Strong lensing in the MareNostrum Universe II: scaling relations and optical depths

The strong lensing events that are observed in compact clusters of galaxies can, both statistically and individually, return important clues about the structural properties of the most massive structures in the Universe. Substantial work is ongoing in order to understand the degree of similarity between the lensing cluster population and the population of clusters as a whole, with members of the former being likely more massive, compact, and substructured than members of the latter. In this work we exploit synthetic clusters extracted from the {\sc MareNostrum Universe} cosmological simulation in order to estimate the correlation between the strong lensing efficiency and other bulk properties of lensing clusters, such as the virial mass and the bolometric X-ray luminosity. We found that a positive correlation exist between all these quantities, with the substantial scatter being smaller for the luminosity-cross section relation. We additionally used the relation between the lensing efficiency and the virial mass in order to construct a synthetic optical depth that agrees well with the true one, while being extremely faster to be evaluated. We finally estimated what fraction of the total giant arc abundance is recovered when galaxy clusters are selected according to their dynamical activity or their X-ray luminosity. Our results show that there is a high probability for high-redshift strong lensing clusters to be substantially far away from dynamical equilibrium, and that $30-40\%$ of the total amount of giant arcs are lost if looking only at very X-ray luminous objects.Comment: 15 pages, 10 figures. Accepted by A&

Cisplatin, 5-fluorouracil and interferon alpha 2b for recurrent or metastatic head and neck cancer.

On the basis of preclinical data suggesting the possibility of maximising the efficacy of 5-fluorouracil and cisplatin by interferon, a pilot clinical trial was initiated in recurrent and/or metastatic head and neck cancer. Thirty-four patients were treated with cisplatin at 100 mg m-2, followed by 5-fluorouracil at 1,000 mg m-2 by continuous infusion for 5 days. Interferon alpha 2b was administered at the dose of 3 million U i.m. daily for 7 days, beginning the day before chemotherapy. Courses were repeated every 3 weeks. Two patients achieved a complete remission, six a partial response, 14 had stable disease and 12 progressed on therapy, for an overall response rate of 23% (95% confidence interval 10-36%). Median survival time was 5 months. Toxicity was severe. Stomatitis, diarrhoea and myelosuppression were the most common side-effects. Because of the poor response rate and the presence of severe toxicity, in our opinion further clinical trials in head and neck cancer should be attempted only after a better definition in preclinical studies of interactions among 5-fluorouracil, cisplatin and interferon

The role of negative maternal affective states and infant temperament in early interactions between infants with cleft lip and their mothers

OBJECTIVES: The study examined the early interaction between mothers and their infants with cleft lip, assessing the role of maternal affective state and expressiveness and differences in infant temperament. METHODS: Mother-infant interactions were assessed in 25 2-month-old infants with cleft lip and 25 age-matched healthy infants. Self-report and behavioral observations were used to assess maternal depressive symptoms and expressions. Mothers rated infant temperament. RESULTS: Infants with cleft lip were less engaged and their mothers showed more difficulty in interaction than control group dyads. Mothers of infants with cleft lip displayed more negative affectivity, but did not report more self-rated depressive symptoms than control group mothers. No group differences were found in infant temperament. CONCLUSIONS: In order to support the mother's experience and facilitate her ongoing parental role, findings highlight the importance of identifying maternal negative affectivity during early interactions, even when they seem have little awareness of their depressive symptoms

Evidence for the Concreteness of Abstract Language: A Meta-Analysis of Neuroimaging Studies

The neural mechanisms subserving the processing of abstract concepts remain largely debated. Even within the embodiment theoretical framework, most authors suggest that abstract concepts are coded in a linguistic propositional format, although they do not completely deny the role of sensorimotor and emotional experiences in coding it. To our knowledge, only one recent proposal puts forward that the processing of concrete and abstract concepts relies on the same mechanisms, with the only difference being in the complexity of the underlying experiences. In this paper, we performed a meta-analysis using the Activation Likelihood Estimates (ALE) method on 33 functional neuroimaging studies that considered activations related to abstract and concrete concepts. The results suggest that (1) concrete and abstract concepts share the recruitment of the temporo-fronto-parietal circuits normally involved in the interactions with the physical world, (2) processing concrete concepts recruits fronto-parietal areas better than abstract concepts, and (3) abstract concepts recruit Broca’s region more strongly than concrete ones. Based on anatomical and physiological evidence, Broca’s region is not only a linguistic region mainly devoted to speech production, but it is endowed with complex motor representations of different biological effectors. Hence, we propose that the stronger recruitment of this region for abstract concepts is expression of the complex sensorimotor experiences underlying it, rather than evidence of a purely linguistic format of its processing

Conceptual Design of Digital Twin for Bio-Methanol Production from Microalgae

In the last decades, microalgae have gained a lot of interest in the energy and chemical industry thanks to their higher biofuel productivity potential rather than other land plants. To better exploit their green nature and renewable power, anaerobic digestion (AD) fits perfectly for the scope. AD is a metabolic process that generates a methane-rich gas, the biogas, which can then be used for clean electricity and chemicals production. High interest has arisen in the field of AD in industrial practice, and a lot of experiments were done to produce biogas from different types of feedstocks. In this manner, microalgae represent a promising opportunity to produce biogas from renewable and self-sustainable organisms. Biogas is mostly used to produce electrical energy and heat through cogeneration cycles or is upgraded to biomethane through the removal of CO2 and impurities, reaching a CH4 purity above 95-97% vol. On the other hand, an interesting perspective of biogas exploitation is its conversion in biofuels such as methanol or dimethyl-ether. This new concept of bio-refining lays the ground for two aspects: The economical valorisation of the biomass with a more valuable product as bio-methanol and the conversion of biogas to biofuel to fix part of the carbon in a chemical molecule, avoiding the re-emission in the atmosphere of CO2. The scope of this work is to present and technically analyse a conceptual design of a circular bio-refinery based on microalgae biomass feedstock with the final output of methanol production. Biogas production from microalgae is modelled with PythonTM (v3.9) while process simulations are computed using state of the art industrial simulation packages like Aspen HYSIS® v11. Interesting factors to analyse are carbon emission, the field of use for functional production, the global process yield and preliminary feasibility analysis

Low Loss MMI Couplers for High Performance MZI Modulators

Optical splitters and combiners which can provide precise splitting with low loss, high thermal stability, large optical bandwidth, high compactness and insensitivity to fabrication tolerances are essential components for high performance MZI based optical modulators. In this paper we theoretically and experimentally investigate the MMI and the reduction in optical loss achievable through the use of linear tapers at the input and output ports. Our data shows that losses can be reduced to below 1dB/MMI without affecting the static extinction when employed in MZIs

Strong lensing in the MareNostrum Universe: biases in the cluster lens population

Strong lensing is one of the most direct probes of the mass distribution in the inner regions of galaxy clusters. It can be used to constrain the density profiles and to measure the mass of the lenses. Moreover, the abundance of strong lensing events can be used to constrain the structure formation and the cosmological parameters through the so-called "arc-statistics" approach. However, several issues related to the usage of strong lensing clusters in cosmological applications are still controversial, leading to the suspect that several biases may affect this very peculiar class of objects. With this study we aim at better understanding the properties of galaxy clusters which can potentially act as strong lenses. We do so by investigating the properties of a large sample of galaxy clusters extracted from the N-body/hydrodynamical simulation MareNostrum Universe. We explore the correlation between the cross section for lensing and many properties of clusters, like the mass, the three-dimensional and projected shapes, their concentrations, the X-ray luminosity and the dynamical activity. We find that the probability of strong alignments between the major axes of the lenses and the line of sight is a growing function of the lensing cross section. In projection, the strong lenses appear rounder within R200, but we find that their cores tend to be more elliptical as the lensing cross section increases. We also find that the cluster concentrations estimated from the projected density profiles tend to be biased high. The X-ray luminosity of strong lensing clusters is higher than that of normal lenses of similar mass and redshift. This is particular significant for the least massive lenses. Finally, we find that the strongest lenses generally exhibit an excess of kinetic energy within the virial radius, indicating that they are more dynamically active than usual clusters.Comment: 22 pages, 18 figures, accepted for publication on A&