Tried it with glasses off too; Sometimes.

I use a small wedge of wood as a tool to pick out food scraps that find themselves lodged between my teeth. I also use a small wedge of wood as a tool to keep a straight door from swinging freely on a crooked house. The small wedge of wood I stuff in between the floor and door as a tool is a controlling apparatus, much like landowners who use fencing to keep people from walking repeatedly through their land and inadvertently creating a path where they shouldn’t. A wooden door stopper will come to adorn a perpendicular-patterned patina across its face

Concert recording 2019-04-07a

[Track 1]. Song to the dark virgin / Florence Price -- [Track 2]. Siete Canciones Populares Españolas I. El Paño Moruno [Track 3]. III. Asturiana [Track 4]. VI. Nana / Manuel de Falla -- [Track 5]. Paysage / Reynaldo Hahn -- [Track 6]. Gloria in D major, RV 589, no. 10. Qui sedes das Dexteram / Antonio Vivaldi -- [Track 7]. Mainacht [Track 8]. O Wüsst\u27 ich doch den Weg zurück. Op. 63. No. 8 / Johannes Brahms -- [Track 9]. Still hurting from The last five years / Jason Robert Brown

Interpretation of hyperchromic nerve cells relative significance of the type of fixative used, of the osmolarity of the cytoplasm and the surrounding fluid in the production of cell shrinkage

No Abstract.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/49986/1/901210110_ftp.pd

Concert recording 2018-04-20a

[Track 1]. Caro mio ben / Giuseppe Giordani -- [Track 2]. Alma del core / Antonio Caldara -- [Track 3]. A little bit in love from Wonderful town / Bernstein -- [Track 4]. Im Abendrot / Franz Schubert -- [Track 5]. Something\u27s coming from West side story / Bernstein -- [Track 6]. Che far senza Euridice from Orfeo e Euridice / Christoph Willibald Gluck -- [Track 7]. What a movie from Trouble in Tahiti / Bernstein -- [Track 8]. Simple song from Mass / Bernstein -- [Track 9]. Round midnight / Thelonius Monk -- [Track 10]. My house from Peter Pan / Bernstein -- [Track 11]. Heaven help my heart from Chess / Andersson & Ulvaeus -- [Track 12]. L\u27heure exquise / Reynaldo Hahn -- [Track 13]. Captain Hook\u27s soliloquy from Peter Pan / Bernstein -- [Track 14]. Two love songs. Extinguish my eyes [Track 15]. When my soul touches yours / Bernstein -- [Track 16]. Go on from Mass / Bernstein -- [Track 17]. Wanderers Nachtlied / Schubert -- [Track 18]. Peter, Peter from Peter Pan / Bernstein -- [Track 19]. L\u27escalve / Édouard Lalo -- [Track 20]. Allerseelen / Richard Strauss -- [Track 21]. Nothing more than this from Candide / Bernstein -- [Track 22]. O del mio dolce ardor / Gluck -- [Track 23]. Governer\u27s serenade from Candide / Bernstein -- [Track 24]. Sogno d\u27or / Giacomo Puccini -- [Track 25]. I understand from On the town / Bernstein -- [Track 26]. Dream with me from Peter Pan / Bernstein -- [Track 27]. Il est doux, il est bon from Herodiade / Jules Massenet -- [Track 28]. Easter from Five mystical songs / Ralph Vaughan Williams -- [Track 29]. One hand, one heart from West side story / Bernstein -- [Track 30]. Porgi amor from Les Nozze di Figaro / Wolfgang Amadeus Mozart -- [Track 31]. Glitter and be gay from Candide / Bernstein

Concert recording 2017-11-06

[Track 1]. Sebben crudele / Antonio Caldara -- [Track 2]. Orpheus with his lute / William Schuman -- [Track 3]. Heaven help my heart -- [Track 4]. Little elegy / John Duke -- [Track 5]. Bel piacere / G.F. Handel -- [Track 6]. I dreamed a dream from Les Miserables / Claude-Michel Schönberg -- [Track 7]. In questa tomba oscura / Ludwig van Beethoven -- [Track 8]. Lasst mich nur auf meinem Sattel gelten! from Freisinn / Robert Shumann -- [Track 9]. Für Musik / Robert Franz -- [Track 10]. Edelweiss from The sound of music / Rodgers & Hammerstein -- [Track 11]. Tu lo sai / Giuseppe Torelli -- [Track 12]. Glück / Max Reger -- [Track 13] Le colibri / Ernest Chausson -- [Track 14] Der Der Schäfer / Hugo Wolf -- [Track 15]. A route to the sky / Jake Heggie -- [Track 16]. Ich liebe dich / Edvard Grieg -- [Track 17]. When it all fall down from Chaplin / Christopher Curtis -- [Track 18]. Voyage a Paris / Francis Poulenc -- [Track 19]. Crucifixion / arr. Hall Johnson -- [Track 20]. Bright is the ring of words / Ralph Vaughan Williams -- [Track 21]. Non t\u27amo piu / Francesco Paolo Tosti -- [Track 22]. Se tu m\u27ami / Alessandro Parisotti -- [Track 23]. I love the way from Something\u27s rotten / Kirkpatrick & Kirkpatrick -- [Track 24]. A madrigal / Herbert Howells -- [Track 25]. El majo discrete / Enrique Granados -- [Track 26]. The roadside fire / Ralph Vaughan Williams -- [Track 27]. Che fiero costume / Giovanni Legrenzi -- [Track 28]. An die Musik / Franz Shubert -- [Track 29]. I will sing new songs of gladness / Anton Dvorak -- [Track 30]. Full fathom five from The tempest / Henry Purcell -- [Track 31]. Nimmerstate Libe / Hugo Wolf -- [Track 32]. Deposuit potentes from Magnificat / Johann Sebastian Bach -- [Track 33]. Vaghissima sembiante / Stefano Donaudy -- [Track 34]. Tormani a vaghegghiar from Alcina / G.F. Handel -- [Track 35]. Nobody knows this little rose / John Duke -- [Track 36]. Let beauty awake / Ralph Vaughan Williams -- [Track 37]. Steal away / arr. Hall Johnson -- [Track 38]. Come paride vezzoso from L\u27elisir d\u27amore / Kirkpatrick & Kirkpatrick -- [Track 39]. Dich, teure Halle from Tannhaüser / Richard Wagner -- [Track 40]. Non t\u27accotare all\u27urna / Giuseppe Verdi -- [Track 41]. Zur Rosenzeit / Edvard Grieg

Concert recording 2017-04-29

[Track 1]. When the children are asleep from Carousel / Richard Rogers & Oscar Hammerstein -- [Track 2]. Quartet from The secret garden / Lucy Simon -- [Track 3]. Agony from Into the woods / Stephen Sondheim -- [Track 4]. Stepsister\u27s lament from Cinderella / Rogers & Hammerstein -- [Track 5]. Only love from The scarlet pimpernel / Frank Wildhorn -- [Track 6]. Schroeder from You\u27re a good man Charlie Brown / Clark Gesner -- [Track 7]. Where in the world from The secret garden [Track 8]. How could I ever know from The secret garden / Lucy Simon -- [Track 9]. Who am I from Peter Pan / Leonard Bernstein -- [Track 10]. Some things are meant to be from Little Women / Jason Howland -- [Track 11]. With you from Ghost / Bruce Joel Rubin -- [Track 12]. When he sees me from Waitress [Track 13]. Never ever getting rid of me from Waitress / Sara Bareilles -- [Track 14]. Sepia life from Grateful / John Bucchino -- [Track 15]. Thank you for the music from Mamma mia / Benny Andersson & Björn Ulvaeus -- [Track 16]. Agony reprise from Into the woods / Stephen Sondheim -- [Track 17]. If I loved you from Carousel / Rodgers & Hammerstein

The Importance of Brain Banks for Molecular Neuropathological Research: The New South Wales Tissue Resource Centre Experience

New developments in molecular neuropathology have evoked increased demands for postmortem human brain tissue. The New South Wales Tissue Resource Centre (TRC) at The University of Sydney has grown from a small tissue collection into one of the leading international brain banking facilities, which operates with best practice and quality control protocols. The focus of this tissue collection is on schizophrenia and allied disorders, alcohol use disorders and controls. This review highlights changes in TRC operational procedures dictated by modern neuroscience, and provides examples of applications of modern molecular techniques to study the neuropathogenesis of many different brain disorders

Thermal modeling of lesion growth with radiofrequency ablation devices

BACKGROUND: Temperature is a frequently used parameter to describe the predicted size of lesions computed by computational models. In many cases, however, temperature correlates poorly with lesion size. Although many studies have been conducted to characterize the relationship between time-temperature exposure of tissue heating to cell damage, to date these relationships have not been employed in a finite element model. METHODS: We present an axisymmetric two-dimensional finite element model that calculates cell damage in tissues and compare lesion sizes using common tissue damage and iso-temperature contour definitions. The model accounts for both temperature-dependent changes in the electrical conductivity of tissue as well as tissue damage-dependent changes in local tissue perfusion. The data is validated using excised porcine liver tissues. RESULTS: The data demonstrate the size of thermal lesions is grossly overestimated when calculated using traditional temperature isocontours of 42°C and 47°C. The computational model results predicted lesion dimensions that were within 5% of the experimental measurements. CONCLUSION: When modeling radiofrequency ablation problems, temperature isotherms may not be representative of actual tissue damage patterns

Dolichol: A Component of the Cellular Antioxidant Machinery

Dolichol, an end product of the mevalonate pathway, has been proposed a biomarker of aging, but its biological role, not to mention its catabolism, has not been fully understood. UV-B radiation was used to induce oxidative stress in isolated rat hepatocytes by the collagenase method. Effects on dolichol, phospholipids-bound polyunsaturated fatty acids (PL PUFA) and known lipid soluble antioxidants [coenzyme Q (CoQ) and α-tocopherol] were studied. The increase in oxidative stress was detected by a probe sensitive to reactive oxygen species (ROS). Peroxidation of lipids was assessed by measuring the release of thiobarbituric acid reactive substances (TBARS). Dolichol, CoQ and α-tocopherol were assessed by high-pressure liquid chromatography (HPLC), PL PUFA by gas-liquid chromatography (GC). UV-B radiation caused an immediate increase in ROS as well as lipid peroxidation and a simultaneous decrease in the levels of dolichol and lipid soluble antioxidants. Decrease in dolichol paralleled changes in CoQ levels and was smaller than that in α-tocopherol. The addition of mevinolin, a competitive inhibitor of the enzyme 3-hydroxy-3-methylglutaryl CoA reductase (HMG-CoAR), magnified the loss of dolichol and was associated with an increase in TBARS production. Changes in PL PUFA were minor. These findings highlight that oxidative stress has very early and similar effects on dolichol and lipid soluble antioxidants. Lower levels of dolichol are associated with enhanced peroxidation of lipids, which suggest that dolichol may have a protective role in the antioxidant machinery of cell membranes and perhaps be a key to understanding some adverse effects of statin therapy

Genomewide association study for onset age in Parkinson disease

<p>Abstract</p> <p>Background</p> <p>Age at onset in Parkinson disease (PD) is a highly heritable quantitative trait for which a significant genetic influence is supported by multiple segregation analyses. Because genes associated with onset age may represent invaluable therapeutic targets to delay the disease, we sought to identify such genetic modifiers using a genomewide association study in familial PD. There have been previous genomewide association studies (GWAS) to identify genes influencing PD susceptibility, but this is the first to identify genes contributing to the variation in onset age.</p> <p>Methods</p> <p>Initial analyses were performed using genotypes generated with the Illumina HumanCNV370Duo array in a sample of 857 unrelated, familial PD cases. Subsequently, a meta-analysis of imputed SNPs was performed combining the familial PD data with that from a previous GWAS of 440 idiopathic PD cases. The SNPs from the meta-analysis with the lowest p-values and consistency in the direction of effect for onset age were then genotyped in a replication sample of 747 idiopathic PD cases from the Parkinson Institute Biobank of Milan, Italy.</p> <p>Results</p> <p>Meta-analysis across the three studies detected consistent association (p < 1 × 10^-5) with five SNPs, none of which reached genomewide significance. On chromosome 11, the SNP with the lowest p-value (rs10767971; p = 5.4 × 10^-7) lies between the genes <it>QSER1 </it>and <it>PRRG4</it>. Near the PARK3 linkage region on chromosome 2p13, association was observed with a SNP (rs7577851; p = 8.7 × 10^-6) which lies in an intron of the <it>AAK1 </it>gene. This gene is closely related to <it>GAK</it>, identified as a possible PD susceptibility gene in the GWAS of the familial PD cases.</p> <p>Conclusion</p> <p>Taken together, these results suggest an influence of genes involved in endocytosis and lysosomal sorting in PD pathogenesis.</p