Automated method for study of drug metabolism

Commercially available equipment can be modified to provide automated system for assaying drug metabolism by continuous flow-through. System includes steps and devices for mixing drug with enzyme and cofactor in the presence of pure oxygen, dialyzing resulting metabolite against buffer, and determining amount of metabolite by colorimetric method

Delayed Diagnoses: Nonspecific Findings and Diagnostic Challenges in Eating Disorders

Objective. Eating disorders commonly present with nonspecific findings, masquerading as other, more common etiologies of malnutrition and wasting. In low-prevalence populations, these ambiguities can complicate clinicians' diagnostic reasoning, resulting in delayed or missed diagnoses. Method. We report the atypical case of a 51-year-old male with a five-year history of unexplained weight loss despite extensive past medical evaluation. Previous documentation of profound lymphopenia and bone marrow atrophy had not been linked to a known association with eating disorders. Results. Evaluation for medical etiologies of wasting was negative. Following psychiatric evaluation, the patient was diagnosed with an eating disorder, not otherwise specified, and admitted to a specialized nutritional rehabilitation program. Conclusion. The nonspecific clinical history, physical exam, and laboratory abnormalities of eating disorders can make these diagnoses challenging and delay appropriate treatment. Clinicians should consider eating disorders in patients with malnutrition, severe lymphopenias, and gelatinous marrow transformation early in their workup, so as to avoid potentially negative outcomes

Thermodynamic phase transitions for Pomeau-Manneville maps

We study phase transitions in the thermodynamic description of Pomeau-Manneville intermittent maps from the point of view of infinite ergodic theory, which deals with diverging measure dynamical systems. For such systems, we use a distributional limit theorem to provide both a powerful tool for calculating thermodynamic potentials as also an understanding of the dynamic characteristics at each instability phase. In particular, topological pressure and Renyi entropy are calculated exactly for such systems. Finally, we show the connection of the distributional limit theorem with non-Gaussian fluctuations of the algorithmic complexity proposed by Gaspard and Wang [Proc. Natl. Acad. Sci. USA 85, 4591 (1988)].Comment: 5 page

Inclinations of small quiet-Sun magnetic features based on a new geometric approach

High levels of horizontal magnetic flux have been reported in the quiet-Sun internetwork, often based on Stokes profile inversions. Here we introduce a new method for deducing the inclination of magnetic elements and use it to test magnetic field inclinations from inversions. We determine accurate positions of a set of small, bright magnetic elements in high spatial resolution images sampling different photospheric heights obtained by the Sunrise balloon-borne solar observatory. Together with estimates of the formation heights of the employed spectral bands, these provide us with the inclinations of the magnetic features. We also compute the magnetic inclination angle of the same magnetic features from the inversion of simultaneously recorded Stokes parameters. Our new, geometric method returns nearly vertical fields (average inclination of around 14 deg with a relatively narrow distribution having a standard deviation of 6 deg). In strong contrast to this, the traditionally used inversions give almost horizontal fields (average inclination of 75+-8 deg) for the same small magnetic features, whose linearly polarised Stokes profiles are adversely affected by noise. The almost vertical field of bright magnetic features from our geometric method is clearly incompatible with the nearly horizontal magnetic fields obtained from the inversions. This indicates that the amount of magnetic flux in horizontal fields deduced from inversions is overestimated in the presence of weak Stokes signals, in particular if Stokes Q and U are close to or under the noise level. By combining the proposed method with inversions we are not just improving the inclination, but also the field strength. This technique allows us to analyse features that are not reliably treated by inversions, thus greatly extending our capability to study the complete magnetic field of the quiet Sun.Comment: 12 pages, 9 figures, 1 table; Accepted for publication in Astronomy & Astrophysic

General lower bounds for evolutionary algorithms

Evolutionary optimization, among which genetic optimization, is a general framework for optimization. It is known (i) easy to use (ii) robust (iii) derivative-free (iv) unfortunately slow. Recent work [8] in particular show that the convergence rate of some widely used evolution strategies (evolutionary optimization for continuous domains) can not be faster than linear (i.e. the logarithm of the distance to the optimum can not decrease faster than linearly), and that the constant in the linear convergence (i.e. the constant C such that the distance to the optimum after n steps is upp er b ounded by C n ) unfortunately converges quickly to 1 as the dimension increases to infinity. We here show a very wide generalization of this result: al l comparison-based algorithms have such a limitation. Note that our result also concerns methods like the Hooke & Jeeves algorithm, the simplex method, or any direct search method that only compares the values to previously seen values of the fitness. But it does not cover methods that use the value of the fitness (see [5] for cases in which the fitness-values are used), even if these methods do not use gradients. The former results deal with convergence with respect to the number of comparisons performed, and also include a very wide family of algorithms with resp ect to the number of function-evaluations. However, there is still place for faster convergence rates, for more original algorithms using the full ranking information of the population and not only selections among the population. We prove that, at least in some particular cases, using the full ranking information can improve these lower bounds, and ultimately provide sup erlinear convergence results

Levy distribution in many-particle quantum systems

Levy distribution, previously used to describe complex behavior of classical systems, is shown to characterize that of quantum many-body systems. Using two complimentary approaches, the canonical and grand-canonical formalisms, we discovered that the momentum profile of a Tonks-Girardeau gas, -- a one-dimensional gas of $N$ impenetrable (hard-core) bosons, harmonically confined on a lattice at finite temperatures, obeys Levy distribution. Finally, we extend our analysis to different confinement setups and demonstrate that the tunable Levy distribution properly reproduces momentum profiles in experimentally accessible regions. Our finding allows for calibration of complex many-body quantum states by using a unique scaling exponent.Comment: 7 pages, 6 figures, results are generalized, new examples are adde

Zero Boil-Off System Testing

Cryogenic propellants such as liquid hydrogen (LH2) and liquid oxygen (LO2) are a part of NASA's future space exploration plans due to their high specific impulse for rocket motors of upper stages. However, the low storage temperatures of LH2 and LO2 cause substantial boil-off losses for long duration missions. These losses can be eliminated by incorporating high performance cryocooler technology to intercept heat load to the propellant tanks and modulating the cryocooler temperature to control tank pressure. The technology being developed by NASA is the reverse turbo-Brayton cycle cryocooler and its integration to the propellant tank through a distributed cooling tubing network coupled to the tank wall. This configuration was recently tested at NASA Glenn Research Center in a vacuum chamber and cryoshroud that simulated the essential thermal aspects of low Earth orbit, its vacuum and temperature. This test series established that the active cooling system integrated with the propellant tank eliminated boil-off and robustly controlled tank pressure

Integration of Langevin Equations with Multiplicative Noise and Viability of Field Theories for Absorbing Phase Transitions

Efficient and accurate integration of stochastic (partial) differential equations with multiplicative noise can be obtained through a split-step scheme, which separates the integration of the deterministic part from that of the stochastic part, the latter being performed by sampling exactly the solution of the associated Fokker-Planck equation. We demonstrate the computational power of this method by applying it to most absorbing phase transitions for which Langevin equations have been proposed. This provides precise estimates of the associated scaling exponents, clarifying the classification of these nonequilibrium problems, and confirms or refutes some existing theories.Comment: 4 pages. 4 figures. RevTex. Slightly changed versio

Cryogenic Boil-Off Reduction System Testing

Cryogenic propellants such as liquid hydrogen (LH2) and liquid oxygen (LO2) are a part of NASA's future space exploration due to the high specific impulse that can be achieved using engines suitable for moving 10's to 100's of metric tons of payload mass to destinations outside of low earth orbit. However, the low storage temperatures of LH2 and LO2 cause substantial boil-off losses for missions with durations greater than several days. The losses can be greatly reduced by incorporating high performance cryocooler technology to intercept heat load to the propellant tanks and by the integration of self-supporting multi-layer insulation. The active thermal control technology under development is the integration of the reverse turbo- Brayton cycle cryocooler to the propellant tank through a distributed cooling network of tubes coupled to a shield in the tank insulation and to the tank wall itself. Also, the self-supporting insulation technology was utilized under the shield to obtain needed tank applied LH2 performance. These elements were recently tested at NASA Glenn Research Center in a series of three tests, two that reduced LH2 boil-off and one to eliminate LO2 boil-off. This test series was conducted in a vacuum chamber that replicated the vacuum of space and the temperatures of low Earth orbit. The test results show that LH2 boil-off was reduced 60% by the cryocooler system operating at 90K and that robust LO2 zero boil-off storage, including full tank pressure control was achieved