline-suggested treatment, could not significantly reduce the number of exacerbations in the considered population; nevertheless, the secondary outcome results demonstrated potential benefits of this compound for relevant clinical outcomes