The Metropolis research. Experimental models and decision-making processes for the adaptive environmental design in climate change

The state of knowledge on climate change adaptation at the international level shows several experiences both in the field of research and urban politics that aim at defining methods and procedures, adaptation plans and guidelines for action. However, the specificity of the issues at the local scale requires further experimentations to implement suitable actions based on downscaling processes. Within the Metropolis project, the research group of the Department of Architecture at the Federico II University of Naples has carried out research work aimed at assessing the capacity of the urban system to adapt to the effects of climate change. The research work resulted in the development of a model of knowledge on the vulnerability to heat waves and pluvial flooding based on the study of the information about the features of the social and physical system. By developing downscaling experimental models, hazard scenarios have been built at the local scale based on the IPCC scenarios on CO2 emissions - Intergovernmental Panel on Climate Change. Finally, a decision-making process has been developed to assess the adaptive capacity of the urban system It allows the making of a long term adaptive design oriented towards processes of urban rehabilitation that are resilient to climate change. The adaptation solutions have been selected grading by their compatibility with the specific context and evaluated for the correspondence to the technological and environmental requirements, to the socio-economic conditions and the effects on the ecosystem

The Metropolis research. Experimental models and decision-making processes for the adaptive environmental design in climate change

The state of knowledge on climate change adaptation at the international level shows several experiences both in the field of research and urban politics that aim at defining methods and procedures, adaptation plans and guidelines for action. However, the specificity of the issues at the local scale requires further experimentations to implement suitable actions based on downscaling processes. Within the Metropolis project, the research group of the Department of Architecture at the Federico II University of Naples has carried out research work aimed at assessing the capacity of the urban system to adapt to the effects of climate change. The research work resulted in the development of a model of knowledge on the vulnerability to heat waves and pluvial flooding based on the study of the information about the features of the social and physical system. By developing downscaling experimental models, hazard scenarios have been built at the local scale based on the IPCC scenarios on CO2 emissions - Intergovernmental Panel on Climate Change. Finally, a decision-making process has been developed to assess the adaptive capacity of the urban system It allows the making of a long term adaptive design oriented towards processes of urban rehabilitation that are resilient to climate change. The adaptation solutions have been selected grading by their compatibility with the specific context and evaluated for the correspondence to the technological and environmental requirements, to the socio-economic conditions and the effects on the ecosystem

Evidence for νμ→ντ\nu_\mu \to \nu_\tau appearance in the CNGS neutrino beam with the OPERA experiment

The OPERA experiment is designed to search for $\nu_{\mu} \rightarrow \nu_{\tau}$ oscillations in appearance mode i.e. through the direct observation of the $\tau$ lepton in $\nu_{\tau}$ charged current interactions. The experiment has taken data for five years, since 2008, with the CERN Neutrino to Gran Sasso beam. Previously, two $\nu_{\tau}$ candidates with a $\tau$ decaying into hadrons were observed in a sub-sample of data of the 2008-2011 runs. Here we report the observation of a third $\nu_\tau$ candidate in the $\tau^-\to\mu^-$ decay channel coming from the analysis of a sub-sample of the 2012 run. Taking into account the estimated background, the absence of $\nu_{\mu} \rightarrow \nu_{\tau}$ oscillations is excluded at the 3.4 $\sigma$ level.Comment: 9 pages, 5 figures, 1 table

Determination of a time-shift in the OPERA set-up using high energy horizontal muons in the LVD and OPERA detectors

The purpose of this work is to report the measurement of a time-shift in the OPERA set-up in a totally independent way from Time Of Flight (TOF) measurements of CNGS neutrino events. The LVD and OPERA experiments are both installed in the same laboratory: LNGS. The relative position of the two detectors, separated by an average distance of ~ 160 m, allows the use of very high energy horizontal muons to cross-calibrate the timing systems of the two detectors, using a TOF technique which is totally independent from TOF of CNGS neutrino events. Indeed, the OPERA-LVD direction lies along the so-called "Teramo anomaly", a region in the Gran Sasso massif where LVD has established, many years ago, the existence of an anomaly in the mountain structure, which exhibits a low m. w. e. thickness for horizontal directions. The "abundant" high-energy horizontal muons (nearly 100 per year) going through LVD and OPERA exist because of this anomaly in the mountain orography. The total live time of the data in coincidence correspond to 1200 days from mid 2007 until March 2012. The time coincidence study of LVD and OPERA detectors is based on 306 cosmic horizontal muon events and shows the existence of a negative time shift in the OPERA set-up of the order of deltaT(AB) = - (73 \pm 9) ns when two calendar periods, A and B, are compared. This result shows a systematic effect in the OPERA timing system from August 2008 until December 2011. The size of the effect is comparable with the neutrino velocity excess recently measured by OPERA. It is probably interesting not to forget that with the MRPC technology developed by the ALICE Bologna group the TOF world record accuracy of 20 ps was reached. That technology can be implemented at LNGS for a high precision determination of TOF with the CNGS neutrino beams of an order of magnitude smaller than the value of the OPERA systematic effect

Infected pancreatic necrosis: outcomes and clinical predictors of mortality. A post hoc analysis of the MANCTRA-1 international study

: The identification of high-risk patients in the early stages of infected pancreatic necrosis (IPN) is critical, because it could help the clinicians to adopt more effective management strategies. We conducted a post hoc analysis of the MANCTRA-1 international study to assess the association between clinical risk factors and mortality among adult patients with IPN. Univariable and multivariable logistic regression models were used to identify prognostic factors of mortality. We identified 247 consecutive patients with IPN hospitalised between January 2019 and December 2020. History of uncontrolled arterial hypertension (p = 0.032; 95% CI 1.135-15.882; aOR 4.245), qSOFA (p = 0.005; 95% CI 1.359-5.879; aOR 2.828), renal failure (p = 0.022; 95% CI 1.138-5.442; aOR 2.489), and haemodynamic failure (p = 0.018; 95% CI 1.184-5.978; aOR 2.661), were identified as independent predictors of mortality in IPN patients. Cholangitis (p = 0.003; 95% CI 1.598-9.930; aOR 3.983), abdominal compartment syndrome (p = 0.032; 95% CI 1.090-6.967; aOR 2.735), and gastrointestinal/intra-abdominal bleeding (p = 0.009; 95% CI 1.286-5.712; aOR 2.710) were independently associated with the risk of mortality. Upfront open surgical necrosectomy was strongly associated with the risk of mortality (p < 0.001; 95% CI 1.912-7.442; aOR 3.772), whereas endoscopic drainage of pancreatic necrosis (p = 0.018; 95% CI 0.138-0.834; aOR 0.339) and enteral nutrition (p = 0.003; 95% CI 0.143-0.716; aOR 0.320) were found as protective factors. Organ failure, acute cholangitis, and upfront open surgical necrosectomy were the most significant predictors of mortality. Our study confirmed that, even in a subgroup of particularly ill patients such as those with IPN, upfront open surgery should be avoided as much as possible. Study protocol registered in ClinicalTrials.Gov (I.D. Number NCT04747990)