574 research outputs found
Parsimonious Mahalanobis Kernel for the Classification of High Dimensional Data
The classification of high dimensional data with kernel methods is considered
in this article. Exploit- ing the emptiness property of high dimensional
spaces, a kernel based on the Mahalanobis distance is proposed. The computation
of the Mahalanobis distance requires the inversion of a covariance matrix. In
high dimensional spaces, the estimated covariance matrix is ill-conditioned and
its inversion is unstable or impossible. Using a parsimonious statistical
model, namely the High Dimensional Discriminant Analysis model, the specific
signal and noise subspaces are estimated for each considered class making the
inverse of the class specific covariance matrix explicit and stable, leading to
the definition of a parsimonious Mahalanobis kernel. A SVM based framework is
used for selecting the hyperparameters of the parsimonious Mahalanobis kernel
by optimizing the so-called radius-margin bound. Experimental results on three
high dimensional data sets show that the proposed kernel is suitable for
classifying high dimensional data, providing better classification accuracies
than the conventional Gaussian kernel
True density of soot particles: A comparison of results highlighting the influence of the organic contents
International audienc
Secretory phospholipase A2 (sPLA2), procalcitonin (PCT) and C-reactive protein (CRP) for the diagnosis and differentiation of septic shock and non-septic shock
Effects of telmisartan and ramipril on adiponectin and blood pressure in patients with type 2 diabetes
<b>Background:</b>
Adiponectin is secreted by adipose tissue and may play a role in cardiovascular disease. We examined adiponectin levels in patients with type 2 diabetes who participated in the Telmisartan vs. Ramipril in Renal Endothelial Dysfunction (TRENDY) study.
<b>Methods</b>
A total of 87 patients were assessed at baseline and following 9 weeks treatment with the angiotensin-receptor blocker telmisartan (final dose, 80 mg; n = 45) or the angiotensin-converting enzyme inhibitor ramipril (final dose, 10 mg; n = 42). Adiponectin levels were measured in plasma by radioimmunoassay.
<b>Results:</b>
Adiponectin levels were inversely correlated with systolic (SBP; r = -0.240, P < 0.05) and diastolic (DBP; r = -0.227, P < 0.05) blood pressure at baseline and following treatment with telmisartan or ramipril (SBP: r = -0.228, P < 0.05; DBP: r = -0.286, P < 0.05). Changes in adiponectin levels were related to changes in SBP (r = -0.357, P < 0.01) and DBP (r = -0.286, P < 0.01). There was a significant increase in adiponectin levels in the telmisartan (0.68 (95% confidence interval (CI), 0.27 to 1.10) <sup>µ</sup>g/ml, P < 0.01) but not in the ramipril group (0.17 (95% CI, -0.56 to 0.90) <sup>µ</sup>g/ml, P = 0.67). Blood pressure reduction in the telmisartan group (DeltaSBP: -13.5 (95% CI, -17.0 to -10.0) mm Hg; ΔDBP: -7.6 (95% CI, -9.8 to -5.3) mm Hg, each P < 0.001) was significantly (P less than or equal to 0.01 for SBP and P < 0.01 for DBP) greater than in the ramipril group (ΔSBP: -6.1 (95% CI, -6.2 to -2.0) mm Hg; ΔDBP: -2.7 (95% CI, -5.0 to -0.5) mm Hg; P < 0.01 and P < 0.05, respectively).
<b>Conclusion:</b>
Adiponectin is correlated with blood pressure in patients with type 2 diabetes. Whether increased adiponectin contributes to the blood pressure–lowering effect of telmisartan needs further study
The genus Boccardia (Polychaeta: Spionidae) associated with mollusc shells on the south coast of South Africa
Three species of Boccardia (B. polybranchia, B. pseudonatrix and B. proboscidea) were associated with mollusc shells on the south and south-east coasts of South Africa. Boccardia polybranchia was widely distributed along the coast and falls within the known distribution range of this species. Comparisons with material from other, international, locations showed that some specimens have been misidentified. No characters could be found to characterize distinct species for different regions within the range of B. polybranchia, as currently recognized. Boccardia pseudonatrix was found only at the most eastern site, increasing its known distribution range. Boccardia proboscidea, a non-indigenous species, was found only on abalone farms and was most abundant in the west
Annexin 5 as a potential regulator of annexin 1 phosphorylation by protein kinase C. In vitro inhibition compared with quantitative data on annexin distribution in human endothelial cells
Pan-European rural monitoring network shows dominance of NH3 gas and NH4NO3 aerosol in inorganic atmospheric pollution load
A comprehensive European dataset on monthly atmospheric NH3, acid gases (HNO3, SO2, HCl), and aerosols (NH4+, NO3-, SO42-, Cl−, Na+, Ca2+, Mg2+) is presented and analysed. Speciated measurements were made with a low-volume denuder and filter pack method (DEnuder for Long-Term Atmospheric sampling, DELTA®) as part of the EU NitroEurope (NEU) integrated project. Altogether, there were 64 sites in 20 countries (2006–2010), coordinated between seven European laboratories. Bulk wet-deposition measurements were carried out at 16 co-located sites (2008–2010). Inter-comparisons of chemical analysis and DELTA® measurements allowed an assessment of comparability between laboratories.
The form and concentrations of the different gas and aerosol components measured varied between individual sites and grouped sites according to country, European regions, and four main ecosystem types (crops, grassland, forests, and semi-natural). The smallest concentrations (with the exception of SO42- and Na+) were in northern Europe (Scandinavia), with broad elevations of all components across other regions. SO2 concentrations were highest in central and eastern Europe, with larger SO2 emissions, but particulate SO42- concentrations were more homogeneous between regions. Gas-phase NH3 was the most abundant single
measured component at the majority of sites, with the largest variability in concentrations across the network. The largest concentrations of NH3, NH4+ and NO-3 were at cropland sites in intensively managed agricultural areas (e.g. Borgo Cioffi in Italy), and the smallest were at remote semi-natural and forest sites (e.g. Lompolojänkkä, Finland), highlighting the potential for NH3 to drive the formation of both NH4+ and NO3- aerosol. In the aerosol phase, NH4+ was highly correlated with both NO3- and SO42-, with a near-1:1 relationship between the equivalent concentrations of NH4+ and sum(NO3- + SO42-) of which around 60 % was as NH4NO3.
Distinct seasonality was also observed in the data, influenced by changes in emissions, chemical interactions, and the influence of meteorology on partitioning between the
main inorganic gases and aerosol species. Springtime maxima in NH3 were attributed to the main period of manure spreading, while the peak in summer and trough in winter were linked to the influence of temperature and rainfall on emissions, deposition, and gas–aerosol-phase equilibrium. Seasonality in SO2 was mainly driven by emissions (combustion), with concentrations peaking in winter, except
in southern Europe, where the peak occurred in summer.
Particulate SO42− showed large peaks in concentrations in
summer in southern and eastern Europe, contrasting with
much smaller peaks occurring in early spring in other regions. The peaks in particulate SO42- coincided with peaks
in NH3 concentrations, attributed to the formation of the
stable (NH4)2SO4. HNO3 concentrations were more complex, related to traffic and industrial emissions, photochemistry, and HNO3:NH4NO3 partitioning. While HNO3 concentrations were seen to peak in the summer in eastern and southern Europe (increased photochemistry), the absence of a spring peak in HNO3 in all regions may be explained by the depletion of HNO3 through reaction with surplus NH3 to form the semi-volatile aerosol NH4NO3. Cooler, wetter conditions in early spring favour the formation and persistence of NH4NO3 in the aerosol phase, consistent with the higher springtime concentrations of NH4+ and NO3−. The seasonal profile of NO3- was mirrored by NH4+, illustrating the influence of gas–aerosol partitioning of NH4NO3 in the seasonality of these components.
Gas-phase NH3 and aerosol NH4NO3 were the dominant
species in the total inorganic gas and aerosol species measured in the NEU network. With the current and projected
trends in SO2, NOx , and NH3 emissions, concentrations of
NH3 and NH4NO3 can be expected to continue to dominate
the inorganic pollution load over the next decades, especially
NH3, which is linked to substantial exceedances of ecological thresholds across Europe. The shift from (NH4)2SO4 to an atmosphere more abundant in NH4NO3 is expected to maintain a larger fraction of reactive N in the gas phase by partitioning to NH3 and HNO3 in warm weather, while NH4NO3 continues to contribute to exceedances of air quality limits for PM2.5
Beating the random walk: a performance assessment of long-term interest rate forecasts
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