Functions of DNA damage machinery in the innate immune response to DNA virus infection.

DNA is potently immunostimulatory, and self-DNA is packaged in the nucleus or mitochondria allowing it to remain silent to cell-intrinsic sensors. However, damaged or mislocalised self-DNA is sensed by our innate immune systems, resulting in the production of type I interferons (IFNI), chemokines and inflammatory cytokines. During DNA virus infection the detection of viral DNA genomes by pattern recognition receptors (PRRs) is essential for the initiation of IFNI responses and host defence against these pathogens. It is intriguing that a number of molecular mechanisms have been found to be common to both of these DNA-induced stress responses and this has potentially important consequences for both sides of the host/pathogen arms race.This is the author accepted manuscript. The final version is available from Elsevier via http://dx.doi.org/10.1016/j.coviro.2015.08.001

Universal statistical properties of poker tournaments

We present a simple model of Texas hold'em poker tournaments which retains the two main aspects of the game: i. the minimal bet grows exponentially with time; ii. players have a finite probability to bet all their money. The distribution of the fortunes of players not yet eliminated is found to be independent of time during most of the tournament, and reproduces accurately data obtained from Internet tournaments and world championship events. This model also makes the connection between poker and the persistence problem widely studied in physics, as well as some recent physical models of biological evolution, and extreme value statistics.Comment: Final longer version including data from Internet and WPT tournament

The Relationship between Aerobic Test Performance and Injuries in Police Recruits

International Journal of Exercise Science 13(4): 1052-1062, 2020. Lower levels of fitness are associated with an increased risk of injury in police recruits. The aim of this study was to determine the relationships between initial aerobic performance assessments and injury risk during police recruit training. Retrospective data from 219 police recruits undergoing training program at a state police training academy, including 20-m Multistage Fitness Test (MSFT) and 30-15 Intermittent Fitness Test (IFT) scores and injury data, were collected. Spearman’s correlation analysis revealed a significant negative correlation between levels of fitness (MSFT rs = - 0.292, p \u3c 0.001: 30-15 IFT rs=- 0.315, p \u3c 0.001) and rates of injury. Furthermore, a Pearson’s correlation showed a strong correlation between MSFT and the 30-15 IFT scores (r = 0.877, p \u3c 0.001). Police recruits with lower fitness were at a higher risk of injury than those with higher fitness over the duration of a recruit training program. These findings indicate that aerobic performance assessments may be used by law enforcement agencies to estimate the relative risks of injury among cadets

Innovating Pedagogy 2017: Exploring new forms of teaching, learning and assessment, to guide educators and policy makers. Open University Innovation Report 6

This series of reports explores new forms of teaching, learning and assessment for an interactive world, to guide teachers and policy makers in productive innovation. This sixth report proposes ten innovations that are already in currency but have not yet had a profound influence on education. To produce it, a group of academics at the Institute of Educational Technology in The Open University collaborated with researchers from the Learning In a NetworKed Society (LINKS) Israeli Center of Research Excellence (I-CORE). Themes: • Big-data inquiry: thinking with data • Learners making science • Navigating post-truth societies • Immersive learning • Learning with internal values • Student-led analytics • Intergroup empathy • Humanistic knowledge-building communities • Open Textbooks • Spaced Learnin

Graduate students navigating social-ecological research: insights from the Long-Term Ecological Research Network

Interdisciplinary, collaborative research capable of capturing the feedbacks between biophysical and social systems can improve the capacity for sustainable environmental decision making. Networks of researchers provide unique opportunities to foster social-ecological inquiry. Although insights into interdisciplinary research have been discussed elsewhere, they rarely address the role of networks and often come from the perspectives of more senior scientists. We have provided graduate student perspectives on interdisciplinary degree paths from within the Long-Term Ecological Research (LTER) Network. Focusing on data from a survey of graduate students in the LTER Network and four self-identified successful graduate student research experiences, we examined the importance of funding, pedagogy, research design and development, communication, networking, and culture and attitude to students pursuing social-ecological research. Through sharing insights from successful graduate student approaches to social-ecological research within the LTER Network, we hope to facilitate dialogue between students, faculty, and networks to improve training for interdisciplinary scientists

Graduate students navigating social-ecological research: insights from the Long-Term Ecological Research Network

Interdisciplinary, collaborative research capable of capturing the feedbacks between biophysical and social systems can improve the capacity for sustainable environmental decision making. Networks of researchers provide unique opportunities to foster social-ecological inquiry. Although insights into interdisciplinary research have been discussed elsewhere, they rarely address the role of networks and often come from the perspectives of more senior scientists. We have provided graduate student perspectives on interdisciplinary degree paths from within the Long-Term Ecological Research (LTER) Network. Focusing on data from a survey of graduate students in the LTER Network and four self-identified successful graduate student research experiences, we examined the importance of funding, pedagogy, research design and development, communication, networking, and culture and attitude to students pursuing social-ecological research. Through sharing insights from successful graduate student approaches to social-ecological research within the LTER Network, we hope to facilitate dialogue between students, faculty, and networks to improve training for interdisciplinary scientists

Quick Start Guide to Soil Methods for Ecologists

Increasingly biologists and ecologists are becoming aware of the vital importance of soil to processes observed above ground and are incorporating soil analyses into their research. Because of the dynamic and heterogeneous nature of soil, proper incorporation of soil analysis into ecological studies requires knowledge and planning. Unfortunately, many ecologists may not be current (or trained at all) in soil science.We provide this review, based on our cumulative \u3e60 years of work in soil science,to help familiarize researchers with essential information to appropriately incorporate soil analyses into ecological studies. Specifically, we provide a brief introduction into soils and then discuss issues related to soil sterilization, choosing a soil for a greenhouse project, sampling soils, and soil analyses