MANAGING THE INCONCEIVABLE: PARTICIPATORY ASSESSMENTS OF IMPACTS AND RESPONSES TO EXTREME CLIMATE CHANGE

A comprehensive understanding of the implications of extreme climate change requires an in-depth exploration of the perceptions and reactions of the affected stakeholder groups and the lay public. The project on “Atlantic sea level rise: Adaptation to imaginable worst-case climate change” (Atlantis) has studied one such case, the collapse of the West Antarctic Ice Sheet and a subsequent 5-6 meter sea-level rise. Possible methods are presented for assessing the societal consequences of impacts and adaptation options in selected European regions by involving representatives of pertinent stakeholders. Results of a comprehensive review of participatory integrated assessment methods with a view to their applicability in climate impact studies are summarized including Simulation-Gaming techniques, the Policy Exercise method, and the Focus Group technique. Succinct presentations of these three methods are provided together with short summaries of relevant earlier applications to gain insights into the possible design options. Building on these insights, four basic versions of design procedures suitable for use in the Atlantis project are presented. They draw on design elements of several methods and combine them to fit the characteristics and fulfill the needs of addressing the problem of extreme sea-level rise. The selected participatory techniques and the procedure designs might well be useful in other studies assessing climate change impacts and exploring adaptation options.sea level rise, West Antarctic ice sheet, climate change

State of the Art and Future Challenges for Integrated Environmental Assessment

A concise review of the evolution of the integrated environmental assessment field is presented. The opening conference of the European Forum on Integrated Environmental Assessment in 1998 is taken as a reference point. A mixed record of notable accomplishments and modest progress is detected in surveying examples in four large areas of concern to the integrated assessment community: modeling, participatory techniques, mega-assessments involving hundreds of people for several years, and organizational and community issues. Plausible reasons for slow progress in participatory assessments are sketched and possible remedies are suggested. Examples of the challenges facing the integrated assessment community are elaborated in three areas: the identification of integrated assessment as a discipline and/or profession by clearly defined distinctive features, thematic issues to be resolved, and methodological improvements that are possible and needed

New records of Zelotes mundus (KULCZYNSKI, 1897) with description of the female

Zelotes mundus (KULCZYNSKI, 1897) wurde nach einem einzelnen männlichen Individuum aus Ungarn beschrieben. In unserem Jahrhundert wurde die Art mehrfach in SE-Europa nachgewiesen und vor allem auch neuerdings häufiger gemeldet (STOJICEVIC 1929, KOLOSVARY 1932, DRENSKY 1936, NIKOLlC 1981, WEISS & MARCU 1979, LOKSA 1981, MILASOWSZKY & ZULKA 1994, SAMU et al. 1996, ZULKA et al. 1997), eine Beschreibung des Weibchens stand aber bisher noch aus

Tabetha Leigh Ewing, Rumor, diplomacy and war in Enlightenment Paris

La période de la guerre de Succession d’Autriche est particulièrement riche en sources d’histoire militaire et diplomatique. Dans le présent ouvrage, Tabetha Leigh Ewing, associate professor du Bard College et fellow du New York Institute for the Humanities (NYU), analyse avec une érudition exemplaire une série de sources qui échappent souvent aux chercheurs. Il s’agit des documents des journaux clandestins, des rapports de police, des nouvelles à la main qui relatent les bruits, les rumeurs,..

Xylan-Degrading Catalytic Flagellar Nanorods

Flagellin, the main component of flagellar filaments, is a protein possessing polymerization ability. In this work, a novel fusion construct of xylanase A from B. subtilis and Salmonella flagellin was created which is applicable to build xylan-degrading catalytic nanorods of high stability. The FliC-XynA chimera when overexpressed in a flagellin deficient Salmonella host strain was secreted into the culture medium by the flagellum-specific export machinery allowing easy purification. Filamentous assemblies displaying high surface density of catalytic sites were produced by ammonium sulfate-induced polymerization. FliC-XynA nanorods were resistant to proteolytic degradation and preserved their enzymatic activity for a long period of time. Furnishing enzymes with self-assembling ability to build catalytic nanorods offers a promising alternative approach to enzyme immobilization onto nanostructured synthetic scaffolds

Insulin-like growth factor-1 in CNS and cerebrovascular aging

Insulin-like growth factor-1 (IGF-1) is an important anabolic hormone that decreases with age. In the past two decades, extensive research has determined that the reduction in IGF-1 is an important component of the age-related decline in cognitive function in multiple species including humans. Deficiency in circulating IGF-1 results in impairment in processing speed and deficiencies in both spatial and working memory. Replacement of IGF-1 or factors that increase IGF-1 to old animals and humans reverses many of these cognitive deficits. Despite the overwhelming evidence for IGF-1 as an important neurotrophic agent, the specific mechanisms through which IGF-1 acts have remained elusive. Recent evidence indicates that IGF-1 is both produced by and has important actions on the cerebrovasculature as well as neurons and glia. Nevertheless, the specific regulation and actions of brain- and vascular-derived IGF-1 is poorly understood. The diverse effects of IGF-1 discovered thus far reveal a complex endocrine and paracrine system essential for integrating many of the functions necessary for brain health. Identification of the mechanisms of IGF-1 actions will undoubtedly provide critical insight into regulation of brain function in general and the causes of cognitive decline with age

Magnetic tweezers for intracellular applications

doi:10.1063/1.1599066 http://rsi.aip.org/rsinak/v74/i9/p4158_s1We have designed and constructed a versatile magnetic tweezer primarily for intracellular investigations. The micromanipulator uses only two coils to simultaneously magnetize to saturation micron-size superparamagnetic particles and generate high magnitude constant field gradients over cellular dimensions. The apparatus resembles a miniaturized Faraday balance, an industrial device used to measure magnetic susceptibility. The device operates in both continuous and pulse modes. Due to its compact size, the tweezers can conveniently be mounted on the stage of an inverted microscope and used for intracellular manipulations. A built-in temperature control unit maintains the sample at physiological temperatures. The operation of the tweezers was tested by moving 1.28 μm diameter magnetic beads inside macrophages with forces near 500 pN.This work was partially supported by the NSF ~Grant No. DBI-9730999!

Soils of the European Union

This report make a detailed summary of the soil resources of the EU. Contents: Acknowledgements 2 1. Introduction 3 2. Materials and methods 4 2.1 Soil Geographical Database of Eurasia at scale 1:1,000,000 (SGDBE) 4 2.2 Nomenclature of soil types 6 2.3 Map legend and representation 6 3. Soils of the European Union: an overview 8 4. Spatial distribution of the major soils in the European Union 11 4.1 Acrisols 11 4.2 Albeluvisols 13 4.3 Andosols 15 4.4 Anthrosols 17 4.5 Arenosols 19 4.6 Calcisols 21 4.7 Cambisols 23 4.8 Chernozems 25 4.9 Fluvisols 27 4.10 Gleysols 29 4.11 Gypsisols 31 4.12 Histosols 33 4.13 Kastanozems 35 4.14 Leptosols 37 4.15 Luvisols 39 4.16 Phaeozems 41 4.17 Planosol 43 4.18 Podzols 45 4.19 Regosols 47 4.20 Solonchaks 49 4.21 Solonetz 51 4.22 Umbrisols 53 4.23 Vertisols 55 5. Concluding remarks 57 References 58 Appendix 1. 59 Appendix 2. 62JRC.H.7-Land management and natural hazard

Environmental properties of cells improve machine learning-based phenotype recognition accuracy

To answer major questions of cell biology, it is often essential to understand the complex phenotypic composition of cellular systems precisely. Modern automated microscopes produce vast amounts of images routinely, making manual analysis nearly impossible. Due to their efficiency, machine learningbased analysis software have become essential tools to perform single-cell-level phenotypic analysis of large imaging datasets. However, an important limitation of such methods is that they do not use the information gained from the cellular micro-and macroenvironment: the algorithmic decision is based solely on the local properties of the cell of interest. Here, we present how various features from the surrounding environment contribute to identifying a cell and how such additional information can improve single-cell-level phenotypic image analysis. The proposed methodology was tested for different sizes of Euclidean and nearest neighbour-based cellular environments both on tissue sections and cell cultures. Our experimental data verify that the surrounding area of a cell largely determines its entity. This effect was found to be especially strong for established tissues, while it was somewhat weaker in the case of cell cultures. Our analysis shows that combining local cellular features with the properties of the cell's neighbourhood significantly improves the accuracy of machine learning-based phenotyping.Peer reviewe