1,973 research outputs found

    Revenue Elasticity of the Main federal Taxes in Mexico

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    An inelastic tax system increases the uncertainty associated with tax revenue collection. This results in continuous short-term adjustments to maintain the stability of tax collection. In this paper, we estimate the revenue elasticity of the principal taxes in Mexico, finding a much greater elasticity than that found in previous studies. A cointegration model between the revenue and taxes is used which satisfies strong exogeneity, providing a basis for congruent and reliable projections. Using this model, the tax revenue projected for 2011 is much lower than the estimates prepared by Mexico’s federal government.Federal taxes, long-term revenue elasticity, cointegration, strong exogeneity, forecasts

    Technical and structural efficiency in Mexican manufacturing: A regional approach

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    This paper applies a stochastic frontier approach to analyze the evolution of technical efficiency in manufacturing as a source of regional growth, taking as a unit of analysis the Mexican states in the period 1988-2008. The main findings of our analysis are threefold. First, technical efficiency was increasing over the analyzed period and acted as a mechanism to reduce the labor productivity gap across states. Second, Mexican regions can increase manufacturing production about one third, on average, using the same amount of inputs which implies ample potential for regional growth. Third, there exists a considerable difference in the level of technological development, measured in terms of structural efficiency, of the north and the central regions with respect to the south that partially explains the labor productivity gap among regions

    Protective effects of Amburoside A, a phenol glucoside from Amburana cearensis, against CCl4-induced hepatotoxicity in rats.

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    The aim of this study was to investigate the possible beneficial effects of amburoside A, AMB [4-(0-b-d-glycopyranosyl) benzyl protocatechoate], against carbon tetrachloride (CCl) toxicity in rats

    Influência da porção extensora do músculo glúteo máximo sobre a inclinação da pelve antes e depois da realização de um protocolo de fadiga

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    INTRODUÇÃO: Há carência na literatura de dados que determinem qual a influência da porção extensora do músculo glúteo máximo na inclinação da pelve no plano sagital e, portanto, na estabilidade lombar. OBJETIVOS: Verificar a influência da porção extensora do músculo glúteo máximo sobre a inclinação da pelve. MÉTODOS: Foram recrutadas 10 voluntárias jovens, saudáveis, com índices de massa corpórea (IMC's) menores que 24,9 kg/m² e com dismetria real de membros inferiores (MMII) inferior a 1 cm. Foram avaliados o IMC, o perímetro pélvico e o comprimento dos MMII e, posteriormente, os graus de inclinação das hemipelves e a assimetria entre elas pela análise de uma fotografia em perfil ortostático usando o SAPO (Software para Avaliação Postural). Em seguida, a porção extensora do músculo glúteo máximo do lado dominante foi induzido à fadiga, após a qual foram determinadas novamente a inclinação das hemipelves e a assimetria entre elas. Testes de Pearson r e teste t de student foram realizados no nível de significância &#945;=0,05. RESULTADOS: Não houve correlação entre as variáveis de confusão e a assimetria dos ângulos das hemipelves. O ângulo da hemipelve apresentou modificação significativa do lado dominante (t=3,760; p=0,004). CONCLUSÕES: A fadiga da porção extensora do músculo glúteo máximo pode gerar um aumento do ângulo de inclinação da pelve homolateral.<br>INTRODUCTION: There is a lack of data in the literature for determining the influences of the extensor portion of the gluteus maximus muscle on pelvic tilting and, thus, on lumbar stability. OBJECTIVES: To assess the influences of the extensor portion of the gluteus maximus muscle on pelvic tilt. METHODS: Ten healthy young subjects were recruited, with a body mass index (BMI) below 24.9 kg/m² and leg length discrepancy below 1 cm. The BMI, pelvic perimeter and lower-limb lengths were assessed and, subsequently, the degrees of hemi-pelvic tilt and asymmetry between them were analyzed using lateral view photographs of the subjects in a standing position, using SAPO (Software for Postural Assessment). Next, fatigue was induced in the extensor portion of the gluteus maximus muscle on the dominant side, and after that the hemi-pelvic tilt and the asymmetry between the hemi-pelvises were reassessed. The Pearson r and Student t tests were conducted at the significance level of &#945;=0.05. RESULTS: There were no significant correlations between the confounding variables and asymmetry of the hemi-pelvic angles. There were significant changes in the hemi-pelvic angle of the dominant side (t=3.760; p=0.004). CONCLUSIONS: Fatigue in the extensor portion of the gluteus maximus muscle can generate increases in the tilt angle of the ipsilateral pelvis

    Influência da porção extensora do músculo glúteo máximo sobre a inclinação da pelve antes e depois da realização de um protocolo de fadiga

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    Introduction: There is a lack of data in the literature for determining the influences of the extensor portion of the gluteus maximus muscle on pelvic tilting and, thus, on lumbar stability. Objectives: To assess the influences of the extensor portion of the gluteus maximus muscle on pelvic tilt. Methods: Ten healthy young subjects were recruited, with a body mass index (BMI) below 24.9 kg/m2 and leg length discrepancy below 1 cm. The BMI, pelvic perimeter and lower-limb lengths were assessed and, subsequently, the degrees of hemi-pelvic tilt and asymmetry between them were analyzed using lateral view photographs of the subjects in a standing position, using SAPO (Software for Postural Assessment). Next, fatigue was induced in the extensor portion of the gluteus maximus muscle on the dominant side, and after that the hemi-pelvic tilt and the asymmetry between the hemi-pelvises were reassessed. The Pearson r and Student t tests were conducted at the significance level of α=0.05. Results: There were no significant correlations between the confounding variables and asymmetry of the hemi-pelvic angles. There were significant changes in the hemi-pelvic angle of the dominant side (t=3.760; p=0.004). Conclusions: Fatigue in the extensor portion of the gluteus maximus muscle can generate increases in the tilt angle of the ipsilateral pelvis.INTRODUÇÃO: Há carência na literatura de dados que determinem qual a influência da porção extensora do músculo glúteo máximo na inclinação da pelve no plano sagital e, portanto, na estabilidade lombar. OBJETIVOS: Verificar a influência da porção extensora do músculo glúteo máximo sobre a inclinação da pelve. MÉTODOS: Foram recrutadas 10 voluntárias jovens, saudáveis, com índices de massa corpórea (IMC's) menores que 24,9 kg/m2 e com dismetria real de membros inferiores (MMII) inferior a 1 cm. Foram avaliados o IMC, o perímetro pélvico e o comprimento dos MMII e, posteriormente, os graus de inclinação das hemipelves e a assimetria entre elas pela análise de uma fotografia em perfil ortostático usando o SAPO (Software para Avaliação Postural). Em seguida, a porção extensora do músculo glúteo máximo do lado dominante foi induzido à fadiga, após a qual foram determinadas novamente a inclinação das hemipelves e a assimetria entre elas. Testes de Pearson r e teste t de student foram realizados no nível de significância α=0,05. RESULTADOS: Não houve correlação entre as variáveis de confusão e a assimetria dos ângulos das hemipelves. O ângulo da hemipelve apresentou modificação significativa do lado dominante (t=3,760; p=0,004). CONCLUSÕES: A fadiga da porção extensora do músculo glúteo máximo pode gerar um aumento do ângulo de inclinação da pelve homolateral

    Characterizing late Quaternary lake-level variability in Lago de Tota, Colombian Andes, with CHIRP seismic stratigraphy

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    Geophysical analysis of lacustrine sediment stratigraphy at Lago de Tota (Tota), Boyaca, Colombia provided evidence for significant lake-level fluctuations through the late Quaternary and produced a record that potentially spans the last 60 ka. CHIRP data collected in 2015 from this large, high-elevation lake in the Eastern Cordillera of the northern hemisphere Colombian Andes reveal a series of off-lap and on-lap sequences in the upper ~ 20 m of the lake’s sediment column that indicate large amplitude changes in lake level. Because 14C dated sediment cores are only available for the upper 3 m of the sediment column, known Holocene sedimentation rates were extrapolated in order to assign preliminary ages to the off-lap and on-lap sequence boundaries below 3 m depth. These data suggest that lake levels at Tota were lower than present during marine isotope stage (MIS) 4 between 60 and 57 ka, relatively high during MIS 3 between 57 and 29 ka, fell to their lowest levels during MIS 2 between 29 and 14 ka, and gradually rose to the modern high stand through a series of transgressions during MIS 1 and the Holocene from ~ 14 ka to the present. These fluctuations are broadly consistent with trends observed in other lake-level reconstructions from the northern (in phase) and southern (out of phase) hemisphere Andes, possibly supporting the idea that millennial-to-orbital-scale South American hydroclimate variability is linked to shifts in the mean latitude of the intertropical convergence zone due to the influence of insolation- and ocean circulation-driven hemispheric temperature gradients during glacial/stadial and interglacial/interstadial events. Although additional geochronological data will be needed to better resolve the timing of the Tota lake-level changes and their relationships with other records, these preliminary results from Tota, as well as the presence of a thick (> 300 m) sedimentary archive, indicate that this site has significant potential to produce high-resolution, quantitative, paleo-hydroclimate data spanning much of the last 1 million years. Because geophysical surveys and long paleoclimate records from northern hemisphere South America are exceedingly rare, these data provide critical insight into regional hydroclimate trends through the Late Quaternary. Additional work, such as the collection of sediment cores spanning the depth interval represented in the CHIRP data, is required, however, in order to place firmer chronological constraints on the hypothesized timing of lake-level fluctuations at Tota and to investigate their paleo-hydroclimatic implications

    Super-Enhancer-Associated LncRNA UCA1 Interacts Directly with AMOT to Activate YAP Target Genes in Epithelial Ovarian Cancer

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    Long noncoding RNAs (lncRNAs) have emerged as critical regulators of tumorigenesis, and yet their mechanistic roles remain challenging to characterize. Here, we integrate functional proteomics with lncRNA-interactome profiling to characterize Urothelial Cancer Associated 1 (UCA1), a candidate driver of ovarian cancer development. Reverse phase protein array (RPPA) analysis indicates that UCA1 activates transcription coactivator YAP and its target genes. In vivo RNA antisense purification (iRAP) of UCA1 interacting proteins identified angiomotin (AMOT), a known YAP regulator, as a direct binding partner. Loss-of-function experiments show that AMOT mediates YAP activation by UCA1, as UCA1 enhances the AMOT-YAP interaction to promote YAP dephosphorylation and nuclear translocation. Together, we characterize UCA1 as a lncRNA regulator of Hippo-YAP signaling and highlight the UCA1-AMOT-YAP signaling axis in ovarian cancer development

    Late Quaternary hydroclimate variability in the Colombian Andes and the potential for deep sediment core recovery at Lago de Tota revealed through CHIRP and airgun-sourced seismic reflection data

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    A geophysical investigation of lacustrine stratigraphy at Lago de Tota (Tota), Boyaca, Colombia provides evidence for significant lake level fluctuations during the late Quaternary from ~60 ka to the present. CHIRP data collected in 2015 from this large, high-elevation lake in the Eastern Cordillera of the Northern Hemisphere (NH) Colombian Andes reveal a series of off-lap and on-lap sequences in the upper ~20 m of the lake’s sediment column that indicate large amplitude changes in lake level. These data, temporally constrained by 14C-dated sediment cores and extrapolated Holocene sedimentation rates, suggest that lake levels at Tota were lower than present during Marine Isotope Stage (MIS) 4 between 60 and 57 ka, relatively high during MIS 3 between 57 and 29 ka, fell to their lowest levels during MIS 2 between 29 and 14 ka, and gradually rose to the modern high-stand through a series of transgressions during MIS 1 and the Holocene from ~14 ka to the present. These fluctuations are broadly consistent with trends observed in other lake level reconstructions from the Northern (in phase) and Southern (out of phase) Hemisphere Andes, possibly supporting the idea that millennial-to-orbital-scale South American hydroclimate variability is linked to shifts in the mean latitude of the Intertropical Convergence Zone (ITCZ) due to the influence of insolation- and ocean circulation-driven hemispheric temperature gradients during glacial/stadial and interglacial/interstadial events. These results, as well as the presence of a thick (>300 m) sedimentary archive, indicate that Tota has significant potential to produce high-resolution, quantitative, paleo- hydroclimate data spanning much of the last 1 million years. Because geophysical surveys and long paleoclimate records from NH South America are exceedingly rare, these data provide critical insight into regional hydroclimate trends through the Late Quaternary
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