Профилактическое и терапевтическое использование пневмококковой вакцины у работающих на промышленном предприятии пациентов с хроническими бронхолегочными заболеваниями

The efficacy of immunization against various pathogens has been proved in a long term practice worldwide. A delayed effect of vaccination with pneumococcal vaccine Pneumo 23 in 243 workers in a large industrial enterprise in Chelyabinsk has been analyzed in the article. One year after the vaccination a second examination was carried out in 102 persons (38 with chronic simple bronchitis (CSB) and 64 with COPD) and 1.5 years after vaccination it was done in 92 persons (59 persons with CSB and 33 with COPD) The efficacy of the vaccination was assessed by the rate, length and severity of exacerbations of chronic respiratory diseases, as well as by clinical symptoms, results of physical examination, lung function parameters, and quality of life. The 1st control group included 33 patients with COPD, the 2nd control group included 57 patients with chronic bronchitis working in the same enterprise. The groups were compatible for age, length of work, duration of the disease and FEV1 . After immunization the exacer bation rate in the vaccinated patients with CSB decreased by 3.6 and 2.5 times within 1 and 1.5 years correspondingly (р < 0.01). The vaccinated patients with COPD demonstrated a 2.4 fold and a 2.2 fold reduction respectively (р < 0.01). The duration of exacerbations in patients with CSB decreased by 1.6 and 1.1 respectively (р < 0.01) and by 1.78 and 1.2 in patients with COPD respectively (р < 0.01). Of vaccinated patients with COPD 39.4 % did not experience any exacerbations during the follow up period compared to 0 % in the control group. The quality of life of the vaccinated patients improved in terms of physical activity, general and psychological health, vitality, reduction of discomfort. The results allow us to recom mend pneumococcal vaccination for wide implementation in high risk industrial workers.Эффективность вакцинации против многих инфекций доказана многолетним мировым опытом. В данной статье анализируются отдаленные (спустя 1,5 года) результаты вакцинации 243 человек, работающих на крупном машиностроительном предприятии г. Челябинска, антипневмококковой вакциной "Пневмо 23". Через год после вакцинации были повторно обследованы 102 человека (38 с хроническим простым бронхитом (ХПБ) и 64 с ХОБЛ), через 1,5 года — 92 человека (59 с ХПБ и 33 с ХОБЛ). Эффективность вакцинации оценивали по частоте, длительности и тяжести обострений ХОБЛ и ХПБ, выраженности клинических симптомов, данным физикального об следования, функции внешнего дыхания, качеству жизни. 1-ю группу контроля составили 33 пациента с ХОБЛ, 2-ю группу контроля 57 больных с хроническим бронхитом, работающих на том же предприятии, сопоставимых по возрасту, стажу работы, длительности за болевания и ОФВ1. Частота обострений у привитых пациентов с ХПБ снизилась через год в 3,6 раза, через 1,5 года — в 2,5 раза (р < 0,01), у привитых больных с ХОБЛ — в 2,4 и 2,2 раза соответственно (р < 0,01). Длительность обострений снизилась в 1,6 и 1,1 раза соответ ственно при ХПБ (р < 0,01) и в 1,78 и 1,2 раза соответственно при ХОБЛ (р < 0,01). Среди привитых пациентов с ХОБЛ 39,4 % не имели обострений за время наблюдения, тогда как в группе контроля таких пациентов не было. После вакцинации улучшилось качество жизни больных с ХОБЛ, в первую очередь физическая активность, общее и психологическое здоровье, жизнеспособность, уменьшились болевые ощущения. Полученные результаты позволяют рекомендовать широкое внедрение пневмококковой вакцинации в группах риска на предприятиях

Fungal Planet description sheets: 1042-1111

Novel species of fungi described in this study include those from various countries as follows: Antarctica, Cladosporium arenosum from marine sediment sand. Argentina, Kosmimatamyces alatophylus (incl. Kosmimatamyces gen. nov.) from soil. Australia, Aspergillus banksianus, Aspergillus kumbius, Aspergillus luteorubrus, Aspergillus malvicolor and Aspergillus nanangensis from soil, Erysiphe medicaginis from leaves of Medicago polymorpha, Hymenotorrendiella communis on leaf litter of Eucalyptus bicostata, Lactifluus albopicri and Lactifluus austropiperatus on soil, Macalpinomyces collinsiae on Eriachne benthamii, Marasmius vagus on soil, Microdochium dawsoniorum from leaves of Sporobolus natalensis, Neopestalotiopsis nebuloides from leaves of Sporobolus elongatus, Pestalotiopsis etonensis from leaves of Sporobolus jacquemontii, Phytophthora personensis from soil associated with dying Grevillea mccutcheonii. Brazil, Aspergillus oxumiae from soil, Calvatia baixaverdensis on soil, Geastrum calycicoriaceum on leaf litter, Greeneria kielmeyerae on leaf spots of Kielmeyera coriacea. Chile, Phytophthora aysenensis on collar rot and stem of Aristotelia chilensis. Croatia, Mollisia gibbospora on fallen branch of Fagus sylvatica. Czech Republic, Neosetophoma hnaniceana from Buxus sempervirens. Ecuador, Exophiala frigidotolerans from soil. Estonia, Elaphomyces bucholtzii in soil. France, Venturia paralias from leaves of Euphorbia paralias. India, Cortinarius balteatoindicus and Cortinarius ulkhagarhiensis on leaf litter. Indonesia, Hymenotorrendiella indonesiana on Eucalyptus urophylla leaf litter. Italy, Penicillium taurinense from indoor chestnut mill. Malaysia, Hemileucoglossum kelabitense on soil, Satchmopsis pini on dead needles of Pinus tecunumanii. Poland, Lecanicillium praecognitum on insects’ frass. Portugal, Neodevriesia aestuarina from saline water. Republic of Korea, Gongronella namwonensis from freshwater. Russia, Candida pellucida from Exomias pellucidus, Heterocephalacria septentrionalis as endophyte from Cladonia rangiferina, Vishniacozyma phoenicis from dates fruit, Volvariella paludosa from swamp. Slovenia, Mallocybe crassivelata on soil. South Africa, Beltraniella podocarpi, Hamatocanthoscypha podocarpi, Coleophoma podocarpi and Nothoseiridium podocarpi (incl. Nothoseiridium gen. nov.) from leaves of Podocarpus latifolius, Gyrothrix encephalarti from leaves of Encephalartos sp., Paraphyton cutaneum from skin of human patient, Phacidiella alsophilae from leaves of Alsophila capensis, and Satchmopsis metrosideri on leaf litter of Metrosideros excelsa. Spain, Cladophialophora cabanerensis from soil, Cortinarius paezii on soil, Cylindrium magnoliae from leaves of Magnolia grandiflora, Trichophoma cylindrospora (incl. Trichophoma gen. nov.) from plant debris, Tuber alcaracense in calcareus soil, Tuber buendiae in calcareus soil. Thailand, Annulohypoxylon spougei on corticated wood, Poaceascoma filiforme from leaves of unknown Poaceae. UK, Dendrostoma luteum on branch lesions of Castanea sativa, Ypsilina buttingtonensis from heartwood of Quercus sp. Ukraine, Myrmecridium phragmiticola from leaves of Phragmites australis. USA, Absidia pararepens from air, Juncomyces californiensis (incl. Juncomyces gen. nov.) from leaves of Juncus effusus, Montagnula cylindrospora from a human skin sample, Muriphila oklahomaensis (incl. Muriphila gen. nov.) on outside wall of alcohol distillery, Neofabraea eucalyptorum from leaves of Eucalyptus macrandra, Diabolocovidia claustri (incl. Diabolocovidia gen. nov.) from leaves of Serenoa repens, Paecilomyces penicilliformis from air, Pseudopezicula betulae from leaves of leaf spots of Populus tremuloides. Vietnam, Diaporthe durionigena on branches of Durio zibethinus and Roridomyces pseudoirritans on rotten wood. Morphological and culture characteristics are supported by DNA barcodes

Fungal Planet description sheets: 1042–1111

Novel species of fungi described in this study include those from various countries as follows: Antarctica, Cladosporium arenosum from marine sediment sand. Argentina, Kosmimatamyces alatophylus (incl. Kosmimatamyces gen. nov.) from soil. Australia, Aspergillus banksianus, Aspergillus kumbius, Aspergillus luteorubrus, Aspergillus malvicolor and Aspergillus nanangensis from soil, Erysiphe medicaginis from leaves of Medicago polymorpha, Hymenotorrendiella communis on leaf litter of Eucalyptus bicostata, Lactifluus albopicri and Lactifluus austropiperatus on soil, Macalpinomyces collinsiae on Eriachne benthamii, Marasmius vagus on soil, Microdochium dawsoniorum from leaves of Sporobolus natalensis, Neopestalotiopsis nebuloides from leaves of Sporobolus elongatus, Pestalotiopsis etonensis from leaves of Sporobolus jacquemontii, Phytophthora personensis from soil associated with dying Grevillea mccutcheonii. Brazil, Aspergillus oxumiae from soil, Calvatia baixaverdensis on soil, Geastrum calycicoriaceum on leaf litter, Greeneria kielmeyerae on leaf spots of Kielmeyera coriacea. Chile, Phytophthora aysenensis on collar rot and stem of Aristotelia chilensis. Croatia, Mollisia gibbospora on fallen branch of Fagus sylvatica. Czech Republic, Neosetophoma hnaniceana from Buxus sempervirens. Ecuador, Exophiala frigidotolerans from soil. Estonia, Elaphomyces bucholtzii in soil. France, Venturia paralias from leaves of Euphorbia paralias. India, Cortinarius balteatoindicus and Cortinarius ulkhagarhiensis on leaf litter. Indonesia, Hymenotorrendiella indonesiana on Eucalyptus urophylla leaf litter. Italy, Penicillium taurinense from indoor chestnut mill. Malaysia, Hemileucoglossum kelabitense on soil, Satchmopsis pini on dead needles of Pinus tecunumanii. Poland, Lecanicillium praecognitum on insects' frass. Portugal, Neodevriesia aestuarina from saline water. Republic of Korea, Gongronella namwonensis from freshwater. Russia, Candida pellucida from Exomias pellucidus, Heterocephalacria septentrionalis as endophyte from Cladonia rangiferina, Vishniacozyma phoenicis from dates fruit, Volvariella paludosa from swamp. Slovenia, Mallocybe crassivelata on soil. South Africa, Beltraniella podocarpi, Hamatocanthoscypha podocarpi, Coleophoma podocarpi and Nothoseiridium podocarpi (incl. Nothoseiridium gen. nov.)from leaves of Podocarpus latifolius, Gyrothrix encephalarti from leaves of Encephalartos sp., Paraphyton cutaneum from skin of human patient, Phacidiella alsophilae from leaves of Alsophila capensis, and Satchmopsis metrosideri on leaf litter of Metrosideros excelsa. Spain, Cladophialophora cabanerensis from soil, Cortinarius paezii on soil, Cylindrium magnoliae from leaves of Magnolia grandiflora, Trichophoma cylindrospora (incl. Trichophoma gen. nov.) from plant debris, Tuber alcaracense in calcareus soil, Tuber buendiae in calcareus soil. Thailand, Annulohypoxylon spougei on corticated wood, Poaceascoma filiforme from leaves of unknown Poaceae. UK, Dendrostoma luteum on branch lesions of Castanea sativa, Ypsilina buttingtonensis from heartwood of Quercus sp. Ukraine, Myrmecridium phragmiticola from leaves of Phragmites australis. USA, Absidia pararepens from air, Juncomyces californiensis (incl. Juncomyces gen. nov.) from leaves of Juncus effusus, Montagnula cylindrospora from a human skin sample, Muriphila oklahomaensis (incl. Muriphila gen. nov.)on outside wall of alcohol distillery, Neofabraea eucalyptorum from leaves of Eucalyptus macrandra, Diabolocovidia claustri (incl. Diabolocovidia gen. nov.)from leaves of Serenoa repens, Paecilomyces penicilliformis from air, Pseudopezicula betulae from leaves of leaf spots of Populus tremuloides. Vietnam, Diaporthe durionigena on branches of Durio zibethinus and Roridomyces pseudoirritans on rotten wood. Morphological and culture characteristics are supported by DNA barcodes

Fungal Planet description sheets: 1042–1111

Novel species of fungi described in this study include those from various countries as follows: Antarctica, Cladosporium arenosum from marine sediment sand. Argentina, Kosmimatamyces alatophylus (incl. Kosmimatamyces gen. nov.) from soil. Australia, Aspergillus banksianus, Aspergillus kumbius, Aspergillus luteorubrus, Aspergillus malvicolor and Aspergillus nanangensis from soil, Erysiphe medicaginis from leaves of Medicago polymorpha, Hymenotorrendiella communis on leaf litter of Eucalyptus bicostata, Lactifluus albopicri and Lactifluus austropiperatus on soil, Macalpinomyces collinsiae on Eriachne benthamii, Marasmius vagus on soil, Microdochium dawsoniorum from leaves of Sporobolus natalensis, Neopestalotiopsis nebuloides from leaves of Sporobolus elongatus, Pestalotiopsis etonensis from leaves of Sporobolus jacquemontii, Phytophthora personensis from soil associated with dying Grevillea mccutcheonii. Brazil, Aspergillus oxumiae from soil, Calvatia baixaverdensis on soil, Geastrum calycicoriaceum on leaf litter, Greeneria kielmeyerae on leaf spots of Kielmeyera coriacea. Chile, Phytophthora aysenensis on collar rot and stem of Aristotelia chilensis. Croatia, Mollisia gibbospora on fallen branch of Fagus sylvatica. Czech Republic, Neosetophoma hnaniceana from Buxus sempervirens. Ecuador, Exophiala frigidotolerans from soil. Estonia, Elaphomyces bucholtzii in soil. France, Venturia paralias from leaves of Euphorbia paralias. India, Cortinarius balteatoindicus and Cortinarius ulkhagarhiensis on leaf litter. Indonesia, Hymenotorrendiella indonesiana on Eucalyptus urophylla leaf litter. Italy, Penicillium taurinense from indoor chestnut mill. Malaysia, Hemileucoglossum kelabitense on soil, Satchmopsis pini on dead needles of Pinus tecunumanii. Poland, Lecanicillium praecognitum on insects' frass. Portugal, Neodevriesia aestuarina from saline water. Republic of Korea, Gongronella namwonensis from freshwater. Russia, Candida pellucida from Exomias pellucidus, Heterocephalacria septentrionalis as endophyte from Cladonia rangiferina, Vishniacozyma phoenicis from dates fruit, Volvariella paludosa from swamp. Slovenia, Mallocybe crassivelata on soil. South Africa, Beltraniella podocarpi, Hamatocanthoscypha podocarpi, Coleophoma podocarpi and Nothoseiridium podocarpi (incl. Nothoseiridium gen. nov.)from leaves of Podocarpus latifolius, Gyrothrix encephalarti from leaves of Encephalartos sp., Paraphyton cutaneum from skin of human patient, Phacidiella alsophilae from leaves of Alsophila capensis, and Satchmopsis metrosideri on leaf litter of Metrosideros excelsa. Spain, Cladophialophora cabanerensis from soil, Cortinarius paezii on soil, Cylindrium magnoliae from leaves of Magnolia grandiflora, Trichophoma cylindrospora (incl. Trichophoma gen. nov.) from plant debris, Tuber alcaracense in calcareus soil, Tuber buendiae in calcareus soil. Thailand, Annulohypoxylon spougei on corticated wood, Poaceascoma filiforme from leaves of unknown Poaceae. UK, Dendrostoma luteum on branch lesions of Castanea sativa, Ypsilina buttingtonensis from heartwood of Quercus sp. Ukraine, Myrmecridium phragmiticola from leaves of Phragmites australis. USA, Absidia pararepens from air, Juncomyces californiensis (incl. Juncomyces gen. nov.) from leaves of Juncus effusus, Montagnula cylindrospora from a human skin sample, Muriphila oklahomaensis (incl. Muriphila gen. nov.)on outside wall of alcohol distillery, Neofabraea eucalyptorum from leaves of Eucalyptus macrandra, Diabolocovidia claustri (incl. Diabolocovidia gen. nov.)from leaves of Serenoa repens, Paecilomyces penicilliformis from air, Pseudopezicula betulae from leaves of leaf spots of Populus tremuloides. Vietnam, Diaporthe durionigena on branches of Durio zibethinus and Roridomyces pseudoirritans on rotten wood. Morphological and culture characteristics are supported by DNA barcodes

навчальний посібник

Законодавче забезпечення правоохоронної діяльності : навч. посіб. / за заг. ред. В. В. Сокуренка. – Харків : Стильна типографія, 2017. – 1164 с. – (до 100-річчя підготовки охоронців правопорядку у Харкові).У навчальному посібнику представлено методичні рекомендації, пропозиції і зауваження до проектів нормативно-правових актів та наукові роз’яснення окремих положень чинного законодавства, розроблені кафедрами факультету № 1 Харківського національного університету внутрішніх справ. Наукові праці, що включено до навчального посібника, безпосередньо стосуються питань удосконалення форм та методів діяльності слідчих і інших підрозділів органів Національної поліції України. Для працівників органів Національної поліції України, науковців, викладачів, ад’юнктів, аспірантів, докторантів, курсантів, студентів та слухачів навчальних закладів юридичного профілю, а також усіх, хто цікавиться питаннями удосконалення діяльності органів Національної поліції України і інших органів правопорядку.The training manual presents methodological recommendations, suggestions and comments on draft normative legal acts and scientific explanations of certain provisions of the current legislation developed by the departments of the faculty No. 1 of the Kharkov National University of Internal Affairs. Scientific works, included in the textbook, directly relate to issues of improving the forms and methods of activity of investigative and other units of the National Police of Ukraine. For employees of the National Police of Ukraine, scientists, teachers, adjuncts, graduate students, doctoral students, cadets, students and students of legal educational institutions, as well as anyone interested in improving the activities of the National Police of Ukraine and other law enforcement agencies.В учебном пособии представлены методические рекомендации, предложения и замечания к проектам нормативно-правовых актов и научные разъяснения отдельных положений действующего законодательства, разработанные кафедрами факультета № 1 Харьковского национального университета внутренних дел. Научные труды, включен в учебного пособия, непосредственно касаются вопросов совершенствования форм и методов деятельности следственных и других подразделений органов Национальной полиции Украины. Для работников органов Национальной полиции Украины, научных работников, преподавателей, адъюнктов, аспирантов, докторантов, курсантов, студентов и слушателей учебных заведений юридического профиля, а также всех, кто интересуется вопросами совершенствования деятельности органов Национальной полиции Украины и других органов правопорядка

The microecological status of candidates for liver transplantation

A method for identifying mixed infections, dysbioses, and inflammatory processes from specific markers (fatty acids, aldehydes, and sterols) by chromatographic mass spectrometry was used to study the microecological status of patients eligible for liver transplantation. Heterogeneous microorganisms (aerobes, anaerobes, actinobacteria, fungi, and viruses) were quantified from molecular markers in an experiment within 3 hours after the samples were sent to the laboratory. The examinees were found to have excessive growth of gram-positive anaerobes (Clostridia, eubacteria), actinobacteria of the genera Streptomyces, Nocardia, and Candida yeasts. Next were staphylococci, streptococci, and gram-negative microorganisms of the group Moraxella/Acinetobacter, Pseudomonas aeruginosa, Helicobacter pylory, and Fusobacterium/Haemophylus. Antibiotics and probiotics were chosen to correct dysbiosis and infection, by taking into account the data available in the literature. The speed and accuracy of the procedure ensure real-time monitoring of a treatment process under control of mass spectrometry

Carotenoids of Traditional Foods from Black Sea Area Countries and their relation with Immune Response

Carotenoids are colourful compounds which provide photoprotection of plants and participate in their photosynthesis. Particularly β-carotene may enhance the human immune response. Some epidemiological studies have suggested an association between carotenoids intake and reduced incidence of some forms of cancer, which might be related with the antioxidant properties of carotenoids, namely by their ability of reducing reactive oxygen species (ROS) damages in cell membranes. Moreover, carotenoids may also influence the activity of redox-sensitive transcription factors and the production of cytokines and prostaglandins. Carotenoids were extracted from Black Sea Area Countries (BSAC) traditional foods with a mixture of hexane/ethanol, 4:3 (v/v). In all samples, a procedure with and without saponification step was applied. Separation and quantification was performed by Ultra High Pressure Liquid Chromatography (UHPLC). Chromatographic separation was performed with a UPLC® BEH guard-column (2.1 x 5 mm, 1.7 µm particle size) and a UPLC® BEH analytical column (2.1 x 50 mm, 1.7 µm particle size). Mobile phases were (A) ultrapure water; (B) acetonitrile/methanol (containing ammonium acetate)/dichloromethane (75:20:5, v/v/v). The flow-rate was 0.5 mL/min. From the 28 analysed traditional foods for carotenoids content, α-carotene was quantified in 7. The highest level was found for rodopian dried beans, followed by vegetable okroshka. β-carotene was quantified in 53.4% of the analysed traditional foods from BSAC. The sample with highest β-carotene content was plums jam followed by kale soup and nettles sour soup. Once more, as it was expected, the group that most contributes for β-carotene intake is the vegetable and vegetables based foods followed by fruit or fruit based foods. Wild plum sauce was the sample that presented the highest β-cryptoxanthin content (63.8 µg/100 g of edible portion). Lycopene was quantified in about 43% of the analysed traditional foods from BSAC. The foods with highest lycopene content were watermelon juice, Ukrainian borsch and sautéed pickled green beans. The analysed traditional foods from BSAC can be considered good sources of bioactive compounds, although it was found a great variability on the content of carotenoids. Due to the putative health benefits of these compounds, the consumption of those with higher content of bioactive compounds should be encouraged and promoted.This project was funded by the European Community’s Seventh Framework Programme (FP7/2007-2013) under grant agreement n.º 227118