Особливості формування уролітів мешканців Дніпропетровської області

Предмет дослідження – морфологія та склад уролітів. Об'єктом досліджень були уроліти мешканців Дніпропетровської області. Мета роботи - вивчення особливостей формування уролітів мешканців Дніпропетровської області

From imaging to simulation: a framework applied to simulate the blood flow in the carotids

In this work we present a methodology to extract information from medical imaging and use it for hemodynamical simulation in arteries. Based on in-vivo magnetic resonance images (MRI), the velocity of the blood flow has been measured at different positions and times. Also, the anatomy of the vessel has been converted into a volume mesh suitable for numerical modeling. This data has been used to solve computationally the dynamics of the fluid inside the artery in healthy and pathologic cases. As an application, we have developed a computational model within the carotids. The next step in the pipeline will be to extend the simulation to fluidstructure interaction (FSI) to find the parameters in an atherosclerotic plaque that could lead to rupture.Peer Reviewe

From imaging to simulation: a framework applied to simulate the blood flow in the carotids

In this work we present a methodology to extract information from medical imaging and use it for hemodynamical simulation in arteries. Based on in-vivo magnetic resonance images (MRI), the velocity of the blood flow has been measured at different positions and times. Also, the anatomy of the vessel has been converted into a volume mesh suitable for numerical modeling. This data has been used to solve computationally the dynamics of the fluid inside the artery in healthy and pathologic cases. As an application, we have developed a computational model within the carotids. The next step in the pipeline will be to extend the simulation to fluidstructure interaction (FSI) to find the parameters in an atherosclerotic plaque that could lead to rupture.Peer Reviewe

Variations in atherosclerosis and remodeling patterns in aorta and carotids

Atherosclerosis is a progressive disease that causes vascular remodeling that can be positive or negative. The evolution of arterial wall thickening and changes in lumen size under current "standard of care" in different arterial beds is unclear. The purpose of this study was to examine arterial remodeling and progression/regression of atherosclerosis in aorta and carotid arteries of individuals at risk for atherosclerosis normalized over a 1-year period. In this study, 28 patients underwent at least 2 black-blood in vivo cardiovascular magnetic resonance (CMR) scans of aorta and carotids over a one-year period (Mean 17.8 ± 7.5 months). Clinical risk profiles for atherosclerosis and medications were documented and patients were followed by their referring physicians under current "standard of care" guidelines. Carotid and aortic wall lumen areas were matched across the time-points from cross-sectional images. The wall area increased by 8.67%, 10.64%, and 13.24% per year (carotid artery, thoracic aorta and abdominal aorta respectively, p < 0.001). The lumen area of the abdominal aorta increased by 4.97% per year (p = 0.002), but the carotid artery and thoracic aorta lumen areas did not change significantly. The use of statin therapy did not change the rate of increase of wall area of carotid artery, thoracic and abdominal aorta, but decreased the rate of change of lumen area of carotid artery (-3.08 ± 11.34 vs. 0.19 ± 12.91 p < 0.05). Results of this study of multiple vascular beds indicated that different vascular locations exhibited varying progression of atherosclerosis and remodeling as monitored by CMR