2-n-Butyl-1,2-benzisothia­zol-3(2H)-one 1,1-dioxide

The crystal packing of the title compound, C11H13NO3S, exhibits weak inter­molecular C—H⋯O hydrogen bonding, which links mol­ecules related by translation along the b axis into chains, and π–π inter­actions [centroid–centroid distance of 3.778 (2) Å between benzene rings]

H-bond competition experiments in solution and the solid state

The H-bonding outcomes in crystal structures of simple molecules, where two potential H-bonds can be formed, have been used to calculate relative H-bond probabilities for 59 combinations of Hbond donors and H-bond acceptors. H-bond probabilities are shown to correlate well with the difference in solution phase free energy between the two competing H-bonds.We acknowledge the financial support from the EPSRC through a CASE award scheme in collaboration with the Cambridge Crystallographic Data Centre.This is the author accepted manuscript. The final version is available from RSC via http://dx.doi.org/10.1039/C5CE02223

Impact of Mixed Solvent on Co-Crystal Solubility, Ternary Phase Diagram, and Crystallization Scale Up

This contribution covers the identification, understanding, and rationale of the interplay between the choice of mixed solvent on the crystallization of the co-crystal system benzoic acid and isonicotinamide (BZ:INA). A critical first step was gauging the impact of solvent choice and composition on the overall crystallization process, across a number of temperature points. This required defining the solubility and phase diagrams of the co-crystal system at specified temperatures, which reflects the cooling by crystallization profile encountered in a batch crystallization step. To this end, identifying and understanding the impact of solvent composition over a selected temperature range on the solubility of co-crystal underpins this contribution

Efecto del uso de antibióticos para la prevención del parto pretérmino en gestantes con diagnóstico de “barro” en líquido amniótico: Revisión sistemática y metaanálisis

Introducción: El parto pretérmino, definido como el nacimiento del producto antes de las 37 semanas de gestación[1] y con un límite inferior mayor a 22 semanas[2], se produce en aproximadamente 15 millones de embarazos cada año[3] por lo que es considerado una morbilidad importante. el hallazgo de “barro” en líquido amniótico ha sido relacionado con una mayor incidencia de parto pretérmino[4,5]. Debido a su posible origen infeccioso se han realizado estudios en su mayoría de tipo cohorte retrospectiva en los cuales se evalúa la efectividad del uso de antibióticos en este tipo de pacientes siendo los resultados no concluyentes. Objetivo: Evaluar la efectividad del uso de antibióticos para la prevención de parto pretérmino en pacientes con diagnóstico de “barro” en líquido amniótico. Métodos: Se realizó la búsqueda sistemática en 5 bases de datos con la finalidad de identificar estudios con diseño de cohorte, así como casos y controles que evalúen la efectividad del uso de antibióticos en pacientes con diagnóstico de “barro” en líquido amniótico, con un grupo control adecuado y cuyo desenlace reportado sea parto pretérmino o rotura prematura de membranas. La selección de estudios y la extracción de datos fue realizada por 2 investigadores de manera independiente. El análisis se realizó a través del cálculo de proporciones de incidencia y odds ratio con intervalos de confianza al 95% utilizando el paquete estadístico STATA. Resultados: Fueron incluidos 4 estudios, 3 de tipo cohorte retrospectiva y 1 de tipo casos y controles. Se encontró que el uso de antibióticos aparentemente no muestra una efectividad en la prevención del parto pretérmino antes de las 37 ni de las 34 semanas de edad gestacional, este resultado fue estadísticamente no significativo (OR=1.09, IC 95% = 0.73 a 1.61, p = 0.131), todos los resultados tuvieron una baja certeza de evidencia. Conclusiones: No se puede concluir que el uso de antibióticos en gestantes con diagnóstico de “barro” en líquido amniótico prevenga la ocurrencia de partos pretérmino. Los datos para ruptura prematura de membranas pretérmino fueron insuficientes

Project Prometheus: Design and Analysis of a Modular Aerostructure for a Small Launch Vehicle

Project Prometheus is a sub-team of the Alabama Rocket Engineering System (ARES) project, which has been in development for about four years. This system is a bi-propellant pressure-fed rocket meant to prove new technology and launch to about 30,000 ft. Project Prometheus is the structural and integration sub-team of Project ARES. The team has worked since August 2020, moving from concept, through preliminary and critical design, and then onto analysis and testing validation and manufacturing. This paper walks through the main requirements, design decisions with rationale, analysis proving the validity of the design, and highlights the important features and the transferability of the concept to other small launch vehicle applications

Open questions in organic crystal polymorphism

From Springer Nature via Jisc Publications RouterHistory: received 2020-09-17, accepted 2020-09-25, registration 2020-09-30, pub-electronic 2020-10-19, online 2020-10-19, collection 2020-12Publication status: PublishedFunder: The Royal Society, Industry Fellowship in AstraZenecaPolymorphs, crystals with different structure and properties but the same molecular composition, arise from the subtle interplay between thermodynamics and kinetics during crystallisation. In this opinion piece, the authors review the latest developments in the field of polymorphism and discuss standing open questions

(2R)-2-(1,3-Dioxoisoindolin-2-yl)-4-(methyl­sulfan­yl)butanoic acid

The title compound, C13H13NO4S, the 1,3-dioxoisoindolin-2-yl unit is planar (r.m.s. deviation 0.0192 Å) and is oriented at a dihedral angle of 79.14 (18)° to the carboxyl­ate group. An intra­molecular C—H⋯O hydrogen bond leads to the formation of a planar (r.m.s. deviation 0.0419 Å)R(5) ring motif. In the crystal, mol­ecules are connected through O—H⋯O and C—H⋯O hydrogen bonds with R 2 2(9) ring motifs into chains extending along the b axis

Factors associated with producing a scientific publication during medical training: evidence from a cross-sectional study of 40 medical schools in Latin America [version 2; peer review: 2 approved]

"Background: Scientific publication during medical training is key to promoting enduring cutting-edge knowledge. The promotion of science among medical students in Latin America is a multisectoral issue that is hampered by the lack of governmental knowledge to invest in national research, as well as by the lack of support from local universities. This study aims to determine the factors associated with the production of a scientific publication during medical training among Latin American medical students of local scientific societies. Methods: This is a secondary data analysis of a cross-sectional study conducted in 2016 that assessed the use of information and communication technologies (ICTs) among medical students from 40 local scientific societies of medical students affiliated with FELSOCEM. Teams from each local scientific society surveyed self-reported scientific publications and explored their association with socioeconomic, academic, and research training conditions. We applied nested models to identify the covariates associated with selfreported scientific publication, obtaining a parsimonious mixedeffects multilevel model grouped by medical scientific society. Results: Of 11,587 participants, the prevalence of scientific publications increased in 36% among medical students affiliated to a Scientific Society of Medical Students [parsimonious prevalence ratio (pPR)=1.36, 95%CI=1.16–1.59], 51% among medical students with advanced English proficiency [pPR=1.51, 95%CI=1.21 – 1.87], 85% among medical students who attended a scientific writing skills course [pPR=1.85, 95%CI=1.59–2.15], 81% among medical students who use Sci-Hub [pPR=1.81, 95%CI=1.50–2.20], and 108% among medical students who have access to a pirated academic account [pPR=2.08, 95%CI=1.83–2.36]. Conclusions: Producing a scientific publication among medical students is associated with being affiliated to a scientific society of medical students, English proficiency, training in scientific writing, use of Sci-Hub, and pirated academic accounts. The results will help clinical educators and medical programs improve resources for training students in high-quality research

Factores asociados al ingreso económico, carga laboral y clima laboral en un grupo de médicos generales jóvenes en Perú

Objetivo: Evaluar los factores asociados al ingreso económico, carga laboral y clima laboral en un grupo de médicos generales jóvenes de Perú. Materiales y métodos: Estudio transversal analítico en médicos generales que asistieron a un evento del Colegio Médico del Perú. Durante dicho evento, se realizó una encuesta para recoger las características de sus dos últimos empleos. Para evaluar las asociaciones de interés se calcularon odds ratios crudos y ajustados (ORa) usando modelos de regresión logística de efectos mixtos. Resultados: Se analizaron 332 empleos reportados por 221 médicos. El ingreso económico bajo (S/ 16,00 por hora o menos) fue menos frecuente para empleos en el Ministerio de Salud – MINSA (ORa: 0,38) o en el seguro social – EsSalud (ORa: 0,09) en comparación con el sector privado, pero más frecuente en mujeres (ORa: 1,94), y en quienes realizaban una labor asistencial (ORa: 4,31). El referir mucha carga laboral fue más frecuente en aquellos con ≥ 30 años (ORa: 2,72), y para empleos en el MINSA (ORa: 3,13) o EsSalud (ORa: 7,98) en comparación con el sector privado. El referir un clima laboral inadecuado no presentó factores  asociados. Conclusiones: Los médicos que tuvieron como empleador un establecimiento privado, las mujeres, y quienes realizaron labor asistencial reportaron empleos con menor ingreso económico. Los médicos de mayor edad y quienes tuvieron como empleador al MINSA o a EsSalud reportaron empleos con mayor carga laboral. El reportar un empleo con un clima laboral inadecuado no tuvo factores asociados