Global universities in local contexts: fostering critical self-reflection and citizenship at branch campuses

There seems to be a race in the global age for universities to be associated with specific attributes: university marketing literature insists on institutions being ‘global’, promising to educate the citizens and leaders of tomorrow thanks to key and transferable skills such as problem solving, research‐based education, independent learning and the ever popular yet rarely defined ‘critical thinking’. Faculties are pressed to demonstrate their progress in the internationalisation of their curriculum, and the trend is fast growing that sees western institutions opening branch campuses abroad, and developing their international network and partnerships

Are plant species able to keep pace with the rapidly changing climate?

Future climate change is predicted to advance faster than the postglacial warming. Migration may therefore become a key driver for future development of biodiversity and ecosystem functioning. For 140 European plant species we computed past range shifts since the last glacial maximum and future range shifts for a variety of Intergovernmental Panel on Climate Change (IPCC) scenarios and global circulation models (GCMs). Range shift rates were estimated by means of species distribution modelling (SDM). With process-based seed dispersal models we estimated species-specific migration rates for 27 dispersal modes addressing dispersal by wind (anemochory) for different wind conditions, as well as dispersal by mammals (dispersal on animal's coat – epizoochory and dispersal by animals after feeding and digestion – endozoochory) considering different animal species. Our process-based modelled migration rates generally exceeded the postglacial range shift rates indicating that the process-based models we used are capable of predicting migration rates that are in accordance with realized past migration. For most of the considered species, the modelled migration rates were considerably lower than the expected future climate change induced range shift rates. This implies that most plant species will not entirely be able to follow future climate-change-induced range shifts due to dispersal limitation. Animals with large day- and home-ranges are highly important for achieving high migration rates for many plant species, whereas anemochory is relevant for only few species

Implementing Pasteur's vision for rabies elimination: the evidence base and the needed policy actions

It has been 129 years since Louis Pasteur's experimental protocol saved the life of a child mauled by a rabid dog, despite incomplete understanding of the etiology or mechanisms by which the miracle cure worked (1). The disease has since been well understood, and highly effective vaccines are available, yet Pasteur's vision for ridding the world of rabies has not been realized. Rabies remains a threat to half the world's population and kills more than 69,000 people each year, most of them children (2). We discuss the basis for this neglect and present evidence supporting the feasibility of eliminating canine-mediated rabies and the required policy actions

The Communicative Functions of Yaani on Tanzania Whatsapp Platforms

The word yaani is one of the conjunctions used in Kiswahili. Yaani by its common and dictionary meaning is used to give further explanations to thoughts or ideas and it means ‘that is’. In recent years, the word has obtained an interesting usage in the language both in the spoken and written communication thereby extending its meaning and usage from the dictionary meaning. This paper therefore seeks to widen the discussion on Kiswahili conjunctions with emphasis on yaani both in terms of providing a characterization of the word as well as placing its discourse usages in the appropriate social context. We try to explore the various discourse usages of yaani on Tanzania WhatsApp platforms. The data collection took into considerations one on one chats and communications on group pages among Tanzanians. From our analysis, we observed that yaani is used to express emotions, regret, surprise, emphasis and can be used as an interrogative word among others. In other contexts, it is observed that yaani is used in sentence initial and final positions as opposed to the usual usage as explained in the dictionary. We recommend in this paper that yaani be given a critical look at its current stage of development in the language

Evidence-based guiding principles to build public trust in personal data use in health systems

Objective: Public trust in health systems is pivotal for their effective and efficient functioning. In particular, public trust is essential for personal data use, as demonstrated in debates in many countries, for example, about whether data from COVID-19 contact tracing apps should be pooled or remain on individuals’ smartphones. Low levels of public trust pose a risk not only to health system legitimacy but can also harm population health. Methods: Synthesising our previous qualitative and theoretical research in the English National Health Service which enabled us to conceptualise the nature of public trust in health systems, we present guiding principles designed to rebuild public trust, if lost, and to maintain high levels of public trust in personal data use within the health system, if not. Results: To build public trust, health system actors need to not rush trust building; engage with the public; keep the public safe; offer autonomy to the public; plan for diverse trust relationships; recognise that trust is shaped by both emotion and rational thought; represent the public interest; and work towards realising a net benefit for the health system and the public. Conclusions: Beyond policymakers and government officials, the guiding principles address a wide range of actors within health systems so that they can work collectively to build public trust. The guiding principles can be used to inform policymaking in health and health care and to analyse the performance of different governments to see if those governments that operate in greater conformity with the guiding principles perform better

Testing Similarity Effects with Dyadic Response Surface Analysis

Dyadic similarity effect hypotheses state that the (dis)similarity between dyad members (e.g. the similarity on a personality dimension) is related to a dyadic outcome variable (e.g. the relationship satisfaction of both partners). Typically, these hypotheses have been investigated by using difference scores or other profile similarity indices as predictors of the outcome variables. These approaches, however, have been vigorously criticized for their conceptual and statistical shortcomings. Here, we introduce a statistical method that is based on polynomial regression and addresses most of these shortcomings: dyadic response surface analysis. This model is tailored for similarity effect hypotheses and fully accounts for the dyadic nature of relationship data. Furthermore, we provide a tutorial with an illustrative example and reproducible R and Mplus scripts that should assist substantive researchers in precisely formulating, testing, and interpreting their dyadic similarity effect hypotheses

Flow cytometry analysis of the effect of allopurinol and the dinitroaniline compound (Chloralin) on the viability and proliferation of Leishmania infantum promastigotes

BACKGROUND: Leishmaniasis is a major parasitic disease in the tropical regions. However, Leishmania infantum has recently emerged as a very important cause of opportunistic infections for individuals positive for human immunodeficiency virus (HIV). However, there is a lack of in vitro tests for assessing the effect of anti-parasitic drugs on the viability and proliferation of Leishmania infantum. The aim of this study is to assess the efficacy of anti-parasitic drugs like allopurinol and Chloralin on the viability and proliferation of L. infantum promastigotes by utilizing two complementary flow cytometric approaches after exposure of the promastigotes to various concentrations of the drugs. RESULTS: The density of the cultures in the presence and absence of allopurinol was determined by haemocytometer enumeration. The two flow cytometric approaches used to monitor the drug effect were: (i) a quantitative method to measure cell division using 5-,6-carboxyfluorescein diacetate succinimidyl ester (CFSE) staining and (ii) evaluation of cell viability by dual-staining with the membrane-permeable nuclear stain, SBRY-14 and propidium iodide. It was found that concentrations of allopurinol above 50 μg/ml yielded a clear decrease in the proliferation rate of the promastigotes. However, the viability results showed that about 46.8% of the promastigotes incubated in the presence of 800 μg/ml of allopurinol were still alive after 96 hours. In sharp contrast, more than 90% of promastigotes treated with Chloralin 10 μM (2.7 μg/ml) were dead after 48 hours of treatment. These flow cytometric findings suggest that allopurinol has a leishmaniostatic effect while the dinitroaniline compound (Chloralin) has a leishmaniocidal effect against promastigotes. CONCLUSIONS: The flow cytometric data on proliferation and viability were consistent with results obtained from haemocytometer counts and allowed us to develop a model for assessing in vitro the effects of medicaments like allopurinol and chloralin on L. infantum promastigotes on a cellular level

A systematic review of strategies to increase access to health services among children in low and middle income countries.

BACKGROUND: Universal Health Coverage is widely endorsed as the pivotal goal in global health, however substantial barriers to accessing health services for children in low and middle-income countries (LMIC) exist. Failure to access healthcare is an important contributor to child mortality in these settings. Barriers to access have been widely studied, however effective interventions to overcome barriers and increase access to services for children are less well documented. METHODS: We conducted a systematic review of effectiveness of interventions aimed at increasing access to health services for children aged 5 years and below in LMIC. Four databases (EMBASE, Global Health, MEDLINE, and PSYCINFO) were searched in January 2016. Studies were included if they evaluated interventions that aimed to increase: health care utilisation; immunisation uptake; and compliance with medication or referral. Randomised controlled trials and non-randomised controlled study designs were included in the review. A narrative approach was used to synthesise results. RESULTS: Fifty seven studies were included in the review. Approximately half of studies (49%) were conducted in sub-Saharan Africa. Most studies were randomised controlled trials (n = 44; 77%) with the remaining studies employing non-randomised designs. Very few studies were judged as high quality. Studies evaluated a diverse range of interventions and various outcomes. Supply side interventions included: delivery of services at or closer to home and service level improvements (eg. integration of services). Demand side interventions included: educational programmes, text messages, and financial or other incentives. Interventions that delivered services at or closer to home and text messages were in general associated with a significant improvement in relevant outcomes. A consistent pattern was not noted for the remaining studies. CONCLUSIONS: This review fills a gap in the literature by providing evidence of the range and effectiveness of interventions that can be used to increase access for children aged ≤5 years in LMIC. It highlights some intervention areas that seem to show encouraging trends including text message reminders and delivery of services at or close to home. However, given the methodological limitations found in existing studies, the results of this review must be interpreted with caution. SYSTEMATIC REVIEW REGISTRATION: PROSPERO CRD420160334200