Ultra-Fast, High-Performance 8x8 Approximate Multipliers by a New Multicolumn 3,3:2 Inexact Compressor and its Derivatives

Multiplier, as a key role in many different applications, is a time-consuming, energy-intensive computation block. Approximate computing is a practical design paradigm that attempts to improve hardware efficacy while keeping computation quality satisfactory. A novel multicolumn 3,3:2 inexact compressor is presented in this paper. It takes three partial products from two adjacent columns each for rapid partial product reduction. The proposed inexact compressor and its derivates enable us to design a high-speed approximate multiplier. Then, another ultra-fast, high-efficient approximate multiplier is achieved utilizing a systematic truncation strategy. The proposed multipliers accumulate partial products in only two stages, one fewer stage than other approximate multipliers in the literature. Implementation results by Synopsys Design Compiler and 45 nm technology node demonstrates nearly 11.11% higher speed for the second proposed design over the fastest existing approximate multiplier. Furthermore, the new approximate multipliers are applied to the image processing application of image sharpening, and their performance in this application is highly satisfactory. It is shown in this paper that the error pattern of an approximate multiplier, in addition to the mean error distance and error rate, has a direct effect on the outcomes of the image processing application.Comment: 21 Pages, 18 Figures, 6 Table

Knowledge and practices concerning the effects of ionizing radiation and x-ray protection methods in dental offices in Babol, 2013

Introduction: As the absorption of radiation in environment is increasing, the present study was performed to evaluate the knowledge and practices of Babol’s dentists about x-ray protection. Materials &Methods: This cross-sectional study was designed to assess the knowledge and practices of dentists. The questionnaires were distributed among 70 dentists in Babol city. Analysis of the collected data was done using the Pearson correlation coefficient in SPSS software version 19 (α=0.05). Results: In this study, 70% and 30% of studied dentists had good and moderate knowledge, respectively. 96% of them were moderate in terms of practice and 70% of them had good awareness towards the use of a lead apron and thyroid collar but 78.6% and 75.7% of offices had no lead apron and thyroid collar. There was a significant relationship between experience and awareness (p=0.003). Conclusion: According to the results, their appropriate knowledge and practice were poor. Therefore, it is necessary to control the dental radiographic centers

Effect of green tea (Camellia sinensis) extract on healing process of surgical wounds in rat

Green tea (Camellia sinensis) has anti-oxidant and anti-inflammatory properties and may enhance wound healing process. The present study, therefore, was aimed to examine the effect of green tea ethanolic extract on wound healing process. For this experimental study, 36 healthy male Wistar rats were randomly designated to three groups of A, B, and C which, respectively treated with, Vaseline þ 0.6% green tea extract, Vaseline and normal saline for 21 days. Wounds’ length and area were measured by caliper every other day and specimens were taken at 3rd, 12th, and 21st day for microscopical examinations. Data were analyzed by SPSS 16 using survival analysis (Breslow test), repeated measured ANOVA, one-way ANOVA and ManneWhitney. P < 0.05 was considered as statistically significant. The mean healing duration of surgical wounds in groups A and B was 14.66 and 20.66 (P ¼ 0.018), respectively. Decrease in healing duration in the group A was significantly higher within the first two weeks compared with control groups (P ¼ 0.05). Microscopic examinations also indicated a significant difference in wound healing process between groups A and C throughout the whole study duration as well as groups A and B during the 3rd week of the study (P < 0.05). Green tea extract could help wound healing process, probably effective on surgical wounds healin

NiO/CNTs Nanocomposite Modified Ionic Liquid Carbon Paste Electrode as a Voltammetric Sensor for Determination of Quercetin

A high sensitive carbon paste electrode modified with NiO/CNTs and ionic liquid (ILs/NiO/CNT/CPE) was describe for voltammetric determination of quercetin. Compared to unmodified carbon paste electrode, the electrochemical response was greatly improved for quercetin electrooxidation. Result shows, the oxidation peak current was increased to about 6.5 times at the surface of ILs/NiO/CNT/CPE compared to CPE. The linear response range and detection limit were found to be 0.08–400 µM and 0.03 µM, respectively. ILs/NiO/CNT/CPE was successfully applied for the determination of quercetin in real samples such as onions, apple and capsule. The results showed that the proposed method is highly selective, sensitive with a fast response for quercetin analysis

Serotonergic system modulation holds promise for L‐DOPA‐induced dyskinesias in hemiparkinsonian rats

The alleged effects of serotonergic agents in alleviating levodopa-induced dyskinesias (LIDs) in parkinsonian patients are debatable. To this end, we systematically reviewed the serotonergic agents used for the treatment of LIDs in a 6-hydroxydopamine model of Parkinson’s disease in rats. We searched MEDLINE via PubMed, Embase, Google Scholar, and Proquest for entries no later than March 2018, and restricted the search to publications on serotonergic agents used for the treatment of LIDs in hemiparkinsonian rats. The initial search yielded 447 citations, of which 49 articles and one conference paper met our inclusion criteria. The results revealed ten different categories of serotonergic agents, including but not limited to 5-HT1A/BR agonists, 5-HT2AR antagonists, selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitor (SNRIs), and tricyclic antidepressants (TCAs), all of which improved LIDs without imposing considerable adverse effects. Although there is promising evidence regarding the role of these agents in relieving LIDs in hemiparkinsonian rats, further studies are needed for the enlightenment of hidden aspect of these molecules in terms of mechanisms and outcomes. Given this, improving the quality of the pre-clinical studies and designing appropriate clinical trials will help fill the bench-to-bedside gap

Predictors of colorectal cancer screening intention among Iranian adults: an application of the preventive health model

Objective: Colorectal cancer is the third most common cancer among adults in Iran. Colorectal cancer screening is the effective way in reducing deaths from this cancer. However, the screening rate of colorectal cancer is very low among Iranian adults. This study investigated predictors of Iranian average-risk adults ' intention to take up colorectal cancer screening with fecal occult blood test using a mediator model.Methods: Participants of this cross-sectional study were comprised of 478 average-risk adults who were selected using a national sampling frame in Hamadan city, west of Iran. The data gathering instrument was a questionnaire based on the preventive health model constructs. Structural equation modeling (SEM) was employed to test the relationship using Smart PLS 2.0 softwareResults: All measures were robust in terms of its reliability and validity. Benefit (b= 0.12, p&lt;0.01), self efficacy (b= 0.36, p&lt;0.01), social support (b= 0.12, p&lt;.05) and barriers (b= -0.14, p&lt;.01) predicted the intention to be screened for CRC. Self efficacy partly mediated effects of social support and perceived barriers on intention. The study model explained approximately 24% of the variance in CRC screening intention with fecal occult blood testConclusion: Our findings indicated that the preventive health model constructs such as self efficacy, social support and barriers are useful in understanding CRC screening intentions and can help health planners in developing effective interventions for encouraging Iranian adults to undergo CRC screening

Proinflammatory Cytokine Gene Polymorphisms in Bullous Pemphigoid

Bullous pemphigoid (BP) is a rare autoimmune skin blistering disease, characterized by the presence of autoantibodies against hemidesmosomal autoantigens. Cytokine expression is altered in BP patients, and several of these differently expressed cytokines, including IL-1α, IL-1β, IL-8, and TNF-α, contribute to disease pathogenesis. Since genetic polymorphisms in the genes of these cytokines might be implicated in susceptibility to BP disease, we aimed at testing this implication in susceptibility to BP in an Iranian cohort. Blood samples were collected from the subjects and genomic DNA was extracted. To detect the single nucleotide polymorphisms (SNPs), IL-1α (rs1800587), IL-1β (rs1143627, rs16944, rs1143634), IL-8 (rs4073), and TNF-α (rs1799964, rs1800630, rs1799724, and rs361525) genes were genotyped in BP patients and healthy controls as well as IL-8 (rs4073) in pemphigus vulgaris (PV) patients. Quantitative gene expression was evaluated by RT-PCR analysis. A significant difference was observed in the distribution of genotypes or alleles of IL-8 SNP between the BP patients and controls. The A-allele of IL-8 SNP is significantly more prevalent in the control individuals compared to the BP patient. To further validate this observation, we included PV patients as an additional control. Again, the A-allele of IL-8 SNP is significantly more prevalent in the PV compared to the BP patients. While we observed a trend toward significant differences regarding alleles of TNF-α rs1799724 as well as alleles of TNF-α rs1799964, this difference was, however, not evident after correction for multiple analysis. There was no significant difference in all other studied SNPs. In contrast to IL-1α, IL-1β, and TNF-α, IL-8 gene expression levels were significantly higher in the patients than that of controls. The minor allele in IL-8 SNP might play a protective role in susceptibility to BP in Iranian patients. Although higher expression levels of IL-8 gene was found in the patients compared with healthy controls, these levels, however, suggest no association with the examined polymorphism. Moreover, further investigation revealed an elevation in gene expression between wild and polymorphic genotypes of IL-1α rs1800587 and TNF-α rs361525 in the patient group and these SNPs are therefore associated with altering the levels of gene expression

Co-transplantation of Human Embryonic Stem Cell-derived Neural Progenitors and Schwann Cells in a Rat Spinal Cord Contusion Injury Model Elicits a Distinct Neurogenesis and Functional Recovery

Co-transplantation of neural progenitors (NPs) with Schwann cells (SCs) might be a way to overcome low rate of neuronal differentiation of NPs following transplantation in spinal cord injury (SCI) and the improvement of locomotor recovery. In this study, we initially generated NPs from human embryonic stem cells (hESCs) and investigated their potential for neuronal differentiation and functional recovery when co-cultured with SCs in vitro and co-transplanted in a rat acute model of contused SCI. Co-cultivation results revealed that the presence of SCs provided a consistent status for hESC-NPs and recharged their neural differentiation toward a predominantly neuronal fate. Following transplantation, a significant functional recovery was observed in all engrafted groups (NPs, SCs, NPs+SCs) relative to the vehicle and control groups. We also observed that animals receiving co-transplants established a better state as assessed with the BBB functional test. Immunohistofluorescence evaluation five weeks after transplantation showed invigorated neuronal differentiation and limited proliferation in the co-transplanted group when compared to the individual hESC-NPs grafted group. These findings have demonstrated that the co-transplantation of SCs with hESC-NPs could offer a synergistic effect, promoting neuronal differentiation and functional recovery

Subnational mapping of HIV incidence and mortality among individuals aged 15–49 years in sub-Saharan Africa, 2000–18 : a modelling study

Background: High-resolution estimates of HIV burden across space and time provide an important tool for tracking and monitoring the progress of prevention and control efforts and assist with improving the precision and efficiency of targeting efforts. We aimed to assess HIV incidence and HIV mortality for all second-level administrative units across sub-Saharan Africa. Methods: In this modelling study, we developed a framework that used the geographically specific HIV prevalence data collected in seroprevalence surveys and antenatal care clinics to train a model that estimates HIV incidence and mortality among individuals aged 15–49 years. We used a model-based geostatistical framework to estimate HIV prevalence at the second administrative level in 44 countries in sub-Saharan Africa for 2000–18 and sought data on the number of individuals on antiretroviral therapy (ART) by second-level administrative unit. We then modified the Estimation and Projection Package (EPP) to use these HIV prevalence and treatment estimates to estimate HIV incidence and mortality by second-level administrative unit. Findings: The estimates suggest substantial variation in HIV incidence and mortality rates both between and within countries in sub-Saharan Africa, with 15 countries having a ten-times or greater difference in estimated HIV incidence between the second-level administrative units with the lowest and highest estimated incidence levels. Across all 44 countries in 2018, HIV incidence ranged from 2 ·8 (95% uncertainty interval 2·1–3·8) in Mauritania to 1585·9 (1369·4–1824·8) cases per 100 000 people in Lesotho and HIV mortality ranged from 0·8 (0·7–0·9) in Mauritania to 676· 5 (513· 6–888·0) deaths per 100 000 people in Lesotho. Variation in both incidence and mortality was substantially greater at the subnational level than at the national level and the highest estimated rates were accordingly higher. Among second-level administrative units, Guijá District, Gaza Province, Mozambique, had the highest estimated HIV incidence (4661·7 [2544·8–8120·3]) cases per 100000 people in 2018 and Inhassunge District, Zambezia Province, Mozambique, had the highest estimated HIV mortality rate (1163·0 [679·0–1866·8]) deaths per 100 000 people. Further, the rate of reduction in HIV incidence and mortality from 2000 to 2018, as well as the ratio of new infections to the number of people living with HIV was highly variable. Although most second-level administrative units had declines in the number of new cases (3316 [81· 1%] of 4087 units) and number of deaths (3325 [81·4%]), nearly all appeared well short of the targeted 75% reduction in new cases and deaths between 2010 and 2020. Interpretation: Our estimates suggest that most second-level administrative units in sub-Saharan Africa are falling short of the targeted 75% reduction in new cases and deaths by 2020, which is further compounded by substantial within-country variability. These estimates will help decision makers and programme implementers expand access to ART and better target health resources to higher burden subnational areas