84 research outputs found
Forensic dissection of lip print as an investigative tool in a mixed Egyptian population
Background: Identification is a major problem facing forensic practitioners, DNA and finger prints are highly useful but sometimes aren’t easily collected from the crime scene. Lip print could be useful in this field being unique to each individual.Aim: The current study aimed at detecting the frequency and gender relation of lip print pattern in an Egyptian sample.Methodology: Samples were collected on white copy paper, divided into four quadrants then examined with magnifying lens for pattern distribution.Results: The study showed that pattern IV was the most frequently represented pattern in the study sample, pattern I & II were more prevalent in males and females respectively. Prevalent pattern in Cairo and Lower Egypt was I while it was IV in Upper Egypt.Conclusion: The lip print pattern can differ due to gender and geographical origin in Egyptian subjects.Keywords: Lip print, Egypt, Gender, Geographical distribution, Identification, Anthropology. Gender differenc
Synthesis, structure characterization and biological evaluation of new 6,8-dichloro-2-methyl-4H-chromen-4-one derivatives
The typical active methyl functionality of 6,8-dichloro-2-methyl-4H-chromen-4-one is utilized to obtain 2-styrylchromones, pyruvate ester and phthalide via reactions with aromatic carboxaldehydes, diethyl oxalate and phthalic anhydride respectively. The phthalide provides illustrative example to convert a heterocyclic compound to an aliphatic one via the effect of alcoholic sodium methoxide. Bromination and cycloaddition reactions of 2-styrylchromones afford vicinal dibromide and adducts respectively. This work presents to the art a typical example of heterocyclic systems transformations through the conversion of the starting chromone to coumarin under the influence of thionyl chloride followed by aqueous potassium hydroxide. Some heterocyclic systems like pyrazole, isoxazol and quinolinone are obtained from the target chromone by treatment with hydrazines, hydroxylamine hydrochloride and ammonium acetate respectively. Thiation of starting chromone interestingly affords a dithiated product instead of the expected monothiated one. Antibacterial and antifungal activities of some synthesized compounds have been screened
Assessment of the Quality of Life, Prevalence of Depression, and the Level of Interleukin 6 in Patients with Pemphigus Vulgaris
Pemphigus vulgaris (PV) is a life-threatening, autoimmune blistering
disease affecting the skin and mucous membranes, exerting a detrimental
effect on the quality of life (QOL). Our aim was to evaluate the psychological
status and QOL of patients with PV and investigate Interleukin-6 (IL-6) as a possible
contributor to the pathogenesis of pemphigus and associated depression.
The study included 22 patients with PV, 21 patients with depression, and 20
normal controls. All the 63 participants were subjected to assessment of their
QOL, psychiatric profile, as well as estimation of serum level of IL-6. All (100%) of
the included patients with PV had a negative effect on their QOL, which was significant
compared with controls (P<0.001). Among patients with PV, 13 patients
(59.1%) had depression. IL-6 was non-significantly elevated in the pemphigus
group when compared with the controls (P=0.057). QOL was significantly worse
in the depressed pemphigus subgroup compared with the non-depressed pemphigus
subgroup (P=0.006 and <0.001) respectively. However, IL-6 was non-significantly
elevated in the depressed pemphigus subgroup compared with the
non-depressed pemphigus subgroup (P=0.095). A marked deterioration in the
QOL was observed in patients with pemphigus. More than 50%, but not all, of
patients with pemphigus had depression. IL-6 was non-significantly elevated in
patients with pemphigu
Assessment of the Quality of Life, Prevalence of Depression, and the Level of Interleukin 6 in Patients with Pemphigus Vulgaris
Pemphigus vulgaris (PV) is a life-threatening, autoimmune blistering disease affecting the skin and mucous membranes, exerting a detrimental
effect on the quality of life (QOL). Our aim was to evaluate the psychological
status and QOL of patients with PV and investigate Interleukin-6 (IL-6) as a possible contributor to the pathogenesis of pemphigus and associated depression.
The study included 22 patients with PV, 21 patients with depression, and 20
normal controls. All the 63 participants were subjected to assessment of their
QOL, psychiatric profile, as well as estimation of serum level of IL-6. All (100%) of
the included patients with PV had a negative effect on their QOL, which was significant compared with controls (P<0.001). Among patients with PV, 13 patients
(59.1%) had depression. IL-6 was non-significantly elevated in the pemphigus
group when compared with the controls (P=0.057). QOL was significantly worse
in the depressed pemphigus subgroup compared with the non-depressed pemphigus subgroup (P=0.006 and <0.001) respectively. However, IL-6 was non-significantly elevated in the depressed pemphigus subgroup compared with the
non-depressed pemphigus subgroup (P=0.095). A marked deterioration in the
QOL was observed in patients with pemphigus. More than 50%, but not all, of
patients with pemphigus had depression. IL-6 was non-significantly elevated in
patients with pemphigus
Facile synthesis of new fused and non-fused heterocyclic systems from a γ-ketoacid
The chemical reactivity of 4-(2-tetryl)-4-oxobut-2-enoic acid towards carbon, nitrogen, oxygen, sulfur nucleophiles and binucleophiles namely o-phenylenediamine, o-aminophenol, and o-aminothiophenol has been studied. The investigated nucleophilic reactions result in the formation of heterocyclic compounds with fused and non-fused systems namely, pyridazinone, tetrhydroquinoline, quinoxalone, oxazinone, thiazole and benzocoumarin
Crude Coal Tar and Ultraviolet (UV) A radiation (Modified Goeckerman Technique) in Treatment of Psoriasis
Background: Psoriasis is a chronic inflammatory dermatosis that has a substantial impact on the quality of life. Goeckerman\u27s technique (GT) has been recruited for the treatment of psoriasis with high clearance rates and long periods of remission.Psoriasis is a chronic inflammatory dermatosis that has a substantial impact on the quality of life. Goeckerman’s technique (GT) has been implemented for the treatment of psoriasis with high clearance rates and long periods of remission. The objective of this article was to evaluate the efficacy and safety of modified GT (crude coal tar 2.5% plus UVA) as an alternative therapeutic modality for psoriatic patients with skin types III-V. Twenty two patients with moderate, severe, and erythrodermic psoriasis were included in this study. All patients received modified GT (crude coal tar 2.5% plus UVA) six days per week for a period of 3 months. Assessment of the rate of reduction of psoriasis area severity index (PASI) was performed, as well as photographic documentation of each patient at baseline and after completion of therapy. There was a significant reduction in PASI scores after therapy in all patients (P=0.001). The rate of PASI reduction after therapy was >50% in 63.6% of patients; 27.3% of patients achieved >75% reduction and 9.1% of patients achieved 26-50% reduction. No serious side effects were reported in any of the patients. Modified GT is a safe and effective therapeutic option for patients with moderate and severe psoriasis.</p
Prevalence, genotyping and risk factors of thermophilic Campylobacter spreading in organic turkey farms in Germany
Background The need for organic food of animal origin has increased rapidly in
recent years. However, effects of organic animal husbandry on food safety have
not been rigorously tested especially in meat turkey flocks. This study
provides for the first time an overview on the prevalence and genetic
diversity of Campylobacter species (spp.) in five organic meat turkey farms
located in different regions in Germany, as well as on potential risk factors
of bacterial spreading. Thirty cloacal swabs as well as water samples and
darkling beetles were collected from each flock and examined for the presence
of Campylobacter by conventional and molecular biological methods. The
isolates were genotyped by flaA-RFLP. Results Campylobacter spp. were detected
in cloacal swabs in all 5 turkey flocks with prevalence ranged from 90.0 to
100 %. 13 cloacal swabs collected from birds in farm III and IV were harboured
mixed population of thermophilic campylobacters. In total, from 158
Campylobacter isolated from turkeys 89 (56.33 %) were identified as C. coli
and 69 (43.76 %) as C. jejuni. Three Campylobacter (2 C. jejuni and 1 C. coli)
were detected in drinkers of two farms and 3 C. coli were isolated from
darkling beetles of one farm. No Campylobacter were isolated from main water
tanks. flaA-RFLP assay showed that turkey farms can harbour more than one
genotype. In a single turkey two different genotypes could be detected. The
genotypes of campylobacters isolated from water samples or beetles were
identical with those isolated from turkeys. No effect was found of some
environmental parameters [ammonia concentration (NH3), carbon dioxide
concentration (CO2), relative humidity (RH) and air temperature)] on
Campylobacter prevalence in organic turkey farms. Additionally, drinking water
and darkling beetles might be considered as risk factors for the spreading of
Campylobacter in turkey flocks. Conclusions This study highlights the high
prevalence and genotypic diversity of Campylobacter spp. isolated from organic
turkey flocks. Further research is needed to assess other potential risk
factors responsible for bacteria spreading in order to mitigate the spread of
Campylobacter in organic turkey flocks by improving biosecurity control
measures
Is there a Link between Human Herpes Virus Infection and Toll-like Receptors in the Pathogenesis of Pityriasis Rosea? A Case-control Study
Human herpesvirus (HHV) 6 and 7 are involved in the pathogenesis of pityriasis rosea (PR). Our aim was to evaluate the role of the innate immune response in PR through the detection of Toll-like receptors (TLR) 2, 3, 4, 7, 8, and 9 expression in the skin of affected patients and to detect the possibility of being induced by HHV-6 and/or HHV-7 viral coexistence in these patients. Twenty-four patients with PR and 24 healthy controls were included in this case-control study. Biopsy was obtained from the PR lesion and from the healthy skin of controls for detection of HHV-6 and 7 as well as TLRs 2, 3, 4, 7, 8, and 9 gene expression using real-time polymerase chain reaction (PCR). Significantly elevated expression of all studied TLRs and significantly higher viral load of HHV-6 and 7 in PR cases were detected. A significant higher expression of TLR2 and 4 in HHV-7 positive cases and a significant positive correlation between TLR9 and HHV-7 viral load were documented. HHV6 and 7 may also be involved in the pathogenesis of PR via TLR pathways </p
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