Magnetism and superconductivity in the t−t′−Jt{-}t^\prime{-}J model

We present a systematic study of the phase diagram of the $t{-}t^\prime{-}J$ model by using the Green's function Monte Carlo (GFMC) technique, implemented within the fixed-node (FN) approximation and a wave function that contains both antiferromagnetic and d-wave pairing. This enables us to study the interplay between these two kinds of order and compare the GFMC results with the ones obtained by the simple variational approach. By using a generalization of the forward-walking technique, we are able to calculate true FN ground-state expectation values of the pair-pair correlation functions. In the case of $t^\prime=0$, there is a large region with a coexistence of superconductivity and antiferromagnetism, that survives up to $\delta_c \sim 0.10$ for $J/t=0.2$ and $\delta_c \sim 0.13$ for $J/t=0.4$. The presence of a finite $t^\prime/t<0$ induces a strong suppression of both magnetic (with $\delta_c \lesssim 0.03$, for $J/t=0.2$ and $t^\prime/t=-0.2$) and pairing correlations. In particular, the latter ones are depressed both in the low-doping regime and around $\delta \sim 0.25$, where strong size effects are present.Comment: 10 pages, 9 figure

Alteration of mesopontine cholinergic function by the lack of KCNQ4 subunit

The pedunculopontine nucleus (PPN), a structure known as a cholinergic member of the reticular activating system (RAS), is source and target of cholinergic neuromodulation and contributes to the regulation of the sleep-wakefulness cycle. The M-current is a voltage-gated potassium current modulated mainly by cholinergic signaling. KCNQ subunits ensemble into ion channels responsible for the M-current. In the central nervous system, KCNQ4 expression is restricted to certain brainstem structures such as the RAS nuclei. Here, we investigated the presence and functional significance of KCNQ4 in the PPN by behavioral studies and the gene and protein expressions and slice electrophysiology using a mouse model lacking KCNQ4 expression. We found that this mouse has alterations in the adaptation to changes in light-darkness cycles, representing the potential role of KCNQ4 in the regulation of the sleep-wakefulness cycle. As cholinergic neurons from the PPN participate in the regulation of this cycle, we investigated whether the cholinergic PPN might also possess functional KCNQ4 subunits. Although the M-current is an electrophysiological hallmark of cholinergic neurons, only a subpopulation of them had KCNQ4-dependent M-current. Interestingly, the absence of the KCNQ4 subunit altered the expression patterns of the other KCNQ subunits in the PPN. We also determined that, in wild-type animals, the cholinergic inputs of the PPN modulated the M-current, and these in turn can modulate the level of synchronization between neighboring PPN neurons. Taken together, the KCNQ4 subunit is present in a subpopulation of PPN cholinergic neurons, and it may contribute to the regulation of the sleep-wakefulness cycle.Fil: Bayasgalan, T.. University of Debrecen; HungríaFil: Stupniki, Sofia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; ArgentinaFil: Kovács, A.. University of Debrecen; HungríaFil: Csemer, A.. University of Debrecen; HungríaFil: Szentesi, P.. University of Debrecen; HungríaFil: Pocsai, K.. University of Debrecen; HungríaFil: Dionisio, Leonardo Raul. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; ArgentinaFil: Spitzmaul, Guillermo Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; ArgentinaFil: Pal, B.. University of Debrecen; Hungrí

Does a short pollard walk transect capture butterfly and bee diversity? A test to inform pollinator monitoring and community science initiatives

1. Widespread declines in insects will threaten ecosystem functioning and services. Nevertheless, a lack of data hinders assessments of population and biodiversity trends for many insect groups and thus effective conservation actions. Implementing cost-effective, unbiased, and accurate monitoring programmes targeting different groups across a larger geographical range has therefore become a key conservation priority. 2. We evaluated a sampling protocol designed for community science initiatives targeting butterflies and bees. Specifically, we tested how well a short (200-m long) version of traditional Pollard walk transects, designed to be accessible for large numbers of community scientists, captures changes in alpha and beta diversity of these two pollinator groups. 3. We used resampling methods to simulate and assess scenarios varying in sampling intensity and frequency. We found that alpha and beta diversity of butterflies and bees were estimated at similar accuracies across different scenarios, which suggests that even short transects can provide useful information on diversity patterns for both taxa. However, common sampling frequencies resulted in low accuracies (e.g. one sample every 10 days finds on average ~50% of the species present at a site). 4. We discuss our results in the context of developing large scale, structured monitoring systems for multiple insect taxa, and how information on biodiversity patterns can inform the expansion of monitoring schemes. We explain why, moving forward, even rapid sampling designs similar to the approach tested here will be useful given a higher potential to involve community scientists, data integration techniques, and the opportunities to sample under-represented habitat type

Addition of tabulated equation of state and neutrino leakage support to IllinoisGRMHD

We have added support for realistic, microphysical, finite-temperature equations of state (EOS) and neutrino physics via a leakage scheme to IllinoisGRMHD, an open-source GRMHD code for dynamical spacetimes in the Einstein Toolkit. These new features are provided by two new, NRPy+-based codes: NRPyEOS, which performs highly efficient EOS table lookups and interpolations, and NRPyLeakage, which implements a new, AMR-capable neutrino leakage scheme in the Einstein Toolkit. We have performed a series of strenuous validation tests that demonstrate the robustness of these new codes, particularly on the Cartesian AMR grids provided by Carpet. Furthermore, we show results from fully dynamical GRMHD simulations of single unmagnetized neutron stars, and magnetized binary neutron star mergers. This new version of IllinoisGRMHD, as well as NRPyEOS and NRPyLeakage, is pedagogically documented in Jupyter notebooks and fully open source. The codes will be proposed for inclusion in an upcoming version of the Einstein Toolkit.Comment: 20 pages, 9 figures. v2 matches PRD versio

Pelvic Trauma: Wses Classification And Guidelines

Complex pelvic injuries are among the most dangerous and deadly trauma related lesions. Different classification systems exist, some are based on the mechanism of injury, some on anatomic patterns and some are focusing on the resulting instability requiring operative fixation. The optimal treatment strategy, however, should keep into consideration the hemodynamic status, the anatomic impairment of pelvic ring function and the associated injuries. The management of pelvic trauma patients aims definitively to restore the homeostasis and the normal physiopathology associated to the mechanical stability of the pelvic ring. Thus the management of pelvic trauma must be multidisciplinary and should be ultimately based on the physiology of the patient and the anatomy of the injury. This paper presents the World Society of Emergency Surgery (WSES) classification of pelvic trauma and the management Guidelines.1

Long-term outcomes of pediatric infections: from traditional infectious diseases to long covid

: There is limited evidence available on the long-term impact of SARS-CoV-2 infection in children. In this article, the authors&nbsp;analyze the&nbsp;recent evidence on pediatric long covid and lessons learnt from a pediatric post-covid unit in Rome, Italy. To gain a better understanding of the concerns raised by parents and physicians in relation to the potential long-term consequences of this novel infection, it is important to recognize that long-term effect&nbsp;of a&nbsp;post-infectious disease is not a new phenomenon

Handing off the outcome of binary neutron star mergers for accurate and long-term post-merger simulations

We perform binary neutron star (BNS) merger simulations in full dynamical general relativity with IllinoisGRMHD, on a Cartesian grid with adaptive-mesh refinement. After the remnant black hole has become nearly stationary, the evolution of the surrounding accretion disk on Cartesian grids over long timescales (1s) is suboptimal, as Cartesian coordinates over-resolve the angular coordinates at large distances, and the accreting plasma flows obliquely across coordinate lines dissipating angular momentum artificially from the disk. To address this, we present the Handoff, a set of computational tools that enables the transfer of general relativistic magnetohydrodynamic (GRMHD) and spacetime data from IllinoisGRMHD to HARM3D, a GRMHD code that specializes in modeling black hole accretion disks in static spacetimes over long timescales, making use of general coordinate systems with spherical topology. We demonstrate that the Handoff allows for a smooth and reliable transition of GRMHD fields and spacetime data, enabling us to efficiently and reliably evolve BNS dynamics well beyond merger. We also discuss future plans, which involve incorporating advanced equations of state and neutrino physics into BNS simulations using the \handoff approach

Broncalt®, class ii medical device, in patients with chronic relapsed upper airways disease: A survey in clinical practice

Chronic respiratory otorhinolaryngological (ORL) diseases may exacerbate. Broncalt® is a class II Medical Device containing: thermal water (Medesano, PR, Italy), hyaluronic acid, and grapefruit seed extract. It could exert a safe and effective anti-inflammatory, washing, and antimicrobial activity. The current survey, conducted in clinical practice of 84 Italian ORL centers, evaluated its safety and efficacy in the treatment of patients with exacerbated chronic upper airways disease. The 459 (254 males, mean age 44.7 years) patients were evaluated at baseline (T0) and after a 2-week treatment (T1), treated or not-treated with Broncalt®. Signs and symptoms severity were measured by visual analogue scale. Broncalt® significantly, quickly, and safely diminished the clinical features in all sub-groups (p&lt;0.001 for all). In conclusion, Broncalt® is a class II Medical Device able to exert a safe, quick, and effective activity in patients with relapsed chronic ORL disorders. (www.actabiomedica.it)

Broncalt®, class II medical device, in patients with acute upper airways disease: A survey in clinical practice

Inflammation is a common pathogenic mechanism involved in many otorhinolaryngological (ORL) disorders. Broncalt® is a class II Medical Device containing: Thermal water (Medesano, PR, Italy), hyaluronic acid, and grapefruit seed extract. It has been reported that it exerted a safe and effective anti-inflammatory, washing, and antimicrobial activity by virtue of these components. Therefore, the aim of the current survey, conducted in clinical practice of 84 Italian ORL centers, was to evaluate its safety and efficacy in the treatment of patients with acute upper airways disease. The 3,533 (1,797 males, mean age 43.5 years) patients were evaluated at baseline (T0) and after a 2-week treatment (T1) with or without Broncalt®. Signs and symptoms severity were measured by visual analogue scale. Broncalt® significantly and safely diminished the clinical features in all sub-groups (p&lt;0.001 for all). Interestingly, Broncalt® significantly induced a faster symptom relief already within 3 days after the start of the treatment. In conclusion, Broncalt® is a class II Medical Device able to exert a safe and effective activity in patients with acute ORL disorders. (www.actabiomedica.it)