Robust Fusion Filtering for Multisensor Time-Varying Uncertain Systems: The Finite Horizon Case

The robust H∞ fusion filtering problem is considered for linear time-varying uncertain systems observed by multiple sensors. A performance index function for this problem is defined as an indefinite quadratic inequality which is solved by the projection method in Krein space. On this basis, a robust centralized finite horizon H∞ fusion filtering algorithm is proposed. However, this centralized fusion method is with poor real time property, as the number of sensors increases. To resolve this difficulty, within the sequential fusion framework, the performance index function is described as a set of quadratic inequalities including an indefinite quadratic inequality. And a sequential robust finite horizon H∞ fusion filtering algorithm is given by solving this quadratic inequality group. Finally, two simulation examples for time-varying/time-invariant multisensor systems are exploited to demonstrate the effectiveness of the proposed methods in the respect of the real time property and filtering accuracy

Solvent-free catalytic oxidation of benzyl alcohol over Au-Pd bimetal deposited on TiO2: comparison of Rutile, Brookite, and Anatase

TiO2 (P25)-supported Au-Pd bimetal nanoparticles displayed excellent performance in the solvent-free benzyl alcohol catalytic oxidation. However, little research attention has been paid to investigate the effects of TiO2 form on the catalytic activity of Au-Pd/TiO2. In the present research, rutile, brookite, and anatase TiO2 were successfully synthesized and subsequently applied as the carrier to load Au-Pd nanoparticles by the deposition-precipitation method. The experimental results indicated that the benzyl alcohol conversion employing the rutile TiO2-supported Au-Pd catalyst is higher than the conversion of anatase and brookite TiO2-loaded Au-Pd catalysts. However, the Au-Pd/TiO2-rutile displayed the lowest and highest selectivity toward benzaldehyde and toluene, respectively. ICP-AES, XRD, XPS, and TEM were conducted to characterize these catalysts. The corresponding experimental results revealed that the excellent performance of Au-Pd/TiO2-rutile catalyst was attributed to both the smaller Au-Pd nanoparticle size distribution and the higher concentrations of Oα and Pd2+ species on the catalyst surface. In the recycle experiments, the Au-Pd/TiO2-rutile catalyst displayed lower reaction stability compared with the Au-Pd/TiO2-anatase and Au-Pd/TiO2-brookite, which might be due to the coverage of larger amount of aldehyde products on the surface

Effects of ulinastatin and docataxel on breast tumor growth and expression of IL-6, IL-8, and TNF-α

<p>Abstract</p> <p>Objective</p> <p>This study investigated the effects of Ulinastatin (UTI) and docataxel (Taxotere, TAX) on tumor growth and expression of interleukin-6 (IL-6), interleukin-8 (IL-8), and tumor necrosis factor-α (TNF-α) in breast cancer.</p> <p>Methods</p> <p>MDA-MB-231 human breast carcinoma cells were cultured in vitro and injected into nude mice to establish breast tumor xenografts in vivo. Cultured cells and mice with tumors were randomly divided into four groups for treatment with TAX, UTI, and TAX+UTI. The effects of these drug treatments on cell proliferation and apoptosis was measured using the MTT assay and the Annexin V/propidium iodide (PI) double-staining method, respectively. IL-6, IL-8, and TNF-α expression levels were determined by measuring mRNA transcripts in cultured cells by RT-PCR and cytokine proteins in solid tumors using immunohistochemistry.</p> <p>Results</p> <p>UTI, TAX, and UTI+TAX inhibited the growth of MDA-MB-231 cells in vitro and tumors in vivo. These two drugs, particularly when used in combination, promote tumor cell apoptosis and down-regulate the expression IL-6, IL-8, and TNF-α cytokines.</p> <p>Conclusion</p> <p>Both UTI and TAX inhibited the growth of MDA-MB-231 breast carcinoma cells. UTI enhanced the inhibitory effect of TAX by a mechanism consistent with the down-regulated expression of IL-6, IL-8, and TNF-α.</p

NeRFTAP: Enhancing Transferability of Adversarial Patches on Face Recognition using Neural Radiance Fields

Face recognition (FR) technology plays a crucial role in various applications, but its vulnerability to adversarial attacks poses significant security concerns. Existing research primarily focuses on transferability to different FR models, overlooking the direct transferability to victim's face images, which is a practical threat in real-world scenarios. In this study, we propose a novel adversarial attack method that considers both the transferability to the FR model and the victim's face image, called NeRFTAP. Leveraging NeRF-based 3D-GAN, we generate new view face images for the source and target subjects to enhance transferability of adversarial patches. We introduce a style consistency loss to ensure the visual similarity between the adversarial UV map and the target UV map under a 0-1 mask, enhancing the effectiveness and naturalness of the generated adversarial face images. Extensive experiments and evaluations on various FR models demonstrate the superiority of our approach over existing attack techniques. Our work provides valuable insights for enhancing the robustness of FR systems in practical adversarial settings

Global burden of colistin-resistant bacteria : mobilized colistin resistance genes study (1980-2018)

Colistin is considered to be an antimicrobial of last-resort for the treatment of multidrug-resistant Gram-negative bacterial infections. The recent global dissemination of mobilized colistin resistance (mcr) genes is an urgent public health threat. An accurate estimate of the global prevalence of mcr genes, their reservoirs and the potential pathways for human transmission are required to implement control and prevention strategies, yet such data are lacking. Publications from four English (PubMed, Scopus, the Cochrane Database of Systematic Reviews and Web of Science) and two Chinese (CNKI and WANFANG) databases published between 18 November 2015 and 30 December 2018 were identified. In this systematic review and meta-analysis, the prevalence of mcr genes in bacteria isolated from humans, animals, the environment and food products were investigated. A total of 974 publications were identified. 202 observational studies were included in the systematic review and 71 in the meta-analysis. mcr genes were reported from 47 countries across six continents and the overall average prevalence was 4.7% (0.1-9.3%). China reported the highest number of mcr-positive strains. Pathogenic Escherichia coli (54%), isolated from animals (52%) and harboring an IncI2 plasmid (34%) were the bacteria with highest prevalence of mcr genes. The estimated prevalence of mcr-1 pathogenic E. coli was higher in food-animals than in humans and food products, which suggests a role for foodborne transmission. This study provides a comprehensive assessment of prevalence of the mcr gene by source, organism, genotype and type of plasmid

Unified Finite Horizon H

This paper addresses the H∞ fusion filtering problem for networked dynamical systems, where measurements may arrive at fusion center in four different scenes and the fusion center could receive none, one, or multiple measurements in a fusion period. A unified H∞ performance criterion function, which is suitable for different measurement arrival scenes, is designed for the filtering process of networked dynamical systems. Then, the H∞ performance criterion function is described as an indefinite quadratic inequality and solved by a novel noise projection method in Krein space. On this basis, a unified finite horizon H∞ filtering method is proposed for networked dynamical systems. Simulation results are provided to illustrate the correctness and the effectiveness of the theoretical analysis

Effects of ulinastatin and docetaxel on breast cancer invasion and expression of uPA, uPAR and ERK

<p>Abstract</p> <p>Objective</p> <p>To investigate the effects of ulinastatin and docetaxel on invasion of breast cancer cells and expression of uPA, uPAR and ERK, breast cancer MDA-MB-231 and MCF-7 cells.</p> <p>Methods</p> <p>The nude mice were treated with PBS, ulinastatin, docetaxel, and ulinastatin plus docetaxel, respectively. Their effects on 1) cell invasion ability was assayed using Transwell; 2) expression of uPA, uPAR and ERK was detected by real time PCR and Western blot; 3) uPA, uPAR and p-ERK protein level in nude mice was quantified by immunohistochemistry.</p> <p>Results</p> <p>1) Treatment with ulinastatin, docetaxel, and ulinastatin plus docetaxel, respectively, significantly inhibited MDA-MB-231 and MCF-7 cell invasion; 2) mRNA and protein levels of uPA, uPAR and ERK1/2 were inhibited by ulinastatin, but enhanced by docetaxel.</p> <p>Conclusion</p> <p>Ulinastatin can enhance the effects of docetaxel on invasion of breast cancer cells. And that uPA, uPAR and p-ERK expression is obviously inhibited by ulinastatin.</p

Bhlhb5 Regulates the Postmitotic Acquisition of Area Identities in Layers II-V of the Developing Neocortex

While progenitor-restricted factors broadly specify area identities in developing neocortex, the downstream regulatory elements involved in acquisition of those identities in post-mitotic neurons are largely unknown. Here, we identify Bhlhb5, a transcription factor expressed in layers II–V, as a post-mitotic regulator of area identity. Bhlhb5 is initially expressed in a high caudomedial to low rostrolateral gradient that transforms into a sharp border between sensory and rostral motor cortices. Bhlhb5-null mice exhibit aberrant expression of area-specific genes and structural organization in the somatosensory and caudal motor cortices. In somatosensory cortex, Bhlhb5-null mice display post-synaptic disorganization of vibrissal barrels. In caudal motor cortex, Bhlhb5-null mice exhibit anomalous differentiation of corticospinal motor neurons, accompanied by failure of corticospinal tract formation. Together, these results demonstrate Bhlhb5’s function as an area-specific transcription factor that regulates the post-mitotic acquisition of area identities and elucidate the genetic hierarchy between progenitors and post-mitotic neurons driving neocortical arealization.Stem Cell and Regenerative Biolog

Transcriptomic-metabolomic reprogramming in EGFR-mutant NSCLC early adaptive drug escape linking TGFβ2-bioenergetics-mitochondrial priming.

The impact of EGFR-mutant NSCLC precision therapy is limited by acquired resistance despite initial excellent response. Classic studies of EGFR-mutant clinical resistance to precision therapy were based on tumor rebiopsies late during clinical tumor progression on therapy. Here, we characterized a novel non-mutational early adaptive drug-escape in EGFR-mutant lung tumor cells only days after therapy initiation, that is MET-independent. The drug-escape cell states were analyzed by integrated transcriptomic and metabolomics profiling uncovering a central role for autocrine TGFβ2 in mediating cellular plasticity through profound cellular adaptive Omics reprogramming, with common mechanistic link to prosurvival mitochondrial priming. Cells undergoing early adaptive drug escape are in proliferative-metabolic quiescent, with enhanced EMT-ness and stem cell signaling, exhibiting global bioenergetics suppression including reverse Warburg, and are susceptible to glutamine deprivation and TGFβ2 inhibition. Our study further supports a preemptive therapeutic targeting of bioenergetics and mitochondrial priming to impact early drug-escape emergence using EGFR precision inhibitor combined with broad BH3-mimetic to interrupt BCL-2/BCL-xL together, but not BCL-2 alone