What does Hirsch index evolution explain us? A case study: Turkish Journal of Chemistry

The evolution of Turkish Journal of Chemistry (Turk J. Chem) Hirsch index (h-index) over the period 1995-2005 is studied and determined in the case of the self and without self-citations. It is seen that the effect of Hirsch index of Turk J. Chem has a highly positive trend during the last five years. It proves that Turk J. Chem is improving itself both in quantity and quality since h-index reflects peer review, and peer review reflects research quality of a journal.Comment: 5 pages, 3 figure

Women Of The Future: The Performative Personhood Of Elizabeth Robins, Djuna Barnes, And The Baroness Elsa Von Freytag-Loringhoven

The New Woman is the term used to describe the changing social norms around women\u27s involvement in public life during the fin-de-siècle. New Women were bold and brash, educated and independent, and, importantly young; the term encapsulated any particular woman who stepped outside of her mother\u27s Victorian social norms. The New Woman was as much a construct of the time as it was a description. The playwright and suffragette Elizabeth Robins performs new womanhood on the stage, and her play Votes for Women! enacts this struggle between New Women and the older generation. Djuna Barnes started her career as a journalist in New York City, embodying the role of the New Woman in her writing and willingness participate in her own journalism. The Baroness Elsa von Freytag-Loringhoven, Dada performance artist and poet, performed a womanist Dadaism, one largely forgotten today. While none of these women identified themselves as New Women, an outside observer can, not unfairly, apply the term to them. In disparate yet connected ways, they each managed to construct the identity of the New Woman through the ways they performed themselves in public

Adaptive Security Framework in Internet of Things (IoT) for Providing Mobile Cloud Computing

Internet of Things (IoT) has immense potential to change many of our daily activities, routines and behaviors. The pervasive nature of the information sources means that a great amount of data pertaining to possibly every aspect of human activity, both public and private, will be produced, transmitted, collected, stored and processed. Consequently, integrity and confidentiality of transmitted data as well as the authentication of (and trust in) the services that offer the data is crucial. Hence, security is a critical functionality for the IoT. Enormous growth of mobile devices capability, critical automation of industry fields and the widespread of wireless communication cast need for seamless provision of mobile web services in the Internet of Things (IoT) environment. These are enriched by mobile cloud computing. However, it poses a challenge for its reliability, data authentication, power consumption and security issues. There is also a need for auto self-operated sensors for geo-sensing, agriculture, automatic cars, factories, roads, medicals application and more. IoT is still highly not reliable in points of integration between how its devices are connected, that is, there is poor utilization of the existing IP security protocols. In this chapter, we propose a deep penetration method for the IoT connected set of devices, along with the mobile cloud. An architecture and testing framework for providing mobile cloud computing in the IoT that is based on the object security, power utilization, latency measures and packet loss rate is explained. Our solution is based on the use of existing security protocols between clients and the mobile hosts as well as a key management protocol between the individual mobile hosts implementing an out-of-band key exchange that is simple in practice, flexible and secure. We study the performance of this approach by evaluating a prototype implementation of our security framework. This chapter, in a preliminary manner, discusses the threats, hacks, misguided packets and over read sensor message. These packets are then translated by hardware and pushed through the web for later-on action or support. Our testing of a set of sensor-triggered scenario and setup clearly indicates the security threats from wireless connected small LAN environments and the overestimated sensor messages resulting from the initial set of the sensor readings, while we emphasize more on the security level of the web services serving the IoT-connected device. Also, we add a remark on how mobile web services and their enabling devices are by far vulnerable to a 4G hack over the utilization of power pack and a serious battery use power draining issues

Estrogen-Induced Modulation of Innate and Adaptive Immune Function

Host defense against infection and disease relies on the reciprocal communication between the immune and neuroendocrine systems where sex hormones exert negative and positive feedback actions on immune functions. Indeed, sex hormones have been implicated in gender dimorphic immune response and in the potentiation of immune-related disorders. The female hormone estrogen plays a role as an immunomodulator and may exert immunosuppressive and immunostimulatory effects. Though many studies focus on estrogen’s role in immunity within the female reproductive tract and autoimmunity, the modulatory effects of estrogen on vaccine responses are largely unexplored. The insufficient efficacy of some vaccines in certain target populations, as for example the elderly population, is well recognized. Hormones fluctuate throughout an individual’s life, and females in particular undergo several necessary reproductive (pregnancy and menopause) and lifestyle (oral contraceptive use) changes which involve sex hormones. Vaccine efficacy might be influenced by endogenous estrogen levels or by exogenous estrogen administration. Therefore, in the pursuit of improved vaccine efficacy, it is necessary to consider such hormonal factors and their contribution to immune status. We have studied estrogen’s role in modulation of vaccine responses using a mouse ovariectomy model where exogenous estrogen delivery can be controlled. Our studies included two different types of vaccines, a bacterial toxoid formulation and a bacterial secreted protein formulation. Results from these studies indicate that estrogen enhances vaccine-specific antibody production by likely supporting a general TH2 pathway and also modulates expression of genes encoding molecules critical in innate immune signaling and required for development of proper adaptive immune responses and antigen clearance through antibody-mediated mechanisms. The level at which estrogen modulates antibody responses appears to be dependent on the route of vaccine administration. The enhancement of specific humoral responses may involve mechanisms involving TLR2 and antibody Fc receptor expression on macrophages, cells that link innate and adaptive immune responses. Advances in our understanding of the relationship between sex hormones and the immune system may provide new insights into the mechanisms by which hormones act and thus may be exploited to guide the design of future vaccine strategies

Edukasi Nyeri Punggung Bawah Pada Masyarakat Desa Jonggol, Jawa Barat

Nyeri punggung bawah merupakah masalah yang kedua terbanyak pasien datang ke poli rawat jalan dan mengganggu kualitas hidup seseorang. Kebanyakan nyeri  ini disebabkan postur  duduk, berdiri ataupun perilaku lain yang menyebabkan nyeri punggung bawah.  Metode. Penyuluhan ini dilakukan dalam bentuk edukasi, pengisian kuesioner oleh responden dan interview pendek, mengenai  perilaku yang memperberat nyeri punggung bawah yang dilakukan kepada masyarakat yang berkumpul di Puskesma jonggol, Kecamatan Jonggol, Jawa Barat, tanggal 6 Juli 2023. Hasil. Kebanyakan responden belum memahami nyeri punggung bawah dan belum mendapatkan informasi mengenai penyakit ini. Perilaku yang memperberat nyeri punggung bawah banyak dilakukan oleh responden. Kesimpulan. Pengabdian kepada masyarakat ini berguna dalam meningkatkan kegiatan promosi penyakit kepada masyarakat yaitu dengan memberikan edukasi mengenai nyeri punggung bawah dan bagaimana mencegahnya

POTENCY OF DEVELOPMENT GRAPTOPYLLUM AS ONE OF INDONESIAN ORIGINAL HERBS; A BIBLIOMETRIC STUDY

Indonesia is home to thousands of herbal medicine, and one of the species that would gain more popularity is the Graptophyllum species. This indigenous Papua island plant grows as a shrub plant in the garden of many houses. This study aims to map the research available about this species and explore the potential effects of this plant. Methods. The bibliometric study was performed to map the articles. Scopus databases and Vosviewer were used in this study. Results. 53 articles were withdrawn from Scopus databases. Indonesia has the highest number of publications and many Indonesian researchers collaborated with authors from Japan, Switzerland, and Sweden. The keywords were divided into three clusters and most of the composition discussed was flavonoid. The species discussed was the Graptophyllum pictum. Conclusion. As one of the Indonesian herbal medicine, Graptophyllum pictum is more popular in its own country. Hopefully, the development of chemical drugs from Graptophyllum pictum will be in its own country

Role of Distal Regulatory Elements in Cancer Progression and Therapy

Enhancer elements comprise of regions of DNA that are distal to gene promoters with a characteristic capacity to affect and regulate gene transcription. Enhancers are enriched in a highly context-specific manner allowing for intricate control of gene expression. Current studies endeavor to elucidate the mechanisms underlying enhancer activation and function to ultimately exploit their specificity in targeted therapeutics. Due to the reported addiction of cancer to aberrant gene transcription, targeting enhancer elements is a promising therapeutic target in various malignancies. In this project, we conduct a series of studies with the general aim of extending the knowledge about the molecular mechanisms by which enhancers drive aberrant transcription in cancer. We focus on epigenetic modulation to exploit enhancer elements as therapeutic or prognostic targets. In the first study included in our project, we evaluated the importance of the super enhancer subcategory of distal regulatory elements in a breast cancer cell line where estrogen plays an important role in driving gene expression through enhancers. Super enhancers are claimed to be a highly active subgroup of distal regulatory elements that is abundantly enriched with transcription factors, span long stretches of DNA, and exhibit preferential efficacy in driving major transcriptional programs in cancer. We identified super enhancers related to estrogen in this system using the standard algorithm and failed to observe a distinct high efficacy of super enhancers compared to typical enhancers. By varying the settings of this algorithm, we also uncovered biases in enhancer identification that extensively influence the results. On the other hand, we observed that major targets of estrogen activation showed a preference for association with super enhancers and concluded that they may indeed tend to regulate the transcription of master regulators. Accordingly, we concluded that the focused attention given to super enhancers should not lead to disregarding typical enhancers which also play a significant and important role in gene transcription regulation. Consequently, in the second study we reviewed the role of enhancers in pancreatic cancer, a malignancy with exceptionally low survival rates. We focused on the application of epigenetic modulators, such as bromodomain and extraterminal proteins inhibitors and histone deactylase inhibitors, in targeting enhancer elements and speculated about mechanisms underlying the reported synergy between these two inhibitors. Interestingly, we used publicly available data to further study the context-specificity of enhancers. Notably, we observed a tendency where the same oncogenic target gene is activated by different enhancers in various systems due to differential expression of transcription factors. Accordingly, we expanded our studies in pancreatic cancer and uncovered a group of subtype-specific super enhancers that drive the cells into a squamous phenotype which correlates with a particularly poor prognosis. Studying the general activation epigenetic profiles of different pancreatic cancer cell lines identified deltaNp63 as a major driver of the squamous molecular identity in cells and patient-derived xenografts. Moreover, extensive analysis of the role of deltaNp63 in driving a more aggressive phenotype uncovered the implication of super enhancers which are supported by a network of interconnected and differentially expressed transcription factors. This pattern resembles the reports of transcription factor regulatory circuitry driving the pluripotent molecular identity of embryonic stem cells. Identification of the same pattern governing differentiation into specific molecular subtypes in pancreatic cancer opens the door to precision-based medicine approaches targeting this circuitry in this particular subtype. Finally, we further investigated the role of enhancer elements in the context of chemotherapeutic resistance in pancreatic cancer. Interestingly, we observed that pro-inflammatory and migratory programs are activated in paclitaxel-resistant cells via activation of BET-dependent enhancers. Furthermore, we observed that BET inhibition sensitizes resistant and sensitive cells to paclitaxel. Notably, super enhancers that we observed to be enriched in resistant cells were associated with genes that correlate with poor prognosis. This study confirmed the patterns we uncovered in the other studies where enhancers and super enhancers drive aberrant transcription activation in cancer and present a promising target for patient treatment. Altogether, this project resulted in 2 peer-reviewed publications in the journals of Transcription and Epigenomes, one manuscript that has been peer-reviewed and is currently under revision in Proceedings of the National Academy of Sciences of the United States of America (PNAS), and another manuscript in preparation for submission. These publications/manuscripts join the growing body of literature investigating the role of enhancers in malignancy and aim to guide new approaches for precision-based medicine.2019-12-1

AN APPLICATION OF FUZZY LOGIC IN URBAN TRAFFIC INCIDENT DETECTION

Traffic congestion in urban areas is an increasing problem around the world. Traffic incidents (such as accidents) are considered as the major source of traffic congestion. Traffic incidents have negative impacts on traffic flow, air pollution and fuel consumption. As a result, increasing interest in finding new techniques to deal with this issue has been shown. Traffic incident-management systems can decrease the effect of such events and keep roads capacity as close as possible to normal levels. Incident detection system is an important part of any incident management system. This thesis proposes a new approach to incident detection in urban traffic networks using fuzzy logic theory with the objective of reducing traffic delays and increasing road safety. The proposed detection system can be then integrated with a traffic incident management system to reduce traffic congestion related to non-recurrent incident situations. A methodology has been established based on fuzzy logic for detecting incident status in urban areas using detector accumulative count differences. Three fuzzy models were developed and evaluated using simulated data (generated using the commercial software: PTV VISSIM by PTV Group). The fuzzy models can detect incident status on a regular basis (every minute). Performance measures were introduced to capture the capabilities of the suggested models in detecting incidents. The dissertation concludes with a summary of the major findings, recommendations and future research

Correlation of Standard and Cone Penetration Tests: Case Study from Tekirdag (Turkey)

World Multidisciplinary Civil Engineering-Architecture-Urban Planning Symposium (WMCAUS) -- JUN 12-16, 2017 -- Prague, CZECH REPUBLICIn geotechnical engineering, the Standard Penetration Test (SPT-N value) is often used as an in-situ test. The Cone Penetration Test (CPT) is based on design and cone resistance (qc) and is becoming increasingly widespread. However, there is also a need for a SPT-CPT correlation association that can be used in the basic design. In this study, the values of the SPT-CPT tests applied to the ground were compared and tried to generate a certain statistical data. SPT and CPT experiments were performed side by side to determine the soil properties. Formulas have been developed using various statistical methods and correlation coefficients have been established between the data obtained for high-medium-low plastic clay and sand and sandy clayey soils. The obtained data were compared with the studies in the literature